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|||||||||| Journal: Awareness and knowledge of pediatricians regarding genetic testing for Fragile X syndrome in Japan: A National Survey of Pediatricians Managing Developmental Delay/Intellectual disability. (Pubmed Central) - May 11, 2025
Addressing these knowledge gaps may enhance FXS diagnostic rates and improve the management of affected individuals and families. Future efforts should focus on strengthening the collaboration between clinical geneticists and general pediatricians and establishing reliable genetic counseling support systems.

|||||||||| Review, Journal: Early adversity and the comorbidity between metabolic disease and psychopathology. (Pubmed Central) - May 11, 2025
We will review molecular and clinical evidence supporting the notion that early adversity is an important risk factor for the comorbidity between metabolic and psychiatric conditions. We will also discuss the possible mechanisms involved: neurometabolic programming, epigenetic alterations and the cumulative effects of altered inflammatory and oxidative pathways linked to early adversity.

|||||||||| Review, Journal: Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) - a scoping review. (Pubmed Central) - May 11, 2025
However, this observation should be interpreted cautiously, as current evidence remains limited and further research is warranted to establish treatment patterns more conclusively. The variability in study designs and reporting standards further highlights the need for standardized methodologies and improved adherence to reporting guidelines to enhance the quality and applicability of future research.

|||||||||| Clinical, Retrospective data, Review, Journal: Comparative efficacy of antidepressant medication for adolescent depression: a network meta-analysis and systematic review. (Pubmed Central) - May 11, 2025
Sertraline showed superiority in clinician-rated severity (CGI-S: SUCRA 100%) and improvement (CGI-I: SUCRA 80.2%). Clinical decisions should prioritize escitalopram for functional recovery and sertraline for severe cases requiring rapid symptom reduction.

|||||||||| Review, Journal: Mainstreaming Diagnostic Genetic Testing and Precision Medicine for Autism Spectrum Disorder: The Role of Child and Adolescent Psychiatrists. (Pubmed Central) - May 11, 2025
The core competencies for child and adolescent psychiatrists include determining the etiology and diagnosisfor all childhood psychopathology, including ID and ASD. Child psychiatrists should recommend and order genetic testing by exomeor genome sequencing on all children with ASD.

|||||||||| Review, Journal: Ethical Considerations in Psychiatric Genomics. (Pubmed Central) - May 11, 2025
The multifactorial nature of psychiatric disorders, characterized by complex genetic and environmental interactions, further complicates ethical considerations. This paper explores ethical issues in psychiatric genomic research, clinical applications, and prevention efforts, emphasizing the need for a multidisciplinary approach and the importance of context sensitivity, particularly in low-and-middle-income countries.

|||||||||| Preclinical, Journal, Metabolomic study: Antidepressant effect of Radix bupleuri - Radix paeoniae alba herb pair on chronic unpredictable mild stress rats based on cortical metabolomics. (Pubmed Central) - May 11, 2025
This paper explores ethical issues in psychiatric genomic research, clinical applications, and prevention efforts, emphasizing the need for a multidisciplinary approach and the importance of context sensitivity, particularly in low-and-middle-income countries. BR-PRA herb-pair alleviated depressive-like behavior in CUMS rats, recovered hippocampus damage, and regulated cerebral cortex metabolism, which may be related to the HPA axis, amino acid metabolism related to lysine and glutamate, and modulation of oxidative stress.

|||||||||| Journal: Townes-Brocks syndrome: genotype-phenotype correlations of SALL1 variants in our series and the literature. (Pubmed Central) - May 11, 2025
A significant increase in deafness, dysplastic ear, and thumb malformations and a significant decrease in renal failure were observed in the individuals carrying a variant located downstream of the region, but the patients were significantly younger. Future studies should aim to elucidate the complex pathophysiological mechanisms and prognosis of TBS, functionally and prospectively.

|||||||||| Review, Journal: Psychiatric Comorbidities in Pediatric Restless Leg Syndrome. (Pubmed Central) - May 11, 2025
Both neurobiologic mechanisms and clinical implication could explain the several comorbidities. In clinical practice, pediatric RLS patients should be evaluated for the presence of psychiatric disorders to tailor multidisciplinary intervention and integrated treatment.

