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122 Companies |
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196 Products |
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196 Products |
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116 Mechanisms of Action |
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3 Trials |
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2338 News |
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- Trial completion: Home Safety Clinical Trial for Alzheimer's Disease (clinicaltrials.gov) - Jan 26, 2012
P1, N=254, Completed, Sponsor: Department of Veterans Affairs
Active, not recruiting --> Completed
- haloperidol / Generic mfg., dexmedetomidine / Generic mfg.
Surgery: DexinDelir: Dexmedetomidine for the Treatment of Delirium After Heart Surgery (clinicaltrials.gov) - Jan 24, 2012
P3, N=3, Terminated, Sponsor: Thorax-Kärlkliniken
Active, not recruiting --> Completed Recruiting --> Terminated; Slow recruitment
- Trial termination: MemoryXL Effects on Mild Cognitive Impairment Patients (clinicaltrials.gov) - Jan 24, 2012
P2, N=10, Terminated, Sponsor: University of Oklahoma
Recruiting --> Terminated; Slow recruitment Completed --> Terminated; Risk/benefit ratio did not indicate further study would be useful, or fair to future subjects.
- haloperidol / Generic mfg., dexmedetomidine / Generic mfg.
Surgery: DexinDelir: Dexmedetomidine for the Treatment of Delirium After Heart Surgery (clinicaltrials.gov) - Jan 24, 2012
P3, N=3, Terminated, Sponsor: Thorax-Kärlkliniken
Completed --> Terminated; Risk/benefit ratio did not indicate further study would be useful, or fair to future subjects. N=75 --> 3
- rivastigmine transdermal / Generic mfg.
New P4 trial: Mild Cognitive Impairment in Parkinson's Disease (clinicaltrials.gov) - Jan 24, 2012
P4, N=28, Recruiting, Sponsor: University of Pennsylvania
- ||||| New P2 trial: Clinical Evaluation of Florbetapir F 18 (18F-AV-45) (clinicaltrials.gov) - Jan 24, 2012
P2, N=1800, Recruiting, Sponsor: Avid Radiopharmaceuticals
- | Albutein 5% (human albumin, 5%) / Grifols
Trial completion: Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid (clinicaltrials.gov) - Jan 22, 2012
P2, N=42, Completed, Sponsor: Instituto Grifols, S.A.
N=75 --> 3 Active, not recruiting --> Completed
- | Trial completion: To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden (clinicaltrials.gov) - Jan 18, 2012
P2, N=25, Completed, Sponsor: AstraZeneca
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Trial completion: Florbetaben (BAY94-9172) PET (Positron Emission Tomography) Imaging in MCI (Mild Cognitive Impairment) Patients (clinicaltrials.gov) - Jan 18, 2012
P1, N=45, Completed, Sponsor: Piramal Imaging SA
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Trial termination: CONCERT PLUS: An Extension of the CONCERT Protocol (DIM18) (clinicaltrials.gov) - Jan 17, 2012
P3, N=672, Terminated, Sponsor: Medivation, Inc.
Active, not recruiting --> Completed Active, not recruiting --> Terminated
- | memantine / Generic mfg.
Trial termination: Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) - Jan 17, 2012
P3, N=369, Terminated, Sponsor: H. Lundbeck A/S
Active, not recruiting --> Terminated Completed --> Terminated
- ||| selisistat (SEN-196) / AOP Orphan Pharma
New P1 trial: Escalating Dose Study in Healthy Volunteers With SEN0014196 (clinicaltrials.gov) - Jan 12, 2012
P1, N=88, Completed, Sponsor: Siena Biotech S.p.A.
- Trial completion: Using Behavioral Programs to Treat Sleep Problems in Individuals With Alzheimer's Disease (clinicaltrials.gov) - Jan 11, 2012
P=N/A, N=132, Completed, Sponsor: University of Washington
Completed --> Terminated Active, not recruiting --> Completed
- ||||||| pregabalin / Generic mfg.
Trial completion: Pregabalin in the Prevention of Postoperative Delirium and Pain (clinicaltrials.gov) - Jan 8, 2012
P3, N=240, Completed, Sponsor: Ottawa Hospital Research Institute
Active, not recruiting --> Completed Recruiting --> Completed
- atenolol / Generic mfg.
