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61 Mechanisms of Action

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|||||||||| Trial completion: Changes of the Single Limb Standing Balance After Total Knee Arthroplasty in Degenerative Osteoarthritis (clinicaltrials.gov) - Dec 21, 2013
P=N/A, N=50, Completed, Sponsor: Ulsan University Hospital
Recruiting --> Completed

|||||||||| New P2 trial: Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis (clinicaltrials.gov) - Dec 19, 2013
P2, N=60, Completed, Sponsor: Winston Salem State University

|||||||||| Enrollment change: Alignment Comparison Between TruMatch (clinicaltrials.gov) - Dec 17, 2013
P=N/A, N=78, Completed, Sponsor: DePuy Orthopaedics
Recruiting --> Completed N=174 --> 78

|||||||||| Trial completion: Lifestyles: Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults (clinicaltrials.gov) - Dec 16, 2013
P=N/A, N=367, Completed, Sponsor: University of Washington
N=174 --> 78 Active, not recruiting --> Completed

|||||||||| New P3 trial: Efficacy and Safety of Glucosamine Sulfate and Chondroitin Sulfate Combination in Treatment of Knee Osteoarthritis (clinicaltrials.gov) - Dec 11, 2013
P3, N=922, Completed, Sponsor: Ache Laboratorios Farmaceuticos S.A.

|||||||||| Enrollment change: Short Term Follow-up of Patient Implanted With the Metatarso-Phalangeal Prosthesis METIS (clinicaltrials.gov) - Dec 10, 2013
P=N/A, N=60, Completed, Sponsor: Integra LifeSciences Services
Active, not recruiting --> Completed N=115 --> 60

|||||||||| Trial completion: Short Term Follow-up of Patient Implanted With the Metatarso-Phalangeal Prosthesis METIS (clinicaltrials.gov) - Dec 10, 2013
P=N/A, N=60, Completed, Sponsor: Integra LifeSciences Services
N=115 --> 60 Active, not recruiting --> Completed

|||||||||| Trial completion: MR Imaging of Knee Osteoarthritis and Acute Knee Injuries (clinicaltrials.gov) - Dec 10, 2013
P=N/A, N=139, Completed, Sponsor: University of California, San Francisco
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment change: Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback (clinicaltrials.gov) - Dec 9, 2013
P1, N=26, Completed, Sponsor: University of Colorado, Denver
Active, not recruiting --> Completed N=20 --> 26

|||||||||| Trial completion: Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback (clinicaltrials.gov) - Dec 9, 2013
P1, N=26, Completed, Sponsor: University of Colorado, Denver
N=20 --> 26 Recruiting --> Completed

|||||||||| Enrollment closed: TCPT: Tai Chi and Physical Therapy for Knee Osteoarthritis (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=180, Active, not recruiting, Sponsor: Tufts Medical Center
Recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment closed, HEOR: Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement (clinicaltrials.gov) - Dec 5, 2013
P=N/A, N=100, Active, not recruiting, Sponsor: Northern Orthopaedic Division, Denmark
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| New P2a trial: A Placebo Controlled, Double Blind, Randomised, 8-week Phase IIa Proof of Concept Study to Assess the Efficacy and Safety of AKR 202 in Patients With Osteoarthritis Pain (clinicaltrials.gov) - Dec 4, 2013
P2a, N=260, Recruiting, Sponsor: Akron Molecules AG

||||||||||  Zilretta (triamcinolone acetonide ER) / Pacira
New P2 trial:  Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee (clinicaltrials.gov) -  Dec 4, 2013
P2, N=40, Active, not recruiting,  Sponsor: Flexion Therapeutics, Inc.

||||||||||  huMSC-derived mesenchymal trophic factors (MTF) / Medistem Panama
New P1/2 trial:  Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis (clinicaltrials.gov) -  Dec 4, 2013
P1/2, N=40, Recruiting,  Sponsor: Translational Biosciences

||||||||||  V-116517 / Purdue
Trial completion:  Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis (OA) of the Knee (clinicaltrials.gov) -  Dec 3, 2013
P2, N=230, Completed,  Sponsor: Purdue Pharma LP
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  Apitox (honeybee venom) / Apimeds
Trial initiation date:  Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis (clinicaltrials.gov) -  Dec 2, 2013
P3, N=330, Recruiting,  Sponsor: Apimeds, Inc.
Active, not recruiting --> Completed Initiation date: Aug 2013 --> Dec 2013

