Essential Thrombocythemia MOAs

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Phase N/A 1 2 3 4 Products	0	3	6	9	12	15	18	21	24	27	30



CD20 inhib




FLT3 inhib




Purinergic receptor P1 agon




JAK2 inhib




IFNα stim




µ-opioid agon




CD20 inhib




HDAC2 inhib




IL-6 inhib




PLK1 inhib




DNA methylation inhib




GCR agon




GM-CSF agon




TNFα inhib




VEGFR-1 inhib




Apoptosis stim




CXCL12 inhib




Calcineurin inhib




Gonadotropin inhib




Hedgehog cell-signalling pathway inhib




IL-10 stim




IL-1β inhib




IL-2 stim




IL-6 inhib




IMPDH inhib




Immunosuppressant




NMDAR antag




PDGFR inhib




PI3K inhib




SMO protein inhib




TGF-β inhib




c-KIT inhib




5-lipoxygenase activating protein inhib




AKT inhib




Apoptosis inducer




Bone morphogenetic protein receptor type II mod




CD20 inhib




Cell cycle inhib




Connective tissue growth factor inhib




Cytokine mod




DGAT-1 inhib




EEF1A2 inhib




Factor X inhib




Farnesyl transferase inhib




GM-CSF agon




HSP90 inhib




Histamine release inhib




IL-12 inhib




IRAK-1 inhib




Integrin inhib



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