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  • ||||||||||  Journal:  The Population-Based Incidence and Prevalence of Catatonia. (Pubmed Central) -  Apr 14, 2025   
    Catatonia is a rare disorder, qualifying as an orphan disease under both European Medicines Agency and U.S. Food and Drug Administration criteria. Further research is needed to rigorously define the epidemiology of catatonia in other populations.
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  Neuroplasticity and Psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models. (Pubmed Central) -  Apr 13, 2025   
    This review examines how classic psychedelics (e.g., LSD, psilocybin, N,N-DMT) and non-classic psychedelics (e.g., ketamine, MDMA) influence neuroplasticity...By elucidating the interplay between psychedelics and neuroplasticity, this review informs the development of targeted interventions for neuropsychiatric disorders and advances understanding of psychedelics' therapeutic potential. "And one finds oneself, to put it all in perspective, in a situation where fifty different onomatopoeias, simultaneous, contradictory, and each constantly changing, would be the most faithful expression of it." Henri Michaux, Mis
  • ||||||||||  Journal:  "Hands on iPad" - How do students with intellectual disability participate in media aspects of digital and inclusive teaching? (Pubmed Central) -  Apr 13, 2025   
    This paper highlights the potential for a discrepancy in participation in inclusive instruction with digital media, which appears problematic concerning the goal of academic participation for all students. Though the paper cannot provide a definitive answer to how students with ID can achieve equal access to digital media, the results of this study show that this discrepancy must be considered as inclusive and digitally supported instruction progresses.
  • ||||||||||  Review, Journal, IO biomarker:  Flavonoids and their role in oxidative stress, inflammation, and human diseases. (Pubmed Central) -  Apr 13, 2025   
    The major part of this article discusses the role of flavonoids in alleviating oxidative stress and inflammation, two common components of many human diseases. The results of epidemiological studies on flavonoids are also presented.
  • ||||||||||  Zulresso (brexanolone) / Sage Therapeutics, Ztalmy (ganaxolone oral) / Marinus, Zurzuvae (zuranolone) / Sage Therapeutics, Biogen
    Review, Journal:  New Directions in Neurosteroid Therapeutics in Neuropsychiatry. (Pubmed Central) -  Apr 13, 2025   
    In this review, we explore GABAergic and other cellular effects of pregnane steroids including novel molecules that have potential therapeutic importance. This work discusses the complex chemical nature of NAS and what is being learned at cellular, molecular, synaptic and brain network levels about key sites of action including GABAARs and other targets.
  • ||||||||||  Review, Journal:  Lipid Dysregulation and Delirium in Older Adults: A Review of the Current Evidence and Future Directions. (Pubmed Central) -  Apr 13, 2025   
    This connection has led to proposed treatments targeting dyslipidemia and associated neuroinflammatory effects in acute-phase delirium. This review aims to synthesize current literature on the relationship between lipid dysregulation and delirium in older adults, highlighting the need for further research into specific neurolipidome constituents and age-related lipid profile changes, potentially uncovering novel therapeutic strategies for delirium.
  • ||||||||||  Biomarker, Review, Journal:  Neuroactive Steroids and the Pathophysiology of PTSD: Biomarkers for Treatment Targeting. (Pubmed Central) -  Apr 13, 2025   
    This broadened precision medicine approach to diagnosis of neuroendocrinopathies associated with PTSD may aid in reducing PTSD risk and facilitating the effective prescribing of PTSD therapeutics. We hope that such an approach will also forestall development of individually variable but common psychiatric, substance abuse, and medical PTSD-comorbidities.
  • ||||||||||  minocycline / Generic mfg.
    Review, Journal:  The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets. (Pubmed Central) -  Apr 13, 2025   
    Although exact identification of such immune subtypes of anxiety disorders and PTSD is still challenging, these patients will likely particularly benefit from therapeutic targeting of aspects of the inflammatory system. Different anti-inflammatory treatment approaches (microglia-directed treatments, pro-inflammatory cytokine inhibitors, COX-inhibitors, phytochemicals and a number of novel anti-inflammatory agents) have indeed shown some efficacy even in non-stratified anxiety patient groups and appear promising as novel alternative or complimentary therapeutic options in specific ("inflammatory") subtypes of anxiety disorder and PTSD patients.
  • ||||||||||  Review, Journal:  GLP-1 receptor agonists, are we witnessing the emergence of a paradigm shift for neuro-cardio-metabolic disorders? (Pubmed Central) -  Apr 13, 2025   
    As ongoing research continues to explore innovative applications and combinations of GLP-1RAs, the landscape of disease management in metabolic and neurological contexts is poised for transformative advancements. This review will also critically assess safety considerations and underscore the need for personalized treatment strategies to optimize patient outcomes in these complex and often comorbid conditions.
  • ||||||||||  fingolimod / Generic mfg.
    Review, Journal:  The potential capacities of FTY720: Novel therapeutic functions, targets, and mechanisms against diseases. (Pubmed Central) -  Apr 12, 2025   
    Additionally, it summarizes FTY720's derivation and development process, the characterization and mechanism of the structure of FTY720-P bound to S1PRs, the clinical safety profile, future challenges, and potential strategies to address them. These insights aim to guide future research and applications of FTY720, maximizing its therapeutic potential.
