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90 Companies |
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50 Mechanisms of Action |
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798 Trials |
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63030 News |
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- | Journal: Associations of long-term joint exposure to multiple ambient air pollutants with the incidence of age-related eye diseases. (Pubmed Central) - Apr 7, 2025
Long-term joint exposure to multiple air pollutants, even at low concentrations, is associated with an increased risk of AREDs incidence, suggesting that reducing air pollution level could improve human ocular health. These findings provide a more comprehensive understanding of air pollution's impact on ocular health in the real world.
- | Journal: Occupational Exposure to Low Dose Ionizing Radiation and the Incidence of Surgically Removed Cataracts and Glaucoma in a Cohort of Ontario Nuclear Power Plant Workers. (Pubmed Central) - Apr 7, 2025
The linear excess risks per 100 mSv (lagged 5 years) for cataract removal surgery was 0.055 (95% CI: -0.042 to 0.163). Our findings provide some evidence that ionizing radiation increases the risk of cataracts but not glaucoma in an occupational cohort whose lifetime cumulative dose rarely exceeded 30 mSv.
- | New trial: Evaluation Of Effect of Axial Length on Cup-To-Disc Ratio Among Non- Glaucomatous Hypertensive Patients (clinicaltrials.gov) - Apr 7, 2025
P=N/A, N=94, Active, not recruiting, Sponsor: Superior University
- |||||| New trial, HEOR: Observational Survey Study on the Impact of Myopia and Its Complications on Quality of Life. (clinicaltrials.gov) - Apr 7, 2025
P=N/A, N=350, Not yet recruiting, Sponsor: Santen SAS
- | Retrospective data, Journal: Visual Field Threshold Changes in Normal Pressure Hydrocephalus Patients With and Without Primary Open-Angle Glaucoma (P4-2.008). (Pubmed Central) - Apr 7, 2025
Dr. khanna has nothing to disclose.
- | brimonidine tartrate / Generic mfg.
Preclinical, Journal: Real-Time In Vivo Monitoring of Eye Drop Concentration Using Boron-Doped Diamond Microelectrodes and Its Relevance to Drug Efficacy. (Pubmed Central) - Apr 7, 2025
A needle-shaped BDD microelectrode, with a respective length and tip diameter of ?200 and ?40 ?m, was used in the in vivo detection of brimonidine tartrate (BRM), which is a widely used antiglaucoma drug...Notably, the pharmacological effect of BRM, i.e., a reduced intraocular pressure, was observed 30 min after administration, lagging behind drug migration. These findings may provide valuable insights into the ocular pharmacokinetics of novel drugs and facilitate the development of more effective therapeutic approaches.
- | Journal: Gap Analysis of Standard Automated Perimetry Concept Representation in Medical Terminologies. (Pubmed Central) - Apr 7, 2025
There is a lack of representation of some SAP data elements in standardized medical terminologies, hampering interoperability and data-sharing. We identified gaps and proposed new concepts for addition to LOINC, aiming to improve SAP data standards and interoperability.
- | Journal: Five-Year Outcomes of iStent inject Implantation With or Without Phacoemulsification in Eyes with Open-Angle Glaucoma. (Pubmed Central) - Apr 7, 2025
We identified gaps and proposed new concepts for addition to LOINC, aiming to improve SAP data standards and interoperability. This 5-year real-world study showed significant and sustained reductions in IOP and topical medication burden following iStent inject trabecular micro-bypass with or without cataract surgery in eyes with mild and moderate open-angle glaucoma.
- | Journal: Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition. (Pubmed Central) - Apr 7, 2025
The FSQ risk score can be a screening tool to identify patients with POAG with increased vascular stiffness and further reduced ONH blood flow during cold stress. The vascular risk score may help tailor individual glaucoma care.
- | Journal: Mapping glaucoma higher qualifications within UK optometry. (Pubmed Central) - Apr 7, 2025
The number of optometrists holding postgraduate higher qualifications in glaucoma and IP in the UK has increased substantially. These data suggest that primary care optometrists are willing to upskill to gain the necessary glaucoma accreditations required to provide glaucoma care, potentially affording significant primary care capacity expansion to existing glaucoma services.
