- |||||||||| Journal: Nature as a source of drugs for ophthalmology. (Pubmed Central) - Mar 29, 2019
Despite technological advances in synthesizing drugs, the pharmaceutical industry still seeks new active compounds from natural sources as well as from revisiting already-established naturally derived compounds. Although a large number of naturally-occurring compounds is known, this review article focuses on the bioactive substances with scientifically-proven benefits for ocular tissues.
- |||||||||| Journal: Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina. (Pubmed Central) - Mar 28, 2019
Furthermore, these kinases and S1P receptors are expressed in mammalian retinal cells and the expression of SPHK1, S1PR2 and S1PR3 increased immediately after light damage, which suggests a function in apoptosis and/or light stress responses in the eye. These findings have numerous implications for understanding the role of S1P signaling in the mechanisms of ocular diseases such as retinal inflammatory and degenerative diseases, neovascular eye diseases, glaucoma and corneal diseases.
- |||||||||| Journal: Visual Assessment of Aqueous Humor Outflow. (Pubmed Central) - Mar 28, 2019
New behaviors including segmental, pulsatile, and dynamic AHO may have relevance to the disease and the level of therapeutic response for IOP-lowering treatments. By better understanding the regulation of segmental, pulsatile, and dynamic AHO, it may be possible to find new and innovative treatments for glaucoma aiming at these new AHO behaviors.
- |||||||||| Clinical, Journal: Preimplantation genetic diagnosis as a strategy to prevent having a child born with an heritable eye disease. (Pubmed Central) - Mar 27, 2019
Our findings underscore the importance an ophthalmologist plays in informing patients regarding the options now available for using prenatal and preimplantation genetic diagnosis to avoid having a child with a potentially devastating genetic form of eye disease or ocular cancer. This strategy is highly relevant, particularly given the limited options currently available for treating these conditions.
- |||||||||| acetazolamide / generics
Journal: 22q11.2 microduplication syndrome and juvenile glaucoma. (Pubmed Central) - Mar 27, 2019
Trabeculectomy may be complicated by persistent hypotony. Deep sclerectomy appears to be a better surgical option, although the presence of a thin sclera may result in conversion to trabeculectomy.
- |||||||||| Review, Journal: Too sweet: Problems of protein glycation in the eye. (Pubmed Central) - Mar 27, 2019
Here, we summarize research regarding glycation-induced ocular tissue dysfunction and its contribution to the onset and development of eye disorders. We also discuss how management of carbohydrate nutrition may provide a low-cost way to ameliorate the progression of AGEs-related diseases, including age related macular degeneration and some cataracts, as they do for cardiovascular disease and diabetes.
- |||||||||| Review, Journal: The peripheral eye: A neurogenic area with potential to treat retinal pathologies? (Pubmed Central) - Mar 27, 2019
When induced to differentiate, cells derived from the CB neurospheres start to express early neural markers but, unlike embryonic stem cells, they are not able to fully differentiate in vitro or generate retinal organoids. Together with previous reports on the neurogenic capacity of CB cells, also reviewed here, our results contribute to the current knowledge about the potentiality of this peripheral region of the eye as a therapeutic source of functional retinal neurons in degenerative diseases.
- |||||||||| Clinical, Journal: Plaque Radiotherapy for Medulloepithelioma in 6 Cases From a Single Center. (Pubmed Central) - Mar 27, 2019
Plaque radiotherapy is a reasonable alternative treatment for localized, small- to medium-size medulloepithelioma. Tumors larger than 11.0 mm, with retrolental cyclitic membrane or extrascelral extension, might still require enucleation.
- |||||||||| Journal: The History of Exfoliation Syndrome. (Pubmed Central) - Mar 27, 2019
There is a prominent association with zonular instability. This study presents the developments in the understanding of the pathomechanism and clinical significance of XFS and explains the problem of terminology in the description of XFS and pseudoexfoliation.
- |||||||||| Biomarker, Journal: Circular and long non-coding RNAs and their role in ophthalmologic diseases. (Pubmed Central) - Mar 27, 2019
The newly discovered non-coding RNAs seem to be the ideal candidate for novel molecular markers and therapeutic strategies. In this review, we summarize current knowledge about gene expression regulators - long non-coding and circular RNA molecules in eye diseases.
- |||||||||| Clinical, Journal: Corneal Biomechanics Using a Scheimpflug-Based Noncontact Device in Normal-Tension Glaucoma and Healthy Controls. (Pubmed Central) - Mar 27, 2019
In conclusion, both SPE-based purification methods worked equally well in terms of analytical performance and reproducibility, whereas the analysis speed and the semi-automation of the SOLAµ spin plates workflow is much more convenient in comparison to the ZIPTIP C18 method. Normal-tension glaucoma eyes demonstrated a small, statistically significant faster corneal inward applanation velocity than normal control eyes.
- |||||||||| Avandia (rosiglitazone) / GSK
Preclinical, Journal: Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma. (Pubmed Central) - Mar 26, 2019
We show that increasing RGC but not glial Ucp2 expression in transgenic animals decreases glaucomatous RGC death, but also that the PPAR-γ agonist rosiglitazone (RSG), an endogenous transcriptional activator of Ucp2, does not significantly alter RGC loss during glaucoma. Together, these data support a model whereby increased Ucp2 expression mediates neuroprotection during a long-term oxidative stressor, but that transcriptional activation alone is insufficient to elicit a neuroprotective effect, motivating further research in to the post-transcriptional regulation of Ucp2.
