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41 Companies |
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29 Products |
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29 Products |
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22 Mechanisms of Action |
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2 Trials |
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854 News |
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- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion, Combination therapy: RDT-ACT: Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial (clinicaltrials.gov) - Dec 19, 2012
P4, N=3063, Completed, Sponsor: Kintampo Health Research Centre, Ghana
Recruiting --> Completed
- | ganaplacide (KAF156) / Novartis
New P2 trial: Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection (clinicaltrials.gov) - Dec 18, 2012
P2, N=40, Recruiting, Sponsor: Novartis Pharmaceuticals
- artemether/lumefantrine / Generic mfg.
Enrollment open: Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg (clinicaltrials.gov) - Dec 18, 2012
P2/3, N=40, Recruiting, Sponsor: Novartis Pharmaceuticals
Recruiting --> Completed Not yet recruiting --> Recruiting
- New P1 trial: LEISH-F3 + GLA-SE and the LEISH-F3 + MPL-SE Vaccine (clinicaltrials.gov) - Dec 13, 2012
P1, N=48, Active, not recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
- chloroquine phosphate / Generic mfg., primaquine / Generic mfg.
Trial completion: Malaria Challenge in Healthy Volunteers (clinicaltrials.gov) - Dec 10, 2012
P1, N=36, Completed, Sponsor: Seattle Biomedical Research Institute
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- Clinical: CM_CCRT: Computerized Cognitive Rehabilitation in Children After Severe Malaria (clinicaltrials.gov) - Dec 4, 2012
P=N/A, N=300, Recruiting, Sponsor: Makerere University
- Trial completion: Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria (clinicaltrials.gov) - Dec 4, 2012
P=N/A, N=123, Completed, Sponsor: Makerere University
Active, not recruiting --> Completed Recruiting --> Completed
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion: Efficacy and Safety of Artesunate-amodiaquine-methylene for Malaria Treatment in Children (clinicaltrials.gov) - Dec 3, 2012
P2, N=180, Completed, Sponsor: University of Heidelberg
Recruiting --> Completed Not yet recruiting --> Completed
- chloroquine phosphate / Generic mfg.
Enrollment change: Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax (clinicaltrials.gov) - Nov 29, 2012
P2, N=20, Completed, Sponsor: Walter Reed Army Institute of Research (WRAIR)
Not yet recruiting --> Completed N=70 --> 20
- chloroquine phosphate / Generic mfg.
Trial completion: Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax (clinicaltrials.gov) - Nov 29, 2012
P2, N=20, Completed, Sponsor: Walter Reed Army Institute of Research (WRAIR)
N=70 --> 20 Active, not recruiting --> Completed
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial withdrawal: Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010 (clinicaltrials.gov) - Nov 28, 2012
P4, N=0, Withdrawn, Sponsor: Epicentre
Active, not recruiting --> Completed Not yet recruiting --> Withdrawn
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Enrollment change: Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010 (clinicaltrials.gov) - Nov 28, 2012
P4, N=0, Withdrawn, Sponsor: Epicentre
Not yet recruiting --> Withdrawn N=221 --> 0
- New P1/2 trial: A Phase I/IIa Sporozoite Challenge Study to Assess the Efficacy of Candidate Combination Malaria Vaccine Approaches Using the ChAd63 and MVA Vectors Encoding the Antigens ME-TRAP, CS and AMA1 (clinicaltrials.gov) - Nov 28, 2012
P1/2, N=48, Completed, Sponsor: University of Oxford
- Trial completion, Viral vector: A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates (clinicaltrials.gov) - Nov 27, 2012
P1/2, N=30, Completed, Sponsor: University of Oxford
N=221 --> 0 Active, not recruiting --> Completed
- Trial completion: Safety and Immunogenicity of New Malaria Vaccine Candidate ChAd63 CS Administered Alone and With MVA CS (clinicaltrials.gov) - Nov 27, 2012
P1, N=24, Completed, Sponsor: University of Oxford
Active, not recruiting --> Completed Active, not recruiting --> Completed
- gentamicin sulfate / Generic mfg.
Trial suspension: WR 279,396 Open Label Treatment Protocol in Tunisia (clinicaltrials.gov) - Nov 26, 2012
P2, N=120, Suspended, Sponsor: U.S. Army Medical Research and Materiel Command
Active, not recruiting --> Completed Recruiting --> Suspended
- artemether/lumefantrine / Generic mfg.
