Osteoarthritis News - LARVOL Sigma

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61 Mechanisms of Action

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|||||||||| Trial termination: Ultrasound (US)-Guided Versus Sham Ultrasound Corticosteroid (CS) Knee Injections (clinicaltrials.gov) - Feb 26, 2012
P=N/A, N=33, Terminated, Sponsor: VA Connecticut Healthcare System
Recruiting --> Terminated

|||||||||| Enrollment change: Ultrasound (US)-Guided Versus Sham Ultrasound Corticosteroid (CS) Knee Injections (clinicaltrials.gov) - Feb 26, 2012
P=N/A, N=33, Terminated, Sponsor: VA Connecticut Healthcare System
Recruiting --> Terminated N=160 --> 33

||||||||||  ropivacaine / Generic mfg.
New P4 trial:  Local Infiltration Versus Block Against Pains After High Tibial Osteotomy (clinicaltrials.gov) -  Feb 21, 2012
P4, N=60, Active, not recruiting,  Sponsor: Northern Orthopaedic Division, Denmark

|||||||||| New P2 trial: Exploring Massage Benefits for Arthritis of the Knee (clinicaltrials.gov) - Feb 21, 2012
P2, N=222, Recruiting, Sponsor: Duke University

|||||||||| New P1 trial: Progressive Rehabilitation Following Total Knee Arthroplasty (clinicaltrials.gov) - Feb 21, 2012
P1, N=162, Recruiting, Sponsor: University of Colorado, Denver

||||||||||  mavatrep (JNJ-39439335) / J&J
Trial completion:  A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-39439335 in Patients With Osteoarthritis (clinicaltrials.gov) -  Feb 19, 2012
P1, N=43, Completed,  Sponsor: Janssen Research & Development, LLC
N=160 --> 33 Active, not recruiting --> Completed

|||||||||| Trial completion: Role of Recombinants in Peach Allergy (clinicaltrials.gov) - Feb 19, 2012
P=N/A, N=148, Completed, Sponsor: Niguarda Hospital
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Safety and Efficacy of MRgFUS for the Treatment of Low Back Pain (clinicaltrials.gov) - Feb 18, 2012
P2, N=50, Completed, Sponsor: InSightec
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: ORTHOVISC Shoulder Osteoarthritis Study (clinicaltrials.gov) - Feb 15, 2012
P3, N=270, Completed, Sponsor: DePuy Mitek
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment change: A Randomized Clinical Study Comparing a Fully-Coated Cementless Stem Versus a Cemented Stem for Total Hip Replacements (clinicaltrials.gov) - Feb 14, 2012
P4, N=48, Completed, Sponsor: Capital District Health Authority, Canada
Active, not recruiting --> Completed N=200 --> 48

|||||||||| Enrollment change: Insomnia and Daytime Function in Osteoarthritis (clinicaltrials.gov) - Feb 14, 2012
P4, N=170, Completed, Sponsor: Sanofi
N=200 --> 48 N=132 --> 170

|||||||||| Trial completion: A Randomized Clinical Study Comparing a Fully-Coated Cementless Stem Versus a Cemented Stem for Total Hip Replacements (clinicaltrials.gov) - Feb 14, 2012
P4, N=48, Completed, Sponsor: Capital District Health Authority, Canada
N=132 --> 170 Recruiting --> Completed

|||||||||| Trial initiation date: A Study to Determine the Performance of the Press Fit Condylar (P.F.C.) Sigma RP-F Knee System (clinicaltrials.gov) - Feb 12, 2012
P4, N=180, Active, not recruiting, Sponsor: DePuy International
Recruiting --> Completed Initiation date: Jan 2001 --> Oct 2004

|||||||||| New P4 trial, HEOR, Cost effectiveness: Spa Therapy in Knee Osteoarthritis: Study on Cost/Effectiveness - Cost/Utility and Possible Mechanisms of Action (clinicaltrials.gov) - Feb 12, 2012
P4, N=100, Active, not recruiting, Sponsor: University of Siena

||||||||||  Shinbaro (GCSB-5) / GC Biopharma, LG Chem
New P3 trial:  Efficacy and Safety of Shinbaro Capsule (clinicaltrials.gov) -  Feb 11, 2012
P3, N=198, Completed,  Sponsor: Green Cross Corporation

|||||||||| New P4 trial: RAPID: Reducing Pain; Preventing Depression (clinicaltrials.gov) - Feb 7, 2012
P4, N=135, Recruiting, Sponsor: University of Pittsburgh

