- |||||||||| Journal, Adverse events, Checkpoint inhibition: Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database. (Pubmed Central) - Jul 26, 2024
The LAG-3 inhibitor relatlimab reported fewer AEs, including pyrexia and pneumonia...This study provides a detailed overview of the 25 most common AEs associated with ICIs, offering valuable insights for clinical decision-making and AE management. Further research is necessary to elucidate the mechanisms underlying these AEs and to develop targeted interventions to enhance the safety and efficacy of ICI therapy in patients with cancer.
- |||||||||| Review, Journal: The Application Potential of the Regulation of Tregs Function by Irisin in the Prevention and Treatment of Immune-Related Diseases. (Pubmed Central) - Jul 26, 2024
This article reviews the relationship between irisin and Tregs, as well as the research progress of irisin in immune-related diseases such as multiple sclerosis, myasthenia gravis, acquired immune deficiency syndrome, type 1 diabetes, sepsis, and rheumatoid arthritis. Studies have revealed that irisin plays an important role in immune regulation by improving the function of Tregs, suggesting its potential application value in the treatment of immune-related diseases.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Lenvima (lenvatinib) / Eisai, Merck (MSD)
Tyrosine Kinase Inhibitors (Alone or in Combination) for the Management of Advanced Thymic Epithelial Tumors (TETs) Among Hispanics (Exhibit Hall) - Jul 24, 2024 - Abstract #IASLCWCLC2024IASLC_WCLC_2451;
Earlier treatment lines favored better PFS, with patients treated with TKI as a fourth line reaching a median of 1.28 months compared to 5.97 months as a second and 6.33 months as a third line (p<0.001). Conclusions : These findings suggest that TKIs are efficacious as second or post-line treatments and represent a viable treatment option for Hispanic patients with advanced TETs.
- |||||||||| Mapping the Distribution of Ectopic Thymus Through Flow Cytometry Analysis of CD3mediumTCRv (Exhibit Hall) - Jul 24, 2024 - Abstract #IASLCWCLC2024IASLC_WCLC_2447;
Conclusions : Our findings emphasize the reliability of flow cytometry as an alternative method for detecting ETs, overcoming the limitations of traditional histological examination. Moreover, we provide a novel distribution map of ETs based on this approach, offering valuable insights to enhance surgical decision-making in MG treatment.
- |||||||||| etoposide IV / Generic mfg.
Real-World Trends in Screening and Evaluation of Paraneoplastic Syndromes among Patients with Small Cell Lung Cancer (Exhibit Hall) - Jul 24, 2024 - Abstract #IASLCWCLC2024IASLC_WCLC_2333;
Patients with presumed SCLC (ICD-9-CM 162.X excluding 162.0, ICD-10-CM C34.X, + etoposide + platinum therapy) were identified based on ?2 claims ?30 days apart...Conclusions : This study revealed a low rate of PNS screening persisted among patients with SCLC despite the introduction of screening recommendations in suspected patients. This finding highlights the importance of increased awareness of neurologic PNS among oncologists, including those in the community, as treatment options are available for patients with neurologic PNS.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Immune-Related Myasthenia Gravis in Patients with NSCLC: A Case Series (Exhibit Hall) - Jul 24, 2024 - Abstract #IASLCWCLC2024IASLC_WCLC_2110;
2021. Abbreviation: AChEI, acetylcholinesterase inhibitor; CT, computerized tomography; ECOG, Eastern Cooperative Oncology Group; ICI, immune checkpoint inhibitor; irAE, immune-related adverse event; MG, myasthenia gravis; MGFA, Myasthenia Gravis Foundation of America; MRI, magnetic resonance imaging; PD-L1, programmed death-ligand 1; RNS, repetitive nerve stimulation
- |||||||||| Vyvgart (efgartigimod alfa-fcab) / argenx, Broteio
Perioperative Efficacy and Safety of Efgartigimod in Thymoma Associated Myasthenia Gravis (Exhibit Hall) - Jul 24, 2024 - Abstract #IASLCWCLC2024IASLC_WCLC_1617;
Conclusions : The satisfactory outcomes support the effectiveness and safety of efgartigimod during the perioperative period of thymectomy for TAMG. Large-scale clinical trials are needed to validate our important findings.
- |||||||||| Review, Journal: Recommendations for the management of myasthenia gravis in Belgium. (Pubmed Central) - Jul 23, 2024
As many new treatments might potentially come to market, a realistic future perspective on the impact of these treatments on clinical practice is given. In conclusion, these recommendations intend to be a guide for neurologists treating patients with MG in Belgium.
- |||||||||| Retrospective data, Journal: A new pragmatic classification system for thymoma associated myasthenia gravis: a retrospective cohort study. (Pubmed Central) - Jul 22, 2024
Here, we propose a novel classification system based on Masaoka stage and Myasthenia Gravis Foundation of America (MGFA) classification, aiming to guide surgical decisions and perioperative management for these patients. Considering both oncological and neurological factors, this novel TAMG classification provides valuable information on outcome stratification and clinical decision-making for TAMG.
