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121 Companies |
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195 Products |
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195 Products |
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116 Mechanisms of Action |
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3 Trials |
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2334 News |
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- | New P2 trial: DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia (clinicaltrials.gov) - Apr 2, 2014
P2, N=90, Recruiting, Sponsor: Chang Gung Memorial Hospital
- New P1 trial: Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects (clinicaltrials.gov) - Apr 2, 2014
P1, N=80, Recruiting, Sponsor: Molecular NeuroImaging
- | irdabisant (CEP-26401) / Teva
Trial completion: Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects (clinicaltrials.gov) - Apr 1, 2014
P1, N=40, Completed, Sponsor: Teva Pharmaceutical Industries
Active, not recruiting --> Completed
- | lanabecestat (AZD3293) / AstraZeneca, Eli Lilly
Biomarker, Trial completion: A Two-part Multiple Dose Study to Assess the Safety and Effects of AZD3293 in Healthy Elderly and Alzheimer's Patients (clinicaltrials.gov) - Apr 1, 2014
P1, N=47, Completed, Sponsor: AstraZeneca
Active, not recruiting --> Completed Recruiting --> Completed
- ||| Enrollment closed: Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline (clinicaltrials.gov) - Mar 31, 2014
P4, N=600, Active, not recruiting, Sponsor: Avid Radiopharmaceuticals
Recruiting --> Completed Recruiting --> Active, not recruiting
- Biomarker, Clinical data, Trial completion: A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers (clinicaltrials.gov) - Mar 31, 2014
P=N/A, N=116, Completed, Sponsor: Korea Institute of Oriental Medicine
Recruiting --> Active, not recruiting Recruiting --> Completed
- Trial completion: COSCA: Determinants of Cognitive Impairment After Acute Coronary Syndrome (clinicaltrials.gov) - Mar 31, 2014
P=N/A, N=49, Completed, Sponsor: University Hospital, Bordeaux
Recruiting --> Completed Active, not recruiting --> Completed
- Trial completion: Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia (clinicaltrials.gov) - Mar 31, 2014
P2, N=36, Completed, Sponsor: Yale University
Active, not recruiting --> Completed Recruiting --> Completed
- acetylcysteine solution / Generic mfg.
Enrollment closed: NACSZ: N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia (clinicaltrials.gov) - Mar 30, 2014
P1, N=24, Active, not recruiting, Sponsor: VA Greater Los Angeles Healthcare System
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion: Efficacy and Safety of Two Pharmacologic Strategies on Neurocognitive Impairment in HIV Infection. The TRIANT-TE Study (clinicaltrials.gov) - Mar 30, 2014
P4, N=33, Completed, Sponsor: Fundacio Lluita Contra la SIDA
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- New P3 trial: The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury (clinicaltrials.gov) - Mar 27, 2014
P3, N=15, Not yet recruiting, Sponsor: Brock University
- | Enrollment closed: PAVeD: Preventing Aggression in Veterans With Dementia (clinicaltrials.gov) - Mar 26, 2014
P3, N=220, Active, not recruiting, Sponsor: Department of Veterans Affairs
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- ||||| donepezil / Generic mfg.
New P4 trial: Safety and Efficacy of Donepezil HCl 23 mg in Patients With Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) - Mar 24, 2014
P4, N=190, Recruiting, Sponsor: Eisai Korea Inc.
- |||| donepezil / Generic mfg.
Enrollment open: Safety and Efficacy of Donepezil HCl 23 mg in Patients With Moderate to Severe Alzheimer's Disease (clinicaltrials.gov) - Mar 24, 2014
P4, N=190, Recruiting, Sponsor: Eisai Korea Inc.