||||||||||  PF-05089771 / Pfizer
New P1 trial:  A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee (clinicaltrials.gov) -  Feb 7, 2012
P1, N=80, Completed,  Sponsor: Pfizer

|||||||||| New P4 trial: Postmarketing Study to Determine Performance of the SIGMA HP (clinicaltrials.gov) - Feb 6, 2012
P4, N=62, Active, not recruiting, Sponsor: DePuy International

|||||||||| New P2/3 trial: Sensorimotor Training Versus Resistance Training in Patients With Knee Osteoarthritis (clinicaltrials.gov) - Feb 5, 2012
P2/3, N=96, Completed, Sponsor: Federal University of S

|||||||||| Trial completion: Preoperative Exercise in Patients Undergoing Total Hip or Knee Replacement (clinicaltrials.gov) - Feb 5, 2012
P=N/A, N=165, Completed, Sponsor: University of Southern Denmark
Initiation date: Jan 2001 --> Oct 2004 Active, not recruiting --> Completed

|||||||||| Trial completion: AR vs PR: Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty (clinicaltrials.gov) - Feb 2, 2012
P=N/A, N=100, Completed, Sponsor: Heekin Orthopedic Research Institute
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Midvastus Versus Medial Parapatellar Approach for Minimally Invasive Total Knee Arthroplasty (clinicaltrials.gov) - Feb 2, 2012
P=N/A, N=40, Completed, Sponsor: Heekin Orthopedic Research Institute
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Multi-Center Comparative Trial of the ASR (clinicaltrials.gov) - Feb 2, 2012
P4, N=300, Completed, Sponsor: DePuy Orthopaedics
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Double-Blind, Randomized, Single Dose Escalation Safety Study of Intraarticular Bone Morphogenic Protein (38A BMP-7) in Subjects With Osteoarthritis (OA) of the Knee (clinicaltrials.gov) - Jan 29, 2012
P1, N=51, Completed, Sponsor: Stryker Biotech
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee (clinicaltrials.gov) - Jan 29, 2012
P2, N=355, Completed, Sponsor: Stryker Biotech
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial withdrawal: MTT: Microplasty Tibial Tray Data Collection (clinicaltrials.gov) - Jan 24, 2012
P=N/A, N=0, Withdrawn, Sponsor: Biomet, Inc.
Active, not recruiting --> Completed Terminated --> Withdrawn

|||||||||| Trial withdrawal: A Clinical Investigation of the Comprehensive (clinicaltrials.gov) - Jan 24, 2012
P=N/A, N=0, Withdrawn, Sponsor: Biomet Orthopedics, LLC
Terminated --> Withdrawn Terminated --> Withdrawn

|||||||||| Enrollment change: MTT: Microplasty Tibial Tray Data Collection (clinicaltrials.gov) - Jan 24, 2012
P=N/A, N=0, Withdrawn, Sponsor: Biomet, Inc.
Terminated --> Withdrawn N=200 --> 0

|||||||||| Enrollment change: A Clinical Investigation of the Comprehensive (clinicaltrials.gov) - Jan 24, 2012
P=N/A, N=0, Withdrawn, Sponsor: Biomet Orthopedics, LLC
N=200 --> 0 N=200 --> 0

||||||||||  cindunistat (SC84250) / Pfizer
Trial withdrawal:  X-Ray Study Investigating The Safety And Efficacy Of SD-6010 In Subjects With Osteoarthritis Of The Knee (clinicaltrials.gov) -  Jan 23, 2012
P3, N=0, Withdrawn,  Sponsor: Pfizer
N=200 --> 0 Not yet recruiting --> Withdrawn

||||||||||  cindunistat (SC84250) / Pfizer
Enrollment change:  X-Ray Study Investigating The Safety And Efficacy Of SD-6010 In Subjects With Osteoarthritis Of The Knee (clinicaltrials.gov) -  Jan 23, 2012
P3, N=0, Withdrawn,  Sponsor: Pfizer
Not yet recruiting --> Withdrawn N=1500 --> 0

||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
New P1/2 trial:  Safety and Efficacy Study of Botulinum Toxin Type A as Treatment for Osteoarthritis Knee Pain (clinicaltrials.gov) -  Jan 23, 2012
P1/2, N=121, Completed,  Sponsor: Allergan

||||||||||  cindunistat (SC84250) / Pfizer
Enrollment change:  A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee (clinicaltrials.gov) -  Jan 22, 2012
P2/3, N=5077, Completed,  Sponsor: Pfizer
N=1500 --> 0 N=1400 --> 5077

