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122 Companies |
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196 Products |
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196 Products |
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116 Mechanisms of Action |
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3 Trials |
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2338 News |
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- | New P1 trial: A Study of Two Doses of 18F-AV-45 in Alzheimer's Disease and Healthy Volunteers (clinicaltrials.gov) - Mar 26, 2012
P1, N=20, Completed, Sponsor: Avid Radiopharmaceuticals
- New P1 trial: A Study of 18F-AV-45 in Healthy Volunteers (clinicaltrials.gov) - Mar 26, 2012
P1, N=9, Completed, Sponsor: Avid Radiopharmaceuticals
- Enrollment change: Memory Disorders Registry (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=12, Completed, Sponsor: Cedars-Sinai Medical Center
N=600 --> 12
- Enrollment change: NAM-MD-31C: Memantine and Cognitive Dysfunction in Bipolar Disorder (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=47, Completed, Sponsor: Cedars-Sinai Medical Center
N=600 --> 12 N=25 --> 47
- Enrollment open: The Talking Sense Communication Programme for Dementia Carers (clinicaltrials.gov) - Mar 25, 2012
P1/2, N=60, Recruiting, Sponsor: University of Portsmouth
N=25 --> 47 Not yet recruiting --> Recruiting
- Trial completion: Memory Disorders Registry (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=12, Completed, Sponsor: Cedars-Sinai Medical Center
Not yet recruiting --> Recruiting Recruiting --> Completed
- Trial completion: NAM-MD-31C: Memantine and Cognitive Dysfunction in Bipolar Disorder (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=47, Completed, Sponsor: Cedars-Sinai Medical Center
Recruiting --> Completed Active, not recruiting --> Completed
- Clinical: Evaluation of PET Scan Timing Relative to AV-45 Injection Time (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=41, Completed, Sponsor: Avid Radiopharmaceuticals
- | LY2886721 / Eli Lilly
New P1/2 trial: Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease (clinicaltrials.gov) - Mar 21, 2012
P1/2, N=128, Terminated, Sponsor: Eli Lilly and Company
- rivastigmine transdermal / Generic mfg.
Trial completion, HEOR: Effects of Exercise and Rivastigmine on Quality of Life of Alzheimer's Disease Patients (clinicaltrials.gov) - Mar 18, 2012
P3, N=40, Completed, Sponsor: Federal University of Bahia
Active, not recruiting --> Completed Recruiting --> Completed
- donepezil / Generic mfg.
Biomarker, Enrollment open: Prediction of Cognitive Properties of New Drug Candidates for Neurodegenerative Diseases in Early Clinical Development (clinicaltrials.gov) - Mar 18, 2012
P1, N=30, Recruiting, Sponsor: University Hospital, Lille
Recruiting --> Completed Not yet recruiting --> Recruiting
- lisdexamfetamine / Generic mfg.
Enrollment open, Monotherapy: Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder. (clinicaltrials.gov) - Mar 16, 2012
P4, N=40, Recruiting, Sponsor: Mclean Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- hydrocodone/paracetamol / Generic mfg.
Enrollment change: LDOT: Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT) (clinicaltrials.gov) - Mar 13, 2012
P4, N=11, Active, not recruiting, Sponsor: Department of Veterans Affairs
Not yet recruiting --> Recruiting N=48 --> 11
- hydrocodone/paracetamol / Generic mfg.
