Muscle Weakness News - LARVOL Sigma

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32 Mechanisms of Action

|||||||||| Trial initiation date: Proprioceptive Postural Control and Diaphragm Paresis (clinicaltrials.gov) - Dec 3, 2013
P=N/A, N=20, Not yet recruiting, Sponsor: Katholieke Universiteit Leuven
Initiation date: Jan 2012 --> Jan 2014

|||||||||| Trial initiation date: Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension (clinicaltrials.gov) - Nov 25, 2013
P=N/A, N=93, Recruiting, Sponsor: Imperial College London
Initiation date: Jan 2012 --> Jan 2014 Initiation date: May 2013 --> Oct 2013

|||||||||| Enrollment open: Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension (clinicaltrials.gov) - Nov 25, 2013
P=N/A, N=93, Recruiting, Sponsor: Imperial College London
Initiation date: May 2013 --> Oct 2013 Not yet recruiting --> Recruiting

||||||||||  prednisone / Generic mfg.
Enrollment change:  EPITOME: Efficacy of Prednisone In the Treatment of Ocular Myasthenia (clinicaltrials.gov) -  Nov 6, 2013
P3, N=11, Terminated,  Sponsor: Michael Benatar
Not yet recruiting --> Recruiting N=88 --> 11

||||||||||  prednisone / Generic mfg.
Trial termination:  EPITOME: Efficacy of Prednisone In the Treatment of Ocular Myasthenia (clinicaltrials.gov) -  Oct 30, 2013
P3, N=11, Terminated,  Sponsor: Michael Benatar
N=88 --> 11 Active, not recruiting --> Terminated; Slow recruitment rate

|||||||||| Enrollment change: Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP) (clinicaltrials.gov) - Oct 15, 2013
P=N/A, N=13, Completed, Sponsor: Imperial College London
Active, not recruiting --> Terminated; Slow recruitment rate N=42 --> 13

|||||||||| Trial completion: Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP) (clinicaltrials.gov) - Oct 15, 2013
P=N/A, N=13, Completed, Sponsor: Imperial College London
N=42 --> 13 Recruiting --> Completed

||||||||||  fluoxetine / Generic mfg.
New P2 trial:  RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke (clinicaltrials.gov) -  Oct 14, 2013
P2, N=40, Not yet recruiting,  Sponsor: University of Alabama at Birmingham

||||||||||  Bridion (sugammadex) / Merck (MSD)
New P3 trial:  SUDIA: Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex (clinicaltrials.gov) -  Oct 10, 2013
P3, N=75, Recruiting,  Sponsor: University Hospital, Antwerp

||||||||||  Bridion (sugammadex) / Merck (MSD)
Enrollment open:  SUDIA: Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex (clinicaltrials.gov) -  Oct 10, 2013
P3, N=75, Recruiting,  Sponsor: University Hospital, Antwerp
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment change: Influence of Physical Therapy for Foot and Ankle in the Gait of Individuals With Diabetic Neuropathy (clinicaltrials.gov) - Sep 9, 2013
P1, N=55, Completed, Sponsor: University of Sao Paulo General Hospital
Not yet recruiting --> Recruiting N=40 --> 55

|||||||||| Trial completion: Influence of Physical Therapy for Foot and Ankle in the Gait of Individuals With Diabetic Neuropathy (clinicaltrials.gov) - Sep 9, 2013
P1, N=55, Completed, Sponsor: University of Sao Paulo General Hospital
N=40 --> 55 Active, not recruiting --> Completed

|||||||||| Enrollment open: DORIAN: Developmental ORIgins of Healthy and Unhealthy AgeiNg: the Role of Maternal Obesity (clinicaltrials.gov) - Aug 25, 2013
P=N/A, N=55, Recruiting, Sponsor: Turku University Hospital
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment change, HEOR: Oxi-Stress: Oxidative Stress and Nutritional Supplementation Intervention Study (clinicaltrials.gov) - Jul 29, 2013
P2, N=21, Completed, Sponsor: University of Saskatchewan
Not yet recruiting --> Recruiting N=154 --> 21

|||||||||| Trial completion, HEOR: Oxi-Stress: Oxidative Stress and Nutritional Supplementation Intervention Study (clinicaltrials.gov) - Jul 29, 2013
P2, N=21, Completed, Sponsor: University of Saskatchewan
N=154 --> 21 Recruiting --> Completed

|||||||||| Enrollment change: Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms (clinicaltrials.gov) - Jul 24, 2013
P2/3, N=50, Active, not recruiting, Sponsor: Catherine Buettner
Recruiting --> Completed N=100 --> 50

