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|||||||||| Retrospective data, Journal: A retrospective study of the correlation of intraocular pressure and ultrasound biomicroscopy parameters with cataract maturity in small breed dogs. (Pubmed Central) - Mar 25, 2025
Among the UBM parameters, CCA and CCL demonstrated a significant correlation with cataract maturity, indicating structural alterations in the ICA might develop in association with cataracts, independent of direct IOP effects. These findings underscore the importance of considering prophylactic glaucoma management in patients with advanced cataracts to mitigate potential complications.

|||||||||| Journal: Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma. (Pubmed Central) - Mar 25, 2025
In addition, the mediation analysis supported that MOPP exerted direct and indirect causal effects on POAG. This finding indicates that MOPP may serve as a potential causal factor in POAG, providing valuable insights into the pathophysiology of POAG as vascular theory.

|||||||||| Journal, Gene Signature: Exploring diagnostic m6A regulators in primary open-angle glaucoma: insight from gene signature and possible mechanisms by which key genes function. (Pubmed Central) - Mar 25, 2025
The differentially expressed m6A regulators in TM tissues may serve as potential diagnostic biomarkers for POAG. And, in HTMCs, the expression level of YTHDC2 mRNA was changed under oxidative stress or TGF-?2 intervention, and then exerted its regulation on cell migration and ECM synthesis capability through m6A modification, which may be an important part of the disease process of POAG.

|||||||||| Journal: Evaluation of Visual, Refractive, and Functional Outcomes after Implantation of an Extended Depth of Focus Intraocular Lens in Patients with Stable and Mild Glaucoma. (Pubmed Central) - Mar 25, 2025
And, in HTMCs, the expression level of YTHDC2 mRNA was changed under oxidative stress or TGF-?2 intervention, and then exerted its regulation on cell migration and ECM synthesis capability through m6A modification, which may be an important part of the disease process of POAG. The new AcrySof

|||||||||| Journal: Six-Month Outcomes from a Prospective, Randomized Study of iStent infinite Versus Hydrus in Open-Angle Glaucoma: The INTEGRITY Study. (Pubmed Central) - Mar 25, 2025
P=N/A
When considering surgical complications as failures, a statistically significantly greater proportion of iStent infinite eyes versus Hydrus eyes had no surgical complications and achieved an unmedicated MDIOP reduction of ??20%. The iStent infinite group also had clinically relevant and statistically significantly superior reduction from baseline in unmedicated MDIOP without surgical complications compared to Hydrus.

|||||||||| Retrospective data, Journal: Double Povidone-Iodine 5% Preparation Before Cataract Surgery for Endophthalmitis Prevention. (Pubmed Central) - Mar 25, 2025
The iStent infinite group also had clinically relevant and statistically significantly superior reduction from baseline in unmedicated MDIOP without surgical complications compared to Hydrus. A double povidone-iodine preparation may provide more robust prophylaxis against postcataract extraction endophthalmitis than a single preparation.

|||||||||| Journal: Akzeptanz von innovativen Perimetriemethoden in Deutschland Virtual Reality-Brillenperimetrie und Tablet-basierte Perimetrie bei Glaukompatienten. (Pubmed Central) - Mar 24, 2025
A double povidone-iodine preparation may provide more robust prophylaxis against postcataract extraction endophthalmitis than a single preparation. Most glaucoma patients surveyed consistently responded favourably to VR headset and tablet-based perimetry, preferring these examinations to conventional hemispherical perimetry.

|||||||||| Journal, HEOR: Standardized Assessment of Health-Related Quality of Life in Patients with Congenital Aniridia. (Pubmed Central) - Mar 24, 2025
Symptoms of congenital aniridia subjects, described by the ANIRIDIA-NET survey, correlated well with clinical findings. Therefore, the questionnaire may provide important information for the treating ophthalmologist for follow-up examination of these patients and improvement in their life quality.

|||||||||| travoprost ophthalmic / Generic mfg.
Journal: Aqueous Humor Concentrations of Travoprost Free Acid and Residual Drug in Explanted Implants from Patients Administered a Travoprost Intracameral Implant. (Pubmed Central) - Mar 24, 2025
P2
Concentrations of TFA in AH through month 24 were above the established efficacious concentration of 0.1 ng/mL for intracameral implants, indicating that adequate TFA levels were achieved to elicit maximal intraocular pressure (IOP)-lowering efficacy, and supported by low levels of IOP in subjects through 24 months. The remaining dose of travoprost in explants at 24 months (i.e., 16%) indicates the potential for efficacious drug delivery beyond 2 years.

