Myasthenia Gravis
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  • ||||||||||  Journal:  Evaluation of outcome measures for myasthenia gravis subgroups. (Pubmed Central) -  Oct 6, 2021   
    Patient-reported scale is an important supplement for a given period. MG-ADL has a better response to severe disease, and MG-QOL15r is more comprehensive for patients in remission or minimal manifestation status.
  • ||||||||||  Firdapse (amifampridine) / BioMarin, Catalyst Pharma
    Journal:  Lambert-Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma. (Pubmed Central) -  Oct 5, 2021   
    One month later patient present a muscle weakness in both lower limbs and fatigability followed by an inability to walk. The diagnosis of LEMS was made from the distinctive electromyogram (EMG) findings and a treatment with Amifampridine (3, 4-diaminopyridine phosphate [3, 4-DAP]) was prescribed with evident efficacy for symptoms.
  • ||||||||||  Subxyphoidal single-port thymectomy for myasthenia gravis with thymic hyperplasia (Carl-Zeiss-Saal, right (ground floor)) -  Oct 2, 2021 - Abstract #DGT2021DGT_167;    
    The minimally invasive subxiphoidal single-port thymectomy is a safe, gentle and cosmetically excellent procedure for the multidisciplinary treatment of myasthenia gravis. Furthermore, the indication for surgery should also be made for thymus hyperplasia in combination with myasthenia gravis as it can lead to an improvement in the clinical symptoms.
  • ||||||||||  9 year results after the introduction of thymus surgery (Carl-Zeiss-Saal, right (ground floor)) -  Oct 2, 2021 - Abstract #DGT2021DGT_166;    
    The thymectomy can be performed thoracoscopically with a high degree of security for the patient. Multiple resections of thymomas are also possible and can be carried out with a good prognosis for the patient, which speaks in favor of a correspondingly tight follow-up regime for this tumor entity.
  • ||||||||||  Clinical, Retrospective data, Journal:  Clinical features and outcome of acquired myasthenia gravis in 94 dogs. (Pubmed Central) -  Oct 2, 2021   
    Multiple resections of thymomas are also possible and can be carried out with a good prognosis for the patient, which speaks in favor of a correspondingly tight follow-up regime for this tumor entity. Clinical remission in MG is less likely in older dogs and dogs presenting with regurgitation or high initial AChR Ab concentration, but more likely in younger dogs and dogs with comorbid endocrine disease.
  • ||||||||||  prednisolone / Generic mfg.
    Biomarker, Journal:  Long-term outcomes and prognostic factors in generalized myasthenia gravis. (Pubmed Central) -  Sep 30, 2021   
    Approximately 60% of the MG patients achieved the treatment goal within 2 years after treatment. PSL dose and the cumulative number of plasmapheresis procedures at 3 months after immunotherapy initiation may help identify treatment-resistant patients with MG.
  • ||||||||||  prednisone / Generic mfg.
    Journal:  Chronic low-dose intravenous immunoglobulins as steroid-sparing therapy in myasthenia gravis. (Pubmed Central) -  Sep 30, 2021   
    PSL dose and the cumulative number of plasmapheresis procedures at 3 months after immunotherapy initiation may help identify treatment-resistant patients with MG. This retrospective study demonstrates that chronic low-dose IVIg treatment in patients with MG improves clinical outcomes and has a prolonged and significant steroid-sparing effect over a period of 3 years.
  • ||||||||||  azithromycin / Generic mfg.
    Clinical, Journal:  Myasthenia gravis and COVID-19: A case series and comparison with literature. (Pubmed Central) -  Sep 30, 2021   
    The results from our study suggest that prior MG activity could partially influence the subsequent clinical outcomes. It emerged also that ongoing long-term immunosuppressive immunotherapy to MG should be maintained during the COVID-19 pandemic and that AZM can be used safely in MG patients and concurrent COVID-19 infection.
  • ||||||||||  Fraxiparine (nadroparin) / Aspen
    Clinical, Review, Journal:  Myasthenia gravis and covid-19 in pregnancy: a review of the literature and case series report. (Pubmed Central) -  Sep 29, 2021   
    Based on our observations in this study it would seem that the coexistence of MG and COVID-19 infection in pregnancy does not elicit exacerbation in neither of those conditions. Further research is needed to confirm or challenge these findings, especially with the prospects of new virus variants emerging in the future.
