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122 Companies |
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195 Products |
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195 Products |
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116 Mechanisms of Action |
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3 Trials |
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2333 News |
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- ||||||| donepezil / Generic mfg.
Trial completion, Enrollment change: A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease (clinicaltrials.gov) - Jan 20, 2015
P3, N=313, Completed, Sponsor: Eisai Limited
Active, not recruiting --> Completed | N=260 --> 313
- samelisant (SUVN-G3031) / Suven Life Sci
New P1 trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects (clinicaltrials.gov) - Jan 20, 2015
P1, N=64, Recruiting, Sponsor: Suven Life Sciences Limited
- | idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
New P1 trial: Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function (clinicaltrials.gov) - Jan 17, 2015
P1, N=32, Not yet recruiting, Sponsor: H. Lundbeck A/S
- donepezil / Generic mfg.
Phase classification, Enrollment change: BRAINz: Efficacy Study of a ZT-1 Implant in Patients Suffering From Alzheimer's Disease (clinicaltrials.gov) - Jan 15, 2015
P=N/A, N=228, Completed, Sponsor: Debiopharm International SA
Active, not recruiting --> Completed | N=260 --> 313 Phase classification: P2 --> P=N/A | N=128 --> 228
- ||||| osoresnontrine (BI 409306) / Boehringer Ingelheim
New P2 trial: BI 409306 in Patients With Cognitive Impairment Due to Alzheimer's Disease. (clinicaltrials.gov) - Jan 15, 2015
P2, N=336, Not yet recruiting, Sponsor: Boehringer Ingelheim
- ||| Trial completion: Bridging Study of C11 Pittsburgh Compound B (PiB) and F18 Flutemetamol Brain Positron Emission Tomography (PET) (clinicaltrials.gov) - Jan 15, 2015
P=N/A, N=89, Completed, Sponsor: Mayo Clinic
Phase classification: P2 --> P=N/A | N=128 --> 228 Enrolling by invitation --> Completed
- donepezil / Generic mfg.
Trial primary completion date: Adjunctive Donepezil Therapy and Genetic Risk Factors of Cognitive Dysfunction in Brain Tumor Survivors (clinicaltrials.gov) - Jan 15, 2015
P=N/A, N=25, Active, not recruiting, Sponsor: Memorial Sloan-Kettering Cancer Center
Enrolling by invitation --> Completed Trial primary completion date: Oct 2014 --> Oct 2015
- || Trial primary completion date: LYLO: " The Eyes Have it " : Ocular Saccade Abnormalities in Prodromal Alzheimer's Disease (clinicaltrials.gov) - Jan 13, 2015
P=N/A, N=90, Recruiting, Sponsor: University Hospital, Bordeaux
Trial primary completion date: Oct 2014 --> Oct 2015 Trial primary completion date: Dec 2014 --> Dec 2015
- | Trial initiation date: Brain-Computer Interface System for Training Memory and Attention in Elderly (clinicaltrials.gov) - Jan 13, 2015
P2/3, N=240, Not yet recruiting, Sponsor: Duke-NUS Graduate Medical School
Trial primary completion date: Dec 2014 --> Dec 2015 Initiation date: Oct 2014 --> Feb 2015
- Trial completion: ASPIS: Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke (clinicaltrials.gov) - Jan 13, 2015
P4, N=202, Completed, Sponsor: Danube University Krems
Initiation date: Oct 2014 --> Feb 2015 Active, not recruiting --> Completed
- || Enrollment change, Trial primary completion date: AMIMAGE 2: Neuroimaging Markers of Alzheimer Disease: a Longitudinal Population Study (clinicaltrials.gov) - Jan 13, 2015
P=N/A, N=300, Recruiting, Sponsor: University Hospital, Bordeaux
Active, not recruiting --> Completed N=400 --> 300 | Trial primary completion date: Sep 2014 --> Sep 2016
- ||||| LMTX (hydromethylthionine) / TauRx
Enrollment closed, Trial primary completion date: Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild Alzheimer's Disease (clinicaltrials.gov) - Jan 9, 2015
P3, N=700, Active, not recruiting, Sponsor: TauRx Therapeutics Ltd
N=400 --> 300 | Trial primary completion date: Sep 2014 --> Sep 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Apr 2016
- | Trial completion, Enrollment change: Pilot Study of the Living With Hope Program for Family Caregivers of Persons With Dementia Residing in Long Term Care (clinicaltrials.gov) - Jan 8, 2015
P=N/A, N=21, Completed, Sponsor: University of Alberta
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Apr 2016 Recruiting --> Completed | N=30 --> 21
- Trial completion: Pilot and Feasibility Study of a Mirrors Intervention for Reducing Delirium in Older Cardiac Surgical Patients (clinicaltrials.gov) - Jan 8, 2015
P=N/A, N=100, Completed, Sponsor: Papworth Hospital NHS Foundation Trust
Recruiting --> Completed | N=30 --> 21 Active, not recruiting --> Completed
- |||| atabecestat (JNJ-54861911) / J&J
Enrollment open: A Safety and Tolerability Study of JNJ-54861911 in Participants With Early Alzheimer's Disease (clinicaltrials.gov) - Jan 7, 2015
P2, N=100, Recruiting, Sponsor: Janssen Research & Development, LLC
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Clinical: Physical Activity and Neuropsychological Outcomes in a Cancer Population (clinicaltrials.gov) - Jan 7, 2015
P=N/A, N=80, Recruiting, Sponsor: University of California, San Diego
- ||| Surgery: Predictors of Postoperative Delirium in Elder Patients After Spine Surgery: Regional Cerebral Oxygen Saturation (clinicaltrials.gov) - Jan 6, 2015
P=N/A, N=109, Recruiting, Sponsor: Yonsei University
- ||| Trial completion: Telephone Resources and Assistance for Caregivers (TRAC) (clinicaltrials.gov) - Jan 2, 2015
P=N/A, N=211, Completed, Sponsor: Rush University Medical Center
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- |||||||||| encenicline (EVP-6124) / Forum Pharmaceuticals, Mitsubishi Tanabe
New P3 trial: Safety Study of MT-4666 in Subjects With Alzheimer's Disease (clinicaltrials.gov) - Dec 30, 2014
P3, N=200, Recruiting, Sponsor: Mitsubishi Tanabe Pharma Corporation
- Trial completion: BIS Monitoring to Detect Deep Sedation (clinicaltrials.gov) - Dec 29, 2014
P=N/A, N=45, Completed, Sponsor: Capital Medical University
Active, not recruiting --> Completed Recruiting --> Completed
- |||| landipirdine (SYN120) / Acorda
Enrollment open: SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE) (clinicaltrials.gov) - Dec 25, 2014
P2, N=80, Recruiting, Sponsor: Biotie Therapies Inc.
Recruiting --> Completed Not yet recruiting --> Recruiting
- || PF-05212377 / Pfizer
Trial primary completion date: Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil (clinicaltrials.gov) - Dec 24, 2014
P2, N=342, Recruiting, Sponsor: Pfizer
Not yet recruiting --> Recruiting Trial primary completion date: May 2016 --> Dec 2016
- ||| osoresnontrine (BI 409306) / