Myasthenia Gravis News - LARVOL Sigma

Myasthenia Gravis	Welcome, Profile Billing Logout

«1 2...85 86 87 88 899091 92 93 94 95...136 137 »

|||||||||| Clinical, Journal: Acute Neuromuscular Disorders in the Pediatric Intensive Care Unit. (Pubmed Central) - Jun 22, 2021
Although acute and acute-on-chronic neuromuscular disorders are encountered relatively rarely in the PICU, familiarity with the presenting features of these disorders is important in facilitating timely diagnosis. This, in turn, enables the institution of effective management strategies, thereby avoiding complications associated with diagnostic delays.

|||||||||| Journal: Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). (Pubmed Central) - Jun 22, 2021
Compared with other immunomodulatory treatments, HSCT is associated with greater short-term risks and requires close interspeciality collaboration between transplant physicians and neurologists with a special interest in these neurological conditions before, during and after treatment in accredited HSCT centres. Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials.

|||||||||| Clinical, Journal: Thymectomy in ocular myasthenia gravis before generalization results in a higher remission rate. (Pubmed Central) - Jun 22, 2021
Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials. Thymectomy in OMG before generalization might result in a higher rate of complete stable remission than thymectomy after generalization.

|||||||||| Observational data, Retrospective data, Journal: Acute onset binocular diplopia: a retrospective observational study of 100 consecutive cases managed at a tertiary eye centre in Saudi Arabia. (Pubmed Central) - Jun 22, 2021
AOBD, though an alarming and distressing condition, carries reassuringly good prognosis in majority of patients. High risk factors for vascular disease in Middle-Eastern population are reflected in microvascular aetiology as the major cause.

|||||||||| Clinical, Journal: Predictors of post-thymectomy long-term neurological remission in thymomatous myasthenia gravis: an analysis from a multi-institutional database. (Pubmed Central) - Jun 22, 2021
Large tumour size and preoperative mild symptoms were predictors for long-term neurological outcome in thymomatous MG. Considering that patients with early onset of MG and no immunosuppressive treatment tend to have large tumours, early surgical intervention for patients with thymomatous MG having mild symptoms might be beneficial for controlling neurological outcomes.

|||||||||| Clinical, Journal: Glycopyrrolate and the Management of "Death Rattle" in Patients with Myasthenia Gravis. (Pubmed Central) - Jun 22, 2021
Agents that antagonize acetylcholine activity (e.g., anticholinergic agents, such as glycopyrrolate) can, therefore, exacerbate myasthenia gravis. We discuss the case of a patient dying with myasthenia gravis that developed problematic "death rattle," and the successful use of glycopyrrolate in treating this symptom.

|||||||||| Journal: Unravelling the role of Receptor for advanced glycation end products (RAGE) and its ligands in Myasthenia Gravis. (Pubmed Central) - Jun 22, 2021
Several studies have shown that the presence of thymic abnormalities, the onset age of MG and the duration of the disease may affect the levels of these proteins in MG patients. Herein, we discuss the emerging role of RAGE and its ligands in MG immunopathogenesis, their clinical significance as promising biomarkers, as well as the potential therapeutic implications of targeting RAGE signaling in MG treatment.

|||||||||| Journal: Noninvasive Ventilation in Myasthenia Gravis. (Pubmed Central) - Jun 22, 2021
NIV has lower incidence of complications. NIV should be tried in patients with impending MC.

|||||||||| Retrospective data, Review, Journal: Autoimmune disease-related primary CNS lymphoma: systematic review and meta-analysis. (Pubmed Central) - Jun 22, 2021
Aggressive polychemotherapy can accomplish long term OS in AD-PCNSL comparable to immunocompetent patients. Age > 60 may serve as a prognostic factor.

|||||||||| Clinical, Journal: Jitter Evaluation in Distant and Adjacent Muscles after Botulinum Neurotoxin Type A Injection in 78 Cases. (Pubmed Central) - Jun 22, 2021
The far abnormal mean jitter (32.6/36.9 µs) occurred 229 and 313 days since the most recent BoNT/A. We suggested that jitter measurement can be done after BoNT/A in a given muscle other than the injected one, after 8 (DM) and 11 (AM) months, with reference >33 µs and >37 µs, respectively.

