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121 Companies |
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195 Products |
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195 Products |
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116 Mechanisms of Action |
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3 Trials |
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2334 News |
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- Enrollment open: PET Imaging Study Using [11C]PIB in Subjects With AD & Healthy Volunteers (clinicaltrials.gov) - Sep 8, 2013
P1, N=30, Recruiting, Sponsor: Dean F. Wong, MD, PhD
Not yet recruiting --> Recruiting
- | New P2 trial: Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia (clinicaltrials.gov) - Sep 5, 2013
P2, N=72, Recruiting, Sponsor: Lawson Health Research Institute
- | avagacestat (BMS-708163) / BMS
Trial termination: A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease (clinicaltrials.gov) - Sep 3, 2013
P2, N=263, Terminated, Sponsor: Bristol-Myers Squibb
Not yet recruiting --> Recruiting Active, not recruiting --> Terminated
- Enrollment open: Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel (clinicaltrials.gov) - Aug 27, 2013
P=N/A, N=150, Recruiting, Sponsor: Uniformed Services University of the Health Sciences
Active, not recruiting --> Terminated Not yet recruiting --> Recruiting
- |||| donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
Trial completion: Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil (clinicaltrials.gov) - Aug 26, 2013
P4, N=102, Completed, Sponsor: Janssen Pharmaceutical K.K.
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- ||| Trial completion: CogMCI study: Efficacy Study of Cognitive Intervention in Amnestic Mild Cognitive Impairment (clinicaltrials.gov) - Aug 26, 2013
P=N/A, N=293, Completed, Sponsor: Inha University Hospital
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Clinical: Imaging the Neural Network Connectivity on Patients With Mild Cognitive Impairment (clinicaltrials.gov) - Aug 20, 2013
P=N/A, N=108, Recruiting, Sponsor: Chang Gung Memorial Hospital
- Cerebrate (pinitol) / Humanetics
Enrollment open: A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease (clinicaltrials.gov) - Aug 19, 2013
P2, N=40, Recruiting, Sponsor: James J. Peters Veterans Affairs Medical Center
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Trial completion: The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease (clinicaltrials.gov) - Aug 19, 2013
P=N/A, N=30, Completed, Sponsor: China Medical University Hospital
Not yet recruiting --> Recruiting Enrolling by invitation --> Completed
- Trial completion: STIMCI: Impact of Transcranial Direct Current Stimulation on Language Functions in Mild Cognitive Impairment (clinicaltrials.gov) - Aug 19, 2013
P=N/A, N=18, Completed, Sponsor: Charite University, Berlin, Germany
Enrolling by invitation --> Completed Recruiting --> Completed
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
New P4 trial: The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease (clinicaltrials.gov) - Aug 12, 2013
P4, N=232, Completed, Sponsor: Charite University, Berlin, Germany
- Enrollment open: Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.) (clinicaltrials.gov) - Aug 12, 2013
P=N/A, N=100, Recruiting, Sponsor: New York Methodist Hospital
Recruiting --> Completed Not yet recruiting --> Recruiting
- Enrollment open: 4-question "RACY" Delirium Screening Tool Validation Study (clinicaltrials.gov) - Aug 11, 2013
P=N/A, N=1200, Recruiting, Sponsor: University of Cape Town
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Trial completion: The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease (clinicaltrials.gov) - Aug 11, 2013
P4, N=232, Completed, Sponsor: Charite University, Berlin, Germany
Not yet recruiting --> Recruiting Not yet recruiting --> Completed
- | New P1/2 trial: Disrupted Sleep, Neuroendocrine Status and the Behavioral Symptoms of AD (clinicaltrials.gov) - Aug 8, 2013
P1/2, N=54, Not yet recruiting, Sponsor: Johns Hopkins University
- Surgery: Amnesia After Surgery for Anterior Communicating Aneurysm? High Resolution Magnetic Resonance (MR) Imaging Findings (clinicaltrials.gov) - Aug 7, 2013
P=N/A, N=14, Completed, Sponsor: Tohoku University
- morphine sulphate / Generic mfg.
Enrollment open: Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients (clinicaltrials.gov) - Aug 5, 2013
P=N/A, N=40, Recruiting, Sponsor: National Cheng-Kung University Hospital
Not yet recruiting --> Completed Not yet recruiting --> Recruiting
- Aplenzin (bupropion hydrobromide ER) / Bausch Health
New P2 trial: Action-HD: Apathy Cure Through Bupropion in Huntington's Disease (clinicaltrials.gov) - Jul 31, 2013
P2, N=40, Active, not recruiting, Sponsor: Charite University, Berlin, Germany
- | Enrollment change: ETNA3: Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease (clinicaltrials.gov) - Jul 30, 2013
P3, N=640, Completed, Sponsor: University Hospital, Bordeaux
Not yet recruiting --> Recruiting N=800 --> 640
- | Trial completion: ETNA3: Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease (clinicaltrials.gov) - Jul 30, 2013
P3, N=640, Completed, Sponsor: University Hospital, Bordeaux
N=800 --> 640 Active, not recruiting --> Completed
- | galantamine hydrobromide / Generic mfg.
