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161 Mechanisms of Action

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||||||||||  Kombiglyze XR (saxagliptin/metformin XR) / AstraZeneca
New P3 trial, Monotherapy:  BMS-AZPCOS: Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis (clinicaltrials.gov) -  Dec 25, 2013
P3, N=36, Recruiting,  Sponsor: BC Women's Hospital & Health Centre

||||||||||  metformin / Generic mfg.
Trial completion:  Efficacy of Metformin and Diane-35 on PCOS Patients,a Randomized, Controlled, Prospective Clinical Trial (clinicaltrials.gov) -  Dec 25, 2013
P=N/A, N=40, Completed,  Sponsor: Chongqing Medical University
Recruiting --> Completed

||||||||||  estradiol valerate / Generic mfg.
Enrollment change:  Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol (clinicaltrials.gov) -  Dec 22, 2013
P4, N=63, Completed,  Sponsor: Meir Medical Center
Recruiting --> Completed N=100 --> 63

||||||||||  estradiol valerate / Generic mfg.
Trial completion:  Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol (clinicaltrials.gov) -  Dec 22, 2013
P4, N=63, Completed,  Sponsor: Meir Medical Center
N=100 --> 63 Not yet recruiting --> Completed

||||||||||  Zomacton (somatropin) / Ferring
Adherence:  ZOMAXEPT: Evaluation of the Adherence and the Patient Acceptability of Zomacton (clinicaltrials.gov) -  Dec 19, 2013
P=N/A, N=90, Not yet recruiting,  Sponsor: Ferring Pharmaceuticals

||||||||||  Pexa-Vec (pexastimogene devacirepvec) / SillaJen
New P2 trial:  Phase 2 Study of JX-594 in Patients With Peritoneal Carcinomatosis of Ovarian Cancer Origin (clinicaltrials.gov) -  Dec 19, 2013
P2, N=25, Not yet recruiting,  Sponsor: Andrea McCart

||||||||||  Avastin (bevacizumab) / Roche
Trial withdrawal, Platinum resistant:  Safety and Efficacy Study of Gemcitabine Plus Bevacizumab in Patients With Platinum-Resistant Ovarian, Primary Peritoneal or Fallopian Tube Cancer (clinicaltrials.gov) -  Dec 18, 2013
P2, N=0, Withdrawn,  Sponsor: Emory University
Not yet recruiting --> Completed Recruiting --> Withdrawn

|||||||||| Trial suspension: Image-guided Adaptive Radiotherapy for Cervix Cancer: Patient Image Acquisition (clinicaltrials.gov) - Dec 18, 2013
P=N/A, N=25, Suspended, Sponsor: Virginia Commonwealth University
Recruiting --> Withdrawn Recruiting --> Suspended

||||||||||  Avastin (bevacizumab) / Roche
Enrollment change, Platinum resistant:  Safety and Efficacy Study of Gemcitabine Plus Bevacizumab in Patients With Platinum-Resistant Ovarian, Primary Peritoneal or Fallopian Tube Cancer (clinicaltrials.gov) -  Dec 18, 2013
P2, N=0, Withdrawn,  Sponsor: Emory University
Recruiting --> Suspended N=37 --> 0

|||||||||| New P2 trial: Effect of Curcumin Addition to Standard Treatment on Tumour-induced Inflammation in Endometrial Carcinoma (clinicaltrials.gov) - Dec 18, 2013
P2, N=10, Recruiting, Sponsor: University Hospital, Gasthuisberg

|||||||||| Enrollment open: Phase III Study Comparing Efficacy and Safety of AFOLIA vs Gonal-f (clinicaltrials.gov) - Dec 18, 2013
P3, N=1106, Recruiting, Sponsor: Finox AG
N=37 --> 0 Not yet recruiting --> Recruiting

|||||||||| Enrollment closed: IVF Clinical Trial of Two Different Treatment Protocols. (clinicaltrials.gov) - Dec 18, 2013
P=N/A, N=564, Active, not recruiting, Sponsor: New Hope Fertility Center
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

||||||||||  Vivelle (estradiol transdermal system) / Sanofi, Hisamitsu, Novartis, Estreva oral (estradiol oral) / EMD Serono, Estrace (estradiol) / AbbVie
Trial completion:  Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism (clinicaltrials.gov) -  Dec 18, 2013
P4, N=41, Completed,  Sponsor: Nemours Children's Clinic
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  Baxdela (delafloxacin) / Menarini, Melinta Therap
New P3 trial:  Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea (clinicaltrials.gov) -  Dec 17, 2013
P3, N=757, Recruiting,  Sponsor: Melinta Therapeutics, Inc.

