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268 Companies |
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176 Products |
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176 Products |
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123 Mechanisms of Action |
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5552 Trials |
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233459 News |
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- | Trial completion date: The Accuracy of Reconstruction of Orbital Walls Fracture Using Prebent Mesh Versus Patient Specific Implant (clinicaltrials.gov) - May 6, 2025
P=N/A, N=20, Completed, Sponsor: Tanta University
Trial completion date: Jun 2024 --> Dec 2024
- | Journal: Applying the jigsaw learning method to structural kinesiology. (Pubmed Central) - May 5, 2025
To enhance the impact of the jigsaw method, we discuss common challenges to the technique and how to overcome these barriers. Thus, we aim to display the potential of the jigsaw method to foster a supportive learning environment in structural kinesiology, despite limitations, to enhance student engagement and learning.
- | Journal: Real-time Precision Tracking System in Periprosthetic Acetabular Osteotomy with Osteotome Chisel Elastic Deformation Consideration. (Pubmed Central) - May 5, 2025
Our model has achieved an impressive R2 value of 0.98781 and an average deformation error of only 0.07 mm in nodes compared to the experiment. Implementing such an osteotome chisel with a deformation tracking system has shown immense potential in increasing surgical accuracy and reducing medical negligence for PAO operations.
- | Journal, HEOR: Global, regional, and national burden of vertebral fractures due to falls from 1990 to 2021 and predictions for the next 15 years: A systematic analysis of the global burden of disease 2021 study. (Pubmed Central) - May 5, 2025
Although the burden of vertebral fractures is on a downward trend, it continues to increase in low and middle SDI regions, as well as among the elderly population. Therefore, targeted preventive measures are still necessary to address the health outcomes related to vertebral fractures.
- | Journal: 3D motion capture data into a kinematic composite score for assessing musculoskeletal impairments. (Pubmed Central) - May 5, 2025
Therefore, targeted preventive measures are still necessary to address the health outcomes related to vertebral fractures. Importantly, the K-Score was not sensitive to BMI (p
- | Journal: Bone pain in fibrous dysplasia does not rely on aberrant sensory nerve sprouting or neuroma formation. (Pubmed Central) - May 5, 2025
Finally, we provide the first analysis of a series of human FD bone biopsies showing that, within the lesional tissue, sensory nerve fibers are few despite the rich vascular network and appear to be well-organized. These data show that albeit sensory nerve fibers are found within FD lesions, bone pain in humans and functional impairment in mice are not associated to pathological sensory nerve sprouting or formation of neuromas in the Gs?-mutated skeleton.
- | Observational data, Journal: Vitamin D and tibial bone density, geometry, and microarchitecture in male military recruits: an observational study and randomized controlled trial. (Pubmed Central) - May 5, 2025
Training decreased trabecular area (-0.1%), thickness (-4.4%), and separation (-2.1%), and increased cortical thickness (0.8%) and area (0.9%) (p???.042). Vitamin D metabolites and their ratios were associated with tibial size and microarchitecture, but vitamin D supplementation had no impact on the adaptive response to military training.
- | Journal: Increased risk of vertebral fractures and reduced risk of femur fractures in patients with chronic hypoparathyroidism: a Nationwide cohort study in Sweden. (Pubmed Central) - May 5, 2025
Vertebral fracture risk was higher while the femur fracture risk was lower compared to controls. Despite higher prevalence of osteoporosis diagnoses, these patients received less frequently osteoporosis medications.
- | zoledronic acid / Generic mfg.
Journal: In early postmenopausal women, zoledronate vs. placebo at baseline and 5 y reduced morphometric vertebral fractures at 10 y. (Pubmed Central) - May 5, 2025
Despite higher prevalence of osteoporosis diagnoses, these patients received less frequently osteoporosis medications. GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
- || Clinical, Journal: Comparison of fracture resistance values of Class 1 composite restorations made with incremental and snowplow techniques. (Pubmed Central) - May 5, 2025
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text]. Application of short fiber reinforced composite with the snowplow technique resulted in lower mechanical values, whereas application with the incremental technique provided high mechanical characteristics like those of the control group.