|||||||||| Journal: Presentation and management of congenital myasthenic syndrome with a homozygous Agrin variant (Pro1448Leu). (Pubmed Central) - Jun 22, 2021
We suggested that jitter measurement can be done after BoNT/A in a given muscle other than the injected one, after 8 (DM) and 11 (AM) months, with reference >33 µs and >37 µs, respectively. No abstract available

|||||||||| Journal: Gene expression profiling of orbital muscles in treatment-resistant ophthalmoplegic myasthenia gravis. (Pubmed Central) - Jun 22, 2021
The gene expression in orbital muscles derived from OP-MG individuals compared with normal controls, support the pathogenic hypothesis previously generated from whole genome sequence analyses. Repression of gene transcripts in OP-MG orbital muscle implicate tissue-specific regulatory mechanisms, which may inform future biomarker discovery approaches.

|||||||||| Clinical, Journal: Respiratory Assessment of Myasthenia Gravis Patients Using Repetitive Nerve Stimulation of Phrenic and Intercostal Nerves. (Pubmed Central) - Jun 22, 2021
RNST of peripheral nerves were negative in two patients who were bulbar sero-negative MG, however, significant decrement was seen in intercostal and phrenic nerve RNST. Intercostal and phrenic nerve RNST are a better test for assessing respiratory involvement specially in patients presenting with bulbar symptoms and having negative RNST of peripheral nerves.

|||||||||| Preclinical, Journal: Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ. (Pubmed Central) - Jun 22, 2021
CMS with acetylcholinesterase (AChE) deficiency are caused by mutations in COLQ, a collagen that anchors AChE in the synapse. To study the pathophysiological mechanisms of the disease in human cells, we have generated iPSC from a patient's Peripheral Blood Mononuclear cells (PBMC) by reprogramming these cells using a non-integrative method using Sendai viruses bearing the four Yamanaka factors Oct3/4, Sox2, Klf4, and L-Myc.

|||||||||| Journal: Acetylcholine receptor antibody positivity rate in ocular myasthenia gravis: a matter of age? (Pubmed Central) - Jun 22, 2021
Our results confirm that current AChR Ab positivity in OMG may be higher than generally thought. In our population, this finding was associated with an increased frequency of late-onset cases.

|||||||||| Journal: Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses. (Pubmed Central) - Jun 22, 2021
Immunoglobulin VH transcriptome sequencing and analysis of recombinant antibodies revealed clonal expansion of DN B cells that were targeted against the vaccine antigen. Our study suggests that DN B cells are expanded in multiple inflammatory neurologic diseases and represent an inducible B cell population that responds to antigenic stimulation, possibly through an extra-follicular maturation pathway.

|||||||||| Journal: Subclinical myasthenia gravis in thymomas. (Pubmed Central) - Jun 22, 2021
One in four patients who experienced no neurological symptoms before thymectomy, appeared to have anti-AChR-antibodies and 91 % of these patients developed clinical MG within six years after the thymectomy. Analyzing anti-AChR-antibodies in the serum is recommended in all suspected thymomas before a thymectomy is performed.

|||||||||| Preclinical, Journal: Generation and characterization of an induced pluripotent stem cell line SDQLCHi018-A from a congenital myasthenic syndrome patient carrying compound heterozygote mutations in RAPSN gene. (Pubmed Central) - Jun 22, 2021
In this study, we generated an induced pluripotent stem cell line (iPSC) derived from a 14-day-old male CMS patient carrying compound heterozygote mutations (c.532-2A > G and c.264C > A/p.Asn88Lys) in RAPSN gene. The established iPSC line harboring the original mutations, possessing a normal karyotype, is able to differentiate into all three germ layers in vitro and expresses pluripotency markers.

|||||||||| Journal: Protein signature of human skin fibroblasts allows the study of the molecular etiology of rare neurological diseases. (Pubmed Central) - Jun 22, 2021
The established iPSC line harboring the original mutations, possessing a normal karyotype, is able to differentiate into all three germ layers in vitro and expresses pluripotency markers. Our combined data reveal that human fibroblasts may serve as an in vitro system to study the molecular etiology of rare neurological diseases exemplified on Allgrove syndrome in an unbiased fashion.