  • ||||||||||  Journal:  Neurodevelopmental or behavioural disorders in children conceived after assisted reproductive technologies: A nationwide cohort study. (Pubmed Central) -  Apr 12, 2025   
    Existing evidence supports the therapeutic benefits of music therapy, massage, and hypnosis on relieving pain and anxiety symptoms in the PPC setting, though the evidence is of low-to-moderate quality. On the basis of the minor observed effects, a potentially higher increased attentiveness of assisted reproductive technology parents, the demonstrated mediation effect of birth weight and preterm birth on the observed association, and the no effect of the within-mother analysis, we find little evidence for increased risk of neurodevelopmental or behavioral disorders in children conceived using assisted reproductive technologies.
  • ||||||||||  Observational data, Journal:  Sleep Quality and Mental Health Among Medical Students: A Cross-Sectional Study. (Pubmed Central) -  Apr 12, 2025   
    A high prevalence of poor sleep quality and symptoms of depression, anxiety, and stress was observed among medical students, with female students exhibiting higher levels of these variables. Furthermore, poorer sleep quality was associated with higher levels of depression, anxiety, and stress.
  • ||||||||||  Journal:  Clinical Characterization and Prediction of Bipolar Disorder Evolution. (Pubmed Central) -  Apr 12, 2025   
    The analytical approach allows us to carry out a prediction of mental disorder evolution as well as a subsequent probability characterization of BD episode progression over time. The presented analytical framework presents a semicontinuous diagnostic tool in the area of mental disorders, specifically applicable to bipolar disorder with corresponding manic episode indexing.
  • ||||||||||  Review, Journal:  Axis I Psychiatric Disorders and Substance Abuse: A Systematic Review of Neuroimaging Findings. (Pubmed Central) -  Apr 12, 2025   
    Significant findings were found on the structure or function of psychiatric patients' brains with comorbid substance abuse, with certain key areas that were further affected by substance use, especially in areas involved in reward processing, with reductions in volume and connectivity and the augmentation of stimuli-related activity. These results present important implications on the current understanding of psychiatric disorders and comorbid substance use, on the importance of neuroradiological tools in the diagnosis and treatment of these disorders, and on the search for potential new targets for the treatment of psychiatric disease and substance addiction.
  • ||||||||||  Implantation of penile prostheses in men 35yrs and younger: a case series (Casanova 501; In Person) -  Apr 12, 2025 - Abstract #AUA2025AUA_3699;    
    Our findings indicate that a substantial proportion of these cases are psychogenic in nature, emphasising the need for comprehensive psychological evaluation prior to surgical intervention. The high satisfaction rates among patients with inflatable prostheses suggest that, despite the challenges posed by younger patients, effective outcomes can be achieved with appropriate selection and management.
  • ||||||||||  Journal:  Parent-child mental health in Ukraine in relation to war trauma and drone attacks. (Pubmed Central) -  Apr 11, 2025   
    The high prevalence of children and parents in Ukraine with symptoms screening positive for mental disorders indicates an urgent need for services for school-age children and parents in this war-affected region. High-intensity drone attacks increase the risk of parents screening positive for PTSD.
  • ||||||||||  Journal:  Circadian Rhythm Defects in Prader-Willi Syndrome Neurons. (Pubmed Central) -  Apr 11, 2025   
    Moreover, treatment with the small molecule Longdaysin effectively lengthened the period length of PWS neurons with a shorter period length, as anticipated based on the mechanism of action of this compound. This work lays the foundation for a deeper understanding of PWS pathophysiology and represents a critical first step toward developing high-throughput assays for drug discovery targeting circadian and sleep dysfunction in PWS.
  • ||||||||||  Preclinical, Review, Journal:  Leveraging animal models to understand non-motor symptoms of Parkinson's disease. (Pubmed Central) -  Apr 11, 2025   
    In this review, we survey the existing literature on the assessment of non-motor signs in parkinsonian rodents and non-human primates. We highlight the gaps in our understanding and suggest how researchers might improve experimental designs to produce more meaningful results with the hope of better understanding the disease and developing better therapies.
  • ||||||||||  Journal:  The contribution of addictovigilance data to the French medical cannabis experimentation. (Pubmed Central) -  Apr 11, 2025   
    Adverse effects of interest will need to be monitored in particular, including neurological disorders (epilepsy exacerbation, cognitive disorders), psychiatric disorders (substance use disorder, suicidal behaviour), and cardiovascular disorders as well as any unexpected AEs. Close addictovigilance monitoring contributes to increasing the awareness of professionals involved in the clinical management of patients treated with medical cannabis.
  • ||||||||||  Journal:  Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress. (Pubmed Central) -  Apr 11, 2025   
    Together, our data demonstrate that the astrocyte transcriptome responds robustly to CSDS and that transcriptional regulation in astrocytes contributes to depressive-like behaviors. A better understanding of transcriptional regulation in astrocytes may reveal unknown molecular mechanisms underlying neuropsychiatric disorders.