- || Clinical, Journal: Push-out force evaluation of titanium cylinders attached to implant supported immediate provisional heat-polymerized acrylic resin with various relining material types and thicknesses. (Pubmed Central) - May 5, 2025
The choice of relining resin material and connection thickness significantly influence the push-out force on titanium cylinders attached to IPHPs. Selecting appropriate resin material types and thicknesses can enhance the long-term stability and clinical performance of IPHPs, reducing the risk of fractures during implant osseointegration period.
- || Clinical, Retrospective data, Journal: Short versus long cephalomedullary nails for intertrochanteric femur fractures: A meta-analysis of randomized controlled trials. (Pubmed Central) - May 5, 2025
Short CMN are associated with shorter duration of surgery, reduced tip-apex distance, and lower intraoperative blood loss compared to long CMN for the fixation of IFFs. However, there were no significant differences in functional outcomes, overall complication rates, reoperation rates, mortality within one year, peri-implant fracture, or lengths of hospital stays.
- || Clinical, Journal: Can kinesio tape negatively affect the treatment by creating a hard floor in plantar fasciitis treatment? A randomized clinical trial. (Pubmed Central) - May 5, 2025
P=N/A
This may be related to the fact that KT application to the sole and heel region creates a hard surface on the heel. r-ESWT application may be more beneficial in PF where activity limitation are prominent.
- | Journal, HEOR: The health-related quality of life among survivors with post-COVID conditions in the United States. (Pubmed Central) - May 5, 2025
Our study corroborates that survivors with PCCs may experience significant adverse impacts on their health and daily life activities. Our results highlight the importance of further studies on PCCs' diagnosis, follow-up, and treatment.
- || Clinical, Preclinical, Journal: Comparing Transperitoneal Retroperitoneal Access and Percutaneous Puncture for Lumbar Disc Degeneration Modeling in Rabbits. (Pubmed Central) - May 5, 2025
These findings highlight the advantages of the trans-retroperitoneal approach in IVDD modeling. This study provides valuable insights into the establishment of IVDD models and lays a foundation for future investigations into effective treatment strategies for low back pain, ultimately improving patient outcomes.
- | Journal: Comparative Analysis of Postoperative Rotational Malalignment in Pediatric Supracondylar Humerus Fractures: Cross Pinning Versus Lateral Para-olecranon Pinning. (Pubmed Central) - May 5, 2025
Both LPOP and CP resulted in similar rotational outcomes; however, LPOP offered shorter anesthesia and surgery times without increasing the risk of complications. LPOP might be a safe and more effective alternative technique, showing equivalent clinical results and lowering the incidence of iatrogenic nerve injuries.
- | Trial completion: SCIPE: Spinal Cord Injury Program in Exercise (clinicaltrials.gov) - May 5, 2025
P=N/A, N=100, Completed, Sponsor: University of Alabama at Birmingham
LPOP might be a safe and more effective alternative technique, showing equivalent clinical results and lowering the incidence of iatrogenic nerve injuries. Active, not recruiting --> Completed
- | Decadron (dexamethasone) / Merck (MSD)
Trial completion date, Trial primary completion date: Intra Op: Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy (clinicaltrials.gov) - May 5, 2025
P4, N=200, Recruiting, Sponsor: University of Missouri-Columbia
Active, not recruiting --> Completed Trial completion date: Oct 2025 --> Oct 2026 | Trial primary completion date: Oct 2025 --> Oct 2026
- | Prolia (denosumab) / Amgen, Evenity (romosozumab-aqqg) / Astellas, Amgen, UCB, alendronate / Generic mfg.
Retrospective data, Journal: Assessing the Efficacy of Romosozumab in Postmenopausal Osteoporosis: An Updated Systematic Review and Meta-analysis. (Pubmed Central) - May 5, 2025
This comprehensive meta-analysis provides robust evidence that romosozumab is an effective and safe treatment option for postmenopausal osteoporosis, with superior effects on BMD and bone formation biomarkers compared with other interventions. These findings support the use of romosozumab to improve clinical outcomes in this patient population.
- | Observational data, Journal: Craniofacial Soft Tissue Injuries: An Observational Study of Bicycling Injuries From a Level 1 Trauma Center. (Pubmed Central) - May 5, 2025
Thus, craniofacial soft tissue injuries in cyclists are influenced by age, sex, and helmet use. Helmet use is associated with decreased odds of soft tissue injury of the upper face but with increased odds of soft tissue injury of the lower facial third.
