Mental Retardation
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  • ||||||||||  Journal:  Sexual Trauma and Mental Distress among Former Ultra-Orthodox Jewish Individuals. (Pubmed Central) -  Jun 24, 2025   
    Bearing in mind that this population is, by definition, vulnerable to high levels of emotional distress, the study results highlight the importance of screening for sexual trauma in order to identify and treat ex-ULTOIs who have experienced sexual abuse. Moreover, therapeutic programs specifically focusing on this vulnerable population are warranted.
  • ||||||||||  Review, Journal:  Brain mechanisms underlying the inhibitory control of thought. (Pubmed Central) -  Jun 24, 2025   
    These unique elements of mental control suggest that hippocampal disinhibition is a transdiagnostic factor underlying intrusive thinking, linking the fronto-temporal control pathway to preclinical models of psychiatric disorders and fear extinction. We suggest that retrieval-stopping deficits may underlie the intrusive thinking that is common across many psychiatric disorders.
  • ||||||||||  Review, Journal:  Brain circuits that regulate social behavior. (Pubmed Central) -  Jun 24, 2025   
    Given the pivotal role of rodents in social behavior research, our review primarily focuses on neural circuits in these animals. Finally, we propose future research directions, including the development of specific behavioral paradigms, the identification of circuits involved in motor output, the integration of activity, transcriptome, and connectome data, the multifunctional roles of neurons with multiple targets, and the interactions among multiple brain regions.
  • ||||||||||  Journal:  Longitudinal impact of stigma resistance on mental health among individuals with mental disorders. (Pubmed Central) -  Jun 24, 2025   
    Theoretically, our findings elucidate how stigma resistance can help individuals with mental disorders improve their mental health by fostering a positive identity and aligning their lives with personal values. Practically, these findings underscore the importance of developing interventions aimed at promoting stigma resistance in these individuals, enabling them to lead more fulfilling and flourishing lives.
  • ||||||||||  Review, Journal:  Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders. (Pubmed Central) -  Jun 24, 2025   
    We will also discuss the potential molecular targets for these therapeutic approaches, including the cAMP pathway, proteins involved in synaptic plasticity as well as pathways involved in new protein synthesis. We place special emphasis on RNA binding proteins and epitranscriptomic mechanisms, as they represent a new frontier with the distinct advantage of rapidly and simultaneously altering the synthesis of many proteins locally.
  • ||||||||||  Review, Journal:  Mechanisms of General Anesthesia. (Pubmed Central) -  Jun 24, 2025   
    An update on the Meyer-Overton correlation is reviewed relative to each mechanism and placed in historical context with early theories. The review ends with a discussion of unresolved questions, including questions concerning endogenous anesthetics, anesthetic stereoselectivity, and aspects of a chain-length cutoff.
  • ||||||||||  Journal:  Comparing the prevalence of substance use disorders between persons with and without autism spectrum disorders. (Pubmed Central) -  Jun 24, 2025   
    Individuals with autism spectrum disorder aged 30-64?years are at an elevated risk of cannabis and hallucinogen use disorders, while this risk is likely compounded by co-occurring mental health conditions, which affect a half of all individuals with autism spectrum disorder and only 23% of individuals without autism spectrum disorder. Research and policy implications are discussed in turn.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Journal:  Clinical signatures of SYNGAP1-related disorders through data integration. (Pubmed Central) -  Jun 24, 2025   
    Our findings suggest that taking a more individualized approach to support the well-being of autistic youth is important. We delineated the seizure, developmental, and behavioral trajectories in SYNGAP1-related disorders, to improve diagnosis, prognosis, and clinical care, and facilitating clinical trial readiness.
  • ||||||||||  iadademstat (ORY-1001) / Oryzon
    Preclinical, Journal:  Recapitulation and reversal of neuropsychiatric phenotypes in a mouse model of human endogenous retrovirus type W expression. (Pubmed Central) -  Jun 24, 2025   
    In conclusion, our study suggests that the expression of HERV-W ENV has the capacity to disrupt various behavioral and cognitive functions and to alter the brain transcriptome in a manner that is highly relevant to neurodevelopmental and psychiatric disorders. Moreover, our study identified epigenetic pathways that may offer avenues for pharmacological interventions against behavioral and cognitive deficits induced by increased HERW-W expression.
  • ||||||||||  Retrospective data, Review, Journal:  Sleep disturbances in autistic children and adolescents: A systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) -  Jun 24, 2025   
    The results indicate that these interventions help to improve several sleep parameters, either by increasing, for example, the total time and quality of sleep, or by reducing the time needed for falling asleep. These approaches offer important treatment options especially for those cases where medication is not feasible, allowing physicians and specialists to propose more targeted and safer solutions for managing sleep difficulties in this population.
