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50 Mechanisms of Action

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|||||||||| New P3 trial: AqueSys Microfistula Implant in Refractory Glaucoma (clinicaltrials.gov) - Jul 12, 2012
P3, N=60, Active, not recruiting, Sponsor: AqueSys, Inc.

||||||||||  latanoprost / Generic mfg.
Clinical:  Clinical Evaluation of Efficacy of SLT to Topical Medication in Lowering IOP (clinicaltrials.gov) -  Jul 11, 2012
P=N/A, N=600, Recruiting,  Sponsor: Aurolab

||||||||||  latanoprost / Generic mfg.
Enrollment closed:  Clinical Evaluation of Safety and Efficacy of Refrigeration Free Latanoprost (clinicaltrials.gov) -  Jul 10, 2012
P=N/A, N=30, Active, not recruiting,  Sponsor: Aurolab
Recruiting --> Active, not recruiting

|||||||||| Monotherapy: A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Who Were Insufficiently Responsive to Monotherapy (clinicaltrials.gov) - Jul 9, 2012
P=N/A, N=4385, Completed, Sponsor: Allergan

|||||||||| Enrollment change: CyCLE: CyPass Clinical Experience Study (clinicaltrials.gov) - Jul 4, 2012
P=N/A, N=2000, Active, not recruiting, Sponsor: Transcend Medical, Inc.
Recruiting --> Active, not recruiting N=500 --> 2000

|||||||||| Enrollment closed: CyCLE: CyPass Clinical Experience Study (clinicaltrials.gov) - Jul 4, 2012
P=N/A, N=2000, Active, not recruiting, Sponsor: Transcend Medical, Inc.
N=500 --> 2000 Enrolling by invitation --> Active, not recruiting

|||||||||| Clinical: Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Glaucoma (clinicaltrials.gov) - Jul 2, 2012
P=N/A, N=100, Completed, Sponsor: Vanak Eye Surgery Center

|||||||||| Enrollment closed: DUETTE: Study of CyPass Implantation In Patients With Open Angle Glaucoma Refractory to Single or Multi-agent Topical Therapy (clinicaltrials.gov) - Jul 2, 2012
P=N/A, N=75, Active, not recruiting, Sponsor: Transcend Medical, Inc.
Enrolling by invitation --> Active, not recruiting Recruiting --> Active, not recruiting

||||||||||  apraclonidine / Generic mfg.
Enrollment closed:  Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma (clinicaltrials.gov) -  Jul 2, 2012
P=N/A, N=138, Active, not recruiting,  Sponsor: Laval University
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Clinical:  A Study of Lumigan® in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) (clinicaltrials.gov) -  Jul 1, 2012
P=N/A, N=10337, Completed,  Sponsor: Allergan

||||||||||  dorzolamide/timolol / Generic mfg.
Trial completion:  12-Month Stability of Diurnal IOP Control on Cosopt (clinicaltrials.gov) -  Jun 26, 2012
P4, N=10, Completed,  Sponsor: West Virginia University
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| Clinical: A Study of Intraocular Pressure (IOP) Reduction in Newly Diagnosed Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) (clinicaltrials.gov) - Jun 25, 2012
P=N/A, N=4812, Completed, Sponsor: Allergan

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Monotherapy:  GANfort (clinicaltrials.gov) -  Jun 25, 2012
P=N/A, N=392, Completed,  Sponsor: Allergan

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Clinical:  Lumigan® in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) (clinicaltrials.gov) -  Jun 25, 2012
P=N/A, N=854, Completed,  Sponsor: Allergan

|||||||||| Enrollment closed: Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy (clinicaltrials.gov) - Jun 10, 2012
P=N/A, N=54, Active, not recruiting, Sponsor: University of Toronto
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment open: DSLT: Direct Application of Selective Laser Trabeculoplasty in Open Angle Glaucoma (clinicaltrials.gov) - Jun 9, 2012
P=N/A, N=20, Recruiting, Sponsor: Sheba Medical Center
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

||||||||||  timolol maleate ophthalmic solution / Generic mfg., travoprost ophthalmic / Generic mfg.
Trial completion, Monotherapy:  Safety and Efficacy of Changing to DuoTrav in Patients Uncontrolled on Timolol (clinicaltrials.gov) -  Jun 6, 2012
P4, N=50, Completed,  Sponsor: Alcon Research
Not yet recruiting --> Recruiting Recruiting --> Completed