Trial termination: A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Jul 29, 2013
P3, N=2051, Terminated, Sponsor: Janssen Research & Development, LLC
Active, not recruiting --> Completed Completed --> Terminated; Due to a pre-specified imbalance of deaths between treatment groups, the DSMB recommended early termination of the trial
- Enrollment closed: Risk Evaluation and Education for Alzheimer's Disease (REVEAL) IV (clinicaltrials.gov) - Jul 29, 2013
P=N/A, N=360, Active, not recruiting, Sponsor: Brigham and Women's Hospital
Completed --> Terminated; Due to a pre-specified imbalance of deaths between treatment groups, the DSMB recommended early termination of the trial Recruiting --> Active, not recruiting
- Enrollment closed: Effects of Mental Stimulation in Patients With Mild Cognitive Impairment (clinicaltrials.gov) - Jul 29, 2013
P2, N=72, Active, not recruiting, Sponsor: Johns Hopkins University
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- Enrollment change, HEOR: Oxi-Stress: Oxidative Stress and Nutritional Supplementation Intervention Study (clinicaltrials.gov) - Jul 29, 2013
P2, N=21, Completed, Sponsor: University of Saskatchewan
Recruiting --> Active, not recruiting N=154 --> 21
- Trial completion, HEOR: Oxi-Stress: Oxidative Stress and Nutritional Supplementation Intervention Study (clinicaltrials.gov) - Jul 29, 2013
P2, N=21, Completed, Sponsor: University of Saskatchewan
N=154 --> 21 Recruiting --> Completed
- | LY2886721 / Eli Lilly
Trial termination: Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease (clinicaltrials.gov) - Jul 23, 2013
P1/2, N=128, Terminated, Sponsor: Eli Lilly and Company
Recruiting --> Completed Recruiting --> Terminated; Study terminated due to abnormal liver biochemical tests in some participants.
- | ABT 354 / AbbVie
New P1 trial: Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors (clinicaltrials.gov) - Jul 23, 2013
P1, N=20, Completed, Sponsor: AbbVie
- ||| ladostigil hemitartrate (TV-3326) / Avraham
Enrollment closed: A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment (clinicaltrials.gov) - Jul 21, 2013
P2, N=200, Active, not recruiting, Sponsor: Avraham Pharmaceuticals Ltd
Recruiting --> Terminated; Study terminated due to abnormal liver biochemical tests in some participants. Recruiting --> Active, not recruiting
- | dexmedetomidine / Generic mfg.
Surgery: Dexmedetomidine to Prevent Agitation After Free Flap Surgery (clinicaltrials.gov) - Jul 18, 2013
P4, N=80, Recruiting, Sponsor: Peking University
- Trial termination: A Phase 0, Open Label, Multi-center Exploratory and Safety Study of [F-18]T807 (clinicaltrials.gov) - Jul 17, 2013
P0, N=11, Terminated, Sponsor: Avid Radiopharmaceuticals
Recruiting --> Active, not recruiting Recruiting --> Terminated; Study was terminated in anticipation of transfer of ownership to Avid Radiopharmaceuticals.
- Trial termination: A Phase 0, Open Label, Multi-Center, Exploratory and Safety Study of [F-18]T808 (clinicaltrials.gov) - Jul 17, 2013
P0, N=12, Terminated, Sponsor: Avid Radiopharmaceuticals
Recruiting --> Terminated; Study was terminated in anticipation of transfer of ownership to Avid Radiopharmaceuticals. Recruiting --> Terminated; Study was terminated in anticipation of transfer of ownership to Avid Radiopharmaceuticals.
- | irdabisant (CEP-26401) / Teva
New P1 trial: Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects (clinicaltrials.gov) - Jul 17, 2013
P1, N=40, Completed, Sponsor: Teva Pharmaceutical Industries
- Enrollment open: Comparison of Hand Feeding Techniques for Persons With Dementia (clinicaltrials.gov) - Jul 16, 2013
P=N/A, N=30, Recruiting, Sponsor: Duke University
Recruiting --> Terminated; Study was terminated in anticipation of transfer of ownership to Avid Radiopharmaceuticals. Active, not recruiting --> Recruiting
- Trial completion: ICU Delirium: a One-week Snapshot of Burden Across the Eastern UK Region (clinicaltrials.gov) - Jul 16, 2013
P=N/A, N=225, Completed, Sponsor: Papworth Hospital NHS Foundation Trust
Active, not recruiting --> Recruiting Not yet recruiting --> Completed
- Enrollment change: HEEBW: Home Evaluation of Exit Barriers in Wandering (clinicaltrials.gov) - Jul 15, 2013
P2, N=19, Completed, Sponsor: Department of Veterans Affairs
Not yet recruiting --> Completed N=48 --> 19
- Clinical: Patients With Behavioural Symptoms and Hospitalized in Cognitive and Behavioural Units (clinicaltrials.gov) - Jul 15, 2013
P=N/A, N=306, Recruiting, Sponsor: Centre Hospitalier Universitaire de Saint Etienne
- | dexmedetomidine / Generic mfg.