Enrollment change, Surgery: Elder Surgery - Functional Recovery Following Beta Blockade (clinicaltrials.gov) - Jan 4, 2012
P4, N=359, Completed, Sponsor: Mount Sinai School of Medicine
Recruiting --> Completed N=600 --> 359
- | resveratrol (DB02709) / Alzheimer's Disease Cooperative Study
Biomarker, New P2 trial: Resveratrol for Alzheimer's Disease (clinicaltrials.gov) - Jan 4, 2012
P2, N=120, Active, not recruiting, Sponsor: Alzheimer's Disease Cooperative Study (ADCS)
- | New P2 trial: Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients (clinicaltrials.gov) - Jan 4, 2012
P2, N=20, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
- | New P1/2 trial: A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET) (clinicaltrials.gov) - Jan 2, 2012
P1/2, N=30, Completed, Sponsor: Avid Radiopharmaceuticals
- Trial withdrawal: Facilitating Numerical Processing With Transcranial Stimulation in Developmental Dyscalculia (clinicaltrials.gov) - Dec 29, 2011
P=N/A, N=0, Withdrawn, Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
N=600 --> 359 Completed --> Withdrawn
- Enrollment change: Facilitating Numerical Processing With Transcranial Stimulation in Developmental Dyscalculia (clinicaltrials.gov) - Dec 29, 2011
P=N/A, N=0, Withdrawn, Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Completed --> Withdrawn N=60 --> 0
- | New P2 trial: Neuroprotection by Cannabinoids in Huntington's Disease (clinicaltrials.gov) - Dec 28, 2011
P2, N=25, Completed, Sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
- Biomarker, Enrollment open: Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment (clinicaltrials.gov) - Dec 27, 2011
P=N/A, N=210, Recruiting, Sponsor: Qualissima
N=60 --> 0 Not yet recruiting --> Recruiting
- Enrollment closed: Online Caregiver Psychoeducation and Support for Alzheimer's (clinicaltrials.gov) - Dec 22, 2011
P2, N=204, Active, not recruiting, Sponsor: Department of Veterans Affairs
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- |||| edonerpic (T-817MA) / Fujifilm Holdings
Trial completion: Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Dec 21, 2011
P2, N=373, Completed, Sponsor: Toyama Chemical Co., Ltd.
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- remifentanil / Generic mfg., sevoflurane / Generic mfg.
Enrollment change: Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia (clinicaltrials.gov) - Dec 20, 2011
P=N/A, N=112, Completed, Sponsor: University of British Columbia
Active, not recruiting --> Completed N=190 --> 112
- remifentanil / Generic mfg., sevoflurane / Generic mfg.
Trial completion: Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia (clinicaltrials.gov) - Dec 20, 2011
P=N/A, N=112, Completed, Sponsor: University of British Columbia
N=190 --> 112 Recruiting --> Completed
- verubecestat (MK-8931) / Merck (MSD)
New P1 trial: A Study of the Safety, Tolerability, and Pharmacodynamics of MK-8931 in Participants With Alzheimer's Disease (MK-8931-010 AM1 [P07820 AM1]) (clinicaltrials.gov) - Dec 19, 2011
P1, N=32, Completed, Sponsor: Merck
- | AD03 / AFFiRiS
Trial completion: MimoVax: Safety and Tolerability of AFFITOPE AD03 (clinicaltrials.gov) - Dec 18, 2011
P1, N=28, Completed, Sponsor: Affiris AG
Recruiting --> Completed Recruiting --> Completed
- atomoxetine / Generic mfg.
Enrollment change: The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) Genotype (clinicaltrials.gov) - Dec 13, 2011
P2, N=11, Terminated, Sponsor: National Institute of Mental Health (NIMH)
Recruiting --> Completed N=180 --> 11
- ||| epothilone D (BMS-241027) / BMS
Biomarker, New P1 trial: Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease (clinicaltrials.gov) - Dec 13, 2011
P1, N=100, Recruiting, Sponsor: Bristol-Myers Squibb
- Trial completion, Surgery: Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up (clinicaltrials.gov) - Dec 12, 2011
P=N/A, N=225, Completed, Sponsor: Lene Krenk
N=180 --> 11 Active, not recruiting --> Completed
- Enrollment change: Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases (clinicaltrials.gov) - Dec 7, 2011
P=N/A, N=70, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
Active, not recruiting --> Completed N=100 --> 70
- Trial completion: Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases (clinicaltrials.gov) - Dec 7, 2011
P=N/A, N=70, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
N=100 --> 70 Recruiting --> Completed
- Trial completion: Assessment of Sleep Disturbance in Alzheimer Disease (clinicaltrials.gov) - Dec 7, 2011
P=N/A, N=70, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
Recruiting --> Completed Recruiting --> Completed
- Trial completion: Use of MEOPA (Equimolar Mixture of Nitrogen Protoxide and Oxygen) for Elderly With Dementia (clinicaltrials.gov) - Dec 7, 2011
P=N/A, N=50, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
Recruiting --> Completed Recruiting --> Completed
- ||||| bradanicline (ATA-101) / CODA Biotherap
New P2 trial: Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia (clinicaltrials.gov) - Dec 6, 2011
P2, N=603, Completed, Sponsor: Targacept Inc.