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- || Biomarker, Enrollment closed: A Non-drug Methods Study in Participants With Alzheimer's Disease (clinicaltrials.gov) - Mar 24, 2014
P1, N=196, Active, not recruiting, Sponsor: Eli Lilly and Company
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- Trial completion: Nitrous Oxide Induction Induces Amnesia in Pediatric Patients (clinicaltrials.gov) - Mar 24, 2014
P=N/A, N=90, Completed, Sponsor: State University of New York at Buffalo
Recruiting --> Active, not recruiting Recruiting --> Completed
- Enrollment change: Outcome Predictors of a Cognitive Intervention in aMCI (clinicaltrials.gov) - Mar 23, 2014
P=N/A, N=110, Active, not recruiting, Sponsor: Ludwig-Maximilians - University of Munich
Recruiting --> Completed N=80 --> 110
- Enrollment closed: Outcome Predictors of a Cognitive Intervention in aMCI (clinicaltrials.gov) - Mar 23, 2014
P=N/A, N=110, Active, not recruiting, Sponsor: Ludwig-Maximilians - University of Munich
N=80 --> 110 Recruiting --> Active, not recruiting
- Clinical: Families Affected by Dementia: A Survey of Caregivers (clinicaltrials.gov) - Mar 20, 2014
P=N/A, N=60, Recruiting, Sponsor: University of Miami
- Enrollment change: IBVM001: Evaluation of 123-I Iodobenzovesamicol (IBVM) and SPECT Imaging of Healthy Subjects and Patients With Alzheimer Disease (clinicaltrials.gov) - Mar 20, 2014
P2, N=26, Completed, Sponsor: Institute for Neurodegenerative Disorders
Recruiting --> Active, not recruiting N=21 --> 26
- | Leqembi (lecanemab) / Biogen, BioArctic, Eisai
New P1 trial, IO biomarker: A Randomized, Double-blind, Placebo-controlled Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamic Response of Repeated Intravenous Infusions of BAN2401 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease (clinicaltrials.gov) - Mar 20, 2014
P1, N=24, Recruiting, Sponsor: Eisai Co., Ltd.
- Trial initiation date: Evaluation of Electronic Florbetapir (18F) Interpretation Training in Japanese Physicians (clinicaltrials.gov) - Mar 18, 2014
P=N/A, N=10, Not yet recruiting, Sponsor: Avid Radiopharmaceuticals
N=21 --> 26 Initiation date: Dec 2013 --> Oct 2014
- |||| Trintellix (vortioxetine) / Lundbeck, Takeda
Trial completion: Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder (clinicaltrials.gov) - Mar 18, 2014
P2, N=602, Completed, Sponsor: Takeda
Initiation date: Dec 2013 --> Oct 2014 Active, not recruiting --> Completed
- memantine / Generic mfg.
Trial completion: Inappropriate Medications Associated With Anticholinesterase and/or Memantine Treatment in the Elderly (clinicaltrials.gov) - Mar 18, 2014
P=N/A, N=636, Completed, Sponsor: University Hospital, Limoges
Active, not recruiting --> Completed Recruiting --> Completed
- Biomarker: A3PM: African American Alzheimer's Progression Markers - CSF and Neuro-Imaging (clinicaltrials.gov) - Mar 16, 2014
P=N/A, N=150, Recruiting, Sponsor: Emory University
- |||||||||| New P3 trial: Re-Read Study to Compare the Brain Uptake of [18F]Flutemetamol With Brain Neuritic Plaque Density Determined Postmortem (clinicaltrials.gov) - Mar 16, 2014
P3, N=107, Active, not recruiting, Sponsor: GE Healthcare
- Trial completion: EXCEL: Exercise for Cognition and Everyday Living for Seniors With Memory Complaints (clinicaltrials.gov) - Mar 16, 2014
P=N/A, N=86, Completed, Sponsor: University of British Columbia
Recruiting --> Completed Active, not recruiting --> Completed
- Enrollment open: The Effect of Repeated Transcranial Magnetic Stimulation on Off-line Resting Electroencephalographic Signal in Alzheimer's Disease (clinicaltrials.gov) - Mar 16, 2014
P=N/A, N=15, Recruiting, Sponsor: Lawson Health Research Institute
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- | bitopertin (DISC-1459) / Disc Medicine
Biomarker, Trial completion: A Study of the Effect of RO4917838 on Biomarker Measures of Cognitive Dysfunction in Participants With Schizophrenia and Schizoaffective Disorder (clinicaltrials.gov) - Mar 16, 2014
P1, N=31, Completed, Sponsor: Hoffmann-La Roche
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- | ketamine / Generic mfg.
Enrollment open: PODCAST: The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial (clinicaltrials.gov) - Mar 13, 2014
P3, N=600, Recruiting, Sponsor: Washington University School of Medicine
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- | Enrollment closed: Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients (clinicaltrials.gov) - Mar 13, 2014
P2, N=20, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- |||||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Enrollment open: STARBRIGHT: Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With an Acetylcholinesterase Inhibitor (clinicaltrials.gov) - Mar 12, 2014
P3, N=720, Recruiting, Sponsor: H. Lundbeck A/S
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- Humalog pen (insulin lispro) / Eli Lilly
Trial withdrawal: Efficacy of Pulsatile IV Insulin on Cognition and Amyloid Burden in Patients With Alzheimer's Disease (clinicaltrials.gov) - Mar 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Louisiana State University Health Sciences Center Shreveport
Not yet recruiting --> Recruiting Not yet recruiting --> Withdrawn
- Humalog pen (insulin lispro) / Eli Lilly
Enrollment change: Efficacy of Pulsatile IV Insulin on Cognition and Amyloid Burden in Patients With Alzheimer's Disease (clinicaltrials.gov) - Mar 11, 2014
P=N/A, N=0, Withdrawn, Sponsor: Louisiana State University Health Sciences Center Shreveport
Not yet recruiting --> Withdrawn N=30 --> 0
- | New P4 trial, Surgery: Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium (clinicaltrials.gov) - Mar 10, 2014
P4, N=110, Recruiting, Sponsor: Johns Hopkins University
- escitalopram / Generic mfg.
