Hemoglobinopathies
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 43 Companies   55 Products   55 Products   60 Mechanisms of Action   1 Trial   670 News 


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  • ||||||||||  Clinical, Retrospective data, Review, Trial primary completion date, Journal:  KNOW-IT: Improving Disease Knowledge in Adolescents With Sickle Cell Disease (clinicaltrials.gov) -  Mar 11, 2015   
    P=N/A,  N=150, Active, not recruiting, 
    Not yet recruiting --> Recruiting Trial primary completion date: Jan 2015 --> Apr 2015
  • ||||||||||  fludarabine IV / Generic mfg., cyclophosphamide / Generic mfg.
    Trial primary completion date:  Sickle Cell Disease Conditioning for Bone Marrow Transplant (clinicaltrials.gov) -  Mar 11, 2015   
    P1,  N=24, Suspended, 
    Trial primary completion date: Jan 2015 --> Apr 2015 Trial primary completion date: Dec 2014 --> Mar 2014
  • ||||||||||  Zolinza (vorinostat) / Merck (MSD)
    Enrollment closed, Enrollment change, Trial primary completion date:  Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease (clinicaltrials.gov) -  Mar 3, 2015   
    P2,  N=5, Active, not recruiting, 
    No longer recruiting --> Completed Recruiting --> Active, not recruiting | N=15 --> 5 | Trial primary completion date: Jul 2013 --> Oct 2014
  • ||||||||||  Instanyl (fentanyl) / Takeda
    Trial completion, Trial primary completion date:  Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis (clinicaltrials.gov) -  Feb 27, 2015   
    P4,  N=200, Completed, 
    Recruiting --> Active, not recruiting | N=15 --> 5 | Trial primary completion date: Jul 2013 --> Oct 2014 Recruiting --> Completed | Trial primary completion date: Sep 2015 --> Feb 2015
  • ||||||||||  Reblozyl (luspatercept-aamt) / BMS, Merck (MSD)
    Trial primary completion date:  Study to Evaluate the Effects of ACE-536 in Patients With Beta-thalassemia (clinicaltrials.gov) -  Feb 6, 2015   
    P2,  N=50, Recruiting, 
    Trial primary completion date: Sep 2015 --> Jan 2016 Trial primary completion date: Dec 2014 --> Nov 2015
  • ||||||||||  hydroxyurea / Generic mfg.
    Trial primary completion date, Adherence:  Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT (clinicaltrials.gov) -  Feb 5, 2015   
    P2,  N=60, Recruiting, 
    Trial primary completion date: Jan 2014 --> May 2015 Trial primary completion date: May 2015 --> Dec 2015
  • ||||||||||  Enrollment open, Trial primary completion date:  Use of Mobile Technology for Intensive Training in Medication Management (clinicaltrials.gov) -  Feb 2, 2015   
    P=N/A,  N=25, Recruiting, 
    Trial primary completion date: May 2015 --> Dec 2015 Not yet recruiting --> Recruiting | Trial primary completion date: May 2016 --> May 2017
  • ||||||||||  Enrollment change:  Microvessels and Heart Problems in Sickle Cell Disease (clinicaltrials.gov) -  Jan 29, 2015   
    P=N/A,  N=65, Completed, 
    Not yet recruiting --> Recruiting | Trial primary completion date: May 2016 --> May 2017 N=50 --> 65
  • ||||||||||  Trial completion, Trial primary completion date:  MAGiC: Magnesium in Crisis (clinicaltrials.gov) -  Jan 26, 2015   
    P2/3,  N=208, Completed, 
    N=50 --> 65 Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Mar 2014
  • ||||||||||  deferoxamine / Generic mfg., deferiprone / Generic mfg.
    Enrollment closed, Trial primary completion date:  Amlodipine for Myocardial Iron in Thalassemia (clinicaltrials.gov) -  Jan 15, 2015   
    P2/3,  N=20, Active, not recruiting, 
    Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Mar 2014 Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Sep 2015
  • ||||||||||  Sanguinate (PEGylated Carboxyhemoglobin bovine) / Prolong Pharma
    Trial suspension:  Safety and Pharmacokinetics of SANGUINATE (clinicaltrials.gov) -  Jan 6, 2015   
    P1,  N=15, Suspended, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Suspended
  • ||||||||||  morphine sulphate / Generic mfg., dextromethorphan / Generic mfg.
    Enrollment change, Trial withdrawal:  Assessment of Opioid Analgesia in Sickle Cell (clinicaltrials.gov) -  Dec 24, 2014   
    P4,  N=0, Withdrawn, 
    Recruiting --> Completed N=62 --> 0 | Completed --> Withdrawn
  • ||||||||||  Trial completion, Enrollment change:  Microvessels and Heart Problems in Sickle Cell Disease (clinicaltrials.gov) -  Dec 13, 2014   
    P=N/A,  N=50, Completed, 
    N=62 --> 0 | Completed --> Withdrawn Recruiting --> Completed | N=85 --> 50
  • ||||||||||  Sanguinate (PEGylated Carboxyhemoglobin bovine) / Prolong Pharma
    Trial completion, Trial primary completion date:  Study of SANGUINATE™ Versus Hydroxyurea in Sickle Cell Disease (SCD) Patients (clinicaltrials.gov) -  Dec 6, 2014   
    P1,  N=24, Completed, 
    Not yet recruiting --> Recruiting Recruiting --> Completed | Trial primary completion date: Oct 2013 --> Jul 2014
  • ||||||||||  Trial completion, Enrollment change:  Carbon Monoxide Levels and Sickle Cell Disease Severity (clinicaltrials.gov) -  Dec 5, 2014   
    P=N/A,  N=106, Completed, 
    Recruiting --> Completed | Trial primary completion date: Oct 2013 --> Jul 2014 Recruiting --> Completed | N=150 --> 106
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment closed, Trial primary completion date:  Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally (clinicaltrials.gov) -  Nov 25, 2014   
    P3,  N=250, Active, not recruiting, 
    Trial primary completion date: Apr 2015 --> Apr 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Jan 2014
  • ||||||||||  Enrollment open:  PArTNER: PATient Navigator to rEduce Readmissions (clinicaltrials.gov) -  Nov 20, 2014   
    P=N/A,  N=1130, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Jan 2014 Not yet recruiting --> Recruiting
  • ||||||||||  Enrollment change, Trial termination, Trial primary completion date:  Treatment of Sickle Cell Anemia With Stem Cell Transplant (clinicaltrials.gov) -  Nov 20, 2014   
    P=N/A,  N=2, Terminated, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2014 --> Jun 2015 N=12 --> 2 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2014 --> Aug 2011; Poor accrual
  • ||||||||||  deferiprone / Generic mfg.
    Trial completion, Enrollment change:  DEEP-1: Pharmacokinetic Study of Deferiprone in Paediatric Patients (clinicaltrials.gov) -  Nov 18, 2014   
    P2,  N=18, Completed, 
    N=12 --> 2 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2014 --> Aug 2011; Poor accrual Recruiting --> Completed | N=30 --> 18
  • ||||||||||  Enrollment closed, Trial primary completion date:  Treatment of Sickle Cell Anemia With Stem Cell Transplant (clinicaltrials.gov) -  Nov 13, 2014   
    P=N/A,  N=12, Active, not recruiting, 
    Recruiting --> Completed | N=30 --> 18 Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Dec 2014
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    Trial primary completion date:  Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease (clinicaltrials.gov) -  Nov 6, 2014   
    P2,  N=15, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Dec 2014 Trial primary completion date: Sep 2014 --> May 2015