  • ||||||||||  Review, Journal:  Roles of cytokines and T cells in the pathogenesis of myasthenia gravis. (Pubmed Central) -  Sep 29, 2021   
    Regarding cytokines, interleukin 17 (IL-17; a Th17-related cytokine), IL-21 (a Tfh-related cytokine), the B-cell activating factor (BAFF; a B-cell-related cytokine), and a proliferation-inducing ligand (APRIL; a B-cell-related cytokine) have been reported to be upregulated and associated with clinical parameters of MG. This review focuses on the current understanding of the involvement of cytokines and lymphocytes in the immunological pathogenesis of MG, which may lead to the development of novel therapies for this disease in the near future.
  • ||||||||||  Clinical, Journal:  Immunotherapy Use in Patients With Lung Cancer and Comorbidities. (Pubmed Central) -  Sep 29, 2021   
    Immune checkpoint inhibitor use in individuals with solid organ transplant carries a substantial risk of organ rejection. Ongoing research into the prediction of ICI efficacy and toxicity may help in patient selection, treatment, and monitoring.
  • ||||||||||  Review, Journal:  The history of acetylcholinesterase inhibitors in the treatment of myasthenia gravis. (Pubmed Central) -  Sep 26, 2021   
    What she saw was a dramatic improvement in the symptoms experienced in patients with myasthenia gravis, and thus became the first documented case of use of physostigmine, an acetylcholinesterase inhibitor, in the treatment of myasthenia gravis. This article is a summary of the history of the use of acetylcholinesterase inhibitors in the treatment of myasthenia gravis.
  • ||||||||||  amoxicillin / Generic mfg.
    Clinical, Journal:  Case 292: Lyme Neuroborreliosis. (Pubmed Central) -  Sep 26, 2021   
    Her medical history was notable for Raynaud syndrome, recurrent streptococcal pharyngitis, and an allergy to amoxicillin...She received ciprofloxacin for presumed urinary tract infection based on urinalysis, which demonstrated few bacteria and was negative for leukocyte esterase, nitrites, and white blood cells...She denied recent travel. High-spatial-resolution MRI of the brain and orbit were performed.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    [VIRTUAL] Orbital Pseudotumor After Kawasaki Disease: A Case Report () -  Sep 25, 2021 - Abstract #AAPNCE2021AAP_NCE_1696;    
    Though this is rare in children, it may occur in relation to Kawasaki disease or other autoimmune processes. CT or MRI with contrast-enhanced sequences allow for diagnosis to facilitate treatment with systemic corticosteroids, which is essential for management.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
    Minimizing Neuromuscular Blockade For Large Anterior Mediastinal Mass Resection (Exhibit Hall) -  Sep 25, 2021 - Abstract #ASA2021ASA_4972;    
    A 35Fr double-lumen tube was placed and lower extremity IV access was ensured. The decision was made to exchange the double for a single-lumen tube and the patient was transferred for extubation in the ICU the morning after surgery.
  • ||||||||||  Concurrent Checkpoint Inhibitor-induced Myocarditis And Myasthenia Gravis (Exhibit Hall) -  Sep 25, 2021 - Abstract #ASA2021ASA_4890;    
    Plasma exchange therapy was initiated without improvement, and family transitioned to comfort care. Patients receiving checkpoint inhibitor immunotherapy may be at unique risk for cardiopulmonary complications.
  • ||||||||||  Perioperative Management Of A Patient In Myasthenic Crisis Undergoing Thymectomy (Exhibit Hall) -  Sep 25, 2021 - Abstract #ASA2021ASA_3627;    
    Perioperative management included use of noninvasive positive pressure ventilation until induction of general anesthesia, avoidance of neuromuscular blocking agents, and maintenance of mechanical ventilation postoperatively. Patients with myasthenia gravis require careful anesthetic planning tailored to the current presentation and medical history.
  • ||||||||||  Review, Journal:  A systematic review of myasthenia gravis complicated with myocarditis. (Pubmed Central) -  Sep 24, 2021   
    The prognosis of patients with MG complicated with myocarditis is poor, and myocardial enzymes and other indexes need to be monitored for patients taking ICI drugs. Patients with dyspnea who are still not ideally treated by mechanical ventilation should be vigilant against the occurrence of MG complicated with myocarditis.