Glaucoma
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  • ||||||||||  Journal:  LCN2 deficiency mitigates the neuroinflammatory damage following acute glaucoma. (Pubmed Central) -  Mar 14, 2025   
    We also identified a novel mechanism for LCN2 in acute high IOP-induced neuroinflammation. LCN2 has the potential to serve as a candidate biomarker for predicting the severity of the neuroinflammatory response following acute glaucoma, which may provide new evidence to retinal repair strategies for better visual function recovery at intervention time points and new targets.
  • ||||||||||  Journal:  Editorial: Update on glaucoma research: from basic science to clinical practice. (Pubmed Central) -  Mar 14, 2025   
    LCN2 has the potential to serve as a candidate biomarker for predicting the severity of the neuroinflammatory response following acute glaucoma, which may provide new evidence to retinal repair strategies for better visual function recovery at intervention time points and new targets. No abstract available
  • ||||||||||  Journal:  Vogt-Koyanagi-Harada-like disease secondary to anticancer treatment: a multicentre case series. (Pubmed Central) -  Mar 14, 2025   
    VKH-like features in the context of emerging novel anticancer therapies represent a unique clinical phenotype in which the cornerstone of management should include high doses of systemic corticosteroids, using immunomodulatory therapy as a second-line treatment in patients with a refractory disorder. In addition, a comprehensive multidisciplinary approach, including an oncologist, should consider the safety of anticancer treatment cessation.
  • ||||||||||  Journal:  Loss of Trabecular Meshwork Stem Cells is Correlated with Open Angle Glaucoma. (Pubmed Central) -  Mar 14, 2025   
    Together the data indicate a clear decline in the number of TMSCs with age and a further reduction in eyes with glaucoma. Although this study does not establish causality, our finding is consistent with the notion that the degeneration or loss of stemness of TMSCs is the cause of reduced TM cellularity which, in turn, is associated with TM dysfunction and the development of elevated IOP.
  • ||||||||||  Journal:  Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma. (Pubmed Central) -  Mar 14, 2025   
    Eyes with MO and UC exhibited distinct cataract grades and complications, necessitating varied surgical strategies; while cataract surgery has proven to be effective in improving the visual acuity in both groups. Our findings hold significant value for guiding clinical treatment decision-making.
  • ||||||||||  Journal:  Core genes and immune dysregulation in primary open-angle glaucoma: A molecular insight. (Pubmed Central) -  Mar 13, 2025   
    Functional enrichment analysis and CIBERSORT algorithm were used to further reveal the changes in the POAG immune environment and find emerging therapeutic targets.ResultsHERPUD1, IQCK, MRPL40, SRSF7 and TMEM243 were identified as risk genes, and the prediction model and nomogram constructed based on them had good early prediction efficiency. At the mechanistic level, the heterogeneity of T cell subsets seems to be a key factor affecting the progression of POAG and has potential therapeutic value.ConclusionsHERPUD1, IQCK, MRPL40, SRSF7, and TMEM243 are of great significance for the early prediction and disease progression of POAG and have the potential value of becoming therapeutic targets.
  • ||||||||||  sirolimus / Generic mfg., nintedanib / Generic mfg., pirfenidone / Generic mfg.
    Review, Journal:  Fighting Bleb Fibrosis After Glaucoma Surgery: Updated Focus on Key Players and Novel Targets for Therapy. (Pubmed Central) -  Mar 13, 2025   
    Based on the most recent literature, modern patho-physiological models of FB fibrosis should consider TGF? and M2c macrophages as pivotal players and favorite targets for therapy, while research on antifibrotic strategies should clinically investigate medications utilized in the management of extra-ocular fibrosis.
  • ||||||||||  Review, Journal:  Link Between Metabolic Syndrome, Inflammation, and Eye Diseases. (Pubmed Central) -  Mar 13, 2025   
    Given the rising global prevalence of metabolic syndrome, addressing this connection is crucial for improving overall patient outcomes and quality of life. Future research should focus on delineating the precise mechanisms linking these diseases as well as exploring targeted interventions that address both metabolic and ocular health.
  • ||||||||||  Review, Journal:  Molecular aspects of cytoprotection by Optineurin during stress and disease. (Pubmed Central) -  Mar 13, 2025   
    We suggest that OPTN deficiency created by mutations may cooperate with stress-induced signalling to enhance or cause neurodegeneration. Other functions of OPTN, such as neurotrophin secretion and vesicle trafficking, may also contribute to cytoprotection.
  • ||||||||||  Journal, Real-world evidence, Real-world:  Risk Factors for Developing Neovascular Glaucoma in Central Retinal Vein Occlusion: Two-Year Real-World Study. (Pubmed Central) -  Mar 12, 2025   
    Patients presenting with CRVO who have comorbidities such as DM, older age, and worse VA warrant closer attention and intensive follow-up for the development of NVG. Additionally, the statistical analysis indicated that the presence of macular edema, increased central macular thickness, CV events, history of glaucoma, and early PRP within 3?months had no significant impact on the likelihood of developing NVG.
  • ||||||||||  Retrospective data, Journal:  Safety of intravitreal injections with the mobile laminar airflow device Operio after more than 10.000 injections. (Pubmed Central) -  Mar 12, 2025   
    Additionally, the statistical analysis indicated that the presence of macular edema, increased central macular thickness, CV events, history of glaucoma, and early PRP within 3?months had no significant impact on the likelihood of developing NVG. The OCR equipped with Operio was easy to set up, safe regarding all IVI-related complications, first and foremost endophthalmitis, helpful in improving the management of IVIS, and allowed us to decongest the operating room for more complex surgeries.