|||||||||| Enrollment closed: Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms (clinicaltrials.gov) - Jul 24, 2013
P2/3, N=50, Active, not recruiting, Sponsor: Catherine Buettner
N=100 --> 50 Recruiting --> Active, not recruiting

|||||||||| Enrollment open: The Impact of Early Mobilization Protocol in Patients in the ICU (clinicaltrials.gov) - Jul 10, 2013
P=N/A, N=33, Recruiting, Sponsor: Universidade Federal de Santa Maria
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

||||||||||  Mayzent (siponimod) / Novartis
Trial termination:  Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis (clinicaltrials.gov) -  Jun 13, 2013
P2, N=29, Terminated,  Sponsor: Novartis Pharmaceuticals
Not yet recruiting --> Recruiting Completed --> Terminated; Trial was prematurely terminated due to enrollment challenges.

||||||||||  ropivacaine / Generic mfg.
Trial completion, Surgery:  Initial Local Anesthetic Dose With Continuous Interscalene Analgesia (clinicaltrials.gov) -  May 21, 2013
P=N/A, N=36, Completed,  Sponsor: William Beaumont Hospitals
Completed --> Terminated; Trial was prematurely terminated due to enrollment challenges. Active, not recruiting --> Completed

|||||||||| New P2 trial: Once-Daily Oral Dose of BeneFlax to Healthy Older Adults (clinicaltrials.gov) - May 1, 2013
P2, N=60, Recruiting, Sponsor: University of Saskatchewan

|||||||||| Trial completion: Functional Recovery in Stroke Patients With Task-Specific Robot-Aided Arm Therapy (clinicaltrials.gov) - Apr 18, 2013
P2/3, N=76, Completed, Sponsor: University of Zurich
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment change: Sedation Optimisation Strategy (S.O.S.) Ventilation (clinicaltrials.gov) - Apr 14, 2013
P3, N=140, Recruiting, Sponsor: University Hospital, Montpellier
Active, not recruiting --> Completed N=180 --> 140

|||||||||| New P4 trial: FacialReinn: Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty (clinicaltrials.gov) - Apr 14, 2013
P4, N=15, Recruiting, Sponsor: University Hospital, Caen

||||||||||  Mayzent (siponimod) / Novartis
Enrollment change:  Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis (clinicaltrials.gov) -  Feb 12, 2013
P2, N=29, Terminated,  Sponsor: Novartis Pharmaceuticals
N=180 --> 140 N=40 --> 29

|||||||||| Trial completion: Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis (clinicaltrials.gov) - Feb 12, 2013
P3, N=40, Completed, Sponsor: Department of Veterans Affairs
N=40 --> 29 Active, not recruiting --> Completed

||||||||||  dexamethasone injection / Generic mfg.
Trial initiation date:  Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction (clinicaltrials.gov) -  Feb 6, 2013
P4, N=195, Recruiting,  Sponsor: Hospital for Special Surgery, New York
Active, not recruiting --> Completed Initiation date: Apr 2012 --> Jul 2012

||||||||||  dexamethasone injection / Generic mfg.
Enrollment open:  Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction (clinicaltrials.gov) -  Feb 6, 2013
P4, N=195, Recruiting,  Sponsor: Hospital for Special Surgery, New York
Initiation date: Apr 2012 --> Jul 2012 Not yet recruiting --> Recruiting

|||||||||| Enrollment closed: ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit (clinicaltrials.gov) - Feb 4, 2013
P1, N=90, Active, not recruiting, Sponsor: Vanderbilt University
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Enrollment open: Multimodal Exercises to Improve Leg Function After Spinal Cord Injury (clinicaltrials.gov) - Jan 22, 2013
P=N/A, N=75, Recruiting, Sponsor: Department of Veterans Affairs
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

|||||||||| Enrollment change: Characteristics of Andersen-Tawil Syndrome (clinicaltrials.gov) - Jan 14, 2013
P=N/A, N=28, Completed, Sponsor: University of Rochester
Not yet recruiting --> Recruiting N=50 --> 28

||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Trial completion:  A Pilot Trial of Rituxan in Refractory Myasthenia Gravis (clinicaltrials.gov) -  Jan 14, 2013
P1/2, N=10, Completed,  Sponsor: University of Vermont
N=50 --> 28 Active, not recruiting --> Completed

|||||||||| Trial completion: Characteristics of Andersen-Tawil Syndrome (clinicaltrials.gov) - Jan 14, 2013
P=N/A, N=28, Completed, Sponsor: University of Rochester
Active, not recruiting --> Completed Recruiting --> Completed