- | Journal: Tetra-anionic porphyrin mimics protein-protein interactions between regulatory particles and the catalytic core, allosterically activating human 20S proteasome. (Pubmed Central) - Apr 7, 2025
By means of an integrated approach, including bioinformatics, enzymatic kinetic analysis, atomic force microscopy, and dynamic docking simulations, we show how binding of H2TPPS affects the closed/open conformational equilibrium of human 20S to ultimately promote substrate gate opening and proteolytic activity. These outcomes support our hypothesis and pave the way to the rational discovery of new proteasome allosteric modulators able to reproduce the key structural elements of regulatory particles responsible for catalytic activation.
- | Journal: Identification of a chromatin regulator signature and potential candidate drugs for primary open-angle glaucoma. (Pubmed Central) - Apr 7, 2025
Finally, we found 10 agents that might be helpful for patients with POAG. Dysregulation of CR expression in TM tissues may be involved in the occurrence and progression of POAG through multiple mechanisms.
- | Journal: BMP4-GPX4 can improve the ferroptosis phenotype of retinal ganglion cells and enhance their differentiation ability after retinal stem cell transplantation in glaucoma with high intraocular pressure. (Pubmed Central) - Apr 7, 2025
Our results demonstrate that BMP4-GPX4 not only reduces oxidative stress and iron accumulation but also promotes neuroprotective factors that support the survival of transplanted RSCs into the host retina. These findings suggest a novel therapeutic approach for glaucoma involving the modulation of the BMP4-GPX4 pathway to protect RGCs and improve visual function through enhanced RSC differentiation.
- | Journal: Dendrimers-Based Hydrogels and Nanogels for Drug Delivery. (Pubmed Central) - Apr 7, 2025
The self-cleaving mechanism of dendrimer hydrogels (DH) leads to enhanced and sustained delivery of the drugs in the treatment of cancer. Recent studies show the use of doxorubicinconjugated nanogel-based PAMAM dendrimer as a capable nanocarrier for the delivery of drugs in the treatment of cancer.
- || Enrollment closed, Trial completion date, Trial primary completion date: Clinical Outcomes in Cataract Surgery With OMNI Canaloplasty vs Cataract Surgery With OMNI Canaloplasty and Hydrus Stent (clinicaltrials.gov) - Apr 7, 2025
P=N/A, N=80, Active, not recruiting, Sponsor: Ridge Eye Care
Recent studies show the use of doxorubicinconjugated nanogel-based PAMAM dendrimer as a capable nanocarrier for the delivery of drugs in the treatment of cancer. Recruiting --> Active, not recruiting | Trial completion date: Oct 2024 --> Oct 2025 | Trial primary completion date: Oct 2024 --> Oct 2025
- | Journal: Measurements of white-to-white corneal diameter and anterior chamber parameters using the Pentacam AXL wave and their correlations in the adult Saudi population. (Pubmed Central) - Apr 7, 2025
Recruiting --> Active, not recruiting | Trial completion date: Oct 2024 --> Oct 2025 | Trial primary completion date: Oct 2024 --> Oct 2025 Males had a significantly (p < 0.01) higher white-to-white corneal diameter (12.12
- | Journal: Unusual Presentation of Extensive Visually Significant Pseudoexfoliative Deposits on an Intraocular Lens Implant in a Pseudophakic Eye: Insights and Implications. (Pubmed Central) - Apr 7, 2025
This case highlights the importance of comprehensive examination for pseudoexfoliation, even in patients with pseudophakia. Visually significant PEX deposition was first reported and should be managed with caution.
- | Journal: Characteristics of Normal Tension Glaucoma Referrals at a Tertiary Care Center and Factors Associated with Unilateral versus Bilateral Disease. (Pubmed Central) - Apr 7, 2025
Clinicians should assess for the presence of systemic diseases associated with vascular dysregulation, myopia, and a family history of glaucoma. Patients with unilateral disease consistent with NTG may benefit from additional workup including neuroimaging or a neuro-ophthalmic evaluation.
- || Glanatec (ripasudil) / Kowa, Rhopressa (netarsudil) / Alcon
Review, Journal: Rho Kinase Inhibitors in Glaucoma Management: Current Perspectives and Future Directions. (Pubmed Central) - Apr 7, 2025
This review aims to provide an overview of ROCK inhibitors, focusing on their mechanisms of action, clinical efficacy, safety profiles, and additional benefits for eye health. Furthermore, further potential applications of ROCK inhibitors in glaucoma management are going to be discussed.