|||||||||| Biomarker, Journal: Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells. (Pubmed Central) - Mar 24, 2025
signaling, and MMP activity are consistent with GTM cells acquiring an EndMT phenotype. In combination with tissue studies, cultured GTM cells are a useful in vitro model for studying the fibrotic process in glaucoma.

|||||||||| nitroprusside / Generic mfg.
Journal: Unlocking the Untapped Potential of Photoresponsive Dual-Gas Nanomedicine in Glaucoma Therapy. (Pubmed Central) - Mar 24, 2025
activates the AKT/p-AKT/eNOS/sGC signaling pathway, while NO binds to soluble guanylate cyclase (sGC), converting guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), relaxing trabecular meshwork cells and enhancing aqueous humor outflow. This dual-gas system demonstrates high therapeutic efficacy in lowering IOP and offers a mechanistic advancement in glaucoma treatment through synergistic gas therapy.

|||||||||| Retrospective data, Journal: Two-year results of Preserflo Microshunt use in Open-angle Glaucoma Surgery. (Pubmed Central) - Mar 24, 2025
This dual-gas system demonstrates high therapeutic efficacy in lowering IOP and offers a mechanistic advancement in glaucoma treatment through synergistic gas therapy. The indication for PRESERFLO

|||||||||| Journal: Vessel density and retinal nerve fiber layer in pathological intraocular pressure. (Pubmed Central) - Mar 24, 2025

|||||||||| Review, Journal: Virtual Reality Visual Field Testing in Glaucoma: Benefits and Drawbacks. (Pubmed Central) - Mar 24, 2025
VRVFT presents several benefits, making it a promising alternative or complement to conventional glaucomatous visual field testing in outpatient clinics and remote settings. Addressing technical limitations and standardizing protocols are essential for broader clinical adoption.

|||||||||| Journal: A Novel Scleral Tunnel Technique for the Prevention of Ahmed Glaucoma Valve Tube Exposure. (Pubmed Central) - Mar 24, 2025
No postoperative complications, including tube exposure, were observed. This novel technique is an effective and minimally invasive method for preventing tube exposure after AGV implantation.

|||||||||| Journal: Patient-Reported Burden of Illness and Unmet Needs in Demodex blepharitis. (Pubmed Central) - Mar 24, 2025
This suggested that the effectiveness of the reported symptom management options was temporary and highlighted an unmet need in treating the root cause of the disease. Patients with Demodex blepharitis were symptomatic, and the commonly used management options for Demodex blepharitis lacked long-term symptom relief or mite eradication, demonstrating a high unmet need in treating patients with Demodex blepharitis.

|||||||||| Journal: Exploring Associations between Race/Ethnicity and Glaucoma Prevalence in a Multicenter Brazilian Study: The ELSA-Brasil. (Pubmed Central) - Mar 24, 2025
Our results reveal a higher prevalence of self-reported glaucoma in non-White groups, especially among Black and mixed-race individuals. Although causality cannot be conclusively established, our data suggest that the increased prevalence of glaucoma in these groups, compared with their White peers, is partially influenced by preventable health conditions.

|||||||||| Journal: Superior segmental optic nerve hypoplasia misdiagnosed as normal tension glaucoma. (Pubmed Central) - Mar 24, 2025
Although causality cannot be conclusively established, our data suggest that the increased prevalence of glaucoma in these groups, compared with their White peers, is partially influenced by preventable health conditions. No abstract available

|||||||||| Journal: A 2-year longitudinal evaluation of the iStent inject (Pubmed Central) - Mar 24, 2025
No abstract available iStent inject implantation safely reduced IOP and medication burden up to 24 months postoperative.

|||||||||| Journal: Artificial Intelligence Models to Identify Patients with High Probability of Glaucoma Using Electronic Health Records. (Pubmed Central) - Mar 24, 2025
Additional research is needed to investigate the impact of protected class characteristics such as race/ethnicity on model performance and fairness. The author(s) have no proprietary or commercial interest in any materials discussed in this article.

|||||||||| mitomycin / Generic mfg.
Journal: Comparing the outcome of delayed postoperative versus intraoperative mitomycin C use in trabeculectomy: A randomized control trial. (Pubmed Central) - Mar 24, 2025
There were higher incidences of hypotony (41.9% vs 36%) in Group I. Incidences of persistent-hypotony (p?=?0.032) and late-hypotony (p?=?0.127) were higher in Group I. Two eyes developed hypotony maculopathy in Group I, while none in Group II. The blebs in Group I were more avascular, cystic and developed thinning, while those in Group II were diffuse and shallow.ConclusionsDelayed postoperative MMC application may be as effective as standard trabeculectomy with MMC in lowering IOP with a lower rate of complications.