|||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Review, Journal: Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common? (Pubmed Central) - Jun 22, 2021
This suggests a role for the HLA class II region and specifically the DRβ1 chain for aberrant priming of autoreactive T-cells toward a chronic immune response skewed toward the production of IgG4 subclass autoantibodies. The aim of this review is to provide an update on findings arguing for a common pathogenic mechanism in IgG4-AID in general and to provide hypotheses about the role of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID.

|||||||||| Clinical, Journal: COLQ-Related Congenital Myasthenic Syndrome in a Child from Western India. (Pubmed Central) - Jun 22, 2021
The aim of this review is to provide an update on findings arguing for a common pathogenic mechanism in IgG4-AID in general and to provide hypotheses about the role of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID. No abstract available

|||||||||| Retrospective data, Journal: Determinants of Suboptimal Outcome Following Thymectomy in Myasthenia Gravis. (Pubmed Central) - Jun 22, 2021
Suboptimal response after thymectomy occurred in one-third of MG patients, more commonly with thymomatous MG. Relationship of preoperative steroid therapy to remission merits evaluation.

|||||||||| Journal: Myasthenic crisis appearing after resection of intracardiac ectopic thymoma with superior vena cava syndrome. (Pubmed Central) - Jun 22, 2021
This is the first report of myasthenic crisis due to intracardiac ectopic thymoma. Residual thymoma is a risk factor for the development of post-thymectomy myasthenia gravis, and long-term follow-up is required.

|||||||||| Journal: MiR-522-3p inhibits proliferation and activation by regulating the expression of SLC31A1 in T cells. (Pubmed Central) - Jun 22, 2021
Overexpressed SLC31A1 reversed the inhibitory effects of miR-522-3p mimic on cell viability, EdU positive cell, cycle progression, and the levels of IL-2 and IL-10 in transfected Jurkat cells. MiR-522-3p expression was down-regulated in TAMG, and miR-522-3p inhibited proliferation and activation by regulating SLC31A1 expression in T cells.

|||||||||| Bridion (sugammadex) / Merck (MSD)
[VIRTUAL] Neostigmine Or Sugammadex: Which Drug To Use In Patients With Minimal Rocuronium Induced Neuromuscular Blockade (Virtual) - Jun 20, 2021 - Abstract #ASA2021ASA_2834;
These savings could potentially be much larger if patients in areas with lower patient acuity were included in the study. NMB reversal practices should be studied more extensively for standardization of practice and reduction of drug costs.

|||||||||| Clinical, Journal: A Case Report of Subclinical Myasthenia Gravis Associated with Castleman's Disease. (Pubmed Central) - Jun 19, 2021
CONCLUSIONS The aim of this case report is to add more to the literature by reporting a rare case of an asymptomatic subclinical Myasthenia Gravis associated with Castleman's disease. It highlights the importance of considering a Castleman's Disease in an asymptomatic case who presented with a mediastinal mass and in order to avoid an unusual intraoperative finding such as massive bleeding by performing a biopsy and an angiography preoperatively.

|||||||||| Review, Journal: Noninfectious neurologic complications of hematopoietic cell transplantation: A systematic review. (Pubmed Central) - Jun 16, 2021
These findings demonstrate that the recipients of HCT had a significantly higher risk of neurological complications and that their early recognition can enhance the monitoring of HCT survivors for the early developmental signs of neurological toxicity. This would facilitate timely interventions, thus ensuring a better quality of life.

|||||||||| Clinical, Journal: Increased rate of complications in myasthenia gravis patients following hip and knee arthroplasty: a nationwide database study in the PearlDiver Database on 257,707 patients. (Pubmed Central) - Jun 16, 2021
90-day incidence of aseptic loosening was the only joint complication with significantly increased odds risk for the MG cohort (OR 5; 95% CI 2-12). Interpretation - Patients with MG exhibited significantly higher risk for multiple systemic complications during the index hospital stay and in the acute post-discharge setting.