- || Review, Journal: Research progress on biomechanical characteristics of the posterior eye and vitreoretinal diseases and optic neuropathy (Pubmed Central) - Apr 7, 2025
However, currently, the research on the biomechanics of the posterior segment of the eye is still in its infancy. The mechanical regulation mechanisms of multiple factors such as age, intraocular pressure, blood flow, and axial length have not been fully elucidated, and aspects such as matrix protein remodeling and post-translational modifications also require in-depth research.
- | Journal: Unveiling the pivotal role of corneal biomechanical parameters in glaucoma diagnosis and therapy (Pubmed Central) - Apr 7, 2025
It emphasizes the need to comprehensively recognize the reference value of corneal biomechanical parameters in glaucoma diagnosis and treatment. The authors aim to collaborate with fellow ophthalmologists in related research, with the ultimate goal of enhancing the diagnostic and therapeutic standards for glaucoma.
- | Preclinical, Journal: Loss of monocyte chemoattractant protein-1 reduced monocyte recruitment and preserved retinal ganglion cells in a mouse model of hypertensive glaucoma. (Pubmed Central) - Apr 6, 2025
Interestingly, expressions of C1q, IL-1?, and TNF-?, cytokines previously shown to be cytotoxic to RGCs, did not differ between WT and KO mice. In summary, genetic ablation of MCP-1 rescued RGCs and decreased myeloid density in the retina without altering pro-inflammatory cytokine expression, supporting a pathogenic role for monocyte recruitment in hypertensive glaucoma.
- | Preclinical, Journal: Regeneration of Retinal Ganglion Cell-Like Cells and Reconstruction of Visual Neural Circuits in mice with Glaucoma. (Pubmed Central) - Apr 6, 2025
In summary, we have identified the microglia as a new type of reprogramming seed cells, and four key genes were found to be involved in regenerating RGC-like cells to restore vision. These findings highlight a new strategy of RGC-like cell regeneration and provide a theoretical basis for treatment of glaucoma in the future.
- | Preclinical, Journal: MicroRNA-106a regulates the apoptosis and oxidative stress of porcine trabecular meshwork cells by targeting FAS. (Pubmed Central) - Apr 6, 2025
Thus, miR-106a promotes PTM cells' viability, suppresses apoptosis and enhances antioxidative stress capacity by targeting FAS in PTM cells. Therefore, our study provides a potential therapeutic target in glaucoma.
- | Journal: Integration of single-cell and bulk transcriptomics reveals ?-hydroxybutyrylation-related signatures in primary open-angle glaucoma. (Pubmed Central) - Apr 6, 2025
In addition, in vitro cellular experiments and animal models revealed that the TAGLN expression trend was consistent with the data from GSE27276 and GSE4316. In conclusion, TAGLN may play an important role in understanding of the molecular mechanisms of POAG and exploration of therapeutic targets.
- | Journal: Intraocular pressure-lowering effects of selective laser trabeculoplasty for normal tension glaucoma patients in Chinese. (Pubmed Central) - Apr 5, 2025
The success was associated with the number of medicines, pre-IOP and the IOP reduction at 1 and 3 months after SLT. SLT has an effect on lowering IOP for NTG patients in Chinese in both SLT eyes and the follow eyes with insufficient efficacy of anti-glaucoma medications, although the effect was not sustained with a longer follow-up.
- | Journal: TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension. (Pubmed Central) - Apr 5, 2025
Together with tissue-specific knock-out or channel inhibition test, the exacerbation of TRPA1 on RGC degeneration as well as selective injury tendency under AOH was confirmed. In virtue of our modified whole-brain clearing method, our data confirmed the innovational method to study the mechanisms behind selective vulnerability of neuronal cells, and in the meantime revealed the potential therapeutic opportunity of targeting TRPA1 for patients suffering from AOH attack.
- | Retrospective data, Journal: Choroidal microvascular dropout and its relationship to progression in primary open-angle and pseudoexfoliation glaucoma. (Pubmed Central) - Apr 5, 2025
In virtue of our modified whole-brain clearing method, our data confirmed the innovational method to study the mechanisms behind selective vulnerability of neuronal cells, and in the meantime revealed the potential therapeutic opportunity of targeting TRPA1 for patients suffering from AOH attack. The progression of CMvD was more frequently observed in PXG eyes than POAG eyes and showed association with faster VF progression in PXG eyes.
