Joint Diseases MOAs - LARVOL Sigma

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Phase N/A 1 2 3 4 Products	0	7	14	21	28	35	42	49	56	63	70



CD20 inhib




IL-6 inhib




CD20 inhib




SYK inhib




TNFα inhib




κ-opioid inhib




COX2 inhib




CD20 inhib




IL-1β inhib




IL-6 inhib




JAK3 inhib




TGF-β1 inhib




THF dehydrogenase inhib




CD40 inhib




GCR agon




GM-CSF agon




IL-17A inhib




Na+ channel inhib




CCR2 receptor inhib




GnRH antag




Histamine H2 receptor antag




Immunosuppressant




NF-κB inhib




NSAID




Nerve growth factor inhib




T-cell activation inhib




p38 inhib




Anti-inflammatory agent




C5aR inhib




CCR2 receptor inhib




Cyclic GMP PDE inhib




IFNα 2b stim




IL-23 inhib




Norepinephrine reuptake inhib




TGF-β1 inhib




Undefined mechanism




c-KIT inhib




mTOR inhib




BAFF inhib




FGF stim




PDGFR inhib




Prostaglandin synthase inhib




Protein 30S ribosomal subunit inhib




Purinergic receptor P2X7 antag




Selective estrogen receptor mod




Serotonin reuptake inhib




TRPV1 agon




iNOS inhib




Acetylcholine inhib




Bcl2 inhib



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