||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Trial completion:  FORCE: Rituximab for the Treatment of Refractory Inflammatory Myopathies and Refractory Myasthenia Gravis (clinicaltrials.gov) -  Dec 9, 2012
P2, N=30, Completed,  Sponsor: Assistance Publique - H
Recruiting --> Completed Recruiting --> Completed

|||||||||| Clinical: Influence of Respiratory Muscle Training in Elderly Hypertensive Women With Respiratory Muscle Weakness (clinicaltrials.gov) - Dec 4, 2012
P=N/A, N=4, Completed, Sponsor: Universidade Federal do Rio Grande do Norte

||||||||||  prednisone / Generic mfg.
Enrollment closed:  Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy (clinicaltrials.gov) -  Dec 3, 2012
P3, N=150, Active, not recruiting,  Sponsor: University of Alabama at Birmingham
Recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment closed: Efficacy of Methotrexate in Myasthenia Gravis (clinicaltrials.gov) - Nov 20, 2012
P2, N=50, Active, not recruiting, Sponsor: University of Kansas
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| Clinical: SR-WBV Training for Frail Elderly in the Skilling up Stage (clinicaltrials.gov) - Oct 10, 2012
P=N/A, N=40, Recruiting, Sponsor: Bern University of Applied Sciences

|||||||||| Clinical: MOBIL: Vibrational-proprioceptive Resistance Exercise Training Versus Neuromuscular Electrical Stimulation Training in Elderly People With Muscle Weakness (clinicaltrials.gov) - Sep 4, 2012
P=N/A, N=150, Recruiting, Sponsor: Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation

|||||||||| Clinical: DesCoM-1: Involvement of Nervous System in Muscle Weakness in COPD Patients (clinicaltrials.gov) - Sep 4, 2012
P=N/A, N=45, Recruiting, Sponsor: Groupe Fontalvie

|||||||||| New P4 trial: Ultrasound Guided Adductor Canal Block Versus Femoral Nerve Block for Quadriceps Strength and Fall-risk (clinicaltrials.gov) - Jul 30, 2012
P4, N=16, Completed, Sponsor: St. Luke's-Roosevelt Hospital Center

|||||||||| Clinical: UROHTLV: Urological Physical Therapy in HTLV-1 With Urinary Symptoms (clinicaltrials.gov) - Jul 25, 2012
P=N/A, N=20, Enrolling by invitation, Sponsor: Hospital Universitário Professor Edgard Santos

|||||||||| Trial initiation date: Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis (clinicaltrials.gov) - Jun 27, 2012
P3, N=40, Completed, Sponsor: Department of Veterans Affairs
Recruiting --> Active, not recruiting Initiation date: Nov 2007 --> Feb 2008

|||||||||| Clinical: Respiratory Muscle Training in Institutionalized Elderly Population (clinicaltrials.gov) - Jun 18, 2012
P=N/A, N=71, Completed, Sponsor: University of Valencia

|||||||||| New P2 trial, Patient reported outcomes: COMPALA: Comparing the Clinical Effects of Posterior Approach Versus Lateral Approach in Osteoarthritis Patients With a THA (clinicaltrials.gov) - Jun 10, 2012
P2, N=80, Recruiting, Sponsor: Odense University Hospital

|||||||||| Clinical: INCA: Inspiratory Muscle Training in Patients With Chronic Heart Failure (clinicaltrials.gov) - May 23, 2012
P=N/A, N=22, Recruiting, Sponsor: Parc de Salut Mar

||||||||||  landogrozumab (LY2495655) / Eli Lilly
New P2 trial:  A Study in Older Participants Who Have Fallen and Have Muscle Weakness (clinicaltrials.gov) -  May 21, 2012
P2, N=172, Completed,  Sponsor: Eli Lilly and Company

|||||||||| Trial completion: Effects of Therapeutic Music Combined With Loaded Sit-to-Stand Resistance Exercise for Children With Spastic Diplegia (clinicaltrials.gov) - May 15, 2012
P=N/A, N=36, Completed, Sponsor: National Taiwan University Hospital
Initiation date: Nov 2007 --> Feb 2008 Recruiting --> Completed

||||||||||  dexamethasone injection / Generic mfg.
New P4 trial:  Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction (clinicaltrials.gov) -  Apr 25, 2012
P4, N=195, Recruiting,  Sponsor: Hospital for Special Surgery, New York

|||||||||| Trial withdrawal: Exercise and Nutritional Intervention for Deconditioned Older Adults (clinicaltrials.gov) - Apr 10, 2012
P=N/A, N=0, Withdrawn, Sponsor: Department of Veterans Affairs
Recruiting --> Completed Active, not recruiting --> Withdrawn