Glaucoma
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  • ||||||||||  Journal:  Complications and Management of Cosmetic Iris Implants. (Pubmed Central) -  Jun 7, 2025   
    Many patients required multiple surgical interventions after explantation, highlighting the long-term morbidity associated with these devices. The authors recommend that cosmetic iris implantation should be banned worldwide given the substantial risks and lack of therapeutic value, and greater regulatory oversight is needed to prevent further harm to patients.
  • ||||||||||  Journal:  Genetic association of attention-deficit/hyperactivity disorder with thirteen ocular disorders. (Pubmed Central) -  Jun 7, 2025   
    This study revealed genetic associations between ADHD and multiple ocular disorders, identifying causal effects of ADHD on an increased risk of corneal ulcer, keratitis, blepharochalasis, and lacrimal system disorders, while showing a protective effect against glaucoma. Conversely, genetic liability to strabismus increased ADHD risk.
  • ||||||||||  Preclinical, Journal:  Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice. (Pubmed Central) -  Jun 6, 2025   
    Taken together, aging causes multiple neurovascular phenotypes in mouse retinas, and OHT causes more severe effects in old mice. This suggests an interaction between aging and OHT that may help explain the increased prevalence of glaucoma in older humans.
  • ||||||||||  Journal:  Histopathological changes in the trabecular meshwork in primary congenital glaucoma. (Pubmed Central) -  Jun 6, 2025   
    The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region. Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.
  • ||||||||||  Journal:  French protocol for diagnosis and management of type 1 interferonopathies. (Pubmed Central) -  Jun 5, 2025   
    Vaccinations should be updated, with live vaccines contraindicated during immunosuppression unless otherwise specified (Supplemental 2). Monitoring development, supporting disability, and coordinating with social and medical institutions are also crucial aspects of care.
  • ||||||||||  Journal:  Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status. (Pubmed Central) -  Jun 5, 2025   
    The mean (SD) difference between the POAG group and control group in pre- and post-VFQ mental health scores was -5.8 (9.4) (95% CI, -9.05 to -2.60; P?=?.048). These findings support the need for further studies to confirm the association between POAG diagnosis and a decrease in mental health score and to develop strategies to inform patients about their POAG diagnosis without producing undue distress, anxiety, and depression.
  • ||||||||||  latanoprost / Generic mfg., dorzolamide/timolol / Generic mfg.
    Reimbursement, US reimbursement, Journal, Medicare:  Medicare Part D Glaucoma Drug Prescribing Patterns by Ophthalmologists from 2018 to 2022. (Pubmed Central) -  Jun 4, 2025   
    An increasing number of claims annually, with the exception of the COVID-19 pandemic onset, reflects the growing prevalence of glaucoma. The utilization of new glaucoma agents, such as rho kinase inhibitors, is rapidly increasing as a new therapeutic option.
  • ||||||||||  Enrollment change, Trial termination:  Automated Applanation Tonometry (clinicaltrials.gov) -  Jun 4, 2025   
    P=N/A,  N=111, Terminated, 
    We also contribute a new dataset consisting of 747 CFPs with GON labels as open access, available at [URL provided on publication]. Recruiting --> Terminated | N=200 --> 111; device updates needed
  • ||||||||||  Journal:  Ocular Findings as the Most Striking Manifestation of a SMAD3 Variant. (Pubmed Central) -  Jun 4, 2025   
    High-grade myopia, premature cataracts, and premature glaucoma are part of the phenotypic spectrum in LDS caused by SMAD3 variants. Inclusion of SMAD3 in molecular gene panels for early-onset high-grade myopia should be considered.
  • ||||||||||  Journal:  From Velocity to Acceleration: A Perspective on Age-Related Visual Field Progression in Glaucoma. (Pubmed Central) -  Jun 4, 2025   
    A cubic model illustrates age-related sensitivity loss in healthy eyes, while a quadratic model captures the interaction between disease duration and baseline age in glaucomatous eyes. These models emphasize that progression accelerates over time and suggest that individualized treatment intensity should consider not only the current rate of VF decline but also its likely acceleration based on patient age and disease course.
  • ||||||||||  Journal:  Intraoperative optical coherence tomography for Ab externo PreserFlo MicroShunt in glaucoma surgery. (Pubmed Central) -  Jun 4, 2025   
    In some cases, iOCT identified initial misplacements, enabling immediate intraoperative adjustments and successful repositioning, ensuring precise and safe implantation in all cases.ConclusionThis innovative application of iOCT offers a means to refine the PMS implantation technique by enhancing intraoperative visualization and positioning accuracy. The integration of iOCT has the potential to enhance the surgical techniques of experienced surgeons as well as to improve the training of junior practitioners.
  • ||||||||||  Journal:  The glymphatic system in oncology: from the perspective of a radiation oncologist. (Pubmed Central) -  Jun 3, 2025   
    This review provides an overview of the structure and functional evaluation methods of the glymphatic system, summarizes the effects of its dysfunction on brain tumor treatment, and explores recent findings on the impact of radiation therapy on glymphatic system functioning. Lastly, it also explores the potential for radiation therapy strategies that account for their effects on the glymphatic system.
  • ||||||||||  Trial completion date, Trial primary completion date:  XEN Glaucoma Gel Stent Versus Trabeculectomy (clinicaltrials.gov) -  Jun 3, 2025   
    P=N/A,  N=196, Recruiting, 
    Lastly, it also explores the potential for radiation therapy strategies that account for their effects on the glymphatic system. Trial completion date: Dec 2025 --> Sep 2026 | Trial primary completion date: Apr 2025 --> Mar 2026
  • ||||||||||  pemrametostat (GSK3326595) / Ipsen
    Journal:  PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/?-Catenin Signaling Cascade. (Pubmed Central) -  Jun 3, 2025   
    Additionally, the role of the protein arginine methyltransferase 5 (PRMT5)-regulated Wnt/?-catenin pathway in RGC senescence was investigated via intravitreal injection of GSK3326595 and CHIR99021 in mice...Taken together, these findings highlight the critical role of the PRMT5-regulated Wnt/?-catenin pathway in RGC senescence and neurodegeneration. Targeting this pathway represents a promising therapeutic strategy for glaucoma.