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160 Mechanisms of Action

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||||||||||  Visanne (dienogest) / Mochida, Bayer
Enrollment open:  Regulatory Post Marketing Surveillance Study in Korea (clinicaltrials.gov) -  Aug 15, 2013
P=N/A, N=3750, Recruiting,  Sponsor: Bayer
Not yet recruiting --> Recruiting

|||||||||| Trial initiation date: Phase I Pilot Study to Evaluate the Prognostic Value of Perfusion CT for Primary Cervical Cancer (clinicaltrials.gov) - Aug 15, 2013
P1, N=20, Suspended, Sponsor: Stanford University
Not yet recruiting --> Recruiting Initiation date: Mar 2013 --> Aug 2013

|||||||||| Enrollment open: Laparoscopic Gynecology Curriculum for Residents (clinicaltrials.gov) - Aug 13, 2013
P=N/A, N=18, Recruiting, Sponsor: St. Michael's Hospital, Toronto
Initiation date: Mar 2013 --> Aug 2013 Not yet recruiting --> Recruiting

||||||||||  Bravelle (urofollitropin) / Ferring
New P3 trial, Head-to-Head:  Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females (clinicaltrials.gov) -  Aug 13, 2013
P3, N=180, Recruiting,  Sponsor: Ferring Pharmaceuticals

|||||||||| Enrollment open: A Study to Compare CAELYX With Topotecan HCL in Patients With Recurrent Epithelial Ovarian Carcinoma Following Failure of First-Line, Platinum-Based Chemotherapy (clinicaltrials.gov) - Aug 13, 2013
P3, N=120, Recruiting, Sponsor: Xian-Janssen Pharmaceutical Ltd.
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

||||||||||  alisertib (MLN8237) / Puma
Enrollment closed:  Alisertib (MLN8237) in Participants With Ovarian, Fallopian Tube or Peritoneal Cancer Preceded by Phase 1 Study of MLN8237 Plus Paclitaxel Treatment of Ovary or Breast Cancer (clinicaltrials.gov) -  Aug 13, 2013
P1/2, N=172, Active, not recruiting,  Sponsor: Millennium Pharmaceuticals, Inc.
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Trial completion: ThermaChoice III Under Local Sedation in the Office Setting (clinicaltrials.gov) - Aug 12, 2013
P=N/A, N=21, Completed, Sponsor: Female Pelvic Medicine & Urogynecology Institute of Michigan
Recruiting --> Active, not recruiting Recruiting --> Completed

||||||||||  Bravelle (urofollitropin) / Ferring
New P3 trial, Head-to-Head:  Evaluation of Efficacy and Safety of Highly Purified Urofollitropin in Chinese Females Undergoing an Assisted Reproductive Technology (ART) Program (clinicaltrials.gov) -  Aug 12, 2013
P3, N=200, Recruiting,  Sponsor: Ferring Pharmaceuticals

||||||||||  topotecan / Generic mfg., carboplatin / Generic mfg., paclitaxel / Generic mfg.
Trial completion, Metastases:  Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Cancer (clinicaltrials.gov) -  Aug 8, 2013
P2, N=80, Completed,  Sponsor: Rigshospitalet, Denmark
Recruiting --> Completed Recruiting --> Completed

||||||||||  Avastin (bevacizumab) / Roche
Trial completion:  ICON-7: Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Newly Diagnosed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer (clinicaltrials.gov) -  Aug 8, 2013
P3, N=1520, Completed,  Sponsor: Medical Research Council
Recruiting --> Completed Recruiting --> Completed

||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg.
Trial completion, Surgery, Metastases:  Timing of Surgery and Chemotherapy in Treating Patients With Newly Diagnosed Advanced Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer (clinicaltrials.gov) -  Aug 8, 2013
P2/3, N=150, Completed,  Sponsor: Royal College of Obstetricians and Gynecologists
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial initiation date: Safer Sex Program for Young African-American Men (clinicaltrials.gov) - Aug 7, 2013
P2, N=620, Recruiting, Sponsor: University of Kentucky
Recruiting --> Completed Initiation date: Jun 2012 --> Sep 2012

