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13 Mechanisms of Action

|||||||||| Trial termination: A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Synchrony Dual Optic Intraocular Lens in Patients Undergoing Cataract Extraction (clinicaltrials.gov) - Mar 5, 2013
P3, N=410, Terminated, Sponsor: Abbott Medical Optics
Active, not recruiting --> Terminated

|||||||||| Enrollment change: A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Synchrony Dual Optic Intraocular Lens in Patients Undergoing Cataract Extraction (clinicaltrials.gov) - Mar 5, 2013
P3, N=410, Terminated, Sponsor: Abbott Medical Optics
Active, not recruiting --> Terminated N=330 --> 410

|||||||||| Trial completion, Surgery: Corneal Incisions With the IntraLase iFS Femtosecond Laser System (clinicaltrials.gov) - Feb 27, 2013
P=N/A, N=37, Completed, Sponsor: Abbott Medical Optics
N=330 --> 410 Active, not recruiting --> Completed

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
Enrollment open:  A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX (clinicaltrials.gov) -  Feb 4, 2013
P2, N=40, Recruiting,  Sponsor: Retinal Consultants of Arizona
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Avastin (bevacizumab) / Roche
New P3 trial, Surgery:  PREMED: PRevention of Macular EDema After Cataract Surgery (clinicaltrials.gov) -  Jan 22, 2013
P3, N=1350, Recruiting,  Sponsor: Maastricht University Medical Center

|||||||||| New P4 trial, Surgery: A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery (clinicaltrials.gov) - Jan 14, 2013
P4, N=35, Recruiting, Sponsor: Technolas Perfect Vision GmbH

|||||||||| New P4 trial, Surgery: Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism (clinicaltrials.gov) - Jan 6, 2013
P4, N=55, Completed, Sponsor: Vienna Institute for Research in Ocular Surgery

|||||||||| Trial completion, Surgery: Lidocaine Usage for Pupil Dilatation (Mydriasis) (clinicaltrials.gov) - Jan 1, 2013
P=N/A, N=100, Completed, Sponsor: Carmel Medical Center
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

||||||||||  mupirocin / Generic mfg.
Enrollment change, Surgery:  Prophylaxis Prior to Cataract Surgery Conjunctival Flora and Optimal Ocular Sterilization Technique Prior to Cataract Surgery (clinicaltrials.gov) -  Dec 19, 2012
P=N/A, N=37, Completed,  Sponsor: University of Chicago
Active, not recruiting --> Completed N=100 --> 37

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
New P3 trial, Surgery:  The Effect of Intravitreal Ozurdex on DME After Cataract Surgery (clinicaltrials.gov) -  Dec 10, 2012
P3, N=24, Recruiting,  Sponsor: University Health Network, Toronto

|||||||||| Trial initiation date, Surgery: VIGADEXA Gel Compared to VIGADEXA Solution Following Cataract Surgery (clinicaltrials.gov) - Nov 13, 2012
P3, N=0, Withdrawn, Sponsor: Alcon Research
N=100 --> 37 Initiation date: Feb 2013 --> Mar 2014

|||||||||| New P1 trial: Clinical Investigation of Expanded Designs of a Multifocal IOL (clinicaltrials.gov) - Oct 24, 2012
P1, N=450, Active, not recruiting, Sponsor: Abbott Medical Optics

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
Enrollment change, Surgery:  Ozurdex for Combined Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema After Cataract Surgery (clinicaltrials.gov) -  Oct 2, 2012
P2, N=6, Completed,  Sponsor: Northern California Retina Vitreous Associates
Initiation date: Feb 2013 --> Mar 2014 N=10 --> 6

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
Trial completion, Surgery:  Ozurdex for Combined Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema After Cataract Surgery (clinicaltrials.gov) -  Oct 2, 2012
P2, N=6, Completed,  Sponsor: Northern California Retina Vitreous Associates
N=10 --> 6 Enrolling by invitation --> Completed

|||||||||| Clinical: Prospective Evaluation of Circularity and Diameter of Femtosecond Laser Versus Manual Anterior Capsulotomy in Singapore National Eye Centre (clinicaltrials.gov) - Sep 24, 2012
P=N/A, N=22, Recruiting, Sponsor: Technolas Perfect Vision GmbH