|||||||||| Review, Journal: Genomics of Attention Deficit Hyperactivity Disorder: What the Clinician Needs to Know. (Pubmed Central) - May 11, 2025
Communication of genetic knowledge in meetings with patients and their relatives and common misconceptions are addressed. The importance of recognizing genetic syndromes masquerading as ADHD or other common psychiatric disorders is emphasized and how genetic information can be used to improve diagnosis and therapy are discussed.

|||||||||| Review, Journal: Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies. (Pubmed Central) - May 11, 2025
Genetic studies are clarifying the etiology of AN, with the goal of eventually informing the development of innovative personalized pharmacologic, nutritional, microbial, and behavioral interventions. We present the current state of genome-wide and epigenome-wide association studies, gut microbiome research, and functional genomics investigations and discuss translating this knowledge into clinical practice.

|||||||||| Journal: Generative AI Models for Developing Neuroimaging Markers of Psychiatric Disorders. (Pubmed Central) - May 11, 2025
We present the current state of genome-wide and epigenome-wide association studies, gut microbiome research, and functional genomics investigations and discuss translating this knowledge into clinical practice. No abstract available

|||||||||| Journal: Epigenetic alterations and microbiota changes in the saliva of individuals with binge-eating spectrum disorders compared with normal weight healthy controls. (Pubmed Central) - May 11, 2025
No abstract available Our findings provide new evidence on the role of epigenetic modifications linked to alterations in salivary microbial composition and diversity in BED and BN, opening new avenues for future research and therapeutic interventions in eating disorders targeting miRNAs and microbiota.

|||||||||| Preclinical, Journal: Neurobehavioral and neurochemical alterations in female mice following pregestational exposure to SARS-CoV-2 lysate protein. (Pubmed Central) - May 11, 2025
These findings highlight long-term neurochemical and behavioral disruptions following environmentally relevant exposure to SARS-CoV-2 lysate protein, which could compromise neurophysiological homeostasis, stress regulation, and maternal investment in non-target mammals. In natural environments, such alterations may reduce individual fitness and population resilience, emphasizing the need to further investigate the ecotoxicological consequences of viral pollutants on terrestrial organisms.

|||||||||| Journal: Reproductive rights of women with severe mental disability and rights of their children in China. (Pubmed Central) - May 11, 2025
In natural environments, such alterations may reduce individual fitness and population resilience, emphasizing the need to further investigate the ecotoxicological consequences of viral pollutants on terrestrial organisms. No abstract available

|||||||||| Journal: Genetic influence and neural pathways underlying the dose-response relationships between wearable-measured physical activity and mental health in adolescence. (Pubmed Central) - May 11, 2025
These findings suggest that excessive moderate and vigorous activity may not be always better for adolescent mental health. Brain functional integration and segregation centered on cognitive control as well as genetic interplay may be the potential neurobiological factors underlying the link between PA and MH.

|||||||||| Journal: Indicators of competitive employment for individuals with intellectual and developmental disabilities (IDDs) in Saudi Arabia: A qualitative study. (Pubmed Central) - May 11, 2025
Regarding basic indicators that will culminate into employment, vocational training, parental support, education and psychological and social quality of life were all included. The importance of a suitable work environment and adequate support were additional determinants allowing individuals with IDD to reach their full potential.

|||||||||| Journal: Adrenal gland volume measurement in depressed patients. (Pubmed Central) - May 11, 2025
AGV is not increased in the well-selected cohort of depressed patients in this study, which contrasts with some previous reports in literature. Further multi-centric studies are required to identify potentially influencing factors such as attempted suicide.

|||||||||| Journal: Multidimensional outcomes associated with chronic fatigue over 12 (Pubmed Central) - May 11, 2025
While there were no sex differences in the rates of chronic fatigue, there were some sex differences in the factors associated with it. Systematic screening and early intervention for chronic fatigue, considering sex-specific factors, may improve multidimensional outcomes in youth with emerging mood disorders.

|||||||||| Journal: Reversing intellectual disabilities in Down syndrome: Hopes or hypes? (Pubmed Central) - May 11, 2025
Systematic screening and early intervention for chronic fatigue, considering sex-specific factors, may improve multidimensional outcomes in youth with emerging mood disorders. No abstract available

|||||||||| Review, Journal: Machine learning approaches for fine-grained symptom estimation in schizophrenia: A comprehensive review. (Pubmed Central) - May 11, 2025
We cover multiple modalities, namely Medical Imaging, Electroencephalograms and Audio-Visual, as the illness symptoms can manifest in a patient's pathology and behaviour. Finally, we analyse the datasets and methodologies used in the studies and identify trends, gaps, as opportunities for future research.