Enrollment change: REDHOT: Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission (clinicaltrials.gov) - Nov 25, 2012
P=N/A, N=17506, Completed, Sponsor: Radboud University
Recruiting --> Suspended N=9000 --> 17506
- Trial completion: TIP3: Comparison of Three Plasmodium Falciparum Isolates in a Controlled Human Malaria Infection (clinicaltrials.gov) - Nov 25, 2012
P=N/A, N=15, Completed, Sponsor: Radboud University
N=9000 --> 17506 Active, not recruiting --> Completed
- artemether/lumefantrine / Generic mfg.
Trial completion: REDHOT: Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission (clinicaltrials.gov) - Nov 25, 2012
P=N/A, N=17506, Completed, Sponsor: Radboud University
Active, not recruiting --> Completed Recruiting --> Completed
- New P1 trial: A Comparison of the Bioavailability of OZ439 When Delivered Directly to the Small Intestine, or Via the Oral Route (clinicaltrials.gov) - Nov 22, 2012
P1, N=11, Completed, Sponsor: Medicines for Malaria Venture
- Enrollment closed: Genetic Association Mapping of Malaria Resistance in Anopheles Gambiae (clinicaltrials.gov) - Nov 19, 2012
P=N/A, N=20, Active, not recruiting, Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting --> Completed Enrolling by invitation --> Active, not recruiting
- artemether/lumefantrine / Generic mfg.
New P4 trial: Pharmacology of Antimalarial Therapy With or Without Antiretroviral Therapy (clinicaltrials.gov) - Nov 18, 2012
P4, N=48, Recruiting, Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group
- | chloroquine phosphate / Generic mfg.
New P1 trial: Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis (clinicaltrials.gov) - Nov 18, 2012
P1, N=30, Active, not recruiting, Sponsor: Sanaria Inc.
- ||| Enrollment closed: Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse (clinicaltrials.gov) - Nov 14, 2012
P2, N=329, Active, not recruiting, Sponsor: GlaxoSmithKline
Enrolling by invitation --> Active, not recruiting Recruiting --> Active, not recruiting
- Trial completion: EP1300 Polyepitope DNA Vaccine Against Plasmodium Falciparum Malaria (clinicaltrials.gov) - Nov 14, 2012
P1, N=39, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- Adherence: Preserving ACTs - Text Reminders to Increase Adherence to ACT Treatment (clinicaltrials.gov) - Nov 5, 2012
P=N/A, N=1792, Completed, Sponsor: Harvard School of Public Health
- New P2 trial: OZ439 PhIIa Study in Plasmodium Falciparum: Extended Observation (clinicaltrials.gov) - Oct 23, 2012
P2, N=32, Recruiting, Sponsor: Medicines for Malaria Venture
- New P1 trial: A Dose-escalation Study to Investigate Safety and Toleration of OZ439 (clinicaltrials.gov) - Oct 23, 2012
P1, N=34, Completed, Sponsor: Medicines for Malaria Venture
- | Fexinidazole Winthrop (fexinidazole) / Sanofi, Lampit (nifurtimox) / Bayer
Enrollment open, Combination therapy, Head-to-Head: Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 (clinicaltrials.gov) - Oct 21, 2012
P2/3, N=510, Recruiting, Sponsor: Drugs for Neglected Diseases
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Enrollment change: Hyperphenylalaninemia in Cerebral Malaria (clinicaltrials.gov) - Oct 18, 2012
P=N/A, N=285, Completed, Sponsor: University of Utah
Not yet recruiting --> Recruiting N=556 --> 285
- Trial completion: Hyperphenylalaninemia in Cerebral Malaria (clinicaltrials.gov) - Oct 18, 2012
P=N/A, N=285, Completed, Sponsor: University of Utah
N=556 --> 285 Recruiting --> Completed
- || Mefliam Plus (artesunate/mefloquine) / Cipla, Oswaldo Cruz Foundation, DNDi
New P3 trial: P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine (clinicaltrials.gov) - Oct 15, 2012
P3, N=250, Recruiting, Sponsor: Menzies School of Health Research
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Enrollment open: AQUAMOD: ANC & Malaria Diagnostic in Pregnancy (clinicaltrials.gov) - Oct 9, 2012
P4, N=7200, Recruiting, Sponsor: Centre Muraz
Recruiting --> Completed Not yet recruiting --> Recruiting
- Trial completion: ACTUGA2: Role and Effectiveness of Rapid Diagnostic Tests in Home-based Management of Malaria (clinicaltrials.gov) - Oct 9, 2012
P=N/A, N=2000, Completed, Sponsor: DBL -Institute for Health Research and Development
Not yet recruiting --> Recruiting Recruiting --> Completed
- | Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
New P4 trial: AQUAMOD: ANC & Malaria Diagnostic in Pregnancy (clinicaltrials.gov) - Oct 7, 2012
P4, N=7200, Recruiting, Sponsor: Centre Muraz
- | Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial initiation date, Combination therapy: QuinAct: Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria (clinicaltrials.gov) - Oct 2, 2012
P3, N=3600, Active, not recruiting, Sponsor: Universiteit Antwerpen
Recruiting --> Completed Initiation date: Feb 2012 --> May 2012
- | Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
New P4 trial: Amodiaquine-Artesunate & Artemether-Lumefantrine Efficacy in Burkina Faso (clinicaltrials.gov) - Sep 30, 2012
P4, N=150, Active, not recruiting, Sponsor: Centre Muraz
- Trial completion: Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi (clinicaltrials.gov) - Sep 25, 2012
P4, N=365, Completed, Sponsor: Centers for Disease Control and Prevention
Initiation date: Feb 2012 --> May 2012 Active, not recruiting --> Completed
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion: Amodiaquine Plus Artesunate Versus Lapdap Plus Artesunate in the Treatment of Uncomplicated P. Falciparum Malaria in Malawi (clinicaltrials.gov) - Sep 25, 2012
P4, N=212, Completed, Sponsor: Centers for Disease Control and Prevention
Active, not recruiting --> Completed Active, not recruiting --> Completed
- sulfadoxine/pyrimethamine / Generic mfg.