||||||||||  cindunistat (SC84250) / Pfizer
Trial completion:  A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee (clinicaltrials.gov) -  Jan 22, 2012
P2/3, N=5077, Completed,  Sponsor: Pfizer
N=1400 --> 5077 Recruiting --> Completed

|||||||||| Enrollment closed: Vanguard Complete Knee Versus Vanguard High Flex Rotating Platform (RP) Knee Study (clinicaltrials.gov) - Jan 19, 2012
P=N/A, N=300, Active, not recruiting, Sponsor: Biomet, Inc.
Recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| New P4 trial: Do We Need Computer Assistance To Improve the Survival of Primary Total Knee Arthroplasty. A Minimum Ten Years Follow-up (clinicaltrials.gov) - Jan 18, 2012
P4, N=520, Completed, Sponsor: Ewha Womans University

||||||||||  Pennsaid (diclofenac sodium topical solution 1.5%) / Miravo
New P3 trial:  Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants (clinicaltrials.gov) -  Jan 17, 2012
P3, N=22, Completed,  Sponsor: Nathan Wei, MD, FACP, FACR:

||||||||||  SAR 113945 / Sanofi
New P1 trial:  Safety, Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis (clinicaltrials.gov) -  Jan 16, 2012
P1, N=24, Completed,  Sponsor: Sanofi

||||||||||  Savella (milnacipran) / AbbVie, Pierre Fabre
New P4 trial:  Milnacipran for Chronic Pain in Knee Osteoarthritis (clinicaltrials.gov) -  Jan 12, 2012
P4, N=36, Completed,  Sponsor: Dr. Norman Harden

||||||||||  Hyruan Plus (sodium hyaluronate) / LG Chem
New P3 trial:  Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis (clinicaltrials.gov) -  Jan 12, 2012
P3, N=287, Completed,  Sponsor: LG Life Sciences

||||||||||  Zorvolex (diclofenac) / Assertio
New P3 trial:  Open-Label Study of Diclofenac Capsules to Treat Osteoarthritis Pain (clinicaltrials.gov) -  Jan 11, 2012
P3, N=600, Active, not recruiting,  Sponsor: Iroko Pharmaceuticals, LLC

|||||||||| Trial completion: CAROT: Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients (clinicaltrials.gov) - Jan 4, 2012
P=N/A, N=192, Completed, Sponsor: Henning Bliddal
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| New P2 trial: The Effects of Intra-articular Injection of Mesenchymal Stem Cells in Knee Joint Osteoarthritis (clinicaltrials.gov) - Jan 3, 2012
P2, N=40, Completed, Sponsor: Royan Institute

|||||||||| Trial completion: Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time (clinicaltrials.gov) - Jan 2, 2012
P3, N=391, Completed, Sponsor: Cephalon
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| New P1 trial, Adverse events: Autologous Chondrocyte Intra-articular Implantation in Patients With Severe Hip Osteoarthritis (clinicaltrials.gov) - Dec 26, 2011
P1, N=6, Completed, Sponsor: Royan Institute

|||||||||| Clinical: 10003 PRO Current Products (clinicaltrials.gov) - Dec 20, 2011
P=N/A, N=840, Recruiting, Sponsor: DePuy Orthopaedics

|||||||||| Trial initiation date: Motion Analysis of EMP Knee Versus Posterior Stabilized Knee Arthroplasty for Osteoarthritis (clinicaltrials.gov) - Dec 19, 2011
P=N/A, N=50, Not yet recruiting, Sponsor: Ottawa Hospital Research Institute
Recruiting --> Completed Initiation date: Jul 2011 --> Jan 2012

|||||||||| New P1 trial, Adverse events: Mesenchymal Stem Cell Transplantation in Osteoarthritis of Hip Joint (clinicaltrials.gov) - Dec 16, 2011
P1, N=6, Completed, Sponsor: Royan Institute

|||||||||| New P4 trial: BONARTH: Benefit of Orthopedic Navigation in the ARThroplasty of the Hip (clinicaltrials.gov) - Dec 14, 2011
P4, N=89, Active, not recruiting, Sponsor: Aesculap AG

||||||||||  ibuprofen-VALE (10% transdermal ibuprofen) / BioChemics
New P2 trial:  Osteoarthritis Topical Treatment (clinicaltrials.gov) -  Dec 14, 2011
P2, N=75, Completed,  Sponsor: BioChemics, Inc.