||||||||||  IDC-G305 / Merck (MSD)
New P1 trial:  A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer (clinicaltrials.gov) -  Dec 17, 2013
P1, N=30, Recruiting,  Sponsor: Immune Design

||||||||||  IDC-G305 / Merck (MSD)
Enrollment open:  A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer (clinicaltrials.gov) -  Dec 17, 2013
P1, N=30, Recruiting,  Sponsor: Immune Design
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg., docetaxel / Generic mfg.
Trial completion:  Carboplatin Plus Paclitaxel or Docetaxel in Treating Patients With Ovarian Epithelial Cancer (clinicaltrials.gov) -  Dec 17, 2013
P3, N=1050, Completed,  Sponsor: University of Glasgow
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

||||||||||  epacadostat (INCB024360) / Incyte
Trial withdrawal, Combination therapy:  Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Are in Remission (clinicaltrials.gov) -  Dec 16, 2013
P1/2, N=0, Withdrawn,  Sponsor: Roswell Park Cancer Institute
Active, not recruiting --> Completed Not yet recruiting --> Withdrawn

||||||||||  epacadostat (INCB024360) / Incyte
Enrollment change, Combination therapy:  Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Are in Remission (clinicaltrials.gov) -  Dec 16, 2013
P1/2, N=0, Withdrawn,  Sponsor: Roswell Park Cancer Institute
Not yet recruiting --> Withdrawn N=92 --> 0

|||||||||| New P4 trial: Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis (clinicaltrials.gov) - Dec 16, 2013
P4, N=0, Completed, Sponsor: AGUNCO Obstetrics and Gynecology Centre

||||||||||  Korlym (mifepristone) / Corcept Therap
New P1 trial:  Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors (clinicaltrials.gov) -  Dec 16, 2013
P1, N=40, Recruiting,  Sponsor: Corcept Therapeutics

||||||||||  medroxyprogesterone injection / Generic mfg.
Trial completion:  DMPA & High Dose Oral Progestin (MPA) Tablets in Outpatient Treatment of Acute Excessive Vaginal Bleeding (clinicaltrials.gov) -  Dec 16, 2013
P4, N=48, Completed,  Sponsor: Women's Health Care Clinic, Torrance, California
N=92 --> 0 Recruiting --> Completed

|||||||||| Trial completion, Surgery: Surgery With or Without Lymphadenectomy and Radiation Therapy in Treating Patients With Endometrial Cancer (clinicaltrials.gov) - Dec 16, 2013
P3, N=2300, Completed, Sponsor: Medical Research Council
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment open: Hysteroscopic Assessment of Fallopian Tubal Patency (clinicaltrials.gov) - Dec 15, 2013
P=N/A, N=500, Recruiting, Sponsor: University of Mississippi Medical Center
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment open: Polycystic Ovary Syndrome - Improving Outcomes (clinicaltrials.gov) - Dec 15, 2013
P4, N=42, Recruiting, Sponsor: Baker IDI Heart and Diabetes Institute
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

||||||||||  Orgalutran (ganirelix acetate) / Organon, Follistim AQ Cartridge (follitropin beta) / Organon
Trial initiation date:  Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH (clinicaltrials.gov) -  Dec 12, 2013
P4, N=135, Completed,  Sponsor: Eugonia
Not yet recruiting --> Recruiting Initiation date: Oct 2003 --> Jan 2007

||||||||||  Orgalutran (ganirelix acetate) / Organon, Follistim AQ Cartridge (follitropin beta) / Organon
Enrollment change:  Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH (clinicaltrials.gov) -  Dec 12, 2013
P4, N=135, Completed,  Sponsor: Eugonia
Initiation date: Oct 2003 --> Jan 2007 N=48 --> 135

|||||||||| Trial completion: HIV Prevention Program for African American Teen Males (clinicaltrials.gov) - Dec 12, 2013
P=N/A, N=840, Completed, Sponsor: University of Kentucky
N=48 --> 135 Active, not recruiting --> Completed

||||||||||  Orgalutran (ganirelix acetate) / Organon, Follistim AQ Cartridge (follitropin beta) / Organon
Trial completion:  Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH (clinicaltrials.gov) -  Dec 12, 2013
P4, N=135, Completed,  Sponsor: Eugonia
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Erbitux (cetuximab) / Eli Lilly
Trial completion:  Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer (clinicaltrials.gov) -  Dec 11, 2013
P1, N=100, Completed,  Sponsor: Gynecologic Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  dexamethasone injection / Generic mfg.
Trial termination, Surgery:  Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions (clinicaltrials.gov) -  Dec 10, 2013
P=N/A, N=22, Terminated,  Sponsor: University Hospital, Gasthuisberg
Active, not recruiting --> Completed Recruiting --> Terminated; Investigator no longer works fulltime at investigational site