Enrollment closed: LDOT: Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT) (clinicaltrials.gov) - Mar 13, 2012
P4, N=11, Active, not recruiting, Sponsor: Department of Veterans Affairs
N=48 --> 11 Recruiting --> Active, not recruiting
- ||||| nelonicline (ABT-126) / AbbVie
New P2 trial: Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors (clinicaltrials.gov) - Mar 7, 2012
P2, N=434, Completed, Sponsor: AbbVie (prior sponsor, Abbott)
- | Enrollment open: Mild Cognitive Impairment and Obstructive Sleep Apnea (clinicaltrials.gov) - Mar 7, 2012
P3, N=110, Recruiting, Sponsor: George Mason University
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- ||||| AZD-5213 / AstraZeneca
New P2a trial: A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment (clinicaltrials.gov) - Mar 6, 2012
P2a, N=81, Completed, Sponsor: AstraZeneca
- | TTP4000 / vTv Therapeutics
New P1 trial: A Safety Study of TTP4000 in Subjects With Alzheimer's Disease (clinicaltrials.gov) - Mar 6, 2012
P1, N=16, Active, not recruiting, Sponsor: TransTech Pharma
- | Levemir (insulin detemir rDNA origin) / Novo Nordisk
New P2 trial: Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 21 Days (clinicaltrials.gov) - Mar 5, 2012
P2, N=60, Completed, Sponsor: University of Washington
- | Trial completion: Ability Of ([18F]-AV-45) PET Scan to Distinguish Alzheimer's Disease Subjects From Cognitively Normal Individuals (clinicaltrials.gov) - Mar 5, 2012
P2, N=28, Completed, Sponsor: Avid Radiopharmaceuticals
Not yet recruiting --> Recruiting Recruiting --> Completed
- ||| Enrollment change: Observational Study of Cognitive Outcomes for Subjects Who Have Had Prior PET Amyloid Imaging With Florbetapir F 18 (18F-AV-45) (clinicaltrials.gov) - Mar 5, 2012
P2, N=152, Completed, Sponsor: Avid Radiopharmaceuticals
Recruiting --> Completed N=100 --> 152
- |||| Trial completion: Observational Study of Cognitive Outcomes for Subjects Who Have Had Prior PET Amyloid Imaging With Florbetapir F 18 (18F-AV-45) (clinicaltrials.gov) - Mar 5, 2012
P2, N=152, Completed, Sponsor: Avid Radiopharmaceuticals
N=100 --> 152 Active, not recruiting --> Completed
- Trial completion: HORIZON PLUS: An Extension of the HORIZON Protocol Evaluating the Safety of Dimebon (Latrepirdine) in Subjects With Huntington Disease (clinicaltrials.gov) - Mar 4, 2012
P3, N=0, Completed, Sponsor: Medivation, Inc.
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Trial completion: Self- Care TALK Study - Promoting Alzheimer's Disease (AD) Spousal Caregiver Health (clinicaltrials.gov) - Mar 4, 2012
P=N/A, N=46, Completed, Sponsor: University of Kansas
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Trial initiation date, Metastases: Palliative and End-of-life Care in Advanced Dementia: Evaluation of a Program of Organization of Care in Long-term Care (clinicaltrials.gov) - Mar 4, 2012
P=N/A, N=175, Recruiting, Sponsor: Laval University
Active, not recruiting --> Completed Initiation date: Jan 2012 --> Sep 2012
- |||||| donepezil / Generic mfg.
Enrollment open: Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease (clinicaltrials.gov) - Mar 4, 2012
P3, N=330, Recruiting, Sponsor: Eisai Co., Ltd.
Initiation date: Jan 2012 --> Sep 2012 Not yet recruiting --> Recruiting
- Enrollment open, HEOR: Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x) (clinicaltrials.gov) - Mar 4, 2012
P2, N=50, Recruiting, Sponsor: Stanford University
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- ||| epothilone D (BMS-241027) / BMS
Biomarker, Enrollment open: Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease (clinicaltrials.gov) - Mar 4, 2012
P1, N=100, Recruiting, Sponsor: Bristol-Myers Squibb
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- | Enrollment change: An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) - Feb 29, 2012
P3, N=34, Completed, Sponsor: Forest Laboratories
Not yet recruiting --> Recruiting N=150 --> 34
- carvedilol / Generic mfg.
Enrollment open: Trial of Carvedilol in Alzheimer's Disease (clinicaltrials.gov) - Feb 27, 2012
P4, N=50, Recruiting, Sponsor: Johns Hopkins University
N=150 --> 34 Not yet recruiting --> Recruiting
- ||| V-950 / Merck (MSD)
Trial completion: A Study of V950 in People With Alzheimer Disease (V950-001 AM7) (clinicaltrials.gov) - Feb 27, 2012
P1, N=86, Completed, Sponsor: Merck Sharp & Dohme Corp.
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- |||||||||| donepezil / Generic mfg.
New P3 trial: Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease (clinicaltrials.gov) - Feb 23, 2012
P3, N=330, Recruiting, Sponsor: Eisai Co., Ltd.
- Enrollment change: Efficacy of 1072nm Infrared Stimulation on Executive Functioning in Dementia (clinicaltrials.gov) - Feb 22, 2012
P1/2, N=11, Completed, Sponsor: Quietmind Foundation
Active, not recruiting --> Completed N=24 --> 11
- |||||| donepezil / Generic mfg.
