Delirium, Dementia, Amnestic, Cognitive Disorders News - LARVOL Sigma

Delirium, Dementia, Amnestic, Cognitive Disorders

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116 Mechanisms of Action

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|||||||||| Enrollment change: ADELAHYDE2: Vascular Alteration and Evolution of Cognitive Impairment (clinicaltrials.gov) - Feb 23, 2014
P=N/A, N=131, Completed, Sponsor: Central Hospital, Nancy, France
N=200 --> 131

|||||||||| Trial completion: ADELAHYDE2: Vascular Alteration and Evolution of Cognitive Impairment (clinicaltrials.gov) - Feb 23, 2014
P=N/A, N=131, Completed, Sponsor: Central Hospital, Nancy, France
N=200 --> 131 Recruiting --> Completed

|||||||||| Trial completion: The Efficacy of Omega-3 Fatty Acids in Maintaining Optimal Mental Health in Elderly People (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=302, Completed, Sponsor: ZonMw: The Netherlands Organisation for Health Research and Development
Recruiting --> Completed No longer recruiting --> Completed

||||||||||  bapineuzumab (AAB-001) / Pfizer, J&J, Perrigo Company
Trial completion:  AAB-001 in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P2a, N=234, Completed,  Sponsor: JANSSEN Alzheimer Immunotherapy Research & Development, LLC
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  rivastigmine / Generic mfg.
Trial completion:  Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P4, N=80, Completed,  Sponsor: Novartis
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  donepezil / Generic mfg., rasagiline / Generic mfg.
Trial completion:  Rasagiline 1 mg and 2 mg Added to Aricept 10 mg Daily in Patients With Mild to Moderate Alzheimer's Disease (AD) (clinicaltrials.gov) -  Feb 22, 2014
P2, N=376, Completed,  Sponsor: Teva Pharmaceutical Industries
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  Xaprila (xaliproden) / Sanofi
Trial completion:  Study of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type (clinicaltrials.gov) -  Feb 22, 2014
P3, N=1455, Completed,  Sponsor: Sanofi
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  Xaprila (xaliproden) / Sanofi
Trial completion:  18-Month Study of the Efficacy of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type (clinicaltrials.gov) -  Feb 22, 2014
P3, N=1306, Completed,  Sponsor: Sanofi
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Curcumin in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Feb 22, 2014
P2, N=33, Completed, Sponsor: John Douglas French Foundation
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  rivastigmine / Generic mfg.
Trial completion:  Efficacy and Safety of Rivastigmine Capsules in Patients With Probable Vascular Dementia (clinicaltrials.gov) -  Feb 22, 2014
P3, N=708, Completed,  Sponsor: Novartis Pharmaceuticals
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) - Feb 22, 2014
P3, N=34, Completed, Sponsor: Forest Laboratories
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  donepezil / Generic mfg.
Trial completion:  Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P3, N=229, Completed,  Sponsor: Eisai Inc.
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: SGS742 in Patients With Mild to Moderate Alzheimer's Disease (AD) (clinicaltrials.gov) - Feb 22, 2014
P2, N=280, Completed, Sponsor: Saegis Pharmaceuticals
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  neramexane (KRP-209) / AbbVie
Trial completion, Monotherapy:  The Safety and Efficacy of Neramexane in Patients With Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P3, N=400, Completed,  Sponsor: Forest Laboratories
No longer recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Risk Evaluation and Education for Alzheimer's Disease (REVEAL) II (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=360, Completed, Sponsor: National Institute on Aging (NIA)
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Huperzine A in Alzheimer's Disease (clinicaltrials.gov) - Feb 22, 2014
P2, N=150, Completed, Sponsor: National Institute on Aging (NIA)
Active, not recruiting --> Completed No longer recruiting --> Completed