||||||||||  Taptiqom (tafluprost/timolol) / Santen, AGC Biologics
Trial completion, Head-to-Head:  Tafluprost-Timolol Fixed Dose Combination Non-Inferiority Study Against Concomitant Administrations (clinicaltrials.gov) -  Jun 6, 2012
P3, N=401, Completed,  Sponsor: Santen Oy
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment change: Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) - Jun 5, 2012
P3, N=160, Completed, Sponsor: Sun Pharma Advanced Research Company Limited
Active, not recruiting --> Completed N=200 --> 160

|||||||||| Trial completion: Efficacy and Safety of SPARC0912 and Reference0912 in Open Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) - Jun 5, 2012
P3, N=590, Completed, Sponsor: Sun Pharma Advanced Research Company Limited
N=200 --> 160 Recruiting --> Completed

|||||||||| Trial completion: Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) - Jun 5, 2012
P3, N=160, Completed, Sponsor: Sun Pharma Advanced Research Company Limited
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial withdrawal: Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Maximum Tolerated Medical Therapy (clinicaltrials.gov) - Jun 4, 2012
P=N/A, N=0, Withdrawn, Sponsor: Sooft Italia
Recruiting --> Completed Not yet recruiting --> Withdrawn

|||||||||| Trial withdrawal: Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Treatment With Either Beta-blockers or Prostaglandins Eye Drops (clinicaltrials.gov) - Jun 4, 2012
P=N/A, N=0, Withdrawn, Sponsor: Sooft Italia
Not yet recruiting --> Withdrawn Not yet recruiting --> Withdrawn

|||||||||| Enrollment change: Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Maximum Tolerated Medical Therapy (clinicaltrials.gov) - Jun 4, 2012
P=N/A, N=0, Withdrawn, Sponsor: Sooft Italia
Not yet recruiting --> Withdrawn N=60 --> 0

|||||||||| Enrollment change: Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Treatment With Either Beta-blockers or Prostaglandins Eye Drops (clinicaltrials.gov) - Jun 4, 2012
P=N/A, N=0, Withdrawn, Sponsor: Sooft Italia
N=60 --> 0 N=130 --> 0

||||||||||  Combigan (brimonidine tartrate/timolol maleate) / AbbVie
Trial completion:  Circadian Ocular Perfusion Pressure and Ocular Blood Flow (clinicaltrials.gov) -  Jun 3, 2012
P4, N=35, Completed,  Sponsor: Alcon Research
N=130 --> 0 Recruiting --> Completed

||||||||||  Retisert (fluocinolone acetonide intravitreal implant) / Bausch Health, EyePoint Pharma
Enrollment change:  Prophylactic Anecortave Acetate in Patients With a Retisert Implant (clinicaltrials.gov) -  Jun 2, 2012
P1, N=12, Completed,  Sponsor: Texas Retina Associates
Recruiting --> Completed N=24 --> 12

||||||||||  Retisert (fluocinolone acetonide intravitreal implant) / Bausch Health, EyePoint Pharma
Trial completion:  Prophylactic Anecortave Acetate in Patients With a Retisert Implant (clinicaltrials.gov) -  Jun 2, 2012
P1, N=12, Completed,  Sponsor: Texas Retina Associates
N=24 --> 12 Active, not recruiting --> Completed

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial completion:  Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN (clinicaltrials.gov) -  May 31, 2012
P4, N=84, Completed,  Sponsor: Alcon Research
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial completion:  Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2% (clinicaltrials.gov) -  May 31, 2012
P3, N=1062, Completed,  Sponsor: Alcon Research
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial withdrawal: A Multi-Dose Study With a Treatment for Open-Angle Glaucoma (clinicaltrials.gov) - May 28, 2012
P2/3, N=0, Withdrawn, Sponsor: Alcon Research
Active, not recruiting --> Completed Terminated --> Withdrawn

|||||||||| Enrollment change: A Multi-Dose Study With a Treatment for Open-Angle Glaucoma (clinicaltrials.gov) - May 28, 2012
P2/3, N=0, Withdrawn, Sponsor: Alcon Research
Terminated --> Withdrawn N=400 --> 0

