Musculoskeletal Diseases
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  • ||||||||||  Trial completion date, Trial primary completion date:  Effects of AlignBabyCleft (ABaCleft) (clinicaltrials.gov) -  Apr 25, 2025   
    P=N/A,  N=30, Not yet recruiting, 
    Trial completion date: Nov 2025 --> Nov 2028 | Trial primary completion date: Nov 2023 --> Nov 2027
  • ||||||||||  Trial completion date, Trial primary completion date:  FNS (FEMORAL NECK SYSTEM) Study (clinicaltrials.gov) -  Apr 25, 2025   
    P=N/A,  N=50, Recruiting, 
    Trial primary completion date: Jun 2024 --> Jun 2025 Trial completion date: May 2025 --> May 2026 | Trial primary completion date: May 2025 --> May 2026
  • ||||||||||  Trial completion date, Trial primary completion date:  Pilot Study of ZetaFuse (clinicaltrials.gov) -  Apr 25, 2025   
    P=N/A,  N=10, Recruiting, 
    Trial completion date: Jan 2025 --> Dec 2026 Trial completion date: Sep 2025 --> Sep 2027 | Trial primary completion date: Sep 2024 --> Sep 2026
  • ||||||||||  Trial completion, Enrollment change, Trial completion date:  Plantar Fasciitis Management on Postural Control (clinicaltrials.gov) -  Apr 25, 2025   
    P=N/A,  N=24, Completed, 
    Trial completion date: Sep 2025 --> Sep 2027 | Trial primary completion date: Sep 2024 --> Sep 2026 Recruiting --> Completed | N=40 --> 24 | Trial completion date: Apr 2025 --> Dec 2024
  • ||||||||||  Preclinical, Journal:  Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation. (Pubmed Central) -  Apr 21, 2025   
    These transcription factors, known for their roles in bone regeneration, skeletal patterning, osteoblast activity, fracture healing, angiogenesis, and key signaling pathways, may act as master regulators of the regenerative gene signatures. Additionally, we developed a deep learning AI model capable of predicting post-amputation time and level from RNA-seq data, indicating that the regenerative probability may be "encoded" in the transcriptomic response to amputation.
  • ||||||||||  Journal:  Stages and future of women's health: A call for a life-course approach. (Pubmed Central) -  Apr 21, 2025   
    It concludes by drawing governments and the global community's attention to the need to focus healthcare systems on universal, gender-sensitive healthcare policies that guarantee accessible, affordable, and high-quality services tailored to women's needs at every stage of life. Policies and programs that support women at every stage of life must take center stage in the quest to create a future where all women, regardless of age or background, can achieve optimal health and well-being.
  • ||||||||||  Journal:  Factors Influencing Growth in Gender Diversity Within Orthopaedic Surgery. (Pubmed Central) -  Apr 21, 2025   
    Presence of practicing female orthopaedic surgeons was associated with growth in certain geographic regions. Future work should investigate factors associated with regional growth if specialties seek to move toward sex representation that reflects the United States population.
  • ||||||||||  Journal:  Has This Child Experienced Physical Abuse?: The Rational Clinical Examination Systematic Review. (Pubmed Central) -  Apr 21, 2025   
    A detailed physical examination that reveals oral injury, bruises on the buttocks or neck, patterned bruises, and subconjunctival hemorrhage in young children should alert clinicians to the possibility of physical abuse. Findings on neuroimaging and ophthalmologic evaluation in infants and young children with head trauma can help clinicians determine the likelihood of physical abuse.
  • ||||||||||  Clinical, Journal:  Removable Boot vs Casting of Toddler's Fractures: A Randomized Clinical Trial. (Pubmed Central) -  Apr 21, 2025   
    P=N/A
    While there was a clinically relevant but not statistically significant trend toward more skin complications in the boot group, there was no difference in caregiver satisfaction, and the boot strategy demonstrated reduced childcare-related challenges. ClinicalTrials.gov Identifier: NCT03971448.
  • ||||||||||  Journal:  Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study. (Pubmed Central) -  Apr 21, 2025   
    Osteosarcopenia, osteoarthritis and frailty exhibit significant causal effects, rendering them risk factors for frailty. Therefore, in clinical practice, patients with osteosarcopenia and osteoarthritis should be required to undergo relevant interventions to reduce the risk of frailty.
  • ||||||||||  Observational data, Journal:  The cost of implant waste in trauma orthopaedic surgery and sustainability considerations: an observational study. (Pubmed Central) -  Apr 21, 2025   
    Targeted interventions, including improved preoperative planning, precision-based implant selection, and enhanced intraoperative decision-making, are essential to reducing waste and improving cost-efficiency and sustainability in surgical practices. Further research should explore the broader economic and environmental impact of implant wastage, incorporating factors such as operative time and carbon footprint to develop comprehensive waste-reduction strategies.
  • ||||||||||  Journal:  Differentiating Chronic Neuropathic Rib Pain: A Case Report. (Pubmed Central) -  Apr 21, 2025   
    Improvement after the use of antihistamines for lumbar stenosis pain is rare and leads to consideration of its use as a treatment option. This article highlights the need to consider neuroma formation in the setting of blunt trauma and the benefits of diagnosis provided by musculoskeletal ultrasound.
  • ||||||||||  Review, Journal:  Peripheral Nerve Stimulation for Rotator Cuff-Induced Chronic Shoulder Pain: A Literature Review. (Pubmed Central) -  Apr 21, 2025   
    Preliminary studies suggest that PNS may be an effective treatment option for chronic shoulder pain due to rotator cuff etiology. To accurately assess the effect of PNS on chronic shoulder pain due to rotator cuff pathology significantly more data, including prospective trials, are required and warrant pursuit.
  • ||||||||||  Journal:  BLEACHER COLLAPSE - A UNIQUE MASS-CASUALTY ORTHOPAEDIC EVENT (Pubmed Central) -  Apr 21, 2025   
    Bleachers are widely used throughout the world for various events. Our experience shows that hospitals should be prepared for this type of unique mass-casualty accident that leads to many musculoskeletal injuries.
  • ||||||||||  Retrospective data, Journal:  DOES KYPHOPLASTY AFFECT THE SIZE OF THE VERTEBRAL BODY? (Pubmed Central) -  Apr 21, 2025   
    Our study demonstrated significant improvements in many parameters, wWith great improvement in the PMHC ratio from 65% to 84%. Further studies with a greater sample of patients and patient-reported outcomes measures (PROMs) are needed to define the success of the surgery.
  • ||||||||||  Journal:  INNOVATIONS IN ORTHOPEDIC SURGERY (Pubmed Central) -  Apr 21, 2025   
    In recent years, we have experienced impressive technological and scientific advances that have brought about a real revolution in our ability to treat complex situations and improve the quality of life of our patients. The current issue of 'Harefuah' presents research and review articles that reflect the new technologies - from advanced imaging, robotics, smart implants, and innovative surgical approaches that allow us to achieve unprecedented precision, reduce risks, and significantly improve the results of treatment and rehabilitation.