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
New P2 trial:  A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX (clinicaltrials.gov) -  Aug 23, 2012
P2, N=40, Recruiting,  Sponsor: Retinal Consultants of Arizona

||||||||||  bromfenac ophthalmic solution / Generic mfg.
Trial completion, Surgery:  Efficacy of Bromfenac Ophthalmic Solution in Patients Undergoing Cataract Surgery (clinicaltrials.gov) -  Aug 14, 2012
P3, N=440, Completed,  Sponsor: Bausch & Lomb Incorporated
Enrolling by invitation --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment closed: Visual Quality Following Aspheric Intraocular Lens (IOL) Implantation - a Comparative Clinical Study (clinicaltrials.gov) - Aug 9, 2012
P3, N=125, Active, not recruiting, Sponsor: Hoya Surgical Optics, Inc.
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Trial withdrawal: Investigation of Corneal Aberrations and Visual Outcomes in Patients Implanted With an AcrySof Toric Intraocular Lens (IOL) (clinicaltrials.gov) - Jul 30, 2012
P=N/A, N=0, Withdrawn, Sponsor: Alcon Research
Recruiting --> Active, not recruiting Recruiting --> Withdrawn

|||||||||| Enrollment change: Investigation of Corneal Aberrations and Visual Outcomes in Patients Implanted With an AcrySof Toric Intraocular Lens (IOL) (clinicaltrials.gov) - Jul 30, 2012
P=N/A, N=0, Withdrawn, Sponsor: Alcon Research
Recruiting --> Withdrawn N=20 --> 0

||||||||||  levofloxacin / Generic mfg., moxifloxacin ophthalmic / Generic mfg.
Enrollment change:  Effect on Wound Healing of Vigamox Versus Cravit (clinicaltrials.gov) -  Jul 18, 2012
P4, N=79, Completed,  Sponsor: Alcon Research
N=20 --> 0 N=50 --> 79

|||||||||| Trial completion: Posterior Capsule Opacification Study (clinicaltrials.gov) - Jul 10, 2012
P4, N=100, Completed, Sponsor: Aurolab
N=50 --> 79 Active, not recruiting --> Completed

|||||||||| Trial completion: Evaluation of the Rotational Stability of The AcrySof Toric Intraocular Lens in the Capsular Bag in High Myopic Subjects (clinicaltrials.gov) - Jul 3, 2012
P=N/A, N=30, Completed, Sponsor: Wenzhou Medical University
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| New P3 trial: Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule (clinicaltrials.gov) - Jun 14, 2012
P3, N=20, Recruiting, Sponsor: Federal University of São Paulo

||||||||||  Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
Trial completion, Surgery:  Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery (clinicaltrials.gov) -  May 29, 2012
P3, N=80, Completed,  Sponsor: Alcon Research
Recruiting --> Completed Recruiting --> Completed

||||||||||  Dexycu (dexamethasone intraocular injection) / EyePoint Pharma, Ocumension Therap
New P2 trial, Surgery:  Efficacy and Safety of IBI-10090 in Ocular Surgery Patients (clinicaltrials.gov) -  May 24, 2012
P2, N=172, Completed,  Sponsor: ICON Bioscience Inc

||||||||||  dexamethasone / Generic mfg.
New P1 trial, Surgery:  A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery (clinicaltrials.gov) -  May 23, 2012
P1, N=8, Terminated,  Sponsor: Allergan

||||||||||  Nevanac (nepafenac) / Novartis
Trial completion, Surgery:  Nepafenac Compared to Placebo for Ocular Pain and Inflammation (clinicaltrials.gov) -  May 17, 2012
P3, N=260, Completed,  Sponsor: Alcon Research
Recruiting --> Completed Recruiting --> Completed

|||||||||| Clinical: Post Approval Study of the AcrySof® IQ Toric Intraocular Lens (IOL) Models SN6AT6-SN6AT9 (clinicaltrials.gov) - May 16, 2012
P=N/A, N=415, Recruiting, Sponsor: Alcon Research

||||||||||  dexamethasone ophthalmic (EGP-437) / Kiora Pharma
New P2 trial, Surgery:  Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Delivery Prior to Implantation of a Posterior Chamber IOL (clinicaltrials.gov) -  May 16, 2012
P2, N=42, Completed,  Sponsor: Eyegate Pharmaceuticals, Inc.

|||||||||| Surgery: Anterior Capsule Polishing Effect on Effective Lens Position (clinicaltrials.gov) - May 13, 2012
P=N/A, N=40, Not yet recruiting, Sponsor: Shandong University

|||||||||| Trial withdrawal: Comparison of Corneal Aberrations and Visual Outcomes in AcrySof IQ Toric Patients Versus Limbal Relaxing Incision (LRI) Patients (clinicaltrials.gov) - Apr 9, 2012
P4, N=0, Withdrawn, Sponsor: Alcon Research
Recruiting --> Completed Terminated --> Withdrawn

|||||||||| Trial completion: Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS) (clinicaltrials.gov) - Mar 27, 2012
P3, N=1020, Completed, Sponsor: National Eye Institute (NEI)
Terminated --> Withdrawn Active, not recruiting --> Completed