|||||||||| Clinical, Journal: Recessive VAMP1 mutations associated with severe congenital myasthenic syndromes - A recognizable clinical phenotype. (Pubmed Central) - Jun 16, 2021
Minimal but definite improvement in muscle power with pyridostigmine was reported in patients 1 and 2. This is the first report of VAMP1 mutations causing CMS from the Indian subcontinent, describing a clinically recognizable severe form of VAMP1-related CMS and highlighting the need for a strong index of suspicion for early genetic diagnosis of potentially treatable CMS phenotypes.

|||||||||| Journal: Development of a Computerized Adaptive Test for Quantifying Chinese Medicine Syndrome of Myasthenia Gravis on Basis of Multidimensional Item Response Theory. (Pubmed Central) - Jun 16, 2021
With adequate factor loadings of symptoms on related syndrome factor, the instrument was evaluated with preliminary interpretation and was suitable for evaluating patients with moderate severity of the spleen and kidney deficiency syndrome. Setting typical symptoms of MG together with systemic discomforts in a computerized adaptive test on the basis of MIRT, this study proposed an innovative research paradigm for quantifying individual condition in the perspective of TCM with application of interdisciplinary approaches.

|||||||||| Clinical, Journal: "Mummy, my eyelids are heavy": A case series of juvenile myasthenia gravis. (Pubmed Central) - Jun 12, 2021
Juvenile myasthenia gravis is relatively rare in toddlers. Early diagnosis and commencement of treatment is important to slow the progression of the disease and avoiding life-threatening events.

|||||||||| Biomarker, Journal: Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis. (Pubmed Central) - Jun 12, 2021
In the third cohort, hsa-circRNA5333-4 had a larger AUC: 0.864 (95% confidence interval [CI] = 0.801-0.928, P < 0.001), a stronger correlation with the Quantitative Myasthenia Gravis Score (qMG): r = 0.505 (P < 0.001) and was correlated with gender and acetylcholine receptor antibody levels (P < 0.05). So hsa-circRNA5333-4 represents a novel biomarker for the diagnosis and monitoring of MG.

|||||||||| Clinical, Journal: Comparison of the Single Simple Question and the Patient Acceptable Symptom state in Myasthenia Gravis. (Pubmed Central) - Jun 11, 2021
The PASS and SSQ patient reported outcomes are closely associated and a SSQ threshold ≥ 72.5% predicts an acceptable MG state. Other demographic and disease-related factors did not influence the PASS response in this study.

|||||||||| Review, Journal: Challenges in diagnosing coexisting ocular myasthenia gravis and thyroid eye disease. (Pubmed Central) - Jun 11, 2021
In patients with thyroid eye disease, securing a diagnosis of OMG may not be possible on the basis of a single positive test. A multimodal approach using clinical, serologic, imaging, and electrodiagnostic data, is typically required.

|||||||||| Journal: Investigating the possible association between NLRP3 gene polymorphisms and myasthenia gravis. (Pubmed Central) - Jun 11, 2021
A multimodal approach using clinical, serologic, imaging, and electrodiagnostic data, is typically required. These preliminary results suggest that there might be some associations between the NLRP3 gene polymorphism and MG.

|||||||||| Clinical, Journal: Developing outcome measures of disease activity in Pediatric Myasthenia. (Pubmed Central) - Jun 11, 2021
Our study suggests that MGC and PM-QOL15 are important disease outcome measures in pediatric myasthenia that are easy to administer and provide reliable assessment of disease activity in the clinic setting. Further studies are needed to validate their use for pediatric clinical research trials.

|||||||||| Clinical, Review, Journal: Ectopic thymoma in the middle mediastinum: A case report and literature review. (Pubmed Central) - Jun 10, 2021
Most of them were located in the upper right mediastinum, adjacent to the right trachea, and in the retro innominate vein area. Thymoma should be considered a differential diagnosis when a mass is observed in the middle mediastinum.