|||||||||| Journal: Enhancing safety of transscleral diode cyclophotocoagulation: Check the tip before use. (Pubmed Central) - Mar 24, 2025
During the procedure, he developed a scleral burn attributed to pigment on the laser probe tip. The burn healed spontaneously with topical treatment alone, highlighting the potential for scleral tissue to heal remarkably without further surgical intervention.ConclusionThis case report underscores the importance of vigilance during TDLC procedures and careful management of potential pigment sources to prevent scleral damage.

|||||||||| Trial completion, Trial completion date, Trial primary completion date: PROTECT: Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma (clinicaltrials.gov) - Mar 24, 2025
P3, N=57, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
The burn healed spontaneously with topical treatment alone, highlighting the potential for scleral tissue to heal remarkably without further surgical intervention.ConclusionThis case report underscores the importance of vigilance during TDLC procedures and careful management of potential pigment sources to prevent scleral damage. Recruiting --> Completed | Trial completion date: Dec 2026 --> Jan 2025 | Trial primary completion date: Jun 2025 --> Jan 2025

|||||||||| Bay11-7082 / Bayer
Journal: Inhibition of AGTR1 attenuates cell proliferation after glaucoma filtration surgery via NF-?B pathway-mediated G0/G1-phase cell cycle arrest. (Pubmed Central) - Mar 23, 2025
In conclusion, our findings indicate that AGTR1 inhibition can attenuate HTF proliferation by leading to cell cycle arrest in the G0/G1 phase through the NF-?B pathway. Targeting AGTR1 is a feasible strategy for mitigating cell proliferation following GFS.

|||||||||| Retrospective data, Journal: Meta-Analysis of Tonometer Correction Formulae to Determine True Normal Intraocular Pressures Across a Diverse Range of Species. (Pubmed Central) - Mar 23, 2025
True normal IOP is relatively conserved across a diverse range of vertebrate species despite uncorrected values from individual tonometers suggesting otherwise. Maintaining true IOP between 10 and 25?mmHg appears to be important in ocular physiology in many vertebrates.

|||||||||| Glanatec (ripasudil) / Kowa, amiodarone / Generic mfg., Rhopressa (netarsudil) / Alcon
Journal: Ripasudil does not induce phospholipid accumulation in human corneal epithelial cells. (Pubmed Central) - Mar 23, 2025
Unlike systemic amiodarone and antimalarials, topical agents do not typically induce the development of this corneal condition...In contrast, ripasudil and Y-27632 lack these structural features. Our results suggest that ripasudil has a low likelihood of inducing cornea verticillata.

|||||||||| Journal: Maculopathy due to hypotony: A diagnostic challenge. (Pubmed Central) - Mar 23, 2025
Given the patient's history of diabetes mellitus, it was initially diagnosed as diabetic macular edema (DME), which delayed appropriate treatment. This led to worsening corneal decompensation, ultimately requiring a corneal transplant in the form of Descemet membrane endothelial keratoplasty (DMEK).

|||||||||| Review, Journal: Innovative approaches to treatment of eye diseases: advances in stem cell therapy use in ophthalmology. (Pubmed Central) - Mar 23, 2025
Unlike conventional treatments that often focus on managing symptoms, stem cells have the unique ability to repair and regenerate damaged tissues, addressing the root causes of the diseases. However, limitations due to economic, regulatory, and ethical challenges have posed barriers to advancing stem cell therapies.

|||||||||| Journal: Intravitreal C3F8 versus SF6: effects on corneal tomography parameters and intraocular pressure in vitreomacular traction treatment. (Pubmed Central) - Mar 23, 2025
However, limitations due to economic, regulatory, and ethical challenges have posed barriers to advancing stem cell therapies. PV with SF6 should be preferred for VMT treatment in angle closure glaucoma, angle closure suspect and advanced glaucoma patients, since the increase in IOP due to angle narrowing in the C3F8 group remained at 24