- Observational data, Journal: Ultrasound biomicroscopy assessment of the subclinical involvement of the aqueous drainage structures after silicone oil tamponade. (Pubmed Central) - Apr 5, 2025
The significant relationship between SOT density and the localization of areas of increased echo-reflectivity supports the actual relationship between SOT trabecular impregnation and UBM findings, even in eyes free from visible emulsions. In the SO2 group, the duration of the intraocular SOT correlated with the extent of the involvement of the filtering structures.
- | Journal: Relationships between distance from the fovea to the disc and macular retinal layer thickness differ between normal and glaucomatous eyes. (Pubmed Central) - Apr 5, 2025
The association between FDD and macular retinal layer thickness varies by retinal layer and the presence of POAG. FDD can significantly affect OCT-determined macular retinal layer thickness, especially GCIPL in POAG eyes and mRNFL in normal eyes.
- | Journal: Retinal neurodegeneration, neuroretinal rim analysis and choroid thickness in pseudoexfoliation syndrome with spectral domain optical coherence tomography. (Pubmed Central) - Apr 5, 2025
Findings also reveal reduced cRNFL thickness in PEX eyes, further supporting the potential for early glaucomatous damage detection. These findings underscore the need for long-term studies to explore PEX-related neurodegeneration and its possible links to broader neurological conditions.
- | Biomarker, Journal: Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis. (Pubmed Central) - Apr 5, 2025
However, there was no significant association observed between blood mtDNA-CN and other NDDs (IVW-P > 0.05). Our findings supported the relationship between mitochondrial dysfunction and development of AD and AMD, and that blood mtDNA-CN may serve as a potential biomarker for the incidence of these two NDDs.
- | Journal: Reverse pupillary block after implantation of a sutureless scleral fixation (SFF) IOL (Carlevale, Soleko). (Pubmed Central) - Apr 5, 2025
Our hypothesis is that indentation of the sclera induces a posterior rotation of the peripheral iris, causing RPB. Our results encourage looking over the Carlevale IOL implantation technique to consider a routinely intraoperative surgical peripheral iridotomy to avoid RPB and its further complications.
- | Journal: Multi-scale Spatio-temporal Transformer-based Imbalanced Longitudinal Learning for Glaucoma Forecasting from Irregular Time Series Images. (Pubmed Central) - Apr 4, 2025
Besides, our method shows excellent generalization capability on the Alzheimer's Disease Neuroimaging Initiative (ADNI) MRI dataset, with an accuracy of 88.2% for mild cognitive impairment and Alzheimer's disease prediction, outperforming the compared method by a large margin. A series of ablation studies further verify the contribution of our proposed components in addressing the irregular sampled and class imbalanced problems.
- | Journal: A Novel Case Study of Unilateral Serous Retinal Detachment in a Glaucoma Patient with Nephrotic Syndrome. (Pubmed Central) - Apr 4, 2025
Prompt recognition of nephrotic syndrome in patients with kidney disease who develop serous retinal detachment is critical. Early treatment with diuretic therapy can significantly resolve ocular complications and potentially improve patient outcomes.
- | Journal: Blood Pressure Lowering and Glaucoma: One Size Does Not Fit All. (Pubmed Central) - Apr 4, 2025
Early treatment with diuretic therapy can significantly resolve ocular complications and potentially improve patient outcomes. No abstract available
- | Journal: Code-Free Deep Learning Glaucoma Detection on Color Fundus Images. (Pubmed Central) - Apr 4, 2025
The capacity of CFDL models to perform glaucoma screening using fundus images presents a compelling proof of concept, empowering clinicians to explore innovative model designs for broad glaucoma screening in the near future. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
- | Journal: Comparison of focal loss volume, global loss volume, retinal nerve fiber layer thickness, and corneal epithelial thickness in eyes with glaucoma and suspicious optic discs. (Pubmed Central) - Apr 4, 2025
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. FLV and GLV were of the greatest value in the assessment of early glaucomatous GCC degeneration.