Enrollment open: A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease (clinicaltrials.gov) - Feb 22, 2012
P3, N=260, Recruiting, Sponsor: Eisai Limited
N=24 --> 11 Not yet recruiting --> Recruiting
- Trial completion: Efficacy of 1072nm Infrared Stimulation on Executive Functioning in Dementia (clinicaltrials.gov) - Feb 22, 2012
P1/2, N=11, Completed, Sponsor: Quietmind Foundation
Not yet recruiting --> Recruiting Recruiting --> Completed
- | escitalopram / Generic mfg.
Trial completion: Escitalopram Treatment of Patients With Agitated Dementia (clinicaltrials.gov) - Feb 22, 2012
P4, N=20, Completed, Sponsor: University of Rochester
Recruiting --> Completed Recruiting --> Completed
- | verubecestat (MK-8931) / Merck (MSD)
New P1 trial: A Two-Part, Single-Dose Study of the Pharmacokinetics of MK-8931 in Subjects With Renal Insufficiency (MK-8931-009 [P08535]) (clinicaltrials.gov) - Feb 21, 2012
P1, N=12, Completed, Sponsor: Merck Sharp & Dohme Corp.
- New P2 trial, HEOR: Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x) (clinicaltrials.gov) - Feb 20, 2012
P2, N=50, Recruiting, Sponsor: Stanford University
- ||| Biomarker, Trial completion, IO biomarker: Study of the Effects of Cerefolin NAC on Inflammation Blood Markers in Older Individuals With Memory Complaints (clinicaltrials.gov) - Feb 16, 2012
P=N/A, N=104, Completed, Sponsor: Rush University Medical Center
Recruiting --> Completed Active, not recruiting --> Completed
- Trial termination: INVADE: Prevention of Stroke and Dementia in Primary Care (clinicaltrials.gov) - Feb 15, 2012
P=N/A, N=3908, Terminated, Sponsor: Technische Universität München
Active, not recruiting --> Completed Completed --> Terminated
- Surgery: Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery (clinicaltrials.gov) - Feb 15, 2012
P=N/A, N=120, Recruiting, Sponsor: Johns Hopkins University
- Trial completion: Dementia Registry for Parkinson's Disease (clinicaltrials.gov) - Feb 12, 2012
P=N/A, N=30, Completed, Sponsor: China Medical University Hospital
Completed --> Terminated Recruiting --> Completed
- selegiline / Generic mfg.
Trial completion, Preclinical: A Study of Decreased Mental Function Associated With HIV (clinicaltrials.gov) - Feb 12, 2012
P=N/A, N=90, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed Active, not recruiting --> Completed
- | haloperidol / Generic mfg.
New P4 trial: HARPOON: Haloperidol Prophylaxis in Older Emergency Department Patients (clinicaltrials.gov) - Feb 7, 2012
P4, N=600, Recruiting, Sponsor: VU University Medical Center
- ||||| galantamine hydrobromide / Generic mfg., rivastigmine transdermal / Generic mfg.
New P4 trial: Efficacy, Safety and Tolerability of Rivastigmine Patch in Patients With Mild to Moderate Alzheimer's Disease Switched From Cholinesterase Inhibitors (clinicaltrials.gov) - Feb 7, 2012
P4, N=110, Recruiting, Sponsor: Novartis Pharmaceuticals
- Trial completion: Evaluation of [18F] FEPPA and PET Imaging as a Marker of Inflammation in Subjects With Neurological Conditions (clinicaltrials.gov) - Feb 6, 2012
P1, N=3, Completed, Sponsor: Institute for Neurodegenerative Disorders
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||||| nelonicline (ABT-126) / AbbVie
New P2 trial: Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Feb 5, 2012
P2, N=438, Completed, Sponsor: AbbVie (prior sponsor, Abbott)
- |||| Trial completion: Open Label Study of TRx0014 in Alzheimer's Disease (clinicaltrials.gov) - Jan 31, 2012
P2, N=111, Completed, Sponsor: TauRx Therapeutics Ltd
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | velusetrag (TD-5108) / Innoviva
Trial completion: Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects (clinicaltrials.gov) - Jan 30, 2012
P1, N=40, Completed, Sponsor: Theravance, Inc.
Active, not recruiting --> Completed Recruiting --> Completed
- ||||| selisistat (SEN-196) / AOP Orphan Pharma
New P2 trial: A Phase II Safety and Tolerability Study With SEN0014196 (clinicaltrials.gov) - Jan 26, 2012
P2, N=144, Completed, Sponsor: Siena Biotech S.p.A.