|||||||||| Preclinical, Journal: Effect of ponatinib on the metabolism of cariprazine in vitro and in vivo and the underlying mechanism. (Pubmed Central) - May 10, 2025
Molecular docking studies had demonstrated that both cariprazine and ponatinib could engage in hydrophobic interactions with residue PHE-304 on CYP3A4. Consequently, when ponatinib is employed in conjunction with cariprazine in a clinical setting, it is imperative to assess the efficacy and adverse effects, and adjust the dosage to attain the optimal efficacy.

|||||||||| Journal: Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients. (Pubmed Central) - May 10, 2025
Consequently, when ponatinib is employed in conjunction with cariprazine in a clinical setting, it is imperative to assess the efficacy and adverse effects, and adjust the dosage to attain the optimal efficacy. These findings highlight the interplay between neuroanatomical changes, amyloid pathology, and systemic inflammation in PD-related sleep dysfunction, suggesting potential therapeutic targets.

|||||||||| Journal: Can the Stroop Test be useful in differentiating specific learning disorder from attention deficit hyperactivity disorder in medication-free children? (Pubmed Central) - May 10, 2025
The findings suggest that the ST may be a valuable tool for diagnosing SLD in patients with ADHD. In particular, the completion time and errors in the fifth section of the ST may serve as useful tools in supporting the diagnostic process.

|||||||||| Journal: Supporting young siblings of children with intellectual disabilities and/or visual impairments with the serious game 'Broodles': A mixed methods randomized controlled trial. (Pubmed Central) - May 10, 2025
Although quantitative data showed small effects, qualitative data revealed a variety of learning outcomes which can contribute to siblings' resilience, and prevention of mental health problems. To unlock its full potential, future studies should examine if additional family-targeted components can enhance the intervention's impact.

|||||||||| Journal: Correlates of physical activity, sedentary time, and cardiovascular disease risk factors in autistic adults without intellectual disabilities. (Pubmed Central) - May 10, 2025
Excessive ST in autistic adults without ID is associated with an increased risk for certain CVD factors, particularly those related to poor mental health. Health interventions should focus on breaking up prolonged sitting as a CVD prevention strategy in this population.

|||||||||| Journal: Listening to music is associated with reduced physiological and subjective stress in people with mild intellectual disabilities: A biofeedback study. (Pubmed Central) - May 10, 2025
Listening to music might be an accessible, inexpensive and empowering strategy for stress reduction and improving emotion regulation, which could also benefit mental and physical health. Several challenges were encountered while implementing the intervention and suggestions for future research are given.

|||||||||| Journal, Video: Effectiveness of video displays versus traditional flashcards for global word learning in students with moderate-severe cognitive disabilities. (Pubmed Central) - May 10, 2025
The study also suggests gradual implementation of these programs in increasing word exposure and intervention duration. Smart-Glove's integration of VVSD with the traditional approach potentially enhances literacy acquisition for children with moderate ID and CCN, offering new possibilities for personalized literacy instruction in special education settings.

|||||||||| Retrospective data, Journal: Anxiety disorders and major depressive disorders in 299 adolescents hospitalized for assessment of common obesity: A retrospective cohort study. (Pubmed Central) - May 10, 2025
Some present with incomplete clinical profiles. MDD and AD are associated with a personal history of violence and a high BES score, reflecting in some adolescents a phenomenon of compensatory binge eating.

|||||||||| Journal: HIV Prevention Behaviors among LGBTQ+?Adolescents: the Protective Role of LGBTQ+-Inclusive School Resources. (Pubmed Central) - May 10, 2025
Gay or queer cisgender boys were consistently in the highest prevalence HIV prevention behavior groups, whereas youth who self-reported they were bisexual/pansexual, asexual, sexual identity questioning, straight or a sexual identity not listed, especially those who lacked LGBTQ+-inclusive school resources, were overrepresented in the low prevalence groups. LGBTQ+-inclusive school resources are important sources of HIV prevention information and may mitigate some HIV-related disparities.