- | Journal: Craniofacial Injuries Related to Racquet Sports: A NEISS Database Query. (Pubmed Central) - May 5, 2025
Despite existing safety guidelines, this study has elucidated the persistence of craniofacial injuries, suggesting the need for increased compliance with guidelines and advancements in equipment design. There is an evident need for more data on sport-specific injuries to guide and develop more effective injury prevention strategies.
- | Journal: Clinical Features and Radiologic Findings of Orbital Bone Remodeling in Pediatric Patients After Orbital Fracture Correction. (Pubmed Central) - May 5, 2025
Most pediatric patients with BOFs experienced successful bone remodeling, regardless of age, fracture type, and size. Surgical correction is recommended for pediatric patients with BOFs to achieve successful bone remodeling.
- | Journal: Management of Adult Condylar and Subcondylar Mandibular Fractures in a Level 1 Trauma Center. (Pubmed Central) - May 5, 2025
Our findings demonstrate that closed reduction is the most common management of condylar and subcondylar fractures. Future directions include ideal timing for operative management and long-term follow-up for temporomandibular joint complications in closed reduction patients.
- | Prolia (denosumab) / Amgen
Journal: Calf circumference predicts changes of bone mineral density in postmenopausal osteoporotic women receiving denosumab. (Pubmed Central) - May 5, 2025
Future directions include ideal timing for operative management and long-term follow-up for temporomandibular joint complications in closed reduction patients. In postmenopausal osteoporotic women, the CC was positively and independently associated with denosumab treatment response.
- || Review, Journal: Why does the patellofemoral cartilage collapse? : A (Pubmed Central) - May 5, 2025
Therapeutically, the main focus should always be on correcting biomechanical imbalances, in order to allow for effective cartilage regeneration. The latter can be achieved by several techniques for cartilage regeneration.
- | Penthrox (methoxyflurane) / Medical Developments International
Journal: Out-of-hospital neck of femur injury: An eight-year observational analysis. (Pubmed Central) - May 5, 2025
According to adjusted analysis, increasing age (Adjusted Odds Ratio (AOR)=1.026, 95% Confidence Interval (CI): 1.021,1.031), paramedic attendance (relative to basic life support-trained personnel, AOR = 3.471 (95%CI 2.921,4.125)), increasing initial pain score (AOR = 1.705 (95%CI 1.665,1.747)), application of a splint (AOR = 1.272 (95%CI 1.147,1.411)) and analgesia administration including opioids and methoxyflurane were associated with clinically meaningful pain reduction...Although most patients with neck of femur fractures reported a clinically meaningful reduction in pain, 30.5% of patients reported moderate to severe pain upon conclusion of out-of-hospital treatment. Expansion of analgesic options available to basic life support-trained patient transport officers, and educating prehospital clinicians on the safety and efficacy of analgesics and splinting practices, represent future opportunities for improvement.
- | Journal: Inter-reader reliability in multi-plane and multi-time point Hallux valgus correction evaluation on post-operative weight-bearing radiographs from a prospective multi-center trial and correlation with patient reported outcome measures. (Pubmed Central) - May 5, 2025
We report excellent reproducibility for HVA in post-operative radiographs but variable- poor to excellent IRR for a range of HV-related parameters assessed on the axial view. There were no major trends in the correlation between the quantitative radiographic foot measurements and PROMs except for some weak correlations.
- | Journal: Running Distance and Biomechanical Risk Factors for Plantar Fasciitis: A 1-yr Prospective 4HAIE Cohort Study - Corrigendum. (Pubmed Central) - May 5, 2025
There were no major trends in the correlation between the quantitative radiographic foot measurements and PROMs except for some weak correlations. No abstract available
- || Review, Journal: Gymnastics Medicine: A New Subspecialty in Sports Medicine. (Pubmed Central) - May 5, 2025
Gymnastics Medicine is a needed subspecialty. There are many medical subspecialties involved with the care of gymnasts who would benefit from a concentrated field, and this field allows those clinicians to collaborate, enhance research, and most importantly, improve the safety and health of athletes in gymnastics.