- | Journal: Optometrists' Assessment of Pseudoexfoliation and Its Impact on Glaucoma Referrals. (Pubmed Central) - Apr 4, 2025
Still, the study's optometrist detected PEX in the majority of patients. The risk of missing high risk patients requiring glaucoma treatment would be reduced if primary care optometrists assess PEX before referral.
- | Journal: Time spent on eye disease screening, optical care, and care navigation within a federally qualified health center. (Pubmed Central) - Apr 4, 2025
The Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program offers a novel approach to eye care by providing free eye disease screenings, optical services, and care navigation at a federally qualified health center to improve vision outcomes and eye health in underserved communities. This time study provides workforce estimates to guide the scaling of similar comprehensive eye care programs in low-resource settings.
- | Retrospective data, Journal: Three-year outcomes of gonioscopy-assisted transluminal trabeculotomy for juvenile-onset (Pubmed Central) - Apr 4, 2025
This time study provides workforce estimates to guide the scaling of similar comprehensive eye care programs in low-resource settings. GATT is a safe and effective surgical option for JOAG, achieving sustained IOP reduction and favorable long-term success rates.
- || Clinical, Retrospective data, Review, Journal: Phacoemulsification combined with trabecular meshwork-Schlemm canal-based minimally invasive glaucoma surgery in primary angle-closure glaucoma: a systematic review and meta-analysis. (Pubmed Central) - Apr 4, 2025
GATT is a safe and effective surgical option for JOAG, achieving sustained IOP reduction and favorable long-term success rates. PEI?
- | Enrollment open: IVMGS: Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients (clinicaltrials.gov) - Apr 4, 2025
P=N/A, N=80, Recruiting, Sponsor: Karolinska Institutet
PEI? Not yet recruiting --> Recruiting
- | dexamethasone / Generic mfg., ursodeoxycholic acid / Generic mfg.
Preclinical, Journal: Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model. (Pubmed Central) - Apr 3, 2025
The proposed formulation improved retinal ganglion cell (RGC) functionality examined by electroretinography. Also, it was able to maintain a neuroretinal thickness similar to that of healthy animals scanned by in vivo optical coherence tomography, and a higher RGC count on histology compared to glaucomatous animals at the end of the study.
- | Journal: Bilateral acute iris transilumination: Description of two cases. (Pubmed Central) - Apr 3, 2025
We report two cases of female patients aged 31 and 37 years respectively with a diagnosis of BAIT syndrome who required management for ocular hypertension secondary to pigment dispersion syndrome including medical therapy and surgical management in one case. It is important to consider BAIT syndrome as a differential diagnosis in pigment dispersion syndrome or pseudo-uveitis cases because of the need for timely management to prevent visual loss secondary to glaucomatous optic neuropathy.
- | Journal: Safety and efficacy profile of irrigating trabeculectomy (Trabectome (Pubmed Central) - Apr 3, 2025
It is important to consider BAIT syndrome as a differential diagnosis in pigment dispersion syndrome or pseudo-uveitis cases because of the need for timely management to prevent visual loss secondary to glaucomatous optic neuropathy. Trabectome
- | Journal: Liposomal topical drug administration surpasses alternative methods in glaucoma therapeutics: a novel paradigm for enhanced treatment. (Pubmed Central) - Apr 3, 2025
Trabectome By overcoming ocular barriers and optimizing drug delivery, liposomal topical administration holds the key to significantly improving glaucoma treatment outcomes.
- | Trial completion date: Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy (clinicaltrials.gov) - Apr 3, 2025
P=N/A, N=55, Recruiting, Sponsor: Wuerzburg University Hospital
By overcoming ocular barriers and optimizing drug delivery, liposomal topical administration holds the key to significantly improving glaucoma treatment outcomes. Trial completion date: Mar 2025 --> Jan 2026
- | New trial: Functional Assessments in Vision Impairment (clinicaltrials.gov) - Apr 3, 2025
P=N/A, N=45, Not yet recruiting, Sponsor: Center for Eye Research Australia
- | Trial completion date: Effect of IOP Lowering on Progressive HM (clinicaltrials.gov) - Apr 3, 2025
P=N/A, N=152, Recruiting, Sponsor: Sun Yat-sen University
Trial completion date: Mar 2025 --> Jan 2026 Trial completion date: Apr 2025 --> Sep 2028