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  • ||||||||||  risperidone / Generic mfg.
    Examining connectomic heterogeneity and connectivity-derived subtypes in schizophrenia (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_862;    
    Based on the connectomic heterogeneity, biotype-guided approaches classify patients into distinct subtypes, providing new insights into the personalized treatment strategies in SCZ. Disorders of the Nervous System: Psychiatric (eg.
  • ||||||||||  Disruption in Cognitive-Affective Circuitry in MDD and its Predicative Power for TMS Efficacy (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_861;    
    Moreover, these alterations of the AN-CCN circuits could predict the treatment efficacy of TMS in an independent dataset, providing more dependable biomarker of MDD, refining the MDD diagnosis and enabling more precise target interventions in the future. Brain Stimulation: Non-invasive Magnetic/TMS Disorders of the Nervous System: Psychiatric (eg.
  • ||||||||||  Brainstem and cerebellar morphometry in misophonia and transdiagnostic emotion dysregulation (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_859;    
    However, adults with emotion dysregulation in the clinical control group also show larger volumes of these structures compared to non-clinical controls, suggesting that greater brainstem morphometry may broadly index psychopathology and/or difficulty regulating emotional distress rather than specifically index misophonia. The results underscore the need to continue developing and refining brainstem segmentation methods to test whether findings are replicable using other software packages.
  • ||||||||||  Polarization of brain dynamics in mania and depression (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_858;    
    See Figure 2. This construct might show how changes in the architecture of intrinsic brain activity may alter the structure of phenomenal experience and behavior in physiology and psychopathology.
  • ||||||||||  Prediction of cerebral blood flow using voxel-wise resting state functional MRI (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_851;    
    This provides an opportunity to study effects of neuropsychiatric illnesses on rCBF because rsfMRI is much more widely available than ASL/SPECT/PET data in large and inclusive datasets such as the UKBB, ABCD and HCP, and ENIGMA Consortium clinical working groups. PVA-corrected rCBF value showed better agreement with ASL-derived CBF values in the testing dataset and SPECT-derived MDD ESs.
  • ||||||||||  Cross-Disorder Brain Vulnerability as Predictor of Treatment Response in First-Episode Schizophrenia (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_848;    
    This study highlights the transdiagnostic similarity of brain morphological abnormalities in SCZ, which might play a role in the prediction of clinical outcomes of SCZ. Disorders of the Nervous System: Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1 Modeling and Analysis Classification and Predictive Modeling 2 Neuroanatomy, Physiology, Metabolism and Neurotransmission: Subcortical Structures
  • ||||||||||  Altered functional connectome for emotion processing in adults with experiences of childhood abuse (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_845;    
    Abused participants displayed increased connectivity of sensory and control networks in response to sad faces and decreased connectivity of sensory, subcortical, attention and control networks in response to disgusted faces. These connectivity changes may support evidence for suboptimal and negatively attuned emotional processing systems, potentially contributing to heightened risk for psychiatric disorders in this population.
  • ||||||||||  Neural links of paranoia in a transdiagnostic sample (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_827;    
    Given this is a transdiagnostic sample, it highlights the importance of TPN-connectivity for feelings of threat and addressing cognitive explanations of internal/external stimuli for the development of paranoia. Next step is to further investigate between- and within connectivity of those TPN-hubs and its relationship to paranoia in comparison with healthy controls.
  • ||||||||||  Comorbid anxiety: A challenge to the dysconnection syndrome hypothesis of major depressive disorder? (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_820;    
    Importantly, transdiagnostic analyses revealed that this pattern of structural hyperconnectivity extended to individuals with subclinical levels of anxious symptomatology and is even detectable in healthy controls with subclinical levels of anxiety. These results challenge the broad applicability of the dysconnection syndrome hypothesis to MDD patients.
  • ||||||||||  Beyond homogeneity: Charting the landscape of heterogeneity in psychiatric electroencephalography (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_818;    
    The extensive heterogeneity in EEG patterns among psychiatric patients underscores the limitations of conventional group-based approaches and highlights the need for more personalized, patient-level analyses that can account for individual differences. Disorders of the Nervous System: Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1 Modeling and Analysis EEG/MEG Modeling and Analysis 2 Other Methods
  • ||||||||||  Exploring the Neurobiological Correlates of Irritability and Suicidality in MDD: A Pilot fMRI Study (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_811;    
    This study also identifies prefrontal activity in MDD is linked to irritability. These findings provide the first neurobiological insights into the relationship between irritability and suicidality in MDD, suggesting that irritability could serve as a valuable behavioral target for suicide risk assessment and intervention.
  • ||||||||||  Identifying the Neural Circuits Involved in Obsessive-Compulsive Disorder (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_795;    
    In particular, these findings are in harmony with the proposed associative circuit of OCD-which links dlPFC, caudate, and thalamus-and is implicated in executive function (e.g., planning) The OCD-relief results also echo existing OCD circuitry models. The right pars orbitalis falls within the proposed sensorimotor circuit that connects anterolateral orbitofrontal cortex, anterior putamen, and thalamus.