- |||||||||| Journal: Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye. (Pubmed Central) - Mar 26, 2019
This is the first histopathological analysis of an eye from a glaucoma patient with a MYOC mutation. Furthermore, this analysis supports our model of MYOC-associated glaucoma, in which MYOC mutations cause abnormal intracellular retention of MYOC within the ER of trabecular meshwork cells as a key step towards development of glaucoma.
- |||||||||| Preclinical, Journal: In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. (Pubmed Central) - Mar 25, 2019
Specifically, using spectral domain optical coherence tomography, we observed that SC in corticosteroid-treated mice was more resistant to collapse at elevated IOPs, reflecting increased TM stiffness determined by inverse finite element modeling. Our noninvasive approach to monitoring TM stiffness in vivo is applicable to other forms of glaucoma and has significant potential to monitor TM function and thus positively affect the clinical care of glaucoma, the leading cause of irreversible blindness worldwide.
- |||||||||| Biomarker, Journal: Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy. (Pubmed Central) - Mar 24, 2019
Levels of vitreous VEGF at the time of PPV were significantly higher in eyes with: vitreous hemorrhage on the first day after PPV (p = 0.003); FVP on the first day and 12 months after PPV (p = 0.002 and p < 0.001, respectively); iris rubeosis on the first day and 12 months after PPV surgery (p < 0.001, and p = 0.001, respectively); NVG on the first day and 12 months after PPV surgery (p = 0.043 and p = 0.011, respectively), compared to the eyes without complications. Preoperative levels of VEGF in vitreous can be a useful biomarker and predictor of the postoperative outcome in terms of intraoperative and postoperative complications.
- |||||||||| Clinical, Review, Journal: The impact of topical intraocular pressure lowering medications on the ocular surface of glaucoma patients: A review. (Pubmed Central) - Mar 24, 2019
The preservatives and active agents in most topical glaucoma medications are implicated in the prevalence of ocular surface discomfort. Whilst clinicians involved in glaucoma care are encouraged to assess the ocular surface routinely, further studies are needed to demonstrate the contributions of other physiochemical properties of these medications to the development of ocular surface disease in these patients.
- |||||||||| Clinical, Review, Journal: Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment. (Pubmed Central) - Mar 24, 2019
In therapy resistant cases, surgical treatment options such as corneal cryotherapy, amniotic membrane transplantation, riboflavin-UVA cross-linking, and penetrating keratoplasty are applied. With early diagnosis and conservative or surgical treatment, acanthamoeba keratitis heals in most cases.
- |||||||||| Journal: Surgical management of glaucoma in Fuchs uveitis syndrome: Trabeculectomy or Ahmed glaucoma valve. (Pubmed Central) - Mar 24, 2019
Cumulative success rates at 6 months were 93% and 58% and 65% and 7% at 36 months according to criterion B in the trabeculectomy and the AGV group, respectively.Kaplan-Meier survival analysis revealed a significant association between surgical method and cumulative success rate over 36 months (based on criteria A: PÂ =Â 0.02, and based on criteria B: PÂ =Â 0.007). The success rate of trabeculectomy was higher than AGV in the surgical management of glaucoma in FUS during a medium-term follow-up.
- |||||||||| Journal: Comparison of rebound tonometry and non-contact airpuff tonometry to Goldmann applanation tonometry. (Pubmed Central) - Mar 24, 2019
There was a significant positive correlation in the meaning of intraocular pressure measurements between rebound tonometry and non-contact airpuff tonometry; non-contact airpuff tonometry and Goldmann applanation tonometry; and Goldmann applanation tonometry and rebound tonometry in all groups. As a result, without need for topical anesthesia, fast measurement and ease-of-use rebound tonometry is a reliable alternative to Goldmann applanation tonometry in different age groups.
- |||||||||| FTY720, Gilenya (fingolimod) / Novartis, Mitsubishi Tanabe
Journal: Nodes of Ranvier in glaucoma. (Pubmed Central) - Mar 23, 2019
After one week of systemic treatment with fingolimod, an immunosuppressant therapy for relapsing-remitting MS, DBA/2J mice showed a substantial reduction in node pathology and mild effects on axon morphology. These data suggest that neurophysiological deficits in the DBA/2J may be due to defects in intact axons and targeting node pathology may be a promising intervention for some types of glaucoma.
- |||||||||| Clinical, Journal: Ascorbic acid metabolites are involved in intraocular pressure control in the general population. (Pubmed Central) - Mar 23, 2019
We show that O-methylascorbate, a circulating Vitamin C metabolite, has a significant IOP-lowering effect, consistent with previous knowledge of the anti-hypertensive and anti-oxidative role of ascorbate compounds. These results enhance understanding of IOP control and may potentially benefit future IOP treatment and reduce vision loss from glaucoma.
- |||||||||| Clinical, Journal: Ecometabolomic Analysis of Wild Populations of Pilocarpus pennatifolius (Rutaceae) Using Unimodal Analyses. (Pubmed Central) - Mar 22, 2019
The most important contributing to the phenolic variation between the sites: mean temperature of the wettest quarter, temperature seasonality, calcium and soil electrical conductivity. This research will have broad implications in a variety of areas including biocontrol for pests, environmental and ecological plant physiology, and strategies for species conservation maximizing phytochemical diversity.
- |||||||||| Clinical, Journal: Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006-2017). (Pubmed Central) - Mar 22, 2019
However, changes were not observed for surgical diseases, infectious and inflammatory causes, or for miscellaneous and unclassified diseases. Orbital implant financing should be increased to ensure better postoperative aesthetic rehabilitation, following enucleation in Hungary.
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