||||||||||  Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Biomarker, Enrollment change:  Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation (clinicaltrials.gov) -  Dec 10, 2013
P2, N=39, Completed,  Sponsor: CONRAD
Recruiting --> Terminated; Investigator no longer works fulltime at investigational site N=30 --> 39

||||||||||  dexamethasone injection / Generic mfg.
Enrollment change, Surgery:  Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions (clinicaltrials.gov) -  Dec 10, 2013
P=N/A, N=22, Terminated,  Sponsor: University Hospital, Gasthuisberg
N=30 --> 39 N=40 --> 22

||||||||||  azithromycin / Generic mfg.
Enrollment change:  Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China (clinicaltrials.gov) -  Dec 10, 2013
P=N/A, N=1373, Completed,  Sponsor: University of California, Los Angeles
N=40 --> 22 N=2640 --> 1373

||||||||||  veliparib (ABT-888) / AbbVie
New P1 trial:  A Study to Evaluate the Effects of Veliparib on Heart Rhythms in Patients With Solid Tumors (clinicaltrials.gov) -  Dec 10, 2013
P1, N=42, Recruiting,  Sponsor: AbbVie

||||||||||  Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Biomarker, Trial completion:  Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation (clinicaltrials.gov) -  Dec 10, 2013
P2, N=39, Completed,  Sponsor: CONRAD
N=2640 --> 1373 Active, not recruiting --> Completed

|||||||||| Trial completion: Effectiveness of Community-Level Behavioral and Biomedical Interventions for Reducing HIV/STIs in Men in Peru (clinicaltrials.gov) - Dec 10, 2013
P=N/A, N=718, Completed, Sponsor: University of California, Los Angeles
Active, not recruiting --> Completed Recruiting --> Completed

||||||||||  azithromycin / Generic mfg.
Trial completion:  Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China (clinicaltrials.gov) -  Dec 10, 2013
P=N/A, N=1373, Completed,  Sponsor: University of California, Los Angeles
Recruiting --> Completed Recruiting --> Completed

|||||||||| Clinical: Randomized Evaluation of a Multi-Component, Rights-Based Sexuality Education Initiative for High School Students (clinicaltrials.gov) - Dec 9, 2013
P=N/A, N=2379, Active, not recruiting, Sponsor: Public Health Institute, California

|||||||||| New P2 trial: Salpingectomy Versus Aspiration of Hydrosalpingeal Fluid Prior to IVF-ET (clinicaltrials.gov) - Dec 9, 2013
P2, N=140, Recruiting, Sponsor: Aljazeera Hospital

|||||||||| Trial withdrawal: Post Operative Continuous Active Combination Sex Steroids for the Prevention of Recurrent Endometrioma Formation (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=0, Withdrawn, Sponsor: University of Oklahoma
Recruiting --> Completed Terminated --> Withdrawn

|||||||||| Trial termination: The Luveris In Vitro Fertilization Trial (clinicaltrials.gov) - Dec 8, 2013
P4, N=14, Terminated, Sponsor: University Reproductive Associates
Terminated --> Withdrawn Active, not recruiting --> Terminated; Drug no longer available by manufacturer

|||||||||| Enrollment change: Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles. (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=75, Completed, Sponsor: University Reproductive Associates
Active, not recruiting --> Terminated; Drug no longer available by manufacturer N=100 --> 75

|||||||||| Enrollment change: The Luveris In Vitro Fertilization Trial (clinicaltrials.gov) - Dec 8, 2013
P4, N=14, Terminated, Sponsor: University Reproductive Associates
N=100 --> 75 N=30 --> 14

|||||||||| Surgery: Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=121, Completed, Sponsor: Seoul National University Hospital

||||||||||  ethinyl estradiol/levonorgestrel / Generic mfg.
Enrollment open:  Treatment of Unacceptable Bleeding Patterns in ETG Implant Users With an Oral Contraceptive (clinicaltrials.gov) -  Dec 8, 2013
P4, N=130, Recruiting,  Sponsor: University of California, Davis
N=30 --> 14 Not yet recruiting --> Recruiting

|||||||||| Enrollment open: FertilEX: Improved Fertility After Exercise in Overweight/Obese Women (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=370, Recruiting, Sponsor: Norwegian University of Science and Technology
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

||||||||||  Estrace topical (estradiol) / AbbVie, Estrace (estradiol) / AbbVie
Enrollment closed:  Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone (clinicaltrials.gov) -  Dec 8, 2013
P=N/A, N=13, Active, not recruiting,  Sponsor: University of Virginia
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Trial completion: In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS) (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=10, Completed, Sponsor: University Reproductive Associates
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| Trial completion: Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles. (clinicaltrials.gov) - Dec 8, 2013
P=N/A, N=75, Completed, Sponsor: University Reproductive Associates
Active, not recruiting --> Completed Active, not recruiting --> Completed