- |||||||||| rivastigmine transdermal / Generic mfg.
New P3 trial: Rivastigmine in the Management of Delirium (clinicaltrials.gov) - Dec 5, 2011
P3, N=440, Recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
- | selisistat (SEN-196) / AOP Orphan Pharma
New P1 trial: A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease (clinicaltrials.gov) - Dec 4, 2011
P1, N=26, Completed, Sponsor: Siena Biotech S.p.A.
- Xadago (safinamide) / Meiji Seika, Eisai, Valeo Pharma, Zambon, Supernus Pharma
Trial completion: EMR701165-024: A Trial to Explore the Potential Benefit of Safinamide on Cognitive Impairment Associated With Parkinson's Disease (clinicaltrials.gov) - Dec 4, 2011
P2, N=103, Completed, Sponsor: Newron Sweden AB
Recruiting --> Completed Active, not recruiting --> Completed
- donepezil / Generic mfg.
Biomarker, New P1 trial: Prediction of Cognitive Properties of New Drug Candidates for Neurodegenerative Diseases in Early Clinical Development (clinicaltrials.gov) - Dec 4, 2011
P1, N=30, Recruiting, Sponsor: University Hospital, Lille
- Trial initiation date: Antipsychotic Discontinuation in Alzheimer's Disease (clinicaltrials.gov) - Dec 1, 2011
P4, N=180, Completed, Sponsor: New York State Psychiatric Institute
Active, not recruiting --> Completed Initiation date: Jan 2004 --> Aug 2004
- Clinical: Cognitive Assessment of Elderly Primary Care Patients (clinicaltrials.gov) - Dec 1, 2011
P=N/A, N=524, Active, not recruiting, Sponsor: University of Pittsburgh
- | SAR228810 / Sanofi
New P1 trial: Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients (clinicaltrials.gov) - Dec 1, 2011
P1, N=48, Active, not recruiting, Sponsor: Sanofi
- Trial completion: Central Auditory Processing Disorders Associated With Blast Exposure (clinicaltrials.gov) - Nov 30, 2011
P=N/A, N=84, Completed, Sponsor: Department of Veterans Affairs
Initiation date: Jan 2004 --> Aug 2004 Active, not recruiting --> Completed
- ||| selisistat (SEN-196) / AOP Orphan Pharma
New P1 trial: PADDINGTON: An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196 (clinicaltrials.gov) - Nov 28, 2011
P1, N=55, Completed, Sponsor: Siena Biotech S.p.A.
- HPP854 / vTv Therapeutics
New P1 trial: Safety Study of HPP854 in Subjects With Mild Cognitive Impairment or a Diagnosis of Mild Alzheimer's Disease (clinicaltrials.gov) - Nov 28, 2011
P1, N=7, Terminated, Sponsor: High Point Pharmaceuticals, LLC.
- || New P3 trial: Mild Cognitive Impairment and Obstructive Sleep Apnea (clinicaltrials.gov) - Nov 27, 2011
P3, N=110, Recruiting, Sponsor: George Mason University
- New P2 trial: Effects of Transcranial Direct Current Stimulation on the Apathy of Alzheimer's Disease (clinicaltrials.gov) - Nov 27, 2011
P2, N=40, Completed, Sponsor: University of Sao Paulo
- Clinical: ALSTIMAG: Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as add-on Treatment for Early Alzheimer's Disease (clinicaltrials.gov) - Nov 22, 2011
P=N/A, N=17, Recruiting, Sponsor: Pr Pierre Vandel
- ||||| donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
New P4 trial: Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil (clinicaltrials.gov) - Nov 21, 2011
P4, N=102, Completed, Sponsor: Janssen Pharmaceutical K.K.