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38 Mechanisms of Action |
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1523 News |
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- |||| Trial completion: The Immunogenicity and Safety of 2012-2013 Trivalent Seasonal Influenza Vaccine (clinicaltrials.gov) - May 26, 2013
P4, N=202, Completed, Sponsor: Sinovac Biotech Co., Ltd
Recruiting --> Completed
- ||||||| RotaTeq (Live attenuated pentavalent Rotavirus oral vaccine) / Merck (MSD), Vaxelis (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, inactivated poliovirus, haemophilus b conjugate and hepatitis B vaccine) / Merck (MSD), Sanofi
Trial completion: Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13 (clinicaltrials.gov) - May 23, 2013
P3, N=1473, Completed, Sponsor: Merck Sharp & Dohme Corp.
Recruiting --> Completed Active, not recruiting --> Completed
- ||||| oseltamivir / Generic mfg.
Trial initiation date: A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants. (clinicaltrials.gov) - May 22, 2013
P3, N=166, Recruiting, Sponsor: Hoffmann-La Roche
Active, not recruiting --> Completed Initiation date: Feb 1966 --> Feb 2008
- Fluzone (influenza vaccine) / Sanofi, Fluzone Intradermal Quadrivalent (influenza vaccine) / Evotec, Sanofi
Trial completion: Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Study (clinicaltrials.gov) - May 22, 2013
P=N/A, N=316, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Initiation date: Feb 1966 --> Feb 2008 Active, not recruiting --> Completed
- ||||| FluMist Quadrivalent (live attenuated influenza vaccine nasal spray) / AstraZeneca, Daiichi Sankyo
New P4 trial: Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults (clinicaltrials.gov) - May 19, 2013
P4, N=300, Completed, Sponsor: MedImmune LLC
- |||||||||| Fluvirin (inactivated influenza virus vaccine) / CSL Behring
New P3 trial, Preclinical: Safety of Two Trivalent Influenza Vaccines Evaluated in Children and Adolescents 4 to 17 Years of Age (clinicaltrials.gov) - May 16, 2013
P3, N=2055, Active, not recruiting, Sponsor: Novartis Vaccines
- ||||| Afluria (influenza vaccine) / CSL Behring
New P4 trial: A Study to Assess the Immunogenicity and Safety of CSL's 2013/2014 Formulation of Enzira (clinicaltrials.gov) - May 16, 2013
P4, N=120, Completed, Sponsor: bioCSL PTY LTD
- Enrollment open: Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant (clinicaltrials.gov) - May 16, 2013
P=N/A, N=60, Recruiting, Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- ||| New P1 trial: Safety and Immunogenicity of Three Dosage Levels of Swine Influenza Vaccine in Children Ages 3 to <9 Years, Adolescents 9 to <18 Years, Adults 18 to <65 Years and Elderly 65 Years and Older. (clinicaltrials.gov) - May 15, 2013
P1, N=600, Active, not recruiting, Sponsor: Novartis Vaccines
- || Dectova (zanamivir) / GSK
Trial completion: A Study of Intravenous Zanamivir in the Treatment of Hospitalized Patients With Influenza Infection (clinicaltrials.gov) - May 15, 2013
P3, N=21, Completed, Sponsor: GlaxoSmithKline
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- || New P3 trial: Clinical Efficacy of Trivalent Live-Attenuated Influenza Vaccine (LAIV) Among Children in Senegal (clinicaltrials.gov) - May 13, 2013
P3, N=1761, Completed, Sponsor: Program for Appropriate Technology in Health
- oseltamivir / Generic mfg.
Enrollment change: A Study of Intravenous Oseltamivir [Tamiflu] in Infants With Influenza (clinicaltrials.gov) - May 12, 2013
P1, N=7, Active, not recruiting, Sponsor: Hoffmann-La Roche
Active, not recruiting --> Completed N=36 --> 7
- oseltamivir / Generic mfg.