||||||||||  Cereact (arundic acid) / Ono Pharma
Trial completion:  Effects of ONO-2506PO in Patients With Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P2, N=647, Completed,  Sponsor: Ono Pharma USA Inc
No longer recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Montessori-Based Activities for Elderly Persons With Dementia (clinicaltrials.gov) - Feb 22, 2014
P2/3, N=300, Completed, Sponsor: Menorah Park
Active, not recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Family Health After Predictive Huntington Disease (HD) Testing (clinicaltrials.gov) - Feb 22, 2014
P3, N=422, Completed, Sponsor: National Institute of Nursing Research (NINR)
No longer recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Bathing Persons With Alzheimer's Disease aT Home (The BATH Study) (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=90, Completed, Sponsor: National Institute of Nursing Research (NINR)
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Alzheimer's Disease Treatment and Illness Perceptions Survey (TIPS) II (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=210, Completed, Sponsor: Alzheimer's Association
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study) (clinicaltrials.gov) - Feb 22, 2014
P3, N=340, Completed, Sponsor: National Institute on Aging (NIA)
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  simvastatin / Generic mfg.
Trial completion:  Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study (clinicaltrials.gov) -  Feb 22, 2014
P3, N=400, Completed,  Sponsor: National Institute on Aging (NIA)
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Phytoestrogens and Memory Decline in Menopause (clinicaltrials.gov) - Feb 22, 2014
P2, N=96, Completed, Sponsor: National Center for Complementary and Alternative Medicine (NCCAM)
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  ibuprofen / Generic mfg.
Trial completion:  The Effect of Short-Term Statins and NSAIDs on Levels of Beta-Amyloid, a Protein Associated With Alzheimer's Disease (clinicaltrials.gov) -  Feb 22, 2014
P4, N=50, Completed,  Sponsor: National Institute of Mental Health (NIMH)
No longer recruiting --> Completed Recruiting --> Completed

||||||||||  quetiapine / Generic mfg.
Trial completion:  Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP) (clinicaltrials.gov) -  Feb 22, 2014
P4, N=60, Completed,  Sponsor: National Institute on Aging (NIA)
Recruiting --> Completed Recruiting --> Completed

||||||||||  aripiprazole / Generic mfg.
Trial completion:  Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type (clinicaltrials.gov) -  Feb 22, 2014
P3, N=0, Completed,  Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Biomarker, Trial completion: Anti-Oxidant Treatment of Alzheimer's Disease (clinicaltrials.gov) - Feb 22, 2014
P1, N=75, Completed, Sponsor: National Institute on Aging (NIA)
No longer recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Direct Current Brain Polarization in Frontotemporal Dementia (clinicaltrials.gov) - Feb 22, 2014
P1, N=6, Completed, Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting --> Completed Recruiting --> Completed

||||||||||  leuprolide acetate for depot suspension / Generic mfg.
Trial completion:  Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (ALADDIN) VP 104 Study (clinicaltrials.gov) -  Feb 22, 2014
P2, N=90, Completed,  Sponsor: Voyager Pharmaceutical Corporation
Recruiting --> Completed No longer recruiting --> Completed

||||||||||  leuprolide acetate for depot suspension / Generic mfg.
Trial completion:  ALADDIN Study: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (clinicaltrials.gov) -  Feb 22, 2014
P2, N=90, Completed,  Sponsor: Voyager Pharmaceutical Corporation
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Healthy Aging and Memory Study (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=650, Completed, Sponsor: National Institute on Aging (NIA)
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  rivastigmine transdermal / Generic mfg.
Trial termination:  Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients (clinicaltrials.gov) -  Feb 20, 2014
P=N/A, N=1, Terminated,  Sponsor: The Cleveland Clinic
No longer recruiting --> Completed Active, not recruiting --> Terminated; Study has been revised to use a different study medication and patient population.