  • ||||||||||  Longitudinal rs-fMRI changes reveal local brain function in patients with schizophrenia (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_791;    
    The two subregions of the frontal gyrus were negatively correlated with the reduction rates of positive and general symptoms respectively, while those of the occipital lobe were positively correlated with word learning and symbol encoding in MCCB. These findings offered new evidence for the hypothesis of abnormal SZ functional activity and potential neurobiological objective indicators for clinical diagnosis and efficacy prediction.
  • ||||||||||  Imaging-based Mechanisms Underlying Longitudinal Clinical Improvements in Schizophrenia (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_784;    
    We propose several potential treatment candidates, such as physical exercise therapies and other lifestyle interventions or focused ultrasound stimulation approaches, to target these mechanisms. Our results pave the way toward applying multimodal neuroimaging to guide treatment strategies in neuropsychiatric disorders such as schizophrenia.
  • ||||||||||  Cardiovascular Burden is Associated With Aberrant EEG Microstates in Euthymic Bipolar Disorder (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_782;    
    Moreover, this study illustrated that cardiovascular burden was associated with aberrant EEG microstates. Future studies are required to validate our present findings and delineate mechanisms beneath the associations between cardiovascular burden and aberrant EEG microstates using a larger study sample.
  • ||||||||||  Stiffness in Nonlinear Brain Connectome: Understanding Brain Mechanisms of ASD (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_746;    
    Explore the overlap between development-related sensitive brain regions and those associated with social abilities and RRB. This could provide insights into how certain cognitive impairments may lessen with age, while others-particularly those related to executive function and memory-may worsen over time.
  • ||||||||||  Habenula alterations in resting state functional connectivity among individuals with autism (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_725;    
    Group-difference results identified atypical Hb hyperconnectivity in ASD within the primary and associative auditory cortices. Age-related effects showed alterations in the anterior cerebellum that have been hypothesized to be a key component of ASD (Wang et al., 2014).
  • ||||||||||  Distinct Control Energy Alterations in Two ADHD Subtypes Linked to Working Memory (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_715;    
    These findings suggest that the structural network in children with ADHD is heterogeneous, highlighting the need for individualized treatment in ADHD and other neurodevelopmental and psychiatric disorders. Disorders of the Nervous System: Neurodevelopmental/ Early Life (eg.
  • ||||||||||  Individualized Cerebellar Damage Predicts the Behavioral Disorders in Children with Brainstem Tumors (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_708;    
    Neuroanatomical deviations were linked to these behavioral disorders, highlighting the importance of the cerebro-brainstem-cerebellar circuits in complex behavioral issues. Early recognition of these cognitive and behavioral changes could improve intervention and surgical strategies, though further research is needed to validate these findings in clinical practice.
  • ||||||||||  Atypical brain functional gradient in children with attention-deficit/hyperactivity disorder (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_695;    
    This study highlights alterations in the principal S-A gradient in children with ADHD and its potential association with symptom severity, providing new insights into the hierarchical network mechanisms underlying functional impairments and suggesting potential biomarkers for the diagnosis and monitoring of disease severity. Disorders of the Nervous System: Neurodevelopmental/ Early Life (eg. ADHD, autism) 1 Modeling and Analysis Connectivity (eg.
  • ||||||||||  Allostatic-interoception network disruption and neuropsychiatric features in neurodegeneration (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_680;    
    This work suggests that altered AIN function may represent a neurobiological mechanism underlying observed clinical symptoms. This finding suggests that difficulties attending, regulating, and responding to the internal physiological condition of the body may lead to increased neuropsychiatric symptomatology in neurodegeneration, and may in part explain the clinical overlap with psychiatric illnesses.
  • ||||||||||  EEG Slowing During REM Sleep and Cholinergic Dysfunction in Isolated REM Sleep Behaviour Disorder (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_663;    
    This suggests that REM EEG slowing is related to early cholinergic dysfunction that precedes and is not explained by structural changes in the BF. As cholinergic dysfunction is a hallmark of dementia in ?-synucleinopathies, REM EEG slowing may serve as a valuable early biomarker for tracking cholinergic network integrity and predicting phenoconversion in iRBD.
  • ||||||||||  Aberrant hierarchical functional system following subcortical infarction (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_615;    
    Notably, this aberrant cortical hierarchy organization was associated with stronger synchronization between functional networks, especially between sensory and association systems. Disorders of the Nervous System: Neurodegenerative/ Late Life (eg.