|||||||||| Trial completion: AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure (clinicaltrials.gov) - May 28, 2012
P4, N=74, Completed, Sponsor: Alcon Research
N=400 --> 0 Recruiting --> Completed

||||||||||  timolol maleate ophthalmic solution / Generic mfg., travoprost ophthalmic / Generic mfg.
Enrollment change, Adherence:  GAS: Glaucoma Adherence Study (clinicaltrials.gov) -  May 27, 2012
P4, N=55, Completed,  Sponsor: Alcon Research
Recruiting --> Completed N=100 --> 55

|||||||||| Trial completion: IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic (clinicaltrials.gov) - May 21, 2012
P=N/A, N=43, Completed, Sponsor: University of Nebraska
N=100 --> 55 Recruiting --> Completed

||||||||||  travoprost ophthalmic / Generic mfg.
Trial completion:  AR-12286 Fixed Dose Combination to Lower Elevated Intraocular Pressure (clinicaltrials.gov) -  May 14, 2012
P2, N=93, Completed,  Sponsor: Aerie Pharmaceuticals
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  bimatoprost/brimonidine/timolol / AbbVie
Enrollment change, Combination therapy:  Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  May 13, 2012
P3, N=184, Recruiting,  Sponsor: Allergan
Active, not recruiting --> Completed N=146 --> 184

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial completion:  Safety and Efficacy of AGN-210669 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  May 13, 2012
P2, N=125, Completed,  Sponsor: Allergan
N=146 --> 184 Active, not recruiting --> Completed

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
Trial completion:  Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension (clinicaltrials.gov) -  May 13, 2012
P2, N=163, Completed,  Sponsor: Allergan
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Lumigan (bimatoprost) / Senju, AbbVie
New P4 trial:  A Safety and Efficacy Study of Bimatoprost 0.01% in Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OH) (clinicaltrials.gov) -  May 7, 2012
P4, N=800, Completed,  Sponsor: Allergan

|||||||||| Trial completion: ELAZOP Switching Study in Korea (clinicaltrials.gov) - May 5, 2012
P4, N=96, Completed, Sponsor: Alcon Research
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| New P4 trial: Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) (clinicaltrials.gov) - May 3, 2012
P4, N=100, Recruiting, Sponsor: EyeTechCare

||||||||||  Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) / Novartis
Trial completion:  Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2% (clinicaltrials.gov) -  May 3, 2012
P3, N=1001, Completed,  Sponsor: Alcon Research
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers (clinicaltrials.gov) - May 2, 2012
P4, N=20, Completed, Sponsor: Oregon Health and Science University
Active, not recruiting --> Completed Enrolling by invitation --> Completed

||||||||||  latanoprost / Generic mfg.
Trial completion:  Safety and Efficacy of Bimatoprost/Timolol Fixed Combination Versus Latanoprost in Patients With Open-Angle Glaucoma Who Have Never Been Treated (clinicaltrials.gov) -  May 1, 2012
P4, N=81, Completed,  Sponsor: Allergan
Enrolling by invitation --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Safety and Efficacy of a New Formulation of Bimatoprost/Timolol Ophthalmic Solution Compared With Bimatoprost/Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension (clinicaltrials.gov) - Apr 26, 2012
P3, N=561, Completed, Sponsor: Allergan
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Zioptan (tafluprost) / Santen, Merck (MSD)
Trial termination:  Use of an Ocular Telemetry Sensor in Tafluprost Treated Patients (clinicaltrials.gov) -  Apr 24, 2012
P4, N=15, Terminated,  Sponsor: Sensimed AG
Active, not recruiting --> Completed Recruiting --> Terminated

||||||||||  latanoprost / Generic mfg.
New P4 trial:  Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma (clinicaltrials.gov) -  Apr 16, 2012
P4, N=120, Recruiting,  Sponsor: University of Cantanzaro

||||||||||  mitomycin / Generic mfg.
Enrollment change, Surgery:  Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery (clinicaltrials.gov) -  Mar 31, 2012
P4, N=20, Completed,  Sponsor: Pro Top & Mediking Company Limited
Recruiting --> Terminated N=40 --> 20

||||||||||  mitomycin / Generic mfg.
Trial completion, Surgery:  Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery (clinicaltrials.gov) -  Mar 31, 2012
P4, N=20, Completed,  Sponsor: Pro Top & Mediking Company Limited
N=40 --> 20 Recruiting --> Completed