||||||||||  Apitox (honeybee venom) / Apimeds
Enrollment open:  Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis (clinicaltrials.gov) -  Dec 2, 2013
P3, N=330, Recruiting,  Sponsor: Apimeds, Inc.
Initiation date: Aug 2013 --> Dec 2013 Not yet recruiting --> Recruiting

|||||||||| Trial completion: After Discharge Management of Low Income Frail Elderly (clinicaltrials.gov) - Dec 1, 2013
P=N/A, N=530, Completed, Sponsor: Summa Health System
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| New P4 trial: Use of FlexHD as Post Trapeziectomy Spacer (clinicaltrials.gov) - Nov 28, 2013
P4, N=60, Recruiting, Sponsor: Cedars Sinai Medical Care Foundation

|||||||||| Trial completion: RASSH: Outcomes of Treatment for Trapeziometacarpal Osteoarthritis (clinicaltrials.gov) - Nov 27, 2013
P=N/A, N=177, Completed, Sponsor: Schulthess Klinik
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment change: A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury (clinicaltrials.gov) - Nov 26, 2013
P3, N=112, Active, not recruiting, Sponsor: Chinese University of Hong Kong
Recruiting --> Completed N=160 --> 112

||||||||||  morphine sulphate / Generic mfg.
Trial completion:  Hormone Function in Men Treated for Pain With Opioids or Placebo (clinicaltrials.gov) -  Nov 26, 2013
P4, N=8, Completed,  Sponsor: National Institute of Nursing Research (NINR)
N=160 --> 112 Active, not recruiting --> Completed

|||||||||| Trial completion, Metastases: Periosteal Stimulation for Knee Osteoarthritis (clinicaltrials.gov) - Nov 25, 2013
P=N/A, N=191, Completed, Sponsor: Department of Veterans Affairs
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment open: Use of FlexHD as Post Trapeziectomy Spacer (clinicaltrials.gov) - Nov 24, 2013
P4, N=60, Recruiting, Sponsor: Cedars Sinai Medical Care Foundation
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Clinical: Study of Patient Outcomes 5 Years After Partial Knee Replacement (clinicaltrials.gov) - Nov 21, 2013
P=N/A, N=185, Enrolling by invitation, Sponsor: Athens Orthopedic Clinic, P.A.
Not yet recruiting --> Recruiting Not yet recruiting --> Enrolling by invitation

|||||||||| Trial completion: EMBARK VA: Exploring Massage Benefits for Arthritis of the Knee for VA Healthcare Users (clinicaltrials.gov) - Nov 21, 2013
P=N/A, N=25, Completed, Sponsor: Duke University
Not yet recruiting --> Enrolling by invitation Recruiting --> Completed

|||||||||| Trial initiation date: Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study (clinicaltrials.gov) - Nov 20, 2013
P=N/A, N=440, Recruiting, Sponsor: University of Edinburgh
Recruiting --> Completed Initiation date: Jun 2013 --> Sep 2013

|||||||||| Enrollment open: Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study (clinicaltrials.gov) - Nov 20, 2013
P=N/A, N=440, Recruiting, Sponsor: University of Edinburgh
Initiation date: Jun 2013 --> Sep 2013 Not yet recruiting --> Recruiting

|||||||||| Trial completion: Early Rehabilitation After Total Hip Replacement (clinicaltrials.gov) - Nov 20, 2013
P=N/A, N=73, Completed, Sponsor: University of Aarhus
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Enrollment open, Surgery: SPARKS: The Study of Physical Activity Rewards After Knee Surgery (clinicaltrials.gov) - Nov 14, 2013
P1/2, N=250, Recruiting, Sponsor: Brigham and Women's Hospital
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment closed: AViKA: Adding Value in Knee Arthroplasty Post-total Knee Replacement (TKR) Care Navigator Trial (clinicaltrials.gov) - Nov 14, 2013
P=N/A, N=300, Active, not recruiting, Sponsor: Brigham and Women's Hospital
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Trial initiation date: Follow up Study of Patients Undergoing Total Hip Arthroplasty CERAFIT (clinicaltrials.gov) - Nov 13, 2013
P1/2, N=50, Not yet recruiting, Sponsor: Laboratoire Ceraver-Osteal
Recruiting --> Active, not recruiting Initiation date: Dec 2011 --> Jan 2014

|||||||||| Trial completion: Evaluation of Exercise Benefits to Promote Health Aging Among Chronically Ill Geriatrics in a Community (clinicaltrials.gov) - Nov 12, 2013
P=N/A, N=160, Completed, Sponsor: Far Eastern Memorial Hospital
Initiation date: Dec 2011 --> Jan 2014 Active, not recruiting --> Completed

|||||||||| Trial termination: Trilogy AB Acetabular Hip System Post Approval Study (clinicaltrials.gov) - Nov 11, 2013
P4, N=32, Terminated, Sponsor: Zimmer, Inc.
Active, not recruiting --> Completed Active, not recruiting --> Terminated; Sponsor business decision unrelated to clinical performance.