||||||||||  rivastigmine transdermal / Generic mfg.
Enrollment change:  Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients (clinicaltrials.gov) -  Feb 20, 2014
P=N/A, N=1, Terminated,  Sponsor: The Cleveland Clinic
Active, not recruiting --> Terminated; Study has been revised to use a different study medication and patient population. N=120 --> 1

||||||||||  donepezil / Generic mfg.
Trial completion:  Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease (clinicaltrials.gov) -  Feb 19, 2014
P2, N=45, Completed,  Sponsor: National Center for Research Resources (NCRR)
N=120 --> 1 Recruiting --> Completed

||||||||||  Ampalex (CX516) / RespireRx
Trial completion:  Treatment of Alzheimer's Disease With CX516 (Ampalex) (clinicaltrials.gov) -  Feb 19, 2014
P2, N=40, Completed,  Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Diagnosis and Natural History Study of Patients With Neurological Conditions (clinicaltrials.gov) - Feb 19, 2014
P=N/A, N=600, Completed, Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
No longer recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Alzheimer's Disease Prevention Trial (clinicaltrials.gov) - Feb 19, 2014
P3, N=0, Completed, Sponsor: National Institute on Aging (NIA)
Recruiting --> Completed No longer recruiting --> Completed

||||||||||  stavudine / Generic mfg.
Trial completion:  A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex (clinicaltrials.gov) -  Feb 19, 2014
P3, N=20, Completed,  Sponsor: Bristol-Myers Squibb
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: HIV Levels in Cerebrospinal Fluid and Brain Function in Patients Receiving Anti-HIV Drugs (clinicaltrials.gov) - Feb 19, 2014
P=N/A, N=100, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  bitopertin (DISC-1459) / Disc Medicine
Biomarker, Enrollment change:  A Study of the Effect of RO4917838 on Biomarker Measures of Cognitive Dysfunction in Participants With Schizophrenia and Schizoaffective Disorder (clinicaltrials.gov) -  Feb 19, 2014
P1, N=31, Completed,  Sponsor: Hoffmann-La Roche
No longer recruiting --> Completed N=40 --> 31

|||||||||| Biomarker, Enrollment open: Accelerated Diffusion MRI for Diagnosis of Hungtington Disease (clinicaltrials.gov) - Feb 18, 2014
P=N/A, N=80, Recruiting, Sponsor: Wang . Jiun-Jie
N=40 --> 31 Not yet recruiting --> Recruiting

|||||||||| Trial suspension, FDG PET: Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging (clinicaltrials.gov) - Feb 13, 2014
P=N/A, N=350, Suspended, Sponsor: Centre Hospitalier Universitaire, Amiens
Not yet recruiting --> Recruiting Recruiting --> Suspended

||||||||||  donepezil / Generic mfg.
New P2 trial:  Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318) (clinicaltrials.gov) -  Feb 13, 2014
P2, N=36, Not yet recruiting,  Sponsor: Merck Sharp & Dohme Corp.

||||||||||  vanutide cridificar (PF-236806) / J&J, Perrigo Company, Pfizer
Enrollment open:  Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Early Alzheimer's Disease (clinicaltrials.gov) -  Feb 13, 2014
P2, N=63, Recruiting,  Sponsor: Pfizer
Recruiting --> Suspended Active, not recruiting --> Recruiting

|||||||||| Enrollment change: Genes, Exercise, Memory and Neurodegeneration (clinicaltrials.gov) - Feb 12, 2014
P=N/A, N=73, Completed, Sponsor: Howard University
Active, not recruiting --> Recruiting N=112 --> 73

|||||||||| Trial completion: Genes, Exercise, Memory and Neurodegeneration (clinicaltrials.gov) - Feb 12, 2014
P=N/A, N=73, Completed, Sponsor: Howard University
N=112 --> 73 Recruiting --> Completed

||||||||||  Targretin oral (bexarotene oral) / ReXceptor
New P1 trial:  A Study to Evaluate the Effect of Bexarotene on Beta-Amyloid and Apolipoprotein E Metabolism in Healthy Subjects (clinicaltrials.gov) -  Feb 11, 2014
P1, N=12, Not yet recruiting,  Sponsor: ReXceptor, Inc.

|||||||||| Biomarker: Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease (clinicaltrials.gov) - Feb 9, 2014
P=N/A, N=60, Recruiting, Sponsor: Duke University
Recruiting --> Completed N=36 --> 60

|||||||||| Biomarker: Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease (clinicaltrials.gov) - Feb 9, 2014
P=N/A, N=60, Recruiting, Sponsor: Duke University
N=36 --> 60 Not yet recruiting --> Recruiting