|||||||||| Enrollment open: Safer Sex Program for Young African-American Men (clinicaltrials.gov) - Aug 7, 2013
P2, N=620, Recruiting, Sponsor: University of Kentucky
Initiation date: Jun 2012 --> Sep 2012 Not yet recruiting --> Recruiting

||||||||||  goserelin acetate / Generic mfg.
Trial completion:  CRUK-OPTION: Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer (clinicaltrials.gov) -  Aug 5, 2013
P3, N=400, Completed,  Sponsor: Anglo Celtic Cooperative Oncology Group
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| New P2 trial: A Phase II Trial of Adjuvant Radiotherapy Combined With Chemotherapy for Patients With High-risk Endometrial Cancer (clinicaltrials.gov) - Aug 5, 2013
P2, N=80, Active, not recruiting, Sponsor: Fan Ming

|||||||||| Enrollment closed: A Phase II Trial of Adjuvant Radiotherapy Combined With Chemotherapy for Patients With High-risk Endometrial Cancer (clinicaltrials.gov) - Aug 5, 2013
P2, N=80, Active, not recruiting, Sponsor: Fan Ming
Recruiting --> Completed Not yet recruiting --> Active, not recruiting

||||||||||  BR-DIM (oral microencapsulated diindolylmethane) / BioResponse
Trial completion:  CRUK-CRISP-1: Diindolylmethane in Treating Patients With Abnormal Cervical Cells (clinicaltrials.gov) -  Aug 5, 2013
P3, N=3000, Completed,  Sponsor: Barts and the London School of Medicine and Dentistry
Not yet recruiting --> Active, not recruiting Recruiting --> Completed

||||||||||  carboplatin / Generic mfg.
Trial completion:  Carboplatin in Treating Patients With Stage IC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (clinicaltrials.gov) -  Aug 5, 2013
P3, N=1300, Completed,  Sponsor: NHS Greater Glasgow and Clyde
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| New P4 trial, Preclinical: Sequential vs. Monophasic Media Impact Trial (SuMMIT) (clinicaltrials.gov) - Aug 4, 2013
P4, N=200, Recruiting, Sponsor: Reproductive Medicine Associates of New Jersey

||||||||||  Chantix (varenicline) / Pfizer
Enrollment change:  Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking (clinicaltrials.gov) -  Aug 4, 2013
P=N/A, N=315, Completed,  Sponsor: Butler Hospital
Active, not recruiting --> Completed N=602 --> 315

|||||||||| Enrollment closed: A Mixed-Methods Approach to Understanding Factors Associated With Cervical Cancer Screening Utilization Among Low-Income, HIV-Positive Women (clinicaltrials.gov) - Aug 4, 2013
P=N/A, N=250, Active, not recruiting, Sponsor: M.D. Anderson Cancer Center
N=602 --> 315 Recruiting --> Active, not recruiting

||||||||||  Chantix (varenicline) / Pfizer
Trial completion:  Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking (clinicaltrials.gov) -  Aug 4, 2013
P=N/A, N=315, Completed,  Sponsor: Butler Hospital
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  clindamycin phosphate / Generic mfg.
Trial initiation date:  Clindamycin to Reduce Preterm Birth in a Low Resource Setting (clinicaltrials.gov) -  Aug 2, 2013
P4, N=1726, Recruiting,  Sponsor: Christiana Care Health Services
Active, not recruiting --> Completed Initiation date: Apr 2013 --> Jul 2013

||||||||||  clindamycin phosphate / Generic mfg.
Enrollment open:  Clindamycin to Reduce Preterm Birth in a Low Resource Setting (clinicaltrials.gov) -  Aug 2, 2013
P4, N=1726, Recruiting,  Sponsor: Christiana Care Health Services
Initiation date: Apr 2013 --> Jul 2013 Not yet recruiting --> Recruiting