  • ||||||||||  Clinical, Journal:  Fractal Dimension Analysis of Peripapillary Microvasculature in Primary Congenital Glaucoma. (Pubmed Central) -  Mar 12, 2025   
    Our results provide additional evidence supporting GATT and PHACOGATT as viable options for the treatment of medically uncontrolled glaucoma patients requiring low and stable IOPs. PCG was associated with lower vascular parameters in the vitreo-retina (large retinal vessels) and ILM-NFL (RPC) layers as detected by OCTA FD.
  • ||||||||||  Journal:  Visual Field Progression in Glaucoma During COVID-19. (Pubmed Central) -  Mar 12, 2025   
    PCG was associated with lower vascular parameters in the vitreo-retina (large retinal vessels) and ILM-NFL (RPC) layers as detected by OCTA FD. In patients with glaucoma on follow up, higher rates and proportions of visual field progression were found post the COVID-19 pandemic compared to pre pandemic.
  • ||||||||||  Journal:  One-Year Outcomes of Gonio Scratch as a Minimally Invasive Glaucoma Surgery with Cataract Removal. (Pubmed Central) -  Mar 12, 2025   
    While higher Social Vulnerability Index scores were linked to reduced odds of glaucoma testing, specific sociodemographic factors - such as limited English proficiency and retirement/disability - further reduced the odds. GS-Phaco achieved sustained IOP reduction and a decrease in medication use at 12 months postoperatively in patients with open-angle glaucoma and cataracts.
  • ||||||||||  Retrospective data, Journal:  Risk factors and protective strategies for hypotony following preserflo microshunt implantation. (Pubmed Central) -  Mar 12, 2025   
    Importantly, intraluminal suture stenting mitigated the risk of hypotony without compromising the short-term surgical outcomes. These findings emphasize the need for careful patient selection and the potential of intraluminal suture stenting as an effective intraoperative strategy to improve the safety and outcomes of PMS implantation.
  • ||||||||||  Journal:  Unusual fundus lesion in mosaic neurofibromatosis type 2. (Pubmed Central) -  Mar 12, 2025   
    Histopathology showed an optic nerve sheath meningioma with intraocular extension. Although ocular abnormalities in NF2 are a relatively rare finding in young children, this case shows that an optic nerve sheath meningioma can show intraocular extension and should be considered in the differential diagnosis for an intraocular mass.
  • ||||||||||  Journal, Monotherapy:  Visual outcomes and adherence challenges in proliferative diabetic retinopathy anti-VEGF monotherapy in the clinical practice setting. (Pubmed Central) -  Mar 12, 2025   
    Although ocular abnormalities in NF2 are a relatively rare finding in young children, this case shows that an optic nerve sheath meningioma can show intraocular extension and should be considered in the differential diagnosis for an intraocular mass. The frequent follow-up appointments and repeat treatments necessary for anti-VEGF monotherapy in PDR can pose challenges to maintaining the required schedule and can result in worse visual acuity outcomes and increased ocular complications.
  • ||||||||||  Journal:  Outcomes of Persistent Exudative Retinal Detachments Following Proton Beam Irradiation for Choroidal Melanoma. (Pubmed Central) -  Mar 12, 2025   
    The frequent follow-up appointments and repeat treatments necessary for anti-VEGF monotherapy in PDR can pose challenges to maintaining the required schedule and can result in worse visual acuity outcomes and increased ocular complications. Choroidal melanoma with a large ERD can be successfully treated with conservative or surgical management after proton beam radiation therapy.
  • ||||||||||  Journal:  Spatial-aware Transformer-GRU Framework for Enhanced Glaucoma Diagnosis from 3D OCT Imaging. (Pubmed Central) -  Mar 12, 2025   
    Experimental results on a large dataset demonstrate the superior performance of the proposed method over state-of-the-art ones, achieving an F1-score of 93.01%, Matthews Correlation Coefficient (MCC) of 69.33%, and AUC of 94.20%. The framework's ability to leverage the valuable information in 3D OCT data holds significant potential for enhancing clinical decision support systems and improving patient outcomes in glaucoma management.
  • ||||||||||  Preclinical, Journal:  Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization. (Pubmed Central) -  Mar 12, 2025   
    AH viscosity positively correlated with VEGF-A concentration, particularly in CNV-induced eyes with elevated VEGF-A levels. The correlation between VEGF-A levels and AH viscosity in an experimental model of corneal neovascularization suggests that AH viscosity could serve as a biomarker for predicting IOP or surgical outcomes in conditions like neovascular glaucoma.
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Persistence of Glaucoma Patients With Web-Browser-Based Visual Field Test (clinicaltrials.gov) -  Mar 12, 2025   
    P=N/A,  N=13, Terminated, 
    Independently of longer axial length, thinner choroidal thickness is a factor associated with lower BCVA in myopic eyes, including eyes with MMD stage 1. N=50 --> 13 | Trial completion date: Dec 2025 --> Mar 2025 | Recruiting --> Terminated | Trial primary completion date: Dec 2025 --> Mar 2025; Testing software discontinued by vendor.