Disease Progression MOAs

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Phase N/A 1 2 3 4 Products	0	5	10	15	20	25	30	35	40	45	50



VEGFR inhib




CD20 inhib




Purinergic receptor P1 agon




VEGFR inhib




AKT inhib




Androgen receptor inhib




PDGFR α antag




CD20 inhib




EGFR inhib




c-KIT inhib




DNA cross linking agent




IFNα stim




IL-6 inhib




FGFR2 inhib




Tubulin inhib




HER2 dimerization inhib




HMG-CoA reductase inhib




TNFα inhib




AKT inhib




BRAF V600E inhib




COX2 inhib




GCR agon




HIF-1 inhib




IGF-1 stim




PI3K inhib




PIGF inhib




GnRH agon




IL-1β inhib




IL-6 inhib




TIE-2 inhib




mTOR inhib




Angiotensin receptor antag




CD20 inhib




Estrogen receptor agon




Glutamic acid decarboxylase gene therapy




IL-2 stim




Immunosuppressant




Insulin receptor agon




NF-κB inhib




Steryl sulfatase inhib




TGF-β inhib




Bcl2 inhib




Bcl2 inhib




CD80 inhib




CXCL12 inhib




Calcineurin inhib




Fatty acid inhib




Fyn inhib




Histamine H1 receptor antag




IL-12 inhib



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