Mental Retardation
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  • ||||||||||  Journal:  The multiscale self-similarity of the weighted human brain connectome. (Pubmed Central) -  Apr 7, 2025   
    This phenomenon is captured by a renormalization technique based on a geometric network model that replicates the observed structure of connectomes across all length scales, using the same connectivity law and weighting function for both weak and strong ties. The observed symmetry represents a signature of criticality in the weighted connectivity of the human brain and raises important questions for future research, such as the existence of symmetry breaking at some scale or whether it is preserved in cases of neurodegeneration or psychiatric disorder.
  • ||||||||||  phenobarbital / Generic mfg.
    Journal:  Novel Spiro-Barbiturates Can Reverse the Action of General Anesthetics on the GABAAR. (Pubmed Central) -  Apr 7, 2025   
    Comparison of the SAR of inhibitory and excitatory barbiturates suggested that conformationally constrained spiro-analogs of phenobarbital might have intermediate allosteric activity...These constitute a new class of GABA-ergic drugs that are null allosteric ligands. They offer the potential to reverse the sedative action of current PAMs and modulate the behavior of diseases resulting from mutations in GABAAR subunits.
  • ||||||||||  Journal:  Report of Hidradenitis Suppurativa in an Individual Affected by Rubinstein-Taybi Syndrome. (Pubmed Central) -  Apr 7, 2025   
    Hidradenitis suppurativa (HS), a chronic inflammatory skin condition characterized by recurrent abscess formation and draining tunnels, has never been described in a patient affected by RTS. In this report, we detail the history of a 32-year-old male with RTS and refractory Hurley stage III HS and discuss the important considerations and risks of managing this unique patient population.
  • ||||||||||  Journal:  Genetic variants and phenotypic data curated for the CAGI6 intellectual disability panel challenge. (Pubmed Central) -  Apr 7, 2025   
    The study highlights the challenges in variant interpretation especially in cases with atypical phenotypic manifestations. Overall, this study provides valuable insights into the genetic causes of NDDs and emphasises the importance of understanding the underlying genetic factors for accurate diagnosis, and intervention development in neurodevelopmental conditions.
  • ||||||||||  Journal:  Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome. (Pubmed Central) -  Apr 7, 2025   
    We argue that this evidence suggests PAT is worthy of study as a new therapy for IBS, and potentially for other disorders of gut-brain interaction (DGBI). Successful application of PAT to gastrointestinal disease would represent a major step beyond mind-body dualism, with potential implications for other functional somatic disorders.
  • ||||||||||  sirolimus / Generic mfg.
    Journal:  Human TSC2 mutant cells exhibit aberrations in early neurodevelopment accompanied by changes in the DNA Methylome. (Pubmed Central) -  Apr 7, 2025   
    TSC is caused by loss of function mutations in the TSC1 or TSC2 genes and consequent dysregulation of signaling via mechanistic Target of Rapamycin Complex 1 (mTORC1)...These alterations in differentiation were coincident with hundreds of differentially methylated DNA regions, including loci associated with key genes in neurodevelopment. Collectively, these data suggest that mutation or loss of TSC2 affects gene regulation and expression at earlier timepoints than previously appreciated, with implications for whether and how prenatal treatment should be pursued.
  • ||||||||||  Journal:  Enhancing outcomes: Culturally adapted social-emotional and behavioral interventions for rural black elementary learners at risk. (Pubmed Central) -  Apr 7, 2025   
    Results indicated a functional relation between the intervention package culturally adapted (SEL + CICO) and a decrease in student rate of externalizing behavior and strong social validity across teachers and students. Hierarchical linear modeling showed a statistically significant decrease in externalizing behavior from baseline to intervention phases, with data suggesting the moderator of grade-level explained variability in the effectiveness of the intervention.
  • ||||||||||  Review, Journal:  How-To Study Dissociative Symptoms in a Broad Range of Mental Disorders: A Methodological Primer. (Pubmed Central) -  Apr 7, 2025   
    Discussing the informative value and limits of various standard and novel methodological approaches, we aim to provide information and nuanced guidance for future research. By these means, we aim to raise and harmonize standards in dissociation research and enable researchers of all career stages to enter, navigate, and make a significant and lasting contribution to research on dissociative symptoms in a broad range of mental disorders, ultimately contributing to a better understanding of dissociative psychopathology.