Enrollment change: A Study of Intravenous Tamiflu (Oseltamivir) in Children With Influenza (clinicaltrials.gov) - May 12, 2013
P1, N=7, Active, not recruiting, Sponsor: Hoffmann-La Roche
N=36 --> 7 N=36 --> 7
- oseltamivir / Generic mfg.
Enrollment closed: A Study of Intravenous Oseltamivir [Tamiflu] in Infants With Influenza (clinicaltrials.gov) - May 12, 2013
P1, N=7, Active, not recruiting, Sponsor: Hoffmann-La Roche
N=36 --> 7 Recruiting --> Active, not recruiting
- oseltamivir / Generic mfg.
Enrollment closed: A Study of Intravenous Tamiflu (Oseltamivir) in Children With Influenza (clinicaltrials.gov) - May 12, 2013
P1, N=7, Active, not recruiting, Sponsor: Hoffmann-La Roche
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- Trial completion: Cell-Mediated Immune Responses to Influenza A/H5N1 Vaccine (clinicaltrials.gov) - May 9, 2013
P=N/A, N=339, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- Trial completion: Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant (clinicaltrials.gov) - May 9, 2013
P=N/A, N=459, Completed, Sponsor: City of Hope Medical Center
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||| Dectova (zanamivir) / GSK
Trial completion, Review: Zanamivir Aqueous Solution Compassionate Use Program Retrospective Chart Review Study (clinicaltrials.gov) - May 8, 2013
P=N/A, N=113, Completed, Sponsor: GlaxoSmithKline
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||| Fluarix (influenza virus trivalent vaccine) / GSK
Trial completion: NANOVAX: A Pilot Study to Evaluate the Safety and Immunogenicity of Low Dose Flu Vaccines (clinicaltrials.gov) - May 7, 2013
P=N/A, N=180, Completed, Sponsor: NanoPass Technologies Ltd
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Trial completion: Phase 3 Study of A Group A, C Polysaccharide Meningococcal and Type b Haemophilus Influenzal Conjugate Vaccine (clinicaltrials.gov) - May 6, 2013
P3, N=900, Completed, Sponsor: Jiangsu Province Centers for Disease Control and Prevention
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | New P4 trial: Safety of H1N1 Influenza Vaccination in Pregnant Women (clinicaltrials.gov) - Apr 28, 2013
P4, N=122, Completed, Sponsor: Jiangsu Province Centers for Disease Control and Prevention
- oseltamivir / Generic mfg., amantadine / Generic mfg.
Enrollment change, Combination therapy, Monotherapy: TCAD vs. Monotherapy for Influenza A in Immunocompromised Patients (clinicaltrials.gov) - Apr 25, 2013
P1/2, N=7, Completed, Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Completed N=70 --> 7
- | New P2 trial: Safety and Immunogenicity of Live Attenuated Influenza H5N2 (clinicaltrials.gov) - Apr 25, 2013
P2, N=150, Completed, Sponsor: Mahidol University
- Enrollment closed: Protecting Pregnant Women From Infectious Diseases (clinicaltrials.gov) - Apr 24, 2013
P=N/A, N=330, Active, not recruiting, Sponsor: Emory University
N=70 --> 7 Recruiting --> Active, not recruiting
- || Clinical data, Enrollment closed: Evaluation of Viral Shedding Patterns and Clinical Outcomes of Influenza Patients (clinicaltrials.gov) - Apr 23, 2013
P=N/A, N=500, Active, not recruiting, Sponsor: Crucell Holland BV
Recruiting --> Active, not recruiting Not yet recruiting --> Active, not recruiting
- oseltamivir / Generic mfg.
Trial termination: Time to Oseltamivir Access When Prescribed by Pharmacists Versus Physicians (ACCESS) (clinicaltrials.gov) - Apr 17, 2013
P4, N=48, Terminated, Sponsor: Trial Management Group Inc.
Not yet recruiting --> Active, not recruiting Recruiting --> Terminated; Insufficient recruitment
- oseltamivir / Generic mfg.