|||||||||| Clinical, Journal: Reader Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis. (Pubmed Central) - Jun 10, 2021
Thymoma should be considered a differential diagnosis when a mass is observed in the middle mediastinum. No abstract available

|||||||||| Clinical, Journal: Author Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis. (Pubmed Central) - Jun 10, 2021
No abstract available No abstract available

|||||||||| Clinical, Journal: Sleep disorders in patients with myastenia gravis (Pubmed Central) - Jun 10, 2021
Thus, given the inconclusive evidence and limited literature, further study of sleep disorders in patients with MG is needed. The topic is relevant and requires further development.

|||||||||| Journal: Paraneoplastic neurological syndromes (Pubmed Central) - Jun 10, 2021
A prompt diagnosis of neurological paraneoplastic syndrome is of major importance as it often reveals the underlying tumour. The treatment relies on both the elimination of the neoplasia and the control of the immune response.

|||||||||| Clinical, Journal: Radiological Characteristics of Extraocular Muscles in Myasthenia Gravis Patients with Ocular Manifestations: A Case-Control Study. (Pubmed Central) - Jun 10, 2021
Isointensity with central hypointensity of EOMs on T2W/FS was also common in the MG group. These findings highlight the importance of muscle involvement in MG and may be helpful for clinical decision-making.

|||||||||| Journal: Vision therapy may reveal symptoms of ocular myasthenia gravis. (Pubmed Central) - Jun 9, 2021
These findings highlight the importance of muscle involvement in MG and may be helpful for clinical decision-making. No abstract available

|||||||||| Clinical, Journal: Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers. (Pubmed Central) - Jun 9, 2021
We also clearly associated MG symptoms with higher IFN-γ, IL-1β and sCD40L serum levels, specifically in MGT patients compared to TOMA patients. Altogether, these analyses allowed the clear identification of histological, in particular the presence of GCs, and biological parameters that would facilitate the evaluation of the probability of the MG outcome postoperatively in thymoma patients.

|||||||||| Journal: Complement deposition at the neuromuscular junction in seronegative myasthenia gravis. (Pubmed Central) - Jun 9, 2021
Altogether, these analyses allowed the clear identification of histological, in particular the presence of GCs, and biological parameters that would facilitate the evaluation of the probability of the MG outcome postoperatively in thymoma patients. No abstract available

|||||||||| Journal: Breaking Down Myasthenic Crisis. (Pubmed Central) - Jun 8, 2021
No abstract available No abstract available

|||||||||| Clinical, Journal: Thymectomy in thymomatous and non-thymomatous myasthenia gravis: analysis of a cohort of 46 patients (Pubmed Central) - Jun 8, 2021
Thymectomy is considered an effective treatment for myasthenia gravis but the benefit is not immediate. The presence of thymoma may determine a worse initial clinical response following thymectomy in patients with myasthenia gravis.

|||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, Journal: Clinical characteristics and immunological abnormalities of Castleman disease complicated with autoimmune diseases. (Pubmed Central) - Jun 8, 2021
Systemic inflammation/immunological abnormalities and organ dysfunction were associated with the occurrence of AID in CD. Impairment of cellular and innate immunity may be a candidate etiology for the coexistence of the two entities.

|||||||||| Review, Journal: Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay. (Pubmed Central) - Jun 8, 2021
Infections are recognized trigger of exacerbations and crisis in MG and patients with MG probably exhibit a mortality higher than the general population during this COVID-19 pandemic. We review the current state of knowledge on MG during the COVID-19 pandemic to focus the immunological and respiratory interplay between these two conditions.

|||||||||| Blincyto (blinatumomab) / Astellas, Amgen, Yervoy (ipilimumab) / Ono Pharma, BMS
Review, Journal: Neurological complications of cancer immunotherapy. (Pubmed Central) - Jun 8, 2021
The approval of ipilimumab, a monoclonal antibody targeting the immune cell receptor CTLA-4, has marked the beginning of the era of immune checkpoint inhibitors...Close clinical monitoring for neurological symptoms is key for early recognition of immunotherapy-related side effects. Comprehensive diagnostic work-up and adequate therapeutic measures are essential to avoid further clinical deterioration and residual neurological deficits.



	Diseases Companies Products Productz Mechanisms of Action Sites