  • ||||||||||  Journal:  AUTS2-related Syndrome: Insights from a large European cohort. (Pubmed Central) -  Jun 24, 2025   
    These approaches offer important treatment options especially for those cases where medication is not feasible, allowing physicians and specialists to propose more targeted and safer solutions for managing sleep difficulties in this population. This study provides a comprehensive clinical characterization of AUTS2-related syndrome, reveals few genotype-phenotype correlations, and suggests that the disruption of the 2 distinct AUTS2 transcripts has a different impact on the clinical phenotype.
  • ||||||||||  Journal:  ?IV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia. (Pubmed Central) -  Jun 24, 2025   
    This study provides a comprehensive clinical characterization of AUTS2-related syndrome, reveals few genotype-phenotype correlations, and suggests that the disruption of the 2 distinct AUTS2 transcripts has a different impact on the clinical phenotype. Importantly, a Random Forest classifier applied to ?IV spectrin imaging achieved up to 98% accuracy in classifying cells by diagnosis in postmortem samples, and by diagnosis or diagnosis
  • ||||||||||  Journal:  Assessing sign language comprehension in adults with intellectual disability and deafness. (Pubmed Central) -  Jun 24, 2025   
    Acceptance by the deaf and hard-of-hearing individuals and the caregivers and time-efficient administration suggest high practicability. We recommend further implementation in clinical practice, albeit with cautious interpretation of the results, and the inclusion of the instruments in research on intellectual disability and deafness.
  • ||||||||||  ecopipam (PSYRX 101) / Paragon Biosci
    Journal:  D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders. (Pubmed Central) -  Jun 24, 2025   
    In contrast, ecopipam, a D1 antagonist already used in the clinic for other neuropsychiatric disorders, rescues ALBs, cognition, D1 hyperactivity, and does not worsen neurodegenerative signs. These results align with recent evidence highlighting the clinical relevance of D1 antagonists for neuropsychiatric disorders and pave the way for their use in managing psychotic symptoms in neurodegenerative disorders such as dementia with Lewy bodies.
  • ||||||||||  Journal:  Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study. (Pubmed Central) -  Jun 24, 2025   
    The risk of all-cause death was the highest among those with intellectual disability, followed by those with schizophrenia spectrum disorder and alcohol use disorder. In conclusion, the risk of suicide and all-cause death increased among those with mental disorders, but there was substantial variation between the types of mental disorders for both suicide and all-cause death.
  • ||||||||||  haloperidol / Generic mfg., amphetamine / Generic mfg.
    Journal:  Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. (Pubmed Central) -  Jun 24, 2025   
    Short-term haloperidol (HAL) treatment reversed behavioral symptoms and the ASM activity...HAL and KARI201 antipsychotic effects were associated with targeting expression of other schizophrenia associated genes like Col6a3, Slc22a8, and Bmal1, or Nr2f6a, respectively, but none affecting expression of sphingolipid regulating genes. Our data provide new insight into a potentially pathogenic mechanism of schizophrenia and suggest a new pharmaco-treatment strategy with reduced side effects.
  • ||||||||||  ketamine / Generic mfg.
    Journal:  Myelin Repair as a Novel Mechanism for Ketamine's Sustained Antidepressant Effects. (Pubmed Central) -  Jun 24, 2025   
    However, the exact role of myelination in ketamine's sustained antidepressant effects remains unclear. In this review, we summarize the relationship between demyelination and depression and discuss the potential mechanisms by which ketamine may exert its antidepressant effects by repairing myelin damage, offering new insights into the role of myelination in antidepressant mechanisms.
  • ||||||||||  Journal:  Rightward brain structural asymmetry in young children with autism. (Pubmed Central) -  Jun 24, 2025   
    Lastly, the GMV laterality patterns of all patient groups were significantly associated with both shared and unique gene expression profiles. Our findings provide evidence for rightward GMV asymmetry of some cortical regions in young ASD children (1-7 years) in a large sample (1030 cases), show that these asymmetries are related to ASD symptoms, and identify genes that are significantly associated with these differences.
  • ||||||||||  Review, Journal:  Indoor Tanning Addiction: Biological Mechanisms and Association with Other Disorders. (Pubmed Central) -  Jun 24, 2025   
    Several psychiatric disorders are comorbidities of tanning addiction and excessive indoor tanning parallels many of the patterns of substance use disorders. In frequent indoor tanners, greater awareness of tanning's addictive potential and further development of interventions aimed at treating this addictive behaviour may be needed to stop indoor tanning.
  • ||||||||||  Review, Journal:  Child Maltreatment and Psychopathology: A Brief Review on the Potential Role of the Hypothalamic-pituitary-adrenal Axis. (Pubmed Central) -  Jun 24, 2025   
    Childhood maltreatment manifests as disruptions to hypothalamic-pituitary-adrenal axis functioning, with the extent varying based on factors, such as the age of onset, parental responsiveness, and the type and characteristics of maltreatment. The complex interplay of these factors contributes to the diversity of hypothalamic-pituitary-adrenal axis responses to stress in maltreated children, creating a spectrum of physiological functioning and vulnerability to psychopathology.