Enrollment change: Time to Oseltamivir Access When Prescribed by Pharmacists Versus Physicians (ACCESS) (clinicaltrials.gov) - Apr 17, 2013
P4, N=48, Terminated, Sponsor: Trial Management Group Inc.
Recruiting --> Terminated; Insufficient recruitment N=294 --> 48
- Enrollment change: Vaccine Acceptance in Pregnant Minority Women (clinicaltrials.gov) - Apr 16, 2013
P=N/A, N=121, Active, not recruiting, Sponsor: Emory University
N=294 --> 48 N=177 --> 121
- Enrollment closed: Vaccine Acceptance in Pregnant Minority Women (clinicaltrials.gov) - Apr 16, 2013
P=N/A, N=121, Active, not recruiting, Sponsor: Emory University
N=177 --> 121 Recruiting --> Active, not recruiting
- | Enrollment closed: A Randomized, Controlled Trial on the Efficacy and Safety of Live-Attenuated Influenza Vaccine (LAIV) Among Children in Bangladesh (clinicaltrials.gov) - Apr 15, 2013
P3, N=1761, Active, not recruiting, Sponsor: Program for Appropriate Technology in Health
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- ||||||| Fluzone (influenza vaccine) / Sanofi
Trial completion: Inactivated Split Virus Seasonal Influenza Vaccine (Vero Cell-Derived) (clinicaltrials.gov) - Apr 15, 2013
P3, N=1929, Completed, Sponsor: Baxter Healthcare Corporation
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- Enrollment change: Effects of Yoga on Objective and Self-reported Health Indicators Among Female and Male Individuals (clinicaltrials.gov) - Apr 11, 2013
P=N/A, N=90, Recruiting, Sponsor: Karolinska Institutet
Active, not recruiting --> Completed N=40 --> 90
- Enrollment open: Effects of Yoga on Objective and Self-reported Health Indicators Among Female and Male Individuals (clinicaltrials.gov) - Apr 11, 2013
P=N/A, N=90, Recruiting, Sponsor: Karolinska Institutet
N=40 --> 90 Active, not recruiting --> Recruiting
- Fluzone (influenza vaccine) / Sanofi
New P4 trial: Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) (clinicaltrials.gov) - Apr 11, 2013
P4, N=21, Completed, Sponsor: Stanford University
- Trial completion: The Effect of Probiotics (L. Helveticus, B. Longum, and B. Bifidum) on Immune Function and Digestive Health (clinicaltrials.gov) - Apr 10, 2013
P=N/A, N=583, Completed, Sponsor: University of Florida
Active, not recruiting --> Recruiting Active, not recruiting --> Completed
- ||||||| Vaxelis (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, inactivated poliovirus, haemophilus b conjugate and hepatitis B vaccine) / Merck (MSD), Sanofi
Trial completion: Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 3, 4 and 12 Months (V419-007) (clinicaltrials.gov) - Apr 8, 2013
P3, N=1250, Completed, Sponsor: Sanofi Pasteur MSD
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Enrollment change: TextFluenza: Using Technology To Promote Flu Vaccination In Underserved Maternal And Child Populations (clinicaltrials.gov) - Apr 7, 2013
P=N/A, N=9213, Completed, Sponsor: Columbia University
Active, not recruiting --> Completed N=16156 --> 9213
- | Fluzone High-Dose Quadrivalent (influenza vaccine) / Evotec, Sanofi
New P4 trial: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017) (clinicaltrials.gov) - Apr 7, 2013
P4, N=90, Active, not recruiting, Sponsor: Stanford University
- Enrollment open: A Phase I Study of Candidate Influenza Vaccines MVA-NP+M1 and ChAdOx1 NP+M1 (clinicaltrials.gov) - Apr 7, 2013
P1, N=48, Recruiting, Sponsor: University of Oxford
N=16156 --> 9213 Not yet recruiting --> Recruiting
- |||||||||| Flublok (influenza vaccine) / Sanofi, Ildong, Shionogi
New P3 trial: Comparison of the Safety of Flublok® Versus Licensed IIV in Healthy, Medically Stable Adults ≥ 50 Years of Age (clinicaltrials.gov) - Apr 3, 2013
