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160 Mechanisms of Action

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|||||||||| Clinical: VICAR2: Validation of Implementation of Cervical Dysplasia Treatment Modalities in HIV-Seropositive Women (clinicaltrials.gov) - Nov 6, 2012
P=N/A, N=166, Recruiting, Sponsor: University of Witwatersrand, South Africa

||||||||||  cisplatin / Generic mfg., erlotinib / Generic mfg.
Trial withdrawal, Combination therapy, Metastases:  Erlotinib, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB-Stage IVA Cervical Cancer (clinicaltrials.gov) -  Nov 5, 2012
P1, N=0, Withdrawn,  Sponsor: Masonic Cancer Center, University of Minnesota
Terminated --> Withdrawn

||||||||||  Talzenna (talazoparib) / Pfizer
Enrollment change, Metastases:  Study of Talazoparib, a PARP Inhibitor, in Patients With Advanced or Recurrent Solid Tumors (clinicaltrials.gov) -  Nov 5, 2012
P1, N=85, Recruiting,  Sponsor: BioMarin Pharmaceutical
Terminated --> Withdrawn N=70 --> 85

|||||||||| Enrollment change, Metastases: A Phase I Study of Ovarian Cancer Peptides Plus GM-CSF and Adjuvant With Ovarian, Tubal or Peritoneal Cancer (clinicaltrials.gov) - Nov 5, 2012
P1, N=8, Completed, Sponsor: Michael Morse, MD
N=70 --> 85 N=16 --> 8

|||||||||| Trial completion, Metastases: A Phase I Study of Ovarian Cancer Peptides Plus GM-CSF and Adjuvant With Ovarian, Tubal or Peritoneal Cancer (clinicaltrials.gov) - Nov 5, 2012
P1, N=8, Completed, Sponsor: Michael Morse, MD
N=16 --> 8 Active, not recruiting --> Completed

||||||||||  flutamide / Generic mfg.
Enrollment change:  Metabolic Syndrome in PCOS: Precursors and Interventions (clinicaltrials.gov) -  Nov 4, 2012
P=N/A, N=97, Completed,  Sponsor: Northwestern University
Active, not recruiting --> Completed N=200 --> 97

||||||||||  cefazolin / Generic mfg., azithromycin / Generic mfg.
New P4 trial:  Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis (clinicaltrials.gov) -  Nov 4, 2012
P4, N=506, Recruiting,  Sponsor: University of Missouri, Kansas City

|||||||||| Biomarker, New P4 trial: Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism (clinicaltrials.gov) - Nov 4, 2012
P4, N=300, Recruiting, Sponsor: Medical University of Graz

||||||||||  trebananib (AMG 386) / Amgen
Enrollment closed, Combination therapy, Metastases:  AMG386 Comb w. Either Pegylated Liposomal Doxorubicin or Topotecan Subjects w. Advanced Recurrent Epithelial Ovarian CR (clinicaltrials.gov) -  Nov 4, 2012
P1, N=103, Active, not recruiting,  Sponsor: Amgen
N=200 --> 97 Recruiting --> Active, not recruiting

||||||||||  flutamide / Generic mfg.
Trial completion:  Metabolic Syndrome in PCOS: Precursors and Interventions (clinicaltrials.gov) -  Nov 4, 2012
P=N/A, N=97, Completed,  Sponsor: Northwestern University
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  indomethacin / Generic mfg.
New P1 trial, Combination therapy:  PIFA: Phase I Platinum Based Chemotherapy Plus Indomethacin (clinicaltrials.gov) -  Oct 30, 2012
P1, N=18, Recruiting,  Sponsor: UMC Utrecht

||||||||||  afuresertib (LAE002) / Laekna Therap
Enrollment open, Combination therapy:  Dose-finding Study in Platinum-Resistant Ovarian Cancer (clinicaltrials.gov) -  Oct 30, 2012
P1/2, N=43, Recruiting,  Sponsor: Accenture
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| New P4 trial: Use of GM-CSF Supplemented IVF Medium in Patients With Recurrent Implantation Failure (clinicaltrials.gov) - Oct 29, 2012
P4, N=100, Recruiting, Sponsor: Centre for Endocrinology and Reproductive Medicine, Italy