Trial completion: The Effect of Folic Acid on Efficacy of Sulfadoxine-pyrimethamine in Pregnant Women in Western Kenya (clinicaltrials.gov) - Sep 25, 2012
P4, N=600, Completed, Sponsor: Centers for Disease Control and Prevention
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion: Intermittent Preventive Treatment With Antimalarials in Kenyan Infants (clinicaltrials.gov) - Sep 25, 2012
P=N/A, N=1516, Completed, Sponsor: Centers for Disease Control and Prevention
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||| gentamicin sulfate / Generic mfg.
Trial completion: Cosmetic Outcome of Leishmaniasis Scar After WR279396 Application (clinicaltrials.gov) - Sep 23, 2012
P=N/A, N=108, Completed, Sponsor: U.S. Army Medical Research and Materiel Command
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Trial initiation date: Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC (clinicaltrials.gov) - Sep 19, 2012
P3, N=500, Recruiting, Sponsor: Institute of Tropical Medicine, Belgium
Active, not recruiting --> Completed Initiation date: Jun 2012 --> Sep 2012
- | Enrollment open: Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC (clinicaltrials.gov) - Sep 19, 2012
P3, N=500, Recruiting, Sponsor: Institute of Tropical Medicine, Belgium
Initiation date: Jun 2012 --> Sep 2012 Not yet recruiting --> Recruiting
- Enrollment open, Viral vector: Adjuvanting Viral Vectored Malaria Vaccines With Matrix M (clinicaltrials.gov) - Sep 18, 2012
P1, N=22, Recruiting, Sponsor: University of Oxford
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- || Fexinidazole Winthrop (fexinidazole) / Sanofi, Lampit (nifurtimox) / Bayer
New P2/3 trial, Combination therapy, Head-to-Head: Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 (clinicaltrials.gov) - Sep 12, 2012
P2/3, N=510, Recruiting, Sponsor: Drugs for Neglected Diseases
- ||||||| ArTiMist (artemether sublingual) / Arovella Therap, LondonPharma
Trial completion, Head-to-Head: Superiority of ArTiMist Versus Quinine in Children With Severe Malaria (clinicaltrials.gov) - Sep 11, 2012
P3, N=151, Completed, Sponsor: Proto Pharma Ltd
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- chloroquine phosphate / Generic mfg., sulfadoxine/pyrimethamine / Generic mfg., artemether/lumefantrine / Generic mfg.
Enrollment change: Efficacy of Chloroquine + Sulfadoxine Pyrimethamine Versus Artemether + Lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in the Philippines (clinicaltrials.gov) - Sep 9, 2012
P=N/A, N=560, Completed, Sponsor: Centers for Disease Control and Prevention
Active, not recruiting --> Completed N=420 --> 560
- chloroquine phosphate / Generic mfg., sulfadoxine/pyrimethamine / Generic mfg.
Enrollment change, Combination therapy: Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy (clinicaltrials.gov) - Sep 9, 2012
P4, N=1614, Completed, Sponsor: Centers for Disease Control and Prevention
N=420 --> 560 N=452 --> 1614
- sulfadoxine/pyrimethamine / Generic mfg.
Enrollment change, Combination therapy: Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria (clinicaltrials.gov) - Sep 9, 2012
P4, N=390, Completed, Sponsor: Centers for Disease Control and Prevention
N=452 --> 1614 N=2000 --> 390