||||||||||  rofecoxib (TRM-201) / Tremeau Pharma
Trial initiation date:  A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement (0966-259) (clinicaltrials.gov) -  Nov 11, 2013
P4, N=11, Terminated,  Sponsor: Merck Sharp & Dohme Corp.
Active, not recruiting --> Terminated; Sponsor business decision unrelated to clinical performance. Initiation date: Jan 2004 --> May 2004

||||||||||  rofecoxib (TRM-201) / Tremeau Pharma
Enrollment change:  A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement (0966-259) (clinicaltrials.gov) -  Nov 11, 2013
P4, N=11, Terminated,  Sponsor: Merck Sharp & Dohme Corp.
Initiation date: Jan 2004 --> May 2004 N=150 --> 11

|||||||||| New P1/2 trial: Treatment of Knee Osteoarthritis by Intra-articular Injection of Bone Marrow Mesenchymal Stem Cells (clinicaltrials.gov) - Nov 11, 2013
P1/2, N=30, Active, not recruiting, Sponsor: Clinica Universidad de Navarra, Universidad de Navarra

|||||||||| Trial completion: TIAA: Time of Intravenous Acetaminophen Administration (clinicaltrials.gov) - Nov 11, 2013
P4, N=126, Completed, Sponsor: Duke University
N=150 --> 11 Recruiting --> Completed

||||||||||  Shinbaro (GCSB-5) / GC Biopharma, LG Chem
Trial completion:  To Evaluate the Safety of 'Shinbaro Capsule'in Patients With Osteoarthritis (clinicaltrials.gov) -  Nov 10, 2013
P4, N=761, Completed,  Sponsor: Green Cross Corporation
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Impracor (ketoprofen) / Harrow Health
Trial withdrawal:  Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee (clinicaltrials.gov) -  Nov 7, 2013
P3, N=0, Withdrawn,  Sponsor: Imprimis Pharmaceuticals, Inc.
Active, not recruiting --> Completed Not yet recruiting --> Withdrawn

||||||||||  Impracor (ketoprofen) / Harrow Health
Enrollment change:  Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee (clinicaltrials.gov) -  Nov 7, 2013
P3, N=0, Withdrawn,  Sponsor: Imprimis Pharmaceuticals, Inc.
Not yet recruiting --> Withdrawn N=350 --> 0

|||||||||| Preclinical: Detecting and Addressing Preclinical Disability (clinicaltrials.gov) - Nov 6, 2013
P=N/A, N=150, Recruiting, Sponsor: McMaster University

||||||||||  meloxicam / Generic mfg.
Trial completion:  Study of Meloxicam Capsules to Treat Osteoarthritis Pain (clinicaltrials.gov) -  Nov 6, 2013
P3, N=403, Completed,  Sponsor: Iroko Pharmaceuticals, LLC
N=350 --> 0 Active, not recruiting --> Completed

|||||||||| Trial withdrawal: Outcomes of Robotic Total Hip Arthroplasty (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=0, Withdrawn, Sponsor: Massachusetts General Hospital
Active, not recruiting --> Completed Not yet recruiting --> Withdrawn

|||||||||| Trial withdrawal, Surgery: Stability of Revision Total Hip Arthroplasty Implants Using Radiostereometric Analysis (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=0, Withdrawn, Sponsor: Massachusetts General Hospital
Not yet recruiting --> Withdrawn Recruiting --> Withdrawn

|||||||||| Trial termination: Outcomes Following Anterior Approach to Total Hip Arthroplasty (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=50, Terminated, Sponsor: McMaster University
Recruiting --> Withdrawn Recruiting --> Terminated

|||||||||| Enrollment change: Outcomes of Robotic Total Hip Arthroplasty (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=0, Withdrawn, Sponsor: Massachusetts General Hospital
Recruiting --> Terminated N=1000 --> 0

|||||||||| Enrollment change, Surgery: Stability of Revision Total Hip Arthroplasty Implants Using Radiostereometric Analysis (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=0, Withdrawn, Sponsor: Massachusetts General Hospital
N=1000 --> 0 N=100 --> 0

|||||||||| Enrollment change: Outcomes Following Anterior Approach to Total Hip Arthroplasty (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=50, Terminated, Sponsor: McMaster University
N=100 --> 0 N=700 --> 50