P3, N=2639, Completed, Sponsor: Protein Sciences Corporation
- FluMist (influenza vaccine, live, intranasal) / AstraZeneca, FluMist Quadrivalent (live attenuated influenza vaccine nasal spray) / AstraZeneca, Daiichi Sankyo
Enrollment change: FLAIR: Effects of Diesel Exhaust Followed by Administration of Nasal Spray Flu Vaccine on Individuals With & Without Allergies (clinicaltrials.gov) - Apr 2, 2013
P=N/A, N=54, Suspended, Sponsor: University of North Carolina, Chapel Hill
Not yet recruiting --> Recruiting N=80 --> 54
- |||| Fluzone (influenza vaccine) / Sanofi, Fluzone Intradermal Quadrivalent (influenza vaccine) / Evotec, Sanofi, Fluzone High-Dose Quadrivalent (influenza vaccine) / Evotec, Sanofi
Trial completion: Study of Fluzone® Influenza Virus Vaccines 2012-2013 Formulation Among Adults. (clinicaltrials.gov) - Apr 1, 2013
P4, N=200, Completed, Sponsor: Sanofi Pasteur, a Sanofi Company
N=80 --> 54 Active, not recruiting --> Completed
- |||| Fluzone (influenza vaccine) / Sanofi
Trial completion: Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Influenza Virus Vaccine (2012-2013 Formulation) (clinicaltrials.gov) - Apr 1, 2013
P4, N=60, Completed, Sponsor: Sanofi Pasteur, a Sanofi Company
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||||| oseltamivir / Generic mfg., nitazoxanide / Generic mfg.
Trial initiation date: Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza (clinicaltrials.gov) - Mar 31, 2013
P3, N=1400, Recruiting, Sponsor: Romark Laboratories L.C.
Active, not recruiting --> Completed Initiation date: Nov 2012 --> Mar 2013
- |||||| oseltamivir / Generic mfg., nitazoxanide / Generic mfg.
Enrollment open: Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza (clinicaltrials.gov) - Mar 31, 2013
P3, N=1400, Recruiting, Sponsor: Romark Laboratories L.C.
Initiation date: Nov 2012 --> Mar 2013 Not yet recruiting --> Recruiting
- || Pentacel (diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and hemophilus b conjugate) / Sanofi
Enrollment closed: Database Surveillance Safety Study of PENTACEL® Vaccine (clinicaltrials.gov) - Mar 27, 2013
P=N/A, N=10000, Active, not recruiting, Sponsor: Sanofi Pasteur, a Sanofi Company
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- |||| Pentacel (diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and hemophilus b conjugate) / Sanofi
Trial completion: Safety of PENTAXIM® Given as a Three-Dose Primary Vaccination at 2, 3, and 4 Months of Age in Infants in China (clinicaltrials.gov) - Mar 27, 2013
P4, N=900, Completed, Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- ||||||| Trial completion: Study of a Quadrivalent Influenza Vaccine Administered Intramuscularly in Children/Adolescents and Adults (clinicaltrials.gov) - Mar 27, 2013
P3, N=1701, Completed, Sponsor: Sanofi Pasteur, a Sanofi Company
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Trial completion: The Safety and Immunogenicity of Haemophilus Influenzae Type b Vaccine in Different Injection Site (clinicaltrials.gov) - Mar 26, 2013
P4, N=680, Completed, Sponsor: Beijing Center for Disease Control and Prevention
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | FLUAD (trivalent inactivated influenza vaccine) / CSL Behring, Vaxigrip (inactivated influenza vaccine (split virion)) / Sanofi
New P2 trial: Immunogenicity and Safety Trial of Adjuvanted and Non-adjuvanted Trivalent Influenza Vaccine in Tropical Africa (clinicaltrials.gov) - Mar 25, 2013
P2, N=296, Completed, Sponsor: Program for Appropriate Technology in Health