  • ||||||||||  Virtual Reality-Based Cognitive Training Enhances Bilateral Hippocampal Functional Connectivity (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_541;    
    In conclusion, our study provides evidence that VR-based multimodal cognitive training can enhance both cognitive performance and functional connectivity in memory-related brain regions in MCI patients. Brain Stimulation: Non-Invasive Stimulation Methods Other 2 Disorders of the Nervous System: Neurodegenerative/ Late Life (eg. Parkinson's, Alzheimer's) 1
  • ||||||||||  Altered Spontaneous Activity Induced by the State-dependent Personalized rTMS (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_530;    
    Combining the emotional film, TMS, and fMRI, this study offers a unique perspective on state-dependent effects and may improve TMS treatment outcomes.This study was supported by the grant from Chengdu Science and Technology Bureau(2024-YF05-02056-SN). Brain Stimulation: TMS 1 Emotion, Motivation and Social Neuroscience: Emotional Perception 2
  • ||||||||||  Brain Network Dynamics in EEG-TMS: A Hidden Markov Model Study (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_522;    
    These states have distinct spatial, temporal, and spectral features, and their engagement correlates with corticospinal excitability. Larger MEPs occur when the motor network is more active before stimulation, highlighting the importance of pre-stimulus neural states in modulating excitability.
  • ||||||||||  Modulating Brain Perfusion, Functional Connectivity, and Metabolite Patterns through tb-TUS (Exhibition Hall 1) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_519;    
    The motor cortex was selected as the initial target due to its well-defined physiology and relatively simple organization compared to other cortical regions, making it suitable for this proof-of-concept investigation. This study provides mechanistic insights into the effects of tFUS on the human brain, informing future research aimed at applying this technique to more complex brain regions and, potentially, treating challenging neuropsychiatric disorders.
  • ||||||||||  Network Simulation Models: Integrating Multiscale Information to Generate Actionable Insights into Complex Psychiatric Illnesses (Room: M3 (Mezzanine Level)) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_431;    
    I'll conclude by raising several critical future challenges, highlighting the field's trajectory from mechanistic explanation to prediction. This includes developing predictive models to guide treatment selection and transitioning from observational studies in psychiatric neuroscience to more powerful causal experimental designs, such as placebo-controlled randomized controlled trials, ultimately moving towards a more personalized and precise approach to understanding and treating complex mental health conditions.
  • ||||||||||  A scalable computational framework for large-scale imaging of neural circuits (Room: M4 (Mezzanine Level)) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_398;    
    Future efforts will focus on interactive annotation of tractography streamlines. A key implication for the neuroimaging software stack is that files can no longer be assumed to live on the local filesystem.
  • ||||||||||  Gendered lifestyles as a data-driven spectrum: Associations with brain morphology and microstructure (Room: M3 (Mezzanine Level)) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_392;    
    This revealed associations with brain morphology and microstructure, uncovering the brain health implications of gender in a specific cultural context. Of note, the UK Biobank dataset is composed of primarily White middle- to late-aged individuals (Allen et al., 2024); as such, our algorithm captured the specific gendered lifestyle dynamics within this population and is not necessarily generalizable to other cultural groups.
  • ||||||||||  T1/2w ratio similarity networks: biological validation and age-related change in the common marmoset (Room: M2 (Mezzanine Level)) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_367;    
    T1/2w increases along a sensory-association axis in marmoset, in line with findings in human [10], however T1/2w similarity shows distinct age-related changes. Less laminated cortical classes increase in similarity relative to the rest of the cortex over adolescence, in line with findings in human [3], though there was notable heterogeneity within classes.
  • ||||||||||  Whole-Brain Mapping of GABA and Glutamate Dysregulation in Patients with Major Depressive Disorder (Room: Great Hall (Mezzanine Level) Doors 6, 7 & 8) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_353;    
    Importantly, our findings offer potential targets for more tailored therapeutic interventions that would restore the balance between excitatory and inhibitory neurotransmission by possibly correcting specific processes associated with each neurotransmitter. Disorders of the Nervous System: Psychiatric (eg.
  • ||||||||||  Altered Signal Propagation Patterns in the Brains of Individuals with Schizophrenia (Room: Great Hall (Mezzanine Level) Doors 6, 7 & 8) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_352;    
    These alterations have implications for integrating and extending previous findings regarding disrupted global signals (Yang, et al., 2014), functional gradients (Wang, et a., 2023), and changes within the default mode and salience networks in the SZ brains (Menon, 2011). In conclusion, this work establishes a foundational framework for identifying potential biomarkers pertinent to a wide array of psychiatric disorders.
  • ||||||||||  modafinil / Generic mfg.
    The neuroreceptors and transporters underlying spontaneous brain activity (Room: Great Hall (Mezzanine Level) Doors 6, 7 & 8) -  Jun 30, 2025 - Abstract #OHBM2025OHBM_343;    
    This neuroreceptor-based framework provides is non-invasive approach to understanding neuromodulatory mechanisms across brain states and conditions, advancing insights into cognition and behavior. Disorders of the Nervous System: Psychiatric (eg. Depression, Anxiety, Schizophrenia) Modeling and Analysis fMRI Connectivity and Network Modeling 1 PET Modeling and Analysis Neuroanatomy, Physiology, Metabolism and Neurotransmission: Transmitter Receptors 2 Physiology, Metabolism and Neurotransmission: Pharmacology and Neurotransmission