- | Journal: Profiling of Anti-FVIII Antibodies in Acquired Haemophilia A: 'Insights into Domain Specificity, Isotype Variability, and Clinical Correlations'. (Pubmed Central) - May 5, 2025
Anti-FVIII antibody profiling reveals distinct patterns in AHA, with IgG4 linked to higher inhibitor levels. The C1C2 domain specificity of the anti-FVIII antibodies suggests a potential role of this FVIII domain in the immunopathology of AHA patients, warranting further investigation to improve prognostic tools.
- | Journal: Where Did the Juice Go on My ICD? (Pubmed Central) - May 5, 2025
The C1C2 domain specificity of the anti-FVIII antibodies suggests a potential role of this FVIII domain in the immunopathology of AHA patients, warranting further investigation to improve prognostic tools. No abstract available
- || Review, Journal: Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review. (Pubmed Central) - May 5, 2025
The main risk factors were dyslipidemia, age, ethnicity, muscle/ joint pain, and sex. This review highlights the importance of further studies on the syndrome, its etiology, diagnosis, follow-up, and treatments.
- | Journal: Infracyanine Green-Based Photodynamic Therapy for Immune-Mediated Keratitis in Horses. (Pubmed Central) - May 5, 2025
InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.
- | Journal: Estimation of plasma TGF-?1 after intra-articular platelet rich plasma injection in-patient with anterior disc displacement with intermittent locking of TMJ disorder. (Pubmed Central) - May 5, 2025
Further studies are needed to optimize this treatment modality. Intra-articular platelet-rich plasma injections effectively increased plasma TGF-?1 levels, reduced pain intensity, and improved mandibular opening range in temporomandibular disorder patients.
- | Journal: Morphological effectiveness of platelet-rich plasma application in the experimental treatment of post immobilization extra-articular contractures of the mandible. (Pubmed Central) - May 5, 2025
Intra-articular platelet-rich plasma injections effectively increased plasma TGF-?1 levels, reduced pain intensity, and improved mandibular opening range in temporomandibular disorder patients. The comprehensive morphological study of experimental material conducted by the authors confirmed the effectiveness of platelet-rich plasma in the treatment of post-immobilization extra-articular contractures of the mandible, thereby expanding the available arsenal of treatment methods for this pathology.
- || Review, Journal: An Analysis of Fencing Injuries in the United States: A 10-Year Database Review. (Pubmed Central) - May 5, 2025
Fractures were more prevalent among females, whereas males had a higher prevalence of lacerations. Understanding the epidemiology and nature of fencing injuries can help inform coaches, athletes, and health care providers about potential risks and injury prevention strategies.
- | Journal: Are Large Language Model-Based Chatbots Effective in Providing Reliable Medical Advice for Achilles Tendinopathy? An International Multispecialist Evaluation. (Pubmed Central) - May 5, 2025
While LLM-based chatbots such as ChatGPT 4.0 can deliver high-quality responses to queries regarding Achilles tendinopathy, the inconsistency among specialist evaluations and the absence of standardized assessment criteria significantly challenge our ability to draw definitive conclusions. These issues underscore the need for a cautious and standardized approach when considering the integration of LLM-based chatbots into clinical settings.
- | Journal: Test-Retest Reliability and Responsiveness for the Simplified Chinese Lower Extremity Functional Scale in Patients With Lower Extremity Musculoskeletal Injuries. (Pubmed Central) - May 5, 2025
This study offers evidence of test-retest reliability and responsiveness with MDC and SCB values for the SC-LEFS in Chinese-speaking patients with nonarthritic lower musculoskeletal extremity injuries. Clinicians should consider 5.1 points as the measurement error and 9.5 points as the threshold for clinically meaningful improvement on the SC-LEFS in patients with lower extremity musculoskeletal injuries over a 4-week treatment period.
