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50 Mechanisms of Action

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||||||||||  Rocklatan (latanoprost/netarsudil) / Aerie Pharma, Rhopressa (netarsudil) / Aerie Pharma
Clinical:  Study Assessing Safety and Efficacy of PG324 Ophthalmic Solution in Patients With Elevated Intraocular Pressure (clinicaltrials.gov) -  May 15, 2014
P2, N=300, Active, not recruiting,  Sponsor: Aerie Pharmaceuticals
Recruiting --> Active, not recruiting

||||||||||  Zioptan (tafluprost) / Santen, Merck (MSD)
Trial primary completion date:  Switching From Preserved to Preserved-free Treatments for Glaucoma. (clinicaltrials.gov) -  May 14, 2014
P3, N=40, Recruiting,  Sponsor: Paolo Fogagnolo
Recruiting --> Active, not recruiting Trial primary completion date: Mar 2012 --> May 2013

||||||||||  Zioptan (tafluprost) / Santen, Merck (MSD)
Trial initiation date:  Switching From Preserved to Preserved-free Treatments for Glaucoma. (clinicaltrials.gov) -  May 14, 2014
P3, N=40, Recruiting,  Sponsor: Paolo Fogagnolo
Trial primary completion date: Mar 2012 --> May 2013 Initiation date: Sep 2011 --> May 2012

||||||||||  Zioptan (tafluprost) / Santen, Merck (MSD)
Trial completion date:  Switching From Preserved to Preserved-free Treatments for Glaucoma. (clinicaltrials.gov) -  May 14, 2014
P3, N=40, Recruiting,  Sponsor: Paolo Fogagnolo
Initiation date: Sep 2011 --> May 2012 Trial completion date: Dec 2012 --> Jun 2014

|||||||||| Enrollment change: Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study (clinicaltrials.gov) - May 14, 2014
P=N/A, N=770, Recruiting, Sponsor: Universitaire Ziekenhuizen Leuven
Trial completion date: Dec 2012 --> Jun 2014 N=120 --> 770

||||||||||  brinzolamide/travoprost / Novartis
New P2 trial:  6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  May 14, 2014
P2, N=288, Not yet recruiting,  Sponsor: Alcon Research

||||||||||  Zioptan (tafluprost) / Santen, Merck (MSD)
Enrollment open:  Switching From Preserved to Preserved-free Treatments for Glaucoma. (clinicaltrials.gov) -  May 14, 2014
P3, N=40, Recruiting,  Sponsor: Paolo Fogagnolo
N=120 --> 770 Active, not recruiting --> Recruiting

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Clinical:  Tolerability of Bimatoprost 0.01% vs Latanoprost Eye Drops (clinicaltrials.gov) -  May 12, 2014
P=N/A, N=200, Recruiting,  Sponsor: MDbackline, LLC

|||||||||| Trial primary completion date: IOP Pattern in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After LPI (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Active, not recruiting --> Recruiting Trial primary completion date: Jun 2014 --> Mar 2014

|||||||||| Trial primary completion date: Intraocular Pressure (IOP) Patterns in Fast Versus Slow Visual Field (VF) Progression Patients (clinicaltrials.gov) - May 11, 2014
P=N/A, N=40, Terminated, Sponsor: Sensimed AG
Trial primary completion date: Jun 2014 --> Mar 2014 Trial primary completion date: Sep 2013 --> May 2014

|||||||||| Trial primary completion date: IOP Fluctuations in Patients With Primary Open-angle Glaucoma, Before and After Selective Laser Trabeculoplasty (clinicaltrials.gov) - May 11, 2014
P=N/A, N=20, Active, not recruiting, Sponsor: Sensimed AG
Trial primary completion date: Sep 2013 --> May 2014 Trial primary completion date: Oct 2013 --> May 2014

|||||||||| Trial primary completion date: IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Trial primary completion date: Oct 2013 --> May 2014 Trial primary completion date: Jun 2014 --> Mar 2014

|||||||||| Trial withdrawal: IOP Pattern in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After LPI (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Trial primary completion date: Jun 2014 --> Mar 2014 Not yet recruiting --> Withdrawn

|||||||||| Trial withdrawal: IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Not yet recruiting --> Withdrawn Active, not recruiting --> Withdrawn

|||||||||| Trial termination: Intraocular Pressure (IOP) Patterns in Fast Versus Slow Visual Field (VF) Progression Patients (clinicaltrials.gov) - May 11, 2014
P=N/A, N=40, Terminated, Sponsor: Sensimed AG
Active, not recruiting --> Withdrawn Recruiting --> Terminated; Low recruitment rate

|||||||||| Trial completion date: IOP Pattern in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After LPI (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Recruiting --> Terminated; Low recruitment rate Trial completion date: Jun 2014 --> Mar 2014