||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen
Trial completion, Preclinical:  Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization) (clinicaltrials.gov) -  Aug 2, 2013
P1/2, N=126, Completed,  Sponsor: Center for Human Reproduction
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Clinical: Improving Knowledge About Infertility; an Online Educational Tool (clinicaltrials.gov) - Aug 1, 2013
P=N/A, N=100, Not yet recruiting, Sponsor: Queen's University

||||||||||  zoledronic acid / Generic mfg.
Trial termination:  Zoledronate in Treating Patients With Cervical Intraepithelial Neoplasia 2/3 or 3 (clinicaltrials.gov) -  Aug 1, 2013
P2, N=12, Terminated,  Sponsor: University of California, San Francisco
Recruiting --> Completed Recruiting --> Terminated; Accrual was insufficient to meet study endpoints

|||||||||| Enrollment change: FOLFIV: Impact of Folates in the Care of the Male Infertility (clinicaltrials.gov) - Aug 1, 2013
P3, N=368, Recruiting, Sponsor: Assistance Publique - H
Recruiting --> Terminated; Accrual was insufficient to meet study endpoints N=780 --> 368

||||||||||  zoledronic acid / Generic mfg.
Enrollment change:  Zoledronate in Treating Patients With Cervical Intraepithelial Neoplasia 2/3 or 3 (clinicaltrials.gov) -  Aug 1, 2013
P2, N=12, Terminated,  Sponsor: University of California, San Francisco
N=780 --> 368 N=44 --> 12

||||||||||  cisplatin / Generic mfg., paclitaxel / Generic mfg.
Enrollment change, Metastases:  Cisplatin and Paclitaxel in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer (clinicaltrials.gov) -  Jul 31, 2013
P1, N=23, Completed,  Sponsor: Gynecologic Oncology Group
N=44 --> 12 N=40 --> 23

||||||||||  cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg., epirubicin / Generic mfg.
Trial completion:  Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer (clinicaltrials.gov) -  Jul 31, 2013
P3, N=400, Completed,  Sponsor: Nordic Society for Gynaecologic Oncology
N=40 --> 23 Active, not recruiting --> Completed

|||||||||| Trial suspension, Biopsy: NIDABRECHE: Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy (clinicaltrials.gov) - Jul 30, 2013
P3, N=358, Suspended, Sponsor: University Hospital, Bordeaux
Active, not recruiting --> Completed Recruiting --> Suspended

|||||||||| Enrollment change: Elecsys HE4 Chinese Reference Value Study (clinicaltrials.gov) - Jul 29, 2013
P=N/A, N=2351, Completed, Sponsor: Chinese PLA General Hospital
Recruiting --> Suspended N=1750 --> 2351

|||||||||| Trial completion: Elecsys HE4 Chinese Reference Value Study (clinicaltrials.gov) - Jul 29, 2013
P=N/A, N=2351, Completed, Sponsor: Chinese PLA General Hospital
N=1750 --> 2351 Recruiting --> Completed

|||||||||| Enrollment change: Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS) (clinicaltrials.gov) - Jul 28, 2013
P3, N=45, Active, not recruiting, Sponsor: Rogerio A. Lobo
Recruiting --> Completed N=60 --> 45

||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg., sorafenib / Generic mfg.
Enrollment change:  Paclitaxel and Carboplatin With Or Without Sorafenib In The First-Line Treatment Of Patients With Ovarian Cancer (clinicaltrials.gov) -  Jul 28, 2013
P2, N=85, Active, not recruiting,  Sponsor: SCRI Development Innovations, LLC
N=60 --> 45 N=60 --> 85

||||||||||  Victoza (liraglutide) / Novo Nordisk
New P4 trial:  Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin (clinicaltrials.gov) -  Jul 28, 2013
P4, N=36, Completed,  Sponsor: University Medical Centre Ljubljana