- || Review, Journal: A Closed Posterior Ankle Dislocation Without Overt Associated Fracture as a Result of a Trampoline Park Injury. (Pubmed Central) - May 5, 2025
Clinicians should consider 5.1 points as the measurement error and 9.5 points as the threshold for clinically meaningful improvement on the SC-LEFS in patients with lower extremity musculoskeletal injuries over a 4-week treatment period. No abstract available
- | Journal: Pathological predictors for curettage and cementation outcome in proximal tibial giant cell tumors. (Pubmed Central) - May 5, 2025
No abstract available The average musculo-skeletal tumor society (MSTS) score was 27.2
- | Journal: Case analysis and finite element analysis of adult head skull fractures in people run over by motor vehicles. (Pubmed Central) - May 5, 2025
Light vehicles and light minicars running over a head usually do not fracture the skull. Head injuries caused by medium vehicles are mainly characterized by multiple skull fractures, and the degree of skull fracture is more serious on the ground side than on the tyre side.
- | Journal: Clinical Characteristics, Histopathological Profile, and Postoperative Outcomes of Tumoral Radiculomedullary Compressions. (Pubmed Central) - May 5, 2025
Meningiomas predominate among intradural extramedullary tumors. Metastases are the most frequent malignant tumors, with prostate adenocarcinoma being the most common histopathological type, often associated with poor neurological outcomes.
- | Biomarker, Journal: Predictive Factors for Tillaux-Chaput Tubercle Fracture: A Case-Control Study. (Pubmed Central) - May 5, 2025
We recommend routine CT scan evaluation for patients >60?years old with stage III or IV pronation-external rotation ankle fractures. Level III, case-control study.
- | Journal: Diagnostic Musculoskeletal Ultrasound in the Evaluation of the Median Nerve. (Pubmed Central) - May 5, 2025
This article reviews the utility of MSK ultrasound in evaluating the median nerve injury, including its anatomy, common injury patterns, sonographic techniques, and clinical implications for professional rehabilitation. By integrating MSK ultrasound into clinical practice, providers can improve the accuracy of diagnosis, monitor healing progression, and guide rehabilitation strategies for optimal patient outcomes.
- | Journal: Plantar Fasciitis: An Autobiographical Case Report From the Perspective of an Athlete and Physician. (Pubmed Central) - May 5, 2025
By integrating MSK ultrasound into clinical practice, providers can improve the accuracy of diagnosis, monitor healing progression, and guide rehabilitation strategies for optimal patient outcomes. Plantar fasciitis (PF) is a common cause of foot pain.
- | Journal: A Rare Atypical Presentation of Bruns-Garland Syndrome: A Case Report and Review of Pathophysiology and Management. (Pubmed Central) - May 5, 2025
This case underscores the need for heightened clinical awareness of atypical BGS presentations and the role of electrodiagnostic and imaging studies in distinguishing it from other neuropathies. Early recognition and comprehensive management are crucial to improving outcomes and preventing further functional decline.
- | Journal: The Perception of Residency Experiences Among Orthopaedic Surgery Residents in the United States Differs by Race and Gender. (Pubmed Central) - May 5, 2025
Early recognition and comprehensive management are crucial to improving outcomes and preventing further functional decline. The results of this study highlight the need to improve equity and inclusion within orthopaedic surgery residencies in order to continue advancing diversity in the field.
- | Journal: Surgical Fixation of Distal Humeral Nonunion in an Elderly Patient Three Years After Injury: A Case Report. (Pubmed Central) - May 5, 2025
Bone union was confirmed four months postoperatively, and the patient regained excellent elbow function with no pain or instability. This case suggests that ORIF can be a viable option even for elderly patients with long-standing distal humeral nonunion when appropriate surgical techniques are employed and articular surfaces are preserved.
- | Journal: Paraneoplastic Sacroiliitis: A Masquerade of Inflammatory Arthritis in Leukemia. (Pubmed Central) - May 5, 2025
This case highlights the importance of considering malignancy in patients presenting with refractory arthritis, particularly when symptoms are atypical or fail to respond to standard treatments. Early recognition and prompt initiation of chemotherapy can significantly improve clinical outcomes.?.
- || Clinical, Journal: [MEP-26] Safety and Efficacy of Endovascular Repair Using Multilayer Flow Modulators for Thoracic Aortic Aneurysms After Type 1 Aortic Dissection. (Pubmed Central) - May 5, 2025
We recommend it as an effective treatment method because it does not obstruct blood flow in the visceral arteries in patients with complex aortic aneurysms. Further randomized clinical trials are necessary to validate the effectivity of multilayer flow modulator stent.