- |||||||||| Journal: Brain signatures of predictive and reactive strategies in a simple delayed reaction time task: an EEG study. (Pubmed Central) - Jun 24, 2025
When analyzing the electrical activity after the GO-signal, we observed that early and late responses are associated with distinct EEG features, with early behavior displaying feature typical of top-down processes. In our experiment, the two behaviors occurred naturally, without external manipulations that could introduce confounding cognitive demands and obscure genuine differences in EEG patterns between strategy-dependent conditions.
- |||||||||| Review, Journal: Treating seizures in SYN1-related epilepsy: a systematic review. (Pubmed Central) - Jun 24, 2025
Based on our systematic literature review, patients with SYN1-related epilepsy show better seizure frequency reduction when treated with LCM, LTG, CBZ, or OXC, compared to VPA and LEV, despite VPA being the most prescribed anti-seizure medication for this syndrome. Hence, sodium channel blockers appear to represent the best therapeutic option for these patients.
- |||||||||| Journal: Pursuit of Digital Innovation in Psychiatric Data Handling Practices in Ireland: Comprehensive Case Study. (Pubmed Central) - Jun 24, 2025
Irish MHS seem to be handling psychiatric data under polycrisis circumstances; therefore, a single-dimensional digitization of records would not be sufficient in addressing the wide range of concerns. In addition to highlighting intertwined challenges in Irish psychiatry and validating the need for innovation in data handling practices in Irish MHS, this study culminated in the proposal of an innovative technological solution that offers a significant contribution to a considerably improved, efficient, and compliant service delivery in mental health care.
- |||||||||| Journal: Encephalitis or schizophrenia as a cause of cognitive decline (Pubmed Central) - Jun 24, 2025
Antipsychotics were ineffective, and no psychiatric illness was identified. The case highlights diagnostic challenges between neurology and psychiatry, suggesting possible neuroinflammation of unknown origin with a poor prognosis for a full recovery.
- |||||||||| Journal: Multigenerational exposures to polluting industries and developmental disabilities. (Pubmed Central) - Jun 24, 2025
The case highlights diagnostic challenges between neurology and psychiatry, suggesting possible neuroinflammation of unknown origin with a poor prognosis for a full recovery. Associations with risk-weighted facility density near the pregnant paternal grandmother were stronger at 5
- |||||||||| Journal: Synaptic activity causes minute-scale changes in BAF complex composition and function. (Pubmed Central) - Jun 24, 2025
These biochemical effects are a convergent phenomenon downstream of multiple calcium-activated signaling pathways in mouse neurons and mouse fibroblasts and correspond to changes in BAF-dependent chromatin accessibility. Our studies imply that BAF decodes signals at the membrane by altering the combinatorial composition of its subunits.
- |||||||||| Journal: Sexual Trauma and Mental Distress among Former Ultra-Orthodox Jewish Individuals. (Pubmed Central) - Jun 24, 2025
Bearing in mind that this population is, by definition, vulnerable to high levels of emotional distress, the study results highlight the importance of screening for sexual trauma in order to identify and treat ex-ULTOIs who have experienced sexual abuse. Moreover, therapeutic programs specifically focusing on this vulnerable population are warranted.
- |||||||||| Review, Journal: Brain mechanisms underlying the inhibitory control of thought. (Pubmed Central) - Jun 24, 2025
These unique elements of mental control suggest that hippocampal disinhibition is a transdiagnostic factor underlying intrusive thinking, linking the fronto-temporal control pathway to preclinical models of psychiatric disorders and fear extinction. We suggest that retrieval-stopping deficits may underlie the intrusive thinking that is common across many psychiatric disorders.
- |||||||||| Review, Journal: Brain circuits that regulate social behavior. (Pubmed Central) - Jun 24, 2025
Given the pivotal role of rodents in social behavior research, our review primarily focuses on neural circuits in these animals. Finally, we propose future research directions, including the development of specific behavioral paradigms, the identification of circuits involved in motor output, the integration of activity, transcriptome, and connectome data, the multifunctional roles of neurons with multiple targets, and the interactions among multiple brain regions.