||||||||||  bendamustine / Generic mfg.
Enrollment change, Metastases:  Open Trial of Bendamustine Hydrochloride in Women With Advanced Ovarian Cancer (clinicaltrials.gov) -  Oct 29, 2012
P2, N=10, Completed,  Sponsor: University of Arizona
Not yet recruiting --> Recruiting N=20 --> 10

||||||||||  bendamustine / Generic mfg.
Trial completion, Metastases:  Open Trial of Bendamustine Hydrochloride in Women With Advanced Ovarian Cancer (clinicaltrials.gov) -  Oct 29, 2012
P2, N=10, Completed,  Sponsor: University of Arizona
N=20 --> 10 Active, not recruiting --> Completed

||||||||||  azithromycin / Generic mfg.
Enrollment open:  RESCUE: Drug Use Investigation Of Azithromycin IV For Community-Acquired Pneumonia Or Pelvic Inflammatory Disease (Regulatory Post Marketing Commitment Plan) (clinicaltrials.gov) -  Oct 28, 2012
P4, N=400, Enrolling by invitation,  Sponsor: Pfizer
Active, not recruiting --> Completed Not yet recruiting --> Enrolling by invitation

|||||||||| Enrollment open, Preclinical: Stress Management for Couples Undergoing In Vitro Fertilization (IVF) (clinicaltrials.gov) - Oct 28, 2012
P2, N=80, Recruiting, Sponsor: Amit Sood
Not yet recruiting --> Enrolling by invitation Active, not recruiting --> Recruiting

||||||||||  azithromycin / Generic mfg.
Trial completion:  Trachoma Elimination Follow-up (clinicaltrials.gov) -  Oct 28, 2012
P4, N=20000, Completed,  Sponsor: University of California, San Francisco
Active, not recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| New P2 trial: [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers (clinicaltrials.gov) - Oct 28, 2012
P2, N=30, Recruiting, Sponsor: University of Iowa

||||||||||  metformin / Generic mfg.
Trial termination:  Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS) (clinicaltrials.gov) -  Oct 27, 2012
P4, N=6, Terminated,  Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting --> Completed Recruiting --> Terminated; Lack of recruitment

||||||||||  metformin / Generic mfg.
Enrollment change:  Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS) (clinicaltrials.gov) -  Oct 27, 2012
P4, N=6, Terminated,  Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting --> Terminated; Lack of recruitment N=21 --> 6

|||||||||| New P1 trial: Healthy Eating for Reproductive Health: Greenville (clinicaltrials.gov) - Oct 25, 2012
P1, N=0, Withdrawn, Sponsor: University of South Carolina

||||||||||  carboplatin / Generic mfg., azacitidine / Generic mfg.
Enrollment change:  Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer (clinicaltrials.gov) -  Oct 25, 2012
P1, N=36, Completed,  Sponsor: M.D. Anderson Cancer Center
N=21 --> 6 N=65 --> 36

||||||||||  carboplatin / Generic mfg., azacitidine / Generic mfg.
Trial completion:  Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer (clinicaltrials.gov) -  Oct 25, 2012
P1, N=36, Completed,  Sponsor: M.D. Anderson Cancer Center
N=65 --> 36 Active, not recruiting --> Completed

|||||||||| Enrollment change: Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels (clinicaltrials.gov) - Oct 24, 2012
P=N/A, N=66, Completed, Sponsor: University of California, Davis
Active, not recruiting --> Completed N=96 --> 66

||||||||||  triptorelin / Generic mfg.
New P4 trial:  Can GnRH Agonist Trigger Prevent Ovarian Hyperstimulation Syndrome? (clinicaltrials.gov) -  Oct 24, 2012
P4, N=6, Terminated,  Sponsor: Elisha Hospital