|||||||||| fluoxetine / Generic mfg.
Journal: NOD-like receptor protein 3 inhibitors in St. John's wort and their potential antidepressant effects. (Pubmed Central) - May 10, 2025
LGBTQ+-inclusive school resources are important sources of HIV prevention information and may mitigate some HIV-related disparities. Furthermore, furohyperforin (7) was demonstrated potent antidepressant activity at 1.25

|||||||||| Journal: Management of Developmental and Epileptic Encephalopathies. (Pubmed Central) - May 10, 2025
Multidisciplinary care in DEEs is paramount. We summarize the current evidence on the management of specific DEEs, focusing on targeted therapies and optimizing outcomes.

|||||||||| Journal: Rates of screening for sexually transmitted infections in adolescents with and without disabilities. (Pubmed Central) - May 10, 2025
Universal testing may help normalize STI screening so that individuals with a higher risk of STIs are not missed. Further research is indicated to identify and mitigate factors that lead to lower rates of screening.

|||||||||| Journal: Childhood adversity is associated with reduced threat-safety discrimination and increased fear generalization in 12- to 16-year-olds. (Pubmed Central) - May 10, 2025
Altered fear learning may be an important process through which adversity increases risk for the development of psychopathology. Longitudinal research is essential to elucidate risk and resilience patterns following childhood adversity.

|||||||||| Journal: Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments. (Pubmed Central) - May 10, 2025
Longitudinal research is essential to elucidate risk and resilience patterns following childhood adversity. These findings are consistent with the notion that low exploratory behaviour following childhood maltreatment is potentially a protective adaptation against internalising symptoms, while disrupted neural processing of reward learning in volatile environments may index latent vulnerability to mental illness.

|||||||||| Journal, Interview: Therapists' perspectives on the Maudsley model anorexia nervosa treatment for adolescents and young adults (MANTRa): A qualitative interview study. (Pubmed Central) - May 10, 2025
The findings suggest how the MANTRa content (e.g. inclusion of additional therapeutic tools), the therapists' training and the format (e.g. provision of a digital version) can be improved to reach maximum impact. Therapists' formulation letters may be an effective therapeutic tool not only for AN but also across the spectrum of psychiatric disorders in adolescents and young adults.

|||||||||| tranexamic acid oral / Generic mfg.
Clinical, Journal: Prevalence and risk factors for postpartum depression two months after cesarean delivery: a prospective multicenter study. (Pubmed Central) - May 10, 2025
Therapists' formulation letters may be an effective therapeutic tool not only for AN but also across the spectrum of psychiatric disorders in adolescents and young adults. Around one woman in 6 had postpartum depression symptoms 2

|||||||||| The role of PET imaging in the detection and assessment of isolated REM sleep behavior disorder (Science Pavilion) - May 10, 2025 - Abstract #SNMMI2025SNMMI_1410;
FDG-PET demonstrated the ability to map patterns of abnormal metabolism specific to iRBD; furthermore, FDG-PET can identify a metabolic pattern that can identify iRBD that progresses to neurodegenerative disease. Therefore, future studies should focus on FDG-PET imaging in iRBD and compare it to standard diagnostic procedure.

|||||||||| Molecular Imaging with the Genetics of Neurological Diseases (Science Pavilion) - May 10, 2025 - Abstract #SNMMI2025SNMMI_1305;
PET imaging is a powerful tool for investigating the biochemical and genetic basis of neurological and psychiatric disorders. Its ability to quantify molecular processes, detect early functional changes, and monitor therapeutic interventions, has significantly advanced our understanding of disease pathogenesis and facilitated the identification of related genetic pathways.

|||||||||| elacridar (GF120918) / GSK
In Vivo Characterization of [18F]ASEM as PET Radioligand of Engineered ?7 Nicotinic Acetylcholine Receptors (Science Pavilion) - May 10, 2025 - Abstract #SNMMI2025SNMMI_1117;
1B). [18F]ASEM demonstrated higher target (PSAM4-GlyR injection site, left-amygdala) uptake compared to the mirror (contralateral site, right-amygdala) under baseline condition (Fig.