||||||||||  Lucentis (ranibizumab) / Roche, Novartis
Enrollment change, Surgery:  Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery (clinicaltrials.gov) -  Mar 25, 2012
P1, N=4, Completed,  Sponsor: Bhagat, Neelakshi, M.D., M.P.H.
Active, not recruiting --> Completed N=10 --> 4

||||||||||  Lucentis (ranibizumab) / Roche, Novartis
Trial completion, Surgery:  Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery (clinicaltrials.gov) -  Mar 25, 2012
P1, N=4, Completed,  Sponsor: Bhagat, Neelakshi, M.D., M.P.H.
N=10 --> 4 Active, not recruiting --> Completed

||||||||||  Dexycu (dexamethasone intraocular injection) / EyePoint Pharma, Ocumension Therap
Enrollment change, Surgery:  Efficacy and Safety Study of IBI-10090 in Patients Undergoing Cataract Surgery (clinicaltrials.gov) -  Mar 21, 2012
P2, N=6, Terminated,  Sponsor: ICON Bioscience Inc
Active, not recruiting --> Completed N=228 --> 6

||||||||||  Ozurdex (dexamethasone intravitreal implant) / AbbVie
New P4 trial, Surgery:  Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema (clinicaltrials.gov) -  Mar 5, 2012
P4, N=20, Recruiting,  Sponsor: Postgraduate Institute of Medical Education and Research

|||||||||| New P3 trial: Visual Quality Following Aspheric Intraocular Lens (IOL) Implantation - a Comparative Clinical Study (clinicaltrials.gov) - Mar 4, 2012
P3, N=125, Active, not recruiting, Sponsor: Hoya Surgical Optics, Inc.

||||||||||  ketorolac ophthalmic / Generic mfg.
New P4 trial, Surgery:  Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery (clinicaltrials.gov) -  Feb 29, 2012
P4, N=80, Recruiting,  Sponsor: University of Campinas, Brazil

||||||||||  Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
Enrollment change, Surgery:  Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery. (clinicaltrials.gov) -  Feb 22, 2012
P4, N=52, Completed,  Sponsor: Edward J. Holland
N=228 --> 6 N=35 --> 52

|||||||||| Enrollment change: Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront (clinicaltrials.gov) - Feb 15, 2012
P4, N=8, Completed, Sponsor: Mark Packer, MD, FACS
N=35 --> 52 N=45 --> 8

|||||||||| Trial completion: Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront (clinicaltrials.gov) - Feb 15, 2012
P4, N=8, Completed, Sponsor: Mark Packer, MD, FACS
N=45 --> 8 Recruiting --> Completed

|||||||||| Trial completion, Surgery: Clear Corneal Incisions and Arcuate Incisions Utilizing FemtoSecond Laser Technology for Cataract Surgery (clinicaltrials.gov) - Feb 14, 2012
P4, N=29, Completed, Sponsor: Innovative Medical
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion, Combination therapy, Surgery: A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma (clinicaltrials.gov) - Feb 4, 2012
P3, N=240, Completed, Sponsor: Glaukos Corporation
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion, Surgery: GUSTO: Guangdong Uptake of Surgery Trial (clinicaltrials.gov) - Jan 31, 2012
P=N/A, N=434, Completed, Sponsor: Sun Yat-sen University
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment change: Accommodation Measurements After Bilateral Implantation of an Aspheric Accommodating Lens and Monofocal Aspheric Lenses (clinicaltrials.gov) - Jan 23, 2012
P4, N=7, Completed, Sponsor: Bausch & Lomb Incorporated
Recruiting --> Completed N=24 --> 7

|||||||||| Trial completion: Accommodation Measurements After Bilateral Implantation of an Aspheric Accommodating Lens and Monofocal Aspheric Lenses (clinicaltrials.gov) - Jan 23, 2012
P4, N=7, Completed, Sponsor: Bausch & Lomb Incorporated
N=24 --> 7 Active, not recruiting --> Completed

|||||||||| Trial completion: ACO: The Role of Capsular Tension Ring (CTR) in Anterior Capsular Contraction (clinicaltrials.gov) - Jan 23, 2012
P4, N=40, Completed, Sponsor: Aurolab
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| New P3 trial, Surgery: VIGADEXA Gel Compared to VIGADEXA Solution Following Cataract Surgery (clinicaltrials.gov) - Jan 22, 2012
P3, N=0, Withdrawn, Sponsor: Alcon Research

|||||||||| Trial completion: Dispervise Ophthalmic Viscoelastic as an Agent to Ensure Watertight Wound Closure After Clear Corneal Cataract Incisions (clinicaltrials.gov) - Jan 16, 2012
P4, N=50, Completed, Sponsor: Innovative Medical
Active, not recruiting --> Completed Recruiting --> Completed