|||||||||| New P2 trial, Preclinical: Stress Management for Couples Undergoing In Vitro Fertilization (IVF) (clinicaltrials.gov) - Oct 24, 2012
P2, N=80, Recruiting, Sponsor: Amit Sood

|||||||||| Trial completion: Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels (clinicaltrials.gov) - Oct 24, 2012
P=N/A, N=66, Completed, Sponsor: University of California, Davis
N=96 --> 66 Recruiting --> Completed

|||||||||| Enrollment open: [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers (clinicaltrials.gov) - Oct 24, 2012
P2, N=30, Recruiting, Sponsor: University of Iowa
Recruiting --> Completed Not yet recruiting --> Recruiting

||||||||||  Vectibix (panitumumab) / Amgen
Trial completion:  PaLiDo: Panitumumab and Pegylated Liposomal Doxorubicin for Platinum-Resistant Epithelial Ovarian Cancer With KRAS Wild-type (clinicaltrials.gov) -  Oct 24, 2012
P2, N=33, Completed,  Sponsor: Vejle Hospital
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

||||||||||  BNC105 / Bionomics
Trial initiation date:  BNC105P Combination Study in Partially Platinum Sensitive Ovarian Cancer Patients (clinicaltrials.gov) -  Oct 21, 2012
P1/2, N=134, Recruiting,  Sponsor: Hoosier Oncology Group
Active, not recruiting --> Completed Initiation date: Jul 2012 --> Oct 2012

|||||||||| New P1 trial, Surgery: Preoperative Warm-up in Gynecologic Surgery (clinicaltrials.gov) - Oct 21, 2012
P1, N=20, Recruiting, Sponsor: Medical University of Vienna

||||||||||  BNC105 / Bionomics
Enrollment open:  BNC105P Combination Study in Partially Platinum Sensitive Ovarian Cancer Patients (clinicaltrials.gov) -  Oct 21, 2012
P1/2, N=134, Recruiting,  Sponsor: Hoosier Oncology Group
Initiation date: Jul 2012 --> Oct 2012 Not yet recruiting --> Recruiting

||||||||||  phenoxodiol (NV06) / MEI
Trial completion:  Phenoxodiol Combined With Either Cisplatin or Paclitaxel in Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer (clinicaltrials.gov) -  Oct 21, 2012
P1/2, N=65, Completed,  Sponsor: MEI Pharma, Inc.
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Enrollment change: IM-862 in Treating Patients With Recurrent Ovarian Cancer (clinicaltrials.gov) - Oct 19, 2012
P1, N=43, Completed, Sponsor: University of Southern California
Active, not recruiting --> Completed N=70 --> 43

|||||||||| Trial completion: IM-862 in Treating Patients With Recurrent Ovarian Cancer (clinicaltrials.gov) - Oct 19, 2012
P1, N=43, Completed, Sponsor: University of Southern California
N=70 --> 43 Active, not recruiting --> Completed

||||||||||  paclitaxel / Generic mfg., gemcitabine / Generic mfg.
Trial completion:  Combination Chemotherapy in Treating Patients With Platinum-Resistant Recurrent Ovarian Cancer (clinicaltrials.gov) -  Oct 19, 2012
P2, N=35, Completed,  Sponsor: University of Southern California
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment closed: EURAS-IUD: European Active Surveillance Study for Intrauterine Devices (clinicaltrials.gov) - Oct 18, 2012
P4, N=60000, Active, not recruiting, Sponsor: Center for Epidemiology and Health Research, Germany
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| New P3 trial: Induction of Puberty With 17-beta Estradiol in Girls With Turner Syndrome (clinicaltrials.gov) - Oct 17, 2012
P3, N=50, Completed, Sponsor: Novo Nordisk