|||||||||| Evaluation of [18F]PF974 as a PET Radiotracer for Imaging PDE4B in the Healthy Human Brain (Science Pavilion) - May 10, 2025 - Abstract #SNMMI2025SNMMI_1111;
[18F]ASEM demonstrated higher target (PSAM4-GlyR injection site, left-amygdala) uptake compared to the mirror (contralateral site, right-amygdala) under baseline condition (Fig. Time-stability analysis revealed that VT values remained stable during the 60

|||||||||| Regional Cerebral Metabolic Pattern Predicts Symptom Progression and Subsequent Meeting of Clinical Criteria for Lewy Body Dementia (SS_1) - May 10, 2025 - Abstract #SNMMI2025SNMMI_880;
Patients with an LBD-type metabolic pattern were more likely to develop key clinical features of LBD within one year and meet diagnostic criteria by an average follow-up of approximately 28.5 months. Even when baseline symptom burdens were similar, patients with LBD-type metabolic patterns still exhibited a greater increase in LBD-specific symptoms over time.

|||||||||| KML29 / Boehringer Ingelheim
Radiosynthesis and Evaluation of Novel 18F Labeled PET Ligands for Imaging Monoacylglycerol Lipase (SS_2) - May 10, 2025 - Abstract #SNMMI2025SNMMI_773;
Compounds (R)-6 and (S)-6 were synthesized with overall yields of 5.1% and 28% over four steps, respectively (Figure 1A). (R)-6 demonstrated an IC50 of 18.57

|||||||||| Visualization of phosphodiesterase 4B in neuroinflammation mouse models with positron emission tomography (SS_2) - May 10, 2025 - Abstract #SNMMI2025SNMMI_772;
It demonstrates high specificity for PDE4B, superior imaging quality, and strong correlation with protein expression. These findings suggest that [18F]PDE-1905 could serve as a valuable tool for studying neuroinflammatory processes.

|||||||||| ifenprodil tartrate / Chiba University Hospital
Quantification of NMDA GluN2B Receptors Occupancy by ifenprodil in Nonhuman Primates Using (S)-[18F]OF-NB1 PET (SS_1) - May 10, 2025 - Abstract #SNMMI2025SNMMI_682;
No significant differences in administered (S)-[18F]OF-NB1 dose, injected mass, or plasma free fraction (fp) were observed among the four scanning sessions. The test

|||||||||| Prezcobix (darunavir/cobicistat) / Gilead, J&J, Tivicay (dolutegravir) / ViiV Healthcare
Effect of Dolutegravir compared to Darunavir/Cobicistat, both with TDF/FTC, in neuropsychiatric effects at 12 weeks of treatment in PLH with baseline neuropsychiatric disorders and no antiretroviral therapy experience () - May 10, 2025 - Abstract #IASHIV2025IAS_HIV_1799;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Monday, 14 July 2025, at 15:30 Central African Time (CAT). If an abstract is part of an official IAS 2025 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.

|||||||||| Dyadic internalized stigma, resilience, and psychiatric distress among people with HIV and their family members: An actor-partner interdependence mediation model analysis () - May 10, 2025 - Abstract #IASHIV2025IAS_HIV_1384;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Monday, 14 July 2025, at 15:30 Central African Time (CAT). If an abstract is part of an official IAS 2025 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.

|||||||||| Predictors of internalising mental disorders among Ugandan children and adolescents living with HIV: A machine learning approach () - May 10, 2025 - Abstract #IASHIV2025IAS_HIV_1107;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Monday, 14 July 2025, at 15:30 Central African Time (CAT). If an abstract is part of an official IAS 2025 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.

|||||||||| High levels of mental distress among youth with HIV in Southern Africa: A description of enrollment into IMPAACT 2016, a randomized controlled trial of a peer-led, group-based mental health intervention () - May 10, 2025 - Abstract #IASHIV2025IAS_HIV_590;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Monday, 14 July 2025, at 15:30 Central African Time (CAT). If an abstract is part of an official IAS 2025 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.

|||||||||| lisdexamfetamine / Generic mfg., topiramate / Generic mfg., dasotraline (SEP-225289) / Sumitomo Pharma
Retrospective data, Review, Journal: Pharmacotherapies for Binge Eating Disorder: Systematic Review and Network Meta-Analysis. (Pubmed Central) - May 9, 2025
However, the landscape of pharmacotherapy for BED lacks robust evidence and methodological standardization. Larger trials with expanded sample sizes and using validated scales are needed to guide clinical practice for this highly prevalent and damaging disorder.



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