|||||||||| Clinical, Retrospective data, Journal: Surgical Outcomes of Baerveldt Glaucoma Implant Versus Ahmed Glaucoma Valve in Neovascular Glaucoma: A Retrospective Multicenter Study. (Pubmed Central) - Mar 23, 2025
PV with SF6 should be preferred for VMT treatment in angle closure glaucoma, angle closure suspect and advanced glaucoma patients, since the increase in IOP due to angle narrowing in the C3F8 group remained at 24 BGI surgery yielded a higher success rate than AGV surgery in patients with NVG for a target IOP of

|||||||||| Journal, Surgery: Evidence-based Guidelines for Keratorefractive Lenticule Extraction Surgery. (Pubmed Central) - Mar 23, 2025
These guidelines provide evidence-based recommendations for KLEx in clinical practice, such as for preoperative screening for keratoconus, surgical planning, and management and prevention of complications and infection. The guidelines are expected to minimize the complications and achieve better outcomes.

|||||||||| Journal, HEOR: Incidence of Uveitis Following Initiation of Prostaglandin Analogs Versus Other Glaucoma Medications: A Study from the SOURCE Repository. (Pubmed Central) - Mar 23, 2025
The guidelines are expected to minimize the complications and achieve better outcomes. The use of PGAs was not associated with higher odds of developing uveitis compared with other classes of topical glaucoma medications.

|||||||||| Journal: Analysis of Legal Verbiage in State Legislation for Insurer Coverage of Early Eyedrop Refills in the United States. (Pubmed Central) - Mar 23, 2025
State laws providing coverage for early eyedrop refills vary in terms of verbiage and requirements necessary to obtain a covered early eyedrop refill. Region, political climate, and year appear to play minor roles in early eyedrop refill verbiage and passage.

|||||||||| Journal: Enhancing Detection of Glaucoma Progression: Utility of 24-2 Visual Field Central Points vs. 10-2 Visual Fields. (Pubmed Central) - Mar 23, 2025
Region, political climate, and year appear to play minor roles in early eyedrop refill verbiage and passage. MD12 RoC and detection rates have a low level of agreement with those of 10-2 and hence do not replace the need for 10-2 VF MD to monitor central damage.

|||||||||| Journal: Validating and updating the OHTS-EGPS model predicting 5-year glaucoma risk among ocular hypertension patients using electronic records. (Pubmed Central) - Mar 23, 2025
Refitting the model achieved modest improvements in performance. Given the poor performance of the OHTS-EGPS model in our population, one should use caution in its application to populations that differ from those in the OHTS and EGPS.

|||||||||| Journal: A Comparative Study of the Hand-held IC200 and Slit Lamp-mounted ST500 rebound tonometers with Goldmann Applanation Tonometry. (Pubmed Central) - Mar 23, 2025
Given the poor performance of the OHTS-EGPS model in our population, one should use caution in its application to populations that differ from those in the OHTS and EGPS. The ST500 shows good agreement with GAT over a large range of IOP and significantly higher repeatability compared to the IC200 and GAT, suggesting it may be advantageous in clinical settings where topical anesthesia or skilled staff are unavailable.

|||||||||| Journal: Distribution of port wine birthmarks and glaucoma outcomes in Sturge-Weber Syndrome. (Pubmed Central) - Mar 23, 2025
Lower eyelid and choroidal angiomas were associated with glaucoma diagnosis, suggesting a spatial relationship with SWS findings. However, leptomeningeal angiomas were not associated, possibly because these are further from the eye.

|||||||||| Journal: Identifiable historic and observable factors may predict progression to exfoliation glaucoma in newly-diagnosed exfoliation patients. (Pubmed Central) - Mar 23, 2025
We determined a set of clinically relevant factors that predicted which newly diagnosed XFS patients progressed to XFG within 3 years. A planned validation will independently confirm if these prognostic indicators hold promise in other settings.

|||||||||| Journal: ChatGPT for addressing patient-centred frequently asked questions in glaucoma clinical practice. (Pubmed Central) - Mar 23, 2025
ChatGPT-3.5 responses to FAQs in glaucoma were generally agreeable in terms of coherency, factuality, comprehensiveness, and safety. However, areas of weakness were identified, precluding recommendations for routine use to provide patients with tailored counseling in glaucoma, especially with respect to development of glaucoma and its management.

|||||||||| Journal: The Multifaceted Non-Genetic Risk Factors for Primary Open-Angle Glaucoma - An Overview of Systematic Reviews. (Pubmed Central) - Mar 23, 2025
Our findings highlight the complexity of the disease and the nature of the factors that may affect various populations. Among the reported associations with low risk of bias, we found the highest effect estimates for OSA and H.