- |||||||||| Journal: A Case of Congenital Myasthenia Gravis due to ChAT Gene Mutation in a Term Neonate: A Case Report. (Pubmed Central) - Jul 22, 2024
The patient had a tracheostomy placed on day 50 and was discharged on day 94 of life on tracheostomy and G-tube, given feeding intolerance. This case illustrates the value of genetic testing in determining the type of CMS to guide management and the importance of obtaining family history to have such syndromes earlier in the differential diagnosis to initiate treatment promptly.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Journal: Pembrolizumab-induced Myasthenia Gravis and Myocarditis. (Pubmed Central) - Jul 22, 2024
While neurologic irAE are underrepresented in literature, their consequences could lead to fatal outcomes. In this report, we describe the case of a patient with excellent performance status prior to pembrolizumab therapy who subsequently suffered myasthenic crisis eventually requiring tracheostomy and long-term mechanical ventilation.
- |||||||||| Review, Journal: Integrated Applied Clinical Pharmacology in the Advancement of Rare and Ultra-Rare Disease Therapeutics. (Pubmed Central) - Jul 22, 2024
Learnings from these programs include the importance of assuring cross-validation of assays throughout a development program and continued commitment to understanding the relationship among the array of Pd end points and clinical outcomes. Using an integrative approach, substantive work remains to be done to meet the unmet needs of patients with rare/ultra-rare disease.
- |||||||||| mycophenolate mofetil / Generic mfg., azathioprine / Generic mfg.
Journal: Azathioprine and mycophenolate mofetil in myasthenia gravis. (Pubmed Central) - Jul 20, 2024
Using an integrative approach, substantive work remains to be done to meet the unmet needs of patients with rare/ultra-rare disease. No abstract available
- |||||||||| Journal: Cooccurrence of Myasthenia Gravis and Epilepsy: A Case Report. (Pubmed Central) - Jul 19, 2024
While the relationship between MG and epilepsy remains unclear, it is known that antiepileptic drugs can exacerbate MG. The rarity of this association suggests a need for cautious selection of antiepileptic treatments to avoid worsening either condition.
- |||||||||| prednisone / Generic mfg., methotrexate / Generic mfg.
Journal: Case report: A patient with brachio-cervical inflammatory myopathy was misdiagnosed as flail arm syndrome. (Pubmed Central) - Jul 18, 2024
Muscle biopsy revealed numerous foci of inflammatory cells distributed throughout the muscle bundle, with predominant CD20, CD138, and CD68 expression, accompanied by a light infiltration of CD3 and CD4 expression. The muscle weakness improved with the combination of oral prednisone (initially 60 mg/day, tapered) and methotrexate (5 mg/week) treatment.
- |||||||||| Hernicore (condoliase) / Seikagaku, Ferring
Intradiscal Condoliase Injection Therapy for elderly Lumbar Disc Herniation (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2504;
Although there was residual pain, the patient's sleep disturbance due to pain improved from the early postoperative period, and patients were highly satisfied with the treatment. Also, their family's level of care decreased.In a hyper-aged society, condoliase-induced chemonucleolysis may be a good treatment for lumbar disc herniation pain that can be considered before surgical treatment.
- |||||||||| ketamine / Generic mfg., warfarin / Generic mfg., enoxaparin sodium / Generic mfg.
Supra Inguinal Fascia Iliaca Block with Sedation Only for Hip Fracture Repair- A Case Report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1379;
Also, their family's level of care decreased.In a hyper-aged society, condoliase-induced chemonucleolysis may be a good treatment for lumbar disc herniation pain that can be considered before surgical treatment. Sedation was facilitated using midazolam 1 mg, propofol infusion 50
- |||||||||| Rituxan (rituximab) / Roche
Journal: Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus. (Pubmed Central) - Jul 16, 2024
Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following immunosuppression with pulse corticosteroids and rituximab, and at 3?months no longer needed bilevel positive airway pressure support.
- |||||||||| Journal, Reflex: Postexercise reflex facilitation in Lambert-Eaton myasthenic syndrome. (Pubmed Central) - Jul 16, 2024
Further investigation identified a small cell neuroendocrine carcinoma of the gallbladder, not previously associated with LEMS. Postexercise reflex facilitation is an important bedside clinical finding that helps clinicians to distinguish LEMS from its mimics.
- |||||||||| Journal: Neurologic disease in the obstetric patient. (Pubmed Central) - Jul 16, 2024
Postexercise reflex facilitation is an important bedside clinical finding that helps clinicians to distinguish LEMS from its mimics. While clinical trials remain sparse, larger population-based studies offer insight into the optimal approach to the parturient with neurologic disease.
- |||||||||| Review, Journal: Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders. (Pubmed Central) - Jul 15, 2024
In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications. Here we highlight the need for further research to fully understand the mechanisms underlying these disorders, and to develop new diagnostic and therapeutic strategies.
- |||||||||| ondansetron/pyridostigmine (DAS-001) / DAS Therap
Trial completion date, Trial primary completion date: Study of Pyridostigmine With Ondansetron in Subjects With Anti-AchR Positive Myasthenia Gravis (clinicaltrials.gov) - Jul 12, 2024
P2, N=24, Recruiting,
We discuss the pathophysiology of ARFID, which remains elusive, and recommend psychiatric assessment when evaluating children post operative tonsillectomy. Trial completion date: Apr 2023 --> Sep 2026 | Trial primary completion date: Apr 2023 --> Jul 2025
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