|||||||||| Enrollment closed: Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer (clinicaltrials.gov) - Jul 25, 2013
P2, N=60, Active, not recruiting, Sponsor: Ohio State University Comprehensive Cancer Center
N=60 --> 85 Recruiting --> Active, not recruiting

|||||||||| Trial completion: Relationship Between Bladder Distention and Hysteroscopy Application (clinicaltrials.gov) - Jul 24, 2013
P=N/A, N=102, Completed, Sponsor: Namik Kemal University
Recruiting --> Active, not recruiting Recruiting --> Completed

||||||||||  Synarel (nafarelin) / Pfizer
Enrollment change:  Natural Versus HRT Cycles in Frozen Embryo Replacement Treatment (clinicaltrials.gov) -  Jul 23, 2013
P4, N=159, Completed,  Sponsor: University of Oxford
Recruiting --> Completed N=100 --> 159

||||||||||  Synarel (nafarelin) / Pfizer
Trial completion:  Natural Versus HRT Cycles in Frozen Embryo Replacement Treatment (clinicaltrials.gov) -  Jul 23, 2013
P4, N=159, Completed,  Sponsor: University of Oxford
N=100 --> 159 Enrolling by invitation --> Completed

|||||||||| New P2 trial: Role of Bladder Training During Post-operative Hospital Stay After Radical Hysterectomy in Patients (clinicaltrials.gov) - Jul 23, 2013
P2, N=111, Completed, Sponsor: Catholic University of the Sacred Heart

|||||||||| Trial completion: Role of Bladder Training During Post-operative Hospital Stay After Radical Hysterectomy in Patients (clinicaltrials.gov) - Jul 23, 2013
P2, N=111, Completed, Sponsor: Catholic University of the Sacred Heart
Enrolling by invitation --> Completed Not yet recruiting --> Completed

||||||||||  leuprolide acetate for depot suspension / Generic mfg.
Enrollment change:  GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles. (clinicaltrials.gov) -  Jul 22, 2013
P=N/A, N=180, Completed,  Sponsor: University of Ioannina
Not yet recruiting --> Completed N=120 --> 180

||||||||||  Zejula (niraparib) / GSK, J&J
Trial completion, Metastases:  A Study of MK4827 in Participants With Advanced Solid Tumors or Hematologic Malignancies (MK-4827-001 AM8) (clinicaltrials.gov) -  Jul 22, 2013
P1, N=113, Completed,  Sponsor: Tesaro, Inc.
N=120 --> 180 Active, not recruiting --> Completed

|||||||||| Trial initiation date, MRI: MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer (clinicaltrials.gov) - Jul 21, 2013
P1/2, N=10, Recruiting, Sponsor: Washington University School of Medicine
Active, not recruiting --> Completed Initiation date: Feb 2010 --> Nov 2010

|||||||||| Enrollment change, MRI: MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer (clinicaltrials.gov) - Jul 21, 2013
P1/2, N=10, Recruiting, Sponsor: Washington University School of Medicine
Initiation date: Feb 2010 --> Nov 2010 N=30 --> 10

|||||||||| New P2 trial, Surgery: CILOVE: Feasibility of Interval Debulking Surgery by Laparoscopy for Peritoneal Carcinosis in Chemosensitive Patients (clinicaltrials.gov) - Jul 21, 2013
P2, N=47, Recruiting, Sponsor: Centre Jean Perrin

||||||||||  veliparib (ABT-888) / AbbVie
Trial completion, Combination therapy:  A Trial of ABT-888 in Combination With Temozolomide Versus Pegylated Liposomal Doxorubicin Alone in Ovarian Cancer (clinicaltrials.gov) -  Jul 21, 2013
P2, N=168, Completed,  Sponsor: AbbVie (prior sponsor, Abbott)
N=30 --> 10 Active, not recruiting --> Completed

|||||||||| Clinical: Internet-based Study of Fertility and Early Pregnancy (PEEPS) (clinicaltrials.gov) - Jul 18, 2013
P=N/A, N=200, Recruiting, Sponsor: Courtney D.Lynch, PhD MPH