|||||||||| Reimbursement, US reimbursement, Journal, Medicare: The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries. (Pubmed Central) - Mar 23, 2025
However, in those with glaucoma, increased glaucoma severity was associated with an increased likelihood of hip fracture. Potential mediating mechanisms requiring further study include fear of falls and physical inactivity in patients with glaucoma.

|||||||||| Journal: The Robison D. Harley, MD Childhood Glaucoma Research Network International Pediatric Glaucoma Registry: The First 872 Cases. (Pubmed Central) - Mar 23, 2025
Differences in family history, disease presentation, and glaucoma type suggest unique country phenotypes. Registry expansion may allow for insight into best practices for pediatric glaucoma.

|||||||||| Journal: National Experience of Technology-based Eye Care Services (TECS): A Comprehensive Ophthalmology Telemedicine Initiative. (Pubmed Central) - Mar 23, 2025
The data provide key information that can be used to improve the deployment of TECS and similar programs, along with the possible future direction of TECS. Moreover, experience from one national ocular telehealth program clearly illustrates that telemedicine can address eye care disparities in the Veteran population and may be used for other vulnerable groups as well.

|||||||||| Clinical, Journal: Optical coherence tomography angiography compared with optical coherence tomography for detection of glaucoma progression with high myopia. (Pubmed Central) - Mar 22, 2025
Overall, this study demonstrates that VD decreases are detectable over time in the highly myopic glaucoma patients. OCTA could be considered in the imaging algorithm in the follow up of glaucoma progression in the highly myopic patients.

|||||||||| Journal: Optimizing deep learning models for glaucoma screening with vision transformers for resource efficiency and the pie augmentation method. (Pubmed Central) - Mar 21, 2025
For both datasets, the AUC values for glaucoma, glaucoma suspects, and no glaucoma were 84.53%, 84.54%, and 91.05%, respectively, which approach the performance of a CNN model that achieved 84.70%, 84.69%, and 93.19%, respectively. Moreover, the incorporation of attention maps from DeiT facilitated the precise localization of clinically significant areas, such as the disc rim and notching, thereby enhancing the overall effectiveness of glaucoma screening.

|||||||||| Journal, HEOR: Mental Health and Quality of Life in Glaucoma Patients: Insights From a Comparative Study. (Pubmed Central) - Mar 21, 2025
The high prevalence of psychiatric comorbidities and increased use of psychiatric medications further illustrate the psychological burden of glaucoma. These findings highlight the need for holistic care approaches that address both the physical and mental health aspects of glaucoma management.

|||||||||| Journal: A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression. (Pubmed Central) - Mar 21, 2025
These findings highlight the need for holistic care approaches that address both the physical and mental health aspects of glaucoma management. Bulk RNA-Seq using dissected eyes from crim1 -/- larvae and controls at 72

|||||||||| Journal: XRCC4-related microcephalic primordial dwarfism: description of a clinical series of 7 cases, phenotype expansion and new diagnostic approaches. (Pubmed Central) - Mar 21, 2025
We therefore extend the phenotype of XRCC4-related MPD and suggest a combination of three functional assays, based on radiosensitivity and V(D)J recombination defect, to improve the interpretation of XRCC4 variants in fast, cost-effective and non-invasive manner. These findings will improve the diagnosis, genetic counselling, follow-up and management of these patients.

|||||||||| Durysta (bimatoprost implant) / AbbVie
Journal: Drug Delivery Systems in Glaucoma- Current Innovations and Future Perspectives. (Pubmed Central) - Mar 20, 2025
In this manuscript, we summarise the limitations of traditional topical anti-glaucoma therapy and study current drug delivery systems to lower IOP, with focus on the only two that have made FDA-approval- Durysta and iDose TR...We also explore the concept of novel nanoparticle-based drug delivery systems, which have the advantage of being highly modifiable and customisable, able to incorporate large amounts of cargo while maintaining a high transfection efficacy, and at a fraction of the cost. Lastly, we propose that nanomedicine, in conjunction with gene therapy, offers a promising solution to the aforementioned challenges of current glaucoma therapy, and can herald a new era of sustained glaucoma treatment.

|||||||||| Journal: Clinical Features, Risk Factors and Outcomes following Surgery for Late Intraocular Lens Decentration in the Dead Bag Syndrome. (Pubmed Central) - Mar 20, 2025
Bilaterality and presence of the Soemmering ring in the majority of cases were new observations warranting further research. Outcomes following surgery were satisfactory.



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