Mental Retardation
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  • ||||||||||  Journal:  Assessing sign language comprehension in adults with intellectual disability and deafness. (Pubmed Central) -  Jun 24, 2025   
    Acceptance by the deaf and hard-of-hearing individuals and the caregivers and time-efficient administration suggest high practicability. We recommend further implementation in clinical practice, albeit with cautious interpretation of the results, and the inclusion of the instruments in research on intellectual disability and deafness.
  • ||||||||||  ecopipam (PSYRX 101) / Paragon Biosci
    Journal:  D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders. (Pubmed Central) -  Jun 24, 2025   
    In contrast, ecopipam, a D1 antagonist already used in the clinic for other neuropsychiatric disorders, rescues ALBs, cognition, D1 hyperactivity, and does not worsen neurodegenerative signs. These results align with recent evidence highlighting the clinical relevance of D1 antagonists for neuropsychiatric disorders and pave the way for their use in managing psychotic symptoms in neurodegenerative disorders such as dementia with Lewy bodies.
  • ||||||||||  Journal:  Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study. (Pubmed Central) -  Jun 24, 2025   
    The risk of all-cause death was the highest among those with intellectual disability, followed by those with schizophrenia spectrum disorder and alcohol use disorder. In conclusion, the risk of suicide and all-cause death increased among those with mental disorders, but there was substantial variation between the types of mental disorders for both suicide and all-cause death.
  • ||||||||||  haloperidol / Generic mfg., amphetamine / Generic mfg.
    Journal:  Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. (Pubmed Central) -  Jun 24, 2025   
    Short-term haloperidol (HAL) treatment reversed behavioral symptoms and the ASM activity...HAL and KARI201 antipsychotic effects were associated with targeting expression of other schizophrenia associated genes like Col6a3, Slc22a8, and Bmal1, or Nr2f6a, respectively, but none affecting expression of sphingolipid regulating genes. Our data provide new insight into a potentially pathogenic mechanism of schizophrenia and suggest a new pharmaco-treatment strategy with reduced side effects.
  • ||||||||||  ketamine / Generic mfg.
    Journal:  Myelin Repair as a Novel Mechanism for Ketamine's Sustained Antidepressant Effects. (Pubmed Central) -  Jun 24, 2025   
    However, the exact role of myelination in ketamine's sustained antidepressant effects remains unclear. In this review, we summarize the relationship between demyelination and depression and discuss the potential mechanisms by which ketamine may exert its antidepressant effects by repairing myelin damage, offering new insights into the role of myelination in antidepressant mechanisms.
  • ||||||||||  Journal:  Rightward brain structural asymmetry in young children with autism. (Pubmed Central) -  Jun 24, 2025   
    Lastly, the GMV laterality patterns of all patient groups were significantly associated with both shared and unique gene expression profiles. Our findings provide evidence for rightward GMV asymmetry of some cortical regions in young ASD children (1-7 years) in a large sample (1030 cases), show that these asymmetries are related to ASD symptoms, and identify genes that are significantly associated with these differences.
  • ||||||||||  Review, Journal:  Indoor Tanning Addiction: Biological Mechanisms and Association with Other Disorders. (Pubmed Central) -  Jun 24, 2025   
    Several psychiatric disorders are comorbidities of tanning addiction and excessive indoor tanning parallels many of the patterns of substance use disorders. In frequent indoor tanners, greater awareness of tanning's addictive potential and further development of interventions aimed at treating this addictive behaviour may be needed to stop indoor tanning.
  • ||||||||||  Review, Journal:  Child Maltreatment and Psychopathology: A Brief Review on the Potential Role of the Hypothalamic-pituitary-adrenal Axis. (Pubmed Central) -  Jun 24, 2025   
    Childhood maltreatment manifests as disruptions to hypothalamic-pituitary-adrenal axis functioning, with the extent varying based on factors, such as the age of onset, parental responsiveness, and the type and characteristics of maltreatment. The complex interplay of these factors contributes to the diversity of hypothalamic-pituitary-adrenal axis responses to stress in maltreated children, creating a spectrum of physiological functioning and vulnerability to psychopathology.
  • ||||||||||  Review, Journal:  Deep brain stimulation for dystonia treatment in cerebral palsy: efficacy exploration. (Pubmed Central) -  Jun 24, 2025   
    While existing controlled studies confirm its safety and effectiveness, a thorough evaluation of long-term efficacy remains crucial. This research highlights the potential of DBS in improving the lives of individuals with dystonic CP, providing hope for further refinement, innovation, and broader clinical application of this therapeutic approach.
  • ||||||||||  Journal:  Case Report: An adult with NCKAP1-related neurodevelopmental disorder and autism spectrum disorder. (Pubmed Central) -  Jun 24, 2025   
    The most common clinical characteristics include ASD, intellectual disability (ID), speech-language problems, repetitive behaviors, and seizures. This case report highlights an adult phenotype of NCKAP1-related NDD with goals to 1.) contribute insight into a rare genetic variant leading to NDD with ASD features and 2.) highlight adult manifestations of NCKAP1-related NDD as a patient in middle adulthood with the condition has not yet been reported.
  • ||||||||||  Journal:  Exploring the predictive value of structural covariance networks for the diagnosis of schizophrenia. (Pubmed Central) -  Jun 24, 2025   
    These patterns of results show that different SCN computation approaches capture different aspects of the disease. While REF-SCNs contain valuable information for discriminating schizophrenia from healthy control individuals, KLS-SCNs may capture more nuanced symptom-level characteristics similar to those captured by PCA of regional GMV.