- |||||||||| Journal: Longitudinal impact of stigma resistance on mental health among individuals with mental disorders. (Pubmed Central) - Jun 24, 2025
Theoretically, our findings elucidate how stigma resistance can help individuals with mental disorders improve their mental health by fostering a positive identity and aligning their lives with personal values. Practically, these findings underscore the importance of developing interventions aimed at promoting stigma resistance in these individuals, enabling them to lead more fulfilling and flourishing lives.
- |||||||||| Review, Journal: Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders. (Pubmed Central) - Jun 24, 2025
We will also discuss the potential molecular targets for these therapeutic approaches, including the cAMP pathway, proteins involved in synaptic plasticity as well as pathways involved in new protein synthesis. We place special emphasis on RNA binding proteins and epitranscriptomic mechanisms, as they represent a new frontier with the distinct advantage of rapidly and simultaneously altering the synthesis of many proteins locally.
- |||||||||| Review, Journal: Mechanisms of General Anesthesia. (Pubmed Central) - Jun 24, 2025
An update on the Meyer-Overton correlation is reviewed relative to each mechanism and placed in historical context with early theories. The review ends with a discussion of unresolved questions, including questions concerning endogenous anesthetics, anesthetic stereoselectivity, and aspects of a chain-length cutoff.
- |||||||||| Journal: Comparing the prevalence of substance use disorders between persons with and without autism spectrum disorders. (Pubmed Central) - Jun 24, 2025
Individuals with autism spectrum disorder aged 30-64?years are at an elevated risk of cannabis and hallucinogen use disorders, while this risk is likely compounded by co-occurring mental health conditions, which affect a half of all individuals with autism spectrum disorder and only 23% of individuals without autism spectrum disorder. Research and policy implications are discussed in turn.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Clinical signatures of SYNGAP1-related disorders through data integration. (Pubmed Central) - Jun 24, 2025 Our findings suggest that taking a more individualized approach to support the well-being of autistic youth is important. We delineated the seizure, developmental, and behavioral trajectories in SYNGAP1-related disorders, to improve diagnosis, prognosis, and clinical care, and facilitating clinical trial readiness.
- |||||||||| iadademstat (ORY-1001) / Oryzon
Preclinical, Journal: Recapitulation and reversal of neuropsychiatric phenotypes in a mouse model of human endogenous retrovirus type W expression. (Pubmed Central) - Jun 24, 2025 In conclusion, our study suggests that the expression of HERV-W ENV has the capacity to disrupt various behavioral and cognitive functions and to alter the brain transcriptome in a manner that is highly relevant to neurodevelopmental and psychiatric disorders. Moreover, our study identified epigenetic pathways that may offer avenues for pharmacological interventions against behavioral and cognitive deficits induced by increased HERW-W expression.
- |||||||||| Retrospective data, Review, Journal: Sleep disturbances in autistic children and adolescents: A systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Jun 24, 2025
The results indicate that these interventions help to improve several sleep parameters, either by increasing, for example, the total time and quality of sleep, or by reducing the time needed for falling asleep. These approaches offer important treatment options especially for those cases where medication is not feasible, allowing physicians and specialists to propose more targeted and safer solutions for managing sleep difficulties in this population.
- |||||||||| Journal: AUTS2-related Syndrome: Insights from a large European cohort. (Pubmed Central) - Jun 24, 2025
These approaches offer important treatment options especially for those cases where medication is not feasible, allowing physicians and specialists to propose more targeted and safer solutions for managing sleep difficulties in this population. This study provides a comprehensive clinical characterization of AUTS2-related syndrome, reveals few genotype-phenotype correlations, and suggests that the disruption of the 2 distinct AUTS2 transcripts has a different impact on the clinical phenotype.
- |||||||||| Journal: ?IV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia. (Pubmed Central) - Jun 24, 2025
This study provides a comprehensive clinical characterization of AUTS2-related syndrome, reveals few genotype-phenotype correlations, and suggests that the disruption of the 2 distinct AUTS2 transcripts has a different impact on the clinical phenotype. Importantly, a Random Forest classifier applied to ?IV spectrin imaging achieved up to 98% accuracy in classifying cells by diagnosis in postmortem samples, and by diagnosis or diagnosis
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