||||||||||  apitolisib (GDC-0980) / Roche
Enrollment closed:  A Study of GDC-0980 in the Treatment of Recurrent or Persistent Endometrial Carcinoma (clinicaltrials.gov) -  Oct 17, 2012
P2, N=56, Active, not recruiting,  Sponsor: Genentech
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| Enrollment closed: FLT PET Imaging for Cervical Cancer (clinicaltrials.gov) - Oct 17, 2012
P2, N=30, Active, not recruiting, Sponsor: University of Iowa
Recruiting --> Active, not recruiting Suspended --> Active, not recruiting

||||||||||  Firmagon (degarelix) / Astellas, Ferring
New P3 trial:  Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS) (clinicaltrials.gov) -  Oct 16, 2012
P3, N=80, Recruiting,  Sponsor: Centre for Endocrinology and Reproductive Medicine, Italy

||||||||||  metformin / Generic mfg.
Enrollment open:  PregMet2: Metformin to Prevent Late Miscarriage and Preterm Delivery in Women With Polycystic Ovary Syndrome (clinicaltrials.gov) -  Oct 16, 2012
P=N/A, N=1000, Recruiting,  Sponsor: Norwegian University of Science and Technology
Suspended --> Active, not recruiting Not yet recruiting --> Recruiting

||||||||||  carboplatin / Generic mfg., cisplatin / Generic mfg.
New P1/2 trial, Metastases:  Feasibility Study of HIPEC for Patients With Stage III or Only Pleural Stage IV Ovarian Carcinoma in First Line Therapy (clinicaltrials.gov) -  Oct 16, 2012
P1/2, N=24, Recruiting,  Sponsor: Jules Bordet Institute

|||||||||| Observational data, Enrollment change: POWER1012: Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products (clinicaltrials.gov) - Oct 15, 2012
P=N/A, N=1543, Completed, Sponsor: American Medical Systems
Not yet recruiting --> Recruiting N=1000 --> 1543

||||||||||  Climara (estradiol) / Bausch Health, Bayer, Lutrelef (gonadorelin acetate) / Ferring
Enrollment closed:  Estrogen Sensitivity and Ovulatory Dysfunction in Obesity (clinicaltrials.gov) -  Oct 15, 2012
P=N/A, N=20, Active, not recruiting,  Sponsor: University of Colorado, Denver
N=1000 --> 1543 Recruiting --> Active, not recruiting

||||||||||  rosiglitazone / Generic mfg.
Trial withdrawal, Immunomodulating:  Effect of Rosiglitazone on Peritoneal Cytokines in Women With Endometriosis (clinicaltrials.gov) -  Oct 15, 2012
P2/3, N=0, Withdrawn,  Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting --> Active, not recruiting Terminated --> Withdrawn

||||||||||  cisplatin / Generic mfg.
Enrollment change, Surgery, Metastases:  Whole-Abdominal Radiation Therapy and Cisplatin in Treating Patients With Stage III or Stage IV Endometrial Cancer That Has Been Removed by Surgery (clinicaltrials.gov) -  Oct 15, 2012
P1, N=12, Completed,  Sponsor: University of Miami Sylvester Comprehensive Cancer Center
Terminated --> Withdrawn N=30 --> 12

||||||||||  rosiglitazone / Generic mfg.
Enrollment change, Immunomodulating:  Effect of Rosiglitazone on Peritoneal Cytokines in Women With Endometriosis (clinicaltrials.gov) -  Oct 15, 2012
P2/3, N=0, Withdrawn,  Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
N=30 --> 12 N=140 --> 0

||||||||||  cisplatin / Generic mfg.
Trial completion, Surgery, Metastases:  Whole-Abdominal Radiation Therapy and Cisplatin in Treating Patients With Stage III or Stage IV Endometrial Cancer That Has Been Removed by Surgery (clinicaltrials.gov) -  Oct 15, 2012
P1, N=12, Completed,  Sponsor: University of Miami Sylvester Comprehensive Cancer Center
N=140 --> 0 Active, not recruiting --> Completed