Enrollment closed: Escitalopram for the Treatment of Depression in Alzheimer's Disease (clinicaltrials.gov) - Mar 9, 2014
P4, N=84, Active, not recruiting, Sponsor: Konkuk University Medical Center
N=30 --> 0 Recruiting --> Active, not recruiting
- |||| crenezumab (MABT5102A) / Roche
Trial completion: A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY) (clinicaltrials.gov) - Mar 9, 2014
P2, N=450, Completed, Sponsor: Genentech
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- Enrollment open: Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation (clinicaltrials.gov) - Mar 6, 2014
P1, N=100, Recruiting, Sponsor: Department of Veterans Affairs
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Aplenzin (bupropion hydrobromide ER) / Bausch Health
Enrollment closed: Action-HD: Apathy Cure Through Bupropion in Huntington's Disease (clinicaltrials.gov) - Mar 6, 2014
P2, N=40, Active, not recruiting, Sponsor: Charite University, Berlin, Germany
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- quetiapine / Generic mfg.
Enrollment open: Efficacy of Quetiapine for Pediatric Delirium (clinicaltrials.gov) - Mar 5, 2014
P1/2, N=50, Recruiting, Sponsor: Weill Medical College of Cornell University
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- ||| Biomarker, Trial completion: Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION (clinicaltrials.gov) - Mar 5, 2014
P=N/A, N=204, Completed, Sponsor: Neuronetrix, Inc.
Not yet recruiting --> Recruiting Recruiting --> Completed
- | Trial suspension: Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer's Disease (clinicaltrials.gov) - Mar 4, 2014
P2, N=200, Suspended, Sponsor: Rock Creek Pharmaceuticals, Inc.
Recruiting --> Completed Recruiting --> Suspended
- ||||| edonerpic (T-817MA) / Fujifilm Holdings
New P2 trial: Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202) (clinicaltrials.gov) - Mar 4, 2014
P2, N=450, Recruiting, Sponsor: Toyama Chemical Co., Ltd.
- |||| Enrollment open: Evaluation of Reader Training Processes (clinicaltrials.gov) - Mar 4, 2014
P4, N=250, Recruiting, Sponsor: Avid Radiopharmaceuticals
Recruiting --> Suspended Not yet recruiting --> Recruiting
- ||||| Caplyta (lumateperone) - Intra / Cellular Therapies
New P1/2 trial: Study of ITI-007 in Healthy Geriatric Volunteers and in Geriatric Patients With Dementia (clinicaltrials.gov) - Mar 3, 2014
P1/2, N=52, Recruiting, Sponsor: Intra-Cellular Therapies, Inc.
- |||||||||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
New P3 trial: STAR Extension: Long-term Safety and Tolerability of Idalopirdine (Lu AE58054) as Adjunctive Treatment to Donepezil in Patients With Mild-moderate Alzheimer's Disease (clinicaltrials.gov) - Mar 3, 2014
P3, N=2490, Not yet recruiting, Sponsor: H. Lundbeck A/S
- Clinical: Effect of Exercises Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease (clinicaltrials.gov) - Feb 26, 2014
P=N/A, N=19, Completed, Sponsor: National Taiwan University Hospital
- ||||| OMS824 / Omeros
New P2 trial: Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease (clinicaltrials.gov) - Feb 26, 2014
P2, N=120, Recruiting, Sponsor: Omeros Corporation
- New P2 trial: Effects of Balance Training in Older Adults With Dementia (clinicaltrials.gov) - Feb 25, 2014
P2, N=19, Completed, Sponsor: National Taiwan University Hospital
- |||| vanutide cridificar (PF-236806) / J&J, Perrigo Company, Pfizer
Trial completion, IO biomarker: ACCTION: Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Feb 25, 2014
P2, N=126, Completed, Sponsor: JANSSEN Alzheimer Immunotherapy Research & Development, LLC
Not yet recruiting --> Recruiting Active, not recruiting --> Completed