|||||||||| Trial completion date: Intraocular Pressure (IOP) Patterns in Fast Versus Slow Visual Field (VF) Progression Patients (clinicaltrials.gov) - May 11, 2014
P=N/A, N=40, Terminated, Sponsor: Sensimed AG
Trial completion date: Jun 2014 --> Mar 2014 Trial completion date: Oct 2013 --> May 2014

|||||||||| Trial completion date: IOP Fluctuations in Patients With Primary Open-angle Glaucoma, Before and After Selective Laser Trabeculoplasty (clinicaltrials.gov) - May 11, 2014
P=N/A, N=20, Active, not recruiting, Sponsor: Sensimed AG
Trial completion date: Oct 2013 --> May 2014 Trial completion date: Oct 2013 --> Jul 2014

|||||||||| Trial completion date: IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Trial completion date: Oct 2013 --> Jul 2014 Trial completion date: Jun 2014 --> Mar 2014

|||||||||| Enrollment change: IOP Pattern in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After LPI (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
Trial completion date: Jun 2014 --> Mar 2014 N=10 --> 0

|||||||||| Enrollment change: Intraocular Pressure (IOP) Patterns in Fast Versus Slow Visual Field (VF) Progression Patients (clinicaltrials.gov) - May 11, 2014
P=N/A, N=40, Terminated, Sponsor: Sensimed AG
N=10 --> 0 N=60 --> 40

|||||||||| Enrollment change: IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy (clinicaltrials.gov) - May 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Sensimed AG
N=60 --> 40 N=20 --> 0

||||||||||  AMA0076 / Akari Therap
New P2 trial:  Multiple Dose-parallel-group Study of AMA0076 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  May 11, 2014
P2, N=80, Recruiting,  Sponsor: Amakem, NV

|||||||||| Enrollment closed: IOP Fluctuations in Patients With Primary Open-angle Glaucoma, Before and After Selective Laser Trabeculoplasty (clinicaltrials.gov) - May 11, 2014
P=N/A, N=20, Active, not recruiting, Sponsor: Sensimed AG
N=20 --> 0 Recruiting --> Active, not recruiting

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial primary completion date, Combination therapy:  Evaluation of Intraocular Pressure Using Simbrinza (clinicaltrials.gov) -  May 8, 2014
P4, N=89, Completed,  Sponsor: Alcon Research
Recruiting --> Active, not recruiting Trial primary completion date: Nov 2014 --> Mar 2014

|||||||||| Trial primary completion date: Central Corneal Thickness in Glaucoma (clinicaltrials.gov) - May 8, 2014
P=N/A, N=700, Completed, Sponsor: Aristotle University Of Thessaloniki
Trial primary completion date: Nov 2014 --> Mar 2014 Trial primary completion date: Jan 2011 --> Jan 2013

|||||||||| Trial primary completion date: Myocilin Variations and Familial Glaucoma in Taxiarchis (clinicaltrials.gov) - May 8, 2014
P=N/A, N=800, Recruiting, Sponsor: Aristotle University Of Thessaloniki
Trial primary completion date: Jan 2011 --> Jan 2013 Trial primary completion date: Jun 2015 --> Jun 2016

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial completion date, Combination therapy:  Evaluation of Intraocular Pressure Using Simbrinza (clinicaltrials.gov) -  May 8, 2014
P4, N=89, Completed,  Sponsor: Alcon Research
Trial primary completion date: Jun 2015 --> Jun 2016 Trial completion date: Nov 2014 --> Mar 2014

|||||||||| Trial completion date: Central Corneal Thickness in Glaucoma (clinicaltrials.gov) - May 8, 2014
P=N/A, N=700, Completed, Sponsor: Aristotle University Of Thessaloniki
Trial completion date: Nov 2014 --> Mar 2014 Trial completion date: Jan 2011 --> Jan 2013

|||||||||| Trial completion date: Myocilin Variations and Familial Glaucoma in Taxiarchis (clinicaltrials.gov) - May 8, 2014
P=N/A, N=800, Recruiting, Sponsor: Aristotle University Of Thessaloniki
Trial completion date: Jan 2011 --> Jan 2013 Trial completion date: Dec 2015 --> Dec 2016

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial completion, Combination therapy:  Evaluation of Intraocular Pressure Using Simbrinza (clinicaltrials.gov) -  May 8, 2014
P4, N=89, Completed,  Sponsor: Alcon Research
Trial completion date: Dec 2015 --> Dec 2016 Recruiting --> Completed

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial primary completion date, Monotherapy:  A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan (clinicaltrials.gov) -  May 1, 2014
P4, N=1834, Completed,  Sponsor: Allergan
Recruiting --> Completed Trial primary completion date: Jun 2014 --> Feb 2014