  • ||||||||||  Journal:  Research progress on the mechanism of acupuncture based on microbiota-gut-brain axis (Pubmed Central) -  Jun 24, 2025   
    Acupuncture adjusts the microbiota-gut-brain axis through regulating the structure and metabolic state of gut microbiota, improving the intestinal microenvironment, restoring the stability of intestinal mucosal barrier and blood-brain barrier, stimulating vagus nerve, reducing inflammation and modulating neurotransmitters, so that nervous system diseases, mental diseases, digestive system diseases and metabolic diseases can be treated. With the latest research trends and the cutting-edge technologies considered, the studies in the future should deepen the mechanism of acupuncture on the physiological pathway for modulating the structure and composition of gut microbiota as well as its holistic elaboration.
  • ||||||||||  Journal:  Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. (Pubmed Central) -  Jun 24, 2025   
    P4
    Next to the implication of altered EV communication in mood disorders, the pronounced differences in plasma EV characteristics and exosomal markers in MDD might inform the development of assays with diagnostic or prognostic value for clinical practice. CLINICALTRIALS.GOV: Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR); https://clinicaltrials.gov/study/NCT02711215; NCT02711215.
  • ||||||||||  Journal:  Cloud-native simulation framework for gossip protocol: Modeling and analyzing network dynamics. (Pubmed Central) -  Jun 24, 2025   
    The simulation analysis provides insights into gossip protocols' behavior in distributed cloud-native systems, evaluating aspects of scalability, reliability, and observability. This investigation contributes to understanding the practical implications and potential applications of gossip protocol within modern cloud-native architectures, which can also apply to conventional network infrastructure.
  • ||||||||||  Journal:  Trajectory patterns of personal growth in the transition to motherhood: The role of fertility treatments and emotional regulation. (Pubmed Central) -  Jun 24, 2025   
    Taken together, these findings provide a useful experimental platform of human origin for the investigation of cell-autonomous and non-cell-autonomous consequences of alterations in astrocytic function caused by neurodevelopmental disorders. The study expands the knowledge regarding the heterogeneity of personal growth trajectories in the transition to motherhood and suggests that certain characteristics may predict the chances of developing in certain pathways rather than in others.
  • ||||||||||  Preclinical, Journal:  Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model. (Pubmed Central) -  Jun 24, 2025   
    We adopted a chronic restraint stress (CRS) rat model and conducted behavioral tests such as the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) to evaluate the therapeutic effects of QZF on depression. Regarding behavioral parameters, the QZF group exhibited significantly higher body mass, sucrose preference ratio, and central zone residence time compared to the model group (P < 0.01, P < 0.01, P < 0.01), and a significantly reduced immobilization time in the forced swimming test (P < 0.001).Network pharmacology and molecular docking studies suggest that QZF may have antidepressant effects by modulating the HIF-1 and JAK-STAT pathways, with key target genes including AKT1, IL-6, MTOR, and TP53, implicated in inflammation, neuroprotection, and apoptosis.In conclusion, this study offers new insights into the modernization and development of Chinese medicine compounds for the comprehensive treatment of depression.
  • ||||||||||  Journal:   (Pubmed Central) -  Jun 24, 2025   
    The use of administrative data on accepted mental disorders complements survey data on mental health at work for different groups of workers. The growth in rates of accepted mental disorders points to the groups to be prioritized for prevention of this category of occupational injury.
  • ||||||||||  Review, Journal:  AI in Medical Questionnaires: Innovations, Diagnosis, and Implications. (Pubmed Central) -  Jun 24, 2025   
    In summary, the integrated application of AI in medical questionnaires has significant potential to improve diagnostic efficiency, accelerate scale development, and promote early intervention. Future research should pay more attention to model interpretability, system compatibility, validation standardization, and ethical governance to effectively address key challenges such as data privacy, clinical integration, and transparency.
  • ||||||||||  Journal:  Central Precocious Puberty and Psychiatric Disorders. (Pubmed Central) -  Jun 24, 2025   
    For depression and ADHD, incidence rates remained increased for at least 8 years after the initial CPP diagnosis. In this retrospective cohort study of patients with CPP, CPP was associated with an increased risk of psychiatric disorders, with evidence supporting long-term mental health outcomes, suggesting that caretakers of children with CPP should be vigilant for the emergence of psychiatric symptoms to initiate psychiatric care at an early stage.
  • ||||||||||  Journal:  Investigating Awareness and Acceptance of Digital Phenotyping in Dhaka's Korail Slum: Qualitative Study. (Pubmed Central) -  Jun 24, 2025   
    While DP holds potential to improve mental health care in underserved communities, addressing barriers related to awareness, privacy, culture, and usability is crucial. Focusing on educational initiatives, robust data protection, cultural adaptation, user-friendly design, and community engagement, DP can become a valuable tool in bridging the mental health care gap in LMICs.
  • ||||||||||  Journal:  The Future of the Psychiatrist. (Pubmed Central) -  Jun 24, 2025   
    We must preserve our skill, unique among physicians, in psychotherapeutic approaches, even as we manage psychiatric illness. We must also adapt and become more tech-savvy, as digital data, mobile and computer-based treatments, electronic medical records, and AI algorithms take on increasing prominence in our field.