  • ||||||||||  Trial completion, Trial primary completion date:  BRIDGE: Building Regulation in Dual Generations 2022-2025 (clinicaltrials.gov) -  Apr 7, 2025   
    P=N/A,  N=197, Completed, 
    By these means, we aim to raise and harmonize standards in dissociation research and enable researchers of all career stages to enter, navigate, and make a significant and lasting contribution to research on dissociative symptoms in a broad range of mental disorders, ultimately contributing to a better understanding of dissociative psychopathology. Recruiting --> Completed | Trial primary completion date: Oct 2024 --> Jun 2024
  • ||||||||||  Journal:  Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function. (Pubmed Central) -  Apr 7, 2025   
    We evaluate MORSE using two measures; the number of distinct optima found in independent runs, and the diversity of the list (with repetitions) of solutions by average pairwise Hamming distance and Shannon entropy. Using these metrics, we provide empirical results demonstrating that MORSE outperforms the Gurobi method and unweighted variations of the MORSE method on a set of 20 Mixed Integer Programming Library (MIPLIB) instances and on a combinatorial optimization problem in cancer genomics.
  • ||||||||||  Journal:  Adaptive Whole-Brain Dynamics Predictive Method: Relevancy to Mental Disorders. (Pubmed Central) -  Apr 7, 2025   
    Applying this refined method to datasets for major depressive disorder (MDD) and autism spectrum disorder (ASD), we identified differences in brain regions between patients and healthy controls, explaining related anomalies. This rigorous validation is crucial for clinical application, paving the way for precise neuropathological identification and novel treatments in neuropsychiatric research, demonstrating substantial potential in clinical neurology.
  • ||||||||||  Journal:  Neuroimaging in post-traumatic stress disorder: a narrative review. (Pubmed Central) -  Apr 7, 2025   
    Emerging data suggest that therapeutic interventions elicit favorable structural modifications in the brain, indicative of therapeutic efficacy. Neuroimaging exploration in mental disorders is a pivotal and promising frontier, poised to deliver significant clinical benefits, augmenting the evidence-based diagnostic and therapeutic domain in mental healthcare.
  • ||||||||||  Journal:  Suicidality and Self-Harm Among Individuals With Traumatic Brain Injury: Risk and Protective Factors and Coping Mechanisms. (Pubmed Central) -  Apr 7, 2025   
    Engaging with health professionals (62%) and seeking support from family (57%) were the most common healthy coping strategies, whereas substance use (38%) and social withdrawal (32%) were the most common unhealthy coping strategies. The findings of this study provide detailed insights into the lived experiences of suicidality and NSSI after moderate-to-severe TBI, how survivors conceptualize factors that may increase or attenuate risk, and common coping strategies.
  • ||||||||||  Journal:  Tauopathy after long-term cervical lymphadenectomy. (Pubmed Central) -  Apr 7, 2025   
    Patients after clinical cervical lymph node dissection showed reduced brain waste in peripheral blood consistent with mouse models. This study suggests the need for further evaluation of the neurologic effects of cervical lymph node dissection, a procedure that affects millions of people each year.
  • ||||||||||  Enrollment closed, Trial completion date, Trial primary completion date:  Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder (clinicaltrials.gov) -  Apr 7, 2025   
    P2,  N=15, Active, not recruiting, 
    It is critical for gastroenterologists to recognize psychiatric comorbidities and implement appropriate measures accordingly. Recruiting --> Active, not recruiting | Trial completion date: Jul 2025 --> Dec 2025 | Trial primary completion date: Jan 2025 --> Aug 2025
  • ||||||||||  Journal:  Medication adherence and attitudes in adolescent psychiatry: Key influences. (Pubmed Central) -  Apr 6, 2025   
    This study emphasizes the necessity of addressing critical factors that influence medication adherence and attitudes toward psychiatric medication among adolescents with psychiatric disorders. In particular, it highlights the importance of considering concern perception, managing side effects, and evaluating polypharmacy to optimize pharmacotherapy in this population.