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial completion date, Monotherapy:  A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan (clinicaltrials.gov) -  May 1, 2014
P4, N=1834, Completed,  Sponsor: Allergan
Trial primary completion date: Jun 2014 --> Feb 2014 Trial completion date: Jun 2014 --> Feb 2014

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Enrollment change, Monotherapy:  A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan (clinicaltrials.gov) -  May 1, 2014
P4, N=1834, Completed,  Sponsor: Allergan
Trial completion date: Jun 2014 --> Feb 2014 N=2500 --> 1834

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial completion, Monotherapy:  A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan (clinicaltrials.gov) -  May 1, 2014
P4, N=1834, Completed,  Sponsor: Allergan
N=2500 --> 1834 Recruiting --> Completed

||||||||||  subconjunctival latanoprost insert (VS-101) / BioLight Life Sci
New P1/2 trial:  A Phase 1/2 Multicenter, Randomized, Study to Evaluate the Safety and Efficacy of VS101 Subconjunctival Latanoprost Insert in Subjects With Open-Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  Apr 30, 2014
P1/2, N=70, Not yet recruiting,  Sponsor: ViSci Ltd.

||||||||||  AMA0076 / Akari Therap
Trial completion:  A Single Centre Study to Evaluate 3 Ophthalmic Formulations in Healthy Subjects (clinicaltrials.gov) -  Apr 30, 2014
P1, N=21, Completed,  Sponsor: Amakem, NV
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Enrollment change:  Effect of SIMBRINZA (clinicaltrials.gov) -  Apr 27, 2014
P4, N=307, Completed,  Sponsor: Alcon Research
Active, not recruiting --> Completed N=200 --> 307

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Enrollment closed:  Effect of SIMBRINZA (clinicaltrials.gov) -  Apr 27, 2014
P4, N=200, Active, not recruiting,  Sponsor: Alcon Research
N=200 --> 307 Recruiting --> Active, not recruiting

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial completion:  Effect of SIMBRINZA (clinicaltrials.gov) -  Apr 27, 2014
P4, N=307, Completed,  Sponsor: Alcon Research
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| Enrollment change: Safety and Efficacy of Bimatoprost/Timolol (Ganfort (clinicaltrials.gov) - Apr 23, 2014
P=N/A, N=756, Completed, Sponsor: Allergan
Active, not recruiting --> Completed N=600 --> 756

|||||||||| Trial completion: Safety and Efficacy of Bimatoprost/Timolol (Ganfort (clinicaltrials.gov) - Apr 23, 2014
P=N/A, N=756, Completed, Sponsor: Allergan
N=600 --> 756 Recruiting --> Completed

|||||||||| Trial completion: Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study (clinicaltrials.gov) - Apr 23, 2014
P=N/A, N=22, Completed, Sponsor: National University Hospital, Singapore
Recruiting --> Completed Recruiting --> Completed

||||||||||  ethacrynic acid / Generic mfg.
Trial initiation date:  Novel Drug Delivery Technique Via Retroject Device (clinicaltrials.gov) -  Apr 22, 2014
P1/2, N=20, Not yet recruiting,  Sponsor: Molly Walsh
Recruiting --> Completed Initiation date: Jan 2014 --> May 2014

|||||||||| New P1 trial: Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma (clinicaltrials.gov) - Apr 21, 2014
P1, N=40, Active, not recruiting, Sponsor: National Centre of Ophthalmology named after academician Zarifa Aliyeva

|||||||||| Enrollment closed: Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma (clinicaltrials.gov) - Apr 18, 2014
P1, N=40, Active, not recruiting, Sponsor: National Centre of Ophthalmology named after academician Zarifa Aliyeva
Initiation date: Jan 2014 --> May 2014 Not yet recruiting --> Active, not recruiting

|||||||||| Trial initiation date, Adherence: iDropper Usability in Glaucoma (clinicaltrials.gov) - Apr 14, 2014
P1, N=22, Recruiting, Sponsor: Care Team Solutions
Not yet recruiting --> Active, not recruiting Initiation date: May 2014 --> Apr 2014

|||||||||| Enrollment open, Adherence: iDropper Usability in Glaucoma (clinicaltrials.gov) - Apr 14, 2014
P1, N=22, Recruiting, Sponsor: Care Team Solutions
Initiation date: May 2014 --> Apr 2014 Not yet recruiting --> Recruiting

||||||||||  cyclosporin A microemulsion / Generic mfg., betamethasone / Generic mfg., cyclosporine ophthalmic emulsion / Generic mfg.
New P2 trial:  BCATS: Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure (clinicaltrials.gov) -  Apr 13, 2014
P2, N=40, Recruiting,  Sponsor: Mashhad University of Medical Sciences

||||||||||  sevoflurane / Generic mfg.
Enrollment open:  The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops (clinicaltrials.gov) -  Apr 8, 2014
P0, N=75, Recruiting,  Sponsor: University of Miami
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting