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12 Mechanisms of Action |
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185 News |
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- Enrollment closed: Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 (clinicaltrials.gov) - Jan 11, 2016
P=N/A, N=43, Active, not recruiting, Sponsor: Chugai Pharmaceutical
Recruiting --> Active, not recruiting
- Trial completion: Can Increased Body Mass Index Prevent Adequate Ultrasound Examination for Trisomy 21 Risk Assessment? (clinicaltrials.gov) - Jan 7, 2016
P=N/A, N=200, Completed, Sponsor: Benha University
Recruiting --> Active, not recruiting Recruiting --> Completed
- || Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
Enrollment closed, Enrollment change, Trial initiation date: Synagis® Liquid 50mg, 100mg for Intramuscular Injection Special Investigation in Immuno Compromised Children With Synagis (clinicaltrials.gov) - Dec 25, 2015
P=N/A, N=250, Active, not recruiting, Sponsor: AbbVie
Recruiting --> Completed Completed --> Active, not recruiting | N=327 --> 250 | Initiation date: Sep 2013 --> Dec 2013
- ||| Trial completion: Prenatal Screening for Down Syndrome With DNAFirst (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=100, Completed, Sponsor: Women and Infants Hospital of Rhode Island
Completed --> Active, not recruiting | N=327 --> 250 | Initiation date: Sep 2013 --> Dec 2013 Active, not recruiting --> Completed
- ||| Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
Trial completion, Enrollment change: Synagis® Liquid 50mg, 100mg for Intramuscular Injection Special Investigation in Immuno Compromised Children With Synagis (clinicaltrials.gov) - Dec 18, 2015
P=N/A, N=327, Completed, Sponsor: AbbVie
Active, not recruiting --> Completed Recruiting --> Completed | N=250 --> 327
- Enrollment open, Preclinical: DEPOSA: T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients (clinicaltrials.gov) - Dec 10, 2015
P=N/A, N=1000, Recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Completed | N=250 --> 327 Not yet recruiting --> Recruiting
- ||| basmisanil (RG1662) / Roche
Enrollment closed: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) (clinicaltrials.gov) - Nov 5, 2015
P2, N=173, Active, not recruiting, Sponsor: Hoffmann-La Roche
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool (clinicaltrials.gov) - Oct 27, 2015
P2, N=87, Completed, Sponsor: Parc de Salut Mar
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Jun 2014
- Enrollment change, Trial termination, Trial primary completion date: Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies (clinicaltrials.gov) - Sep 17, 2015
P=N/A, N=50, Terminated, Sponsor: Sequenom, Inc.
Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Jun 2014 N=1000 --> 50 | Recruiting --> Terminated | Trial primary completion date: Feb 2015 --> Sep 2015; Slow enrollment of eligible subjects
- | basmisanil (RG1662) / Roche
Enrollment open: A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age (clinicaltrials.gov) - Sep 2, 2015
P2, N=36, Recruiting, Sponsor: Hoffmann-La Roche
N=1000 --> 50 | Recruiting --> Terminated | Trial primary completion date: Feb 2015 --> Sep 2015; Slow enrollment of eligible subjects Not yet recruiting --> Recruiting
- Trial completion, Enrollment change, Trial primary completion date: Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model (clinicaltrials.gov) - Aug 15, 2015
P=N/A, N=30, Completed, Sponsor: University of Arkansas
Not yet recruiting --> Recruiting Recruiting --> Completed | N=60 --> 30 | Trial primary completion date: Jan 2016 --> Aug 2015
- Enrollment change, Trial termination, Trial primary completion date: Detecting Early Onset Pre-eclampsia and Use of Placental Growth Factor (PlGF) for Marker of Trisomy 21 (clinicaltrials.gov) - Aug 12, 2015
P=N/A, N=370, Terminated, Sponsor: OVO R & D
Recruiting --> Completed | N=60 --> 30 | Trial primary completion date: Jan 2016 --> Aug 2015 N=2000 --> 370 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Jun 2015; The technique has been approved and validated
- || Enrollment closed, Trial primary completion date: Prenatal Screening for Down Syndrome With DNAFirst (clinicaltrials.gov) - Jul 17, 2015
P=N/A, N=100, Active, not recruiting, Sponsor: Women and Infants Hospital of Rhode Island
N=2000 --> 370 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Jun 2015; The technique has been approved and validated Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Jul 2015
- || Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
Trial primary completion date: Synagis® Liquid 50mg, 100mg for Intramuscular Injection Special Investigation in Immuno Compromised Children With Synagis (clinicaltrials.gov) - Jul 14, 2015
P=N/A, N=250, Recruiting, Sponsor: AbbVie
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Jul 2015 Trial primary completion date: Sep 2015 --> Dec 2015
- Trial completion, Trial primary completion date: SAOS/T21: Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome (clinicaltrials.gov) - Jul 9, 2015
P=N/A, N=97, Completed, Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Trial primary completion date: Sep 2015 --> Dec 2015 Active, not recruiting --> Completed | Trial primary completion date: Jun 2015 --> Feb 2015
- | basmisanil (RG1662) / Roche
New P2 trial: A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age (clinicaltrials.gov) - Jun 30, 2015
P2, N=36, Not yet recruiting, Sponsor: Hoffmann-La Roche
- Enrollment open: Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 (clinicaltrials.gov) - Jun 20, 2015
P=N/A, N=40, Recruiting, Sponsor: Chugai Pharmaceutical
Active, not recruiting --> Completed | Trial primary completion date: Jun 2015 --> Feb 2015 Not yet recruiting --> Recruiting
- Enrollment open: Can Increased Body Mass Index Prevent Adequate Ultrasound Examination for Trisomy 21 Risk Assessment? (clinicaltrials.gov) - Jun 15, 2015
P=N/A, N=200, Recruiting, Sponsor: Benha University
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- New trial: Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome (clinicaltrials.gov) - May 22, 2015
P=N/A, N=42, Recruiting, Sponsor: Hoffmann-La Roche
- New trial: Can Increased Body Mass Index Prevent Adequate Ultrasound Examination for Trisomy 21 Risk Assessment? (clinicaltrials.gov) - May 14, 2015
P=N/A, N=200, Not yet recruiting, Sponsor: Benha University
- Biomarker, Enrollment closed: Biomarkers in Samples From Patients With Down Syndrome and Acute Megakaryoblastic Leukemia (clinicaltrials.gov) - May 6, 2015
P=N/A, N=10, Active, not recruiting, Sponsor: Children's Oncology Group
Not yet recruiting --> Recruiting Completed --> Active, not recruiting
- New trial: Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 (clinicaltrials.gov) - Apr 30, 2015
P=N/A, N=40, Not yet recruiting, Sponsor: Chugai Pharmaceutical
- New trial, Preclinical: DEPOSA: T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients (clinicaltrials.gov) - Apr 23, 2015
P=N/A, N=1000, Not yet recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
- ||| Enrollment open, Trial primary completion date: RCT/DD: DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities (clinicaltrials.gov) - Apr 14, 2015
P=N/A, N=64, Recruiting, Sponsor: Kingkaew Pajareya
Completed --> Active, not recruiting Not yet recruiting --> Recruiting | Trial primary completion date: Mar 2015 --> Mar 2017
- Enrollment closed: Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome (clinicaltrials.gov) - Apr 8, 2015
P=N/A, N=27, Active, not recruiting, Sponsor: Children's Hospital of Philadelphia
Not yet recruiting --> Recruiting | Trial primary completion date: Mar 2015 --> Mar 2017 Completed --> Active, not recruiting
- ||| basmisanil (RG1662) / Roche
Trial completion, Enrollment change, Trial primary completion date: A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) (clinicaltrials.gov) - Jan 28, 2015
P=N/A, N=118, Completed, Sponsor: Hoffmann-La Roche
Completed --> Active, not recruiting Recruiting --> Completed | N=170 --> 118 | Trial primary completion date: Dec 2015 --> Dec 2014
- Trial primary completion date: Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model (clinicaltrials.gov) - Jan 26, 2015
P=N/A, N=60, Recruiting, Sponsor: University of Arkansas
Recruiting --> Completed | N=170 --> 118 | Trial primary completion date: Dec 2015 --> Dec 2014 Trial primary completion date: Jan 2015 --> Jan 2016
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) (clinicaltrials.gov) - Dec 25, 2014
P=N/A, N=170, Recruiting, Sponsor: Hoffmann-La Roche
Trial primary completion date: Jan 2015 --> Jan 2016 Trial primary completion date: Sep 2015 --> Dec 2015
- || Trial primary completion date: Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=3333, Active, not recruiting, Sponsor: Sequenom, Inc.
Trial primary completion date: Sep 2015 --> Dec 2015 Trial primary completion date: Jun 2014 --> Feb 2014
- || Enrollment closed, Enrollment change: Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=3062, Active, not recruiting, Sponsor: Sequenom, Inc.
Trial primary completion date: Jun 2014 --> Feb 2014 Recruiting --> Active, not recruiting | N=2200 --> 3062
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) (clinicaltrials.gov) - Nov 25, 2014
P2, N=180, Recruiting, Sponsor: Hoffmann-La Roche
Recruiting --> Active, not recruiting | N=2200 --> 3062 Trial primary completion date: Dec 2015 --> Aug 2015
- Trial primary completion date: Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite (clinicaltrials.gov) - Nov 7, 2014
P=N/A, N=300, Recruiting, Sponsor: Oregon Health and Science University
Trial primary completion date: Dec 2015 --> Aug 2015 Trial primary completion date: Jun 2014 --> Jun 2015
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) (clinicaltrials.gov) - Nov 4, 2014
P2, N=180, Recruiting, Sponsor: Hoffmann-La Roche
Trial primary completion date: Jun 2014 --> Jun 2015 Trial primary completion date: Aug 2015 --> Dec 2015
- Trial completion: Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia (clinicaltrials.gov) - Oct 31, 2014
P3, N=25, Completed, Sponsor: Fred Hutchinson Cancer Research Center
Trial primary completion date: Aug 2015 --> Dec 2015 Active, not recruiting --> Completed
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) (clinicaltrials.gov) - Oct 22, 2014
P2, N=180, Recruiting, Sponsor: Hoffmann-La Roche
Active, not recruiting --> Completed Trial primary completion date: Nov 2015 --> Aug 2015
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) (clinicaltrials.gov) - Oct 17, 2014
P2, N=180, Recruiting, Sponsor: Hoffmann-La Roche
Trial primary completion date: Nov 2015 --> Aug 2015 Trial primary completion date: Aug 2015 --> Nov 2015
- || basmisanil (RG1662) / Roche
Trial primary completion date: A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) (clinicaltrials.gov) - Oct 17, 2014
P=N/A, N=170, Recruiting, Sponsor: Hoffmann-La Roche
Trial primary completion date: Aug 2015 --> Nov 2015 Trial primary completion date: Aug 2014 --> Sep 2015
- ||| Trial completion, Enrollment change, Trial primary completion date: Use of eHealth in Communication With Patients About Prenatal Diagnosis (clinicaltrials.gov) - Oct 17, 2014
P=N/A, N=1150, Completed, Sponsor: Odense University Hospital
Trial primary completion date: Aug 2014 --> Sep 2015 Not yet recruiting --> Completed | N=600 --> 1150 | Trial primary completion date: Feb 2014 --> Aug 2014
- | rivastigmine / Generic mfg.
Trial completion: DS-Riv: Rivastigmine Study in Adolescents With Down Syndrome (clinicaltrials.gov) - Oct 10, 2014
P1/2, N=42, Completed, Sponsor: Duke University
Not yet recruiting --> Completed | N=600 --> 1150 | Trial primary completion date: Feb 2014 --> Aug 2014 Active, not recruiting --> Completed
- ||| Clinical: Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies (clinicaltrials.gov) - Aug 27, 2014
P=N/A, N=1000, Recruiting, Sponsor: Sequenom, Inc.
- || Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
Trial initiation date: Synagis® Liquid 50mg, 100mg for Intramuscular Injection Special Investigation in Immuno Compromised Children With Synagis (clinicaltrials.gov) - Aug 19, 2014
P=N/A, N=250, Recruiting, Sponsor: AbbVie
Active, not recruiting --> Completed Initiation date: Dec 2013 --> Sep 2013
- Enrollment open: Intensive Dysarthria Sessions in Adults and Children With Down Syndrome (clinicaltrials.gov) - Aug 11, 2014
P=N/A, N=12, Recruiting, Sponsor: Duke University
Initiation date: Dec 2013 --> Sep 2013 Not yet recruiting --> Recruiting
- Trial completion, Enrollment change, Trial primary completion date: Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome (clinicaltrials.gov) - Aug 11, 2014
P=N/A, N=27, Completed, Sponsor: Children's Hospital of Philadelphia
Not yet recruiting --> Recruiting Recruiting --> Completed | N=87 --> 27 | Trial primary completion date: Dec 2014 --> Mar 2014
- Enrollment closed, Trial primary completion date: SAOS/T21: Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome (clinicaltrials.gov) - Aug 5, 2014
P=N/A, N=120, Active, not recruiting, Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Recruiting --> Completed | N=87 --> 27 | Trial primary completion date: Dec 2014 --> Mar 2014 Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Jun 2015
- ||| Trial completion: Non-invasive Chromosomal Examination of Trisomy Study (clinicaltrials.gov) - Jul 14, 2014
P=N/A, N=18955, Completed, Sponsor: Ariosa Diagnostics, Inc
Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Jun 2015 Active, not recruiting --> Completed
- Enrollment open: Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model (clinicaltrials.gov) - Jun 26, 2014
P=N/A, N=60, Recruiting, Sponsor: University of Arkansas
Active, not recruiting --> Completed Active, not recruiting --> Recruiting
- ||| Enrollment open: Prenatal Screening for Down Syndrome With DNAFirst (clinicaltrials.gov) - Jun 24, 2014
P=N/A, N=100, Recruiting, Sponsor: Women and Infants Hospital of Rhode Island
Active, not recruiting --> Recruiting Not yet recruiting --> Recruiting
- ||| Enrollment open, Trial initiation date: Prenatal Screening for Down Syndrome With DNAFirst (clinicaltrials.gov) - Jun 19, 2014
P=N/A, N=100, Not yet recruiting, Sponsor: Women and Infants Hospital of Rhode Island
Not yet recruiting --> Recruiting Initiation date: Nov 2013 --> Mar 2014 | Not yet recruiting --> Recruiting
- Clinical: Phenotypic Specific Communication Intervention for Children With Down Syndrome (clinicaltrials.gov) - Jun 4, 2014
P=N/A, N=82, Recruiting, Sponsor: Vanderbilt University
- Biomarker: Down Syndrome Biomarker Initiative (DSBI) (clinicaltrials.gov) - May 18, 2014
P=N/A, N=12, Active, not recruiting, Sponsor: Alzheimer's Disease Cooperative Study (ADCS)