Surgery: Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery (clinicaltrials.gov) - Jul 15, 2013
P4, N=132, Recruiting, Sponsor: New York University School of Medicine
- ||| Circadin (melatonin prolonged release) / Lundbeck, Neurim, Flynn Pharma, Grupo Insud, Biocodex, Kuhnil Pharma
Enrollment change: Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor (clinicaltrials.gov) - Jul 14, 2013
P2, N=73, Completed, Sponsor: Neurim Pharmaceuticals Ltd.
N=48 --> 19 N=140 --> 73
- Trial completion: HEEBW: Home Evaluation of Exit Barriers in Wandering (clinicaltrials.gov) - Jul 14, 2013
P2, N=19, Completed, Sponsor: Department of Veterans Affairs
N=140 --> 73 Active, not recruiting --> Completed
- |||| Circadin (melatonin prolonged release) / Lundbeck, Neurim, Flynn Pharma, Grupo Insud, Biocodex, Kuhnil Pharma
Trial completion: Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor (clinicaltrials.gov) - Jul 14, 2013
P2, N=73, Completed, Sponsor: Neurim Pharmaceuticals Ltd.
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Trial completion: Effects of Green Tea Consumption on Homocysteine Metabolism and Cognitive Dysfunction (clinicaltrials.gov) - Jul 13, 2013
P=N/A, N=15, Completed, Sponsor: University of Shizuoka
Active, not recruiting --> Completed Recruiting --> Completed
- GSK2647544 / GSK
Enrollment change: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single, Oral Escalating Doses of GSK2647544 in Healthy Volunteers (clinicaltrials.gov) - Jul 10, 2013
P1, N=27, Completed, Sponsor: GlaxoSmithKline
Recruiting --> Completed N=16 --> 27
- | GSK2647544 / GSK
Trial completion: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single, Oral Escalating Doses of GSK2647544 in Healthy Volunteers (clinicaltrials.gov) - Jul 10, 2013
P1, N=27, Completed, Sponsor: GlaxoSmithKline
N=16 --> 27 Recruiting --> Completed
- Enrollment change: Pre-CREST-2X: Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability (clinicaltrials.gov) - Jul 8, 2013
P2, N=24, Completed, Sponsor: Massachusetts General Hospital
Recruiting --> Completed N=60 --> 24
- Enrollment open: IU-CHOICE: Indiana University Dementia Screening Trial (clinicaltrials.gov) - Jul 8, 2013
P=N/A, N=4000, Recruiting, Sponsor: Regenstrief Institute, IU Center for Aging Research
N=60 --> 24 Not yet recruiting --> Recruiting
- Trial completion: Pre-CREST-2X: Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability (clinicaltrials.gov) - Jul 8, 2013
P2, N=24, Completed, Sponsor: Massachusetts General Hospital
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- ||| MK-7622 / Merck (MSD)
Trial initiation date: Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012) (clinicaltrials.gov) - Jul 8, 2013
P2a, N=830, Recruiting, Sponsor: Merck Sharp & Dohme Corp.
Active, not recruiting --> Completed Initiation date: May 2013 --> Oct 2013
- ||| PF-02545920 / Pfizer
Trial initiation date: Study Evaluating The Safety, Tolerability And Brain Function Of 2 Doses Of PF-0254920 In Subjects With Early Huntington's Disease (clinicaltrials.gov) - Jul 6, 2013
P2, N=56, Recruiting, Sponsor: Pfizer
Initiation date: May 2013 --> Oct 2013 Initiation date: Jun 2013 --> Sep 2013
- Trial initiation date: PreDeLight-ICU: Prevention of Delirium With Light in the Intensive Care Unit (clinicaltrials.gov) - Jul 2, 2013
P=N/A, N=96, Recruiting, Sponsor: Charite University, Berlin, Germany
Initiation date: Jun 2013 --> Sep 2013 Initiation date: Dec 2012 --> Jul 2013
- Enrollment open: PreDeLight-ICU: Prevention of Delirium With Light in the Intensive Care Unit (clinicaltrials.gov) - Jul 2, 2013
P=N/A, N=96, Recruiting, Sponsor: Charite University, Berlin, Germany
Initiation date: Dec 2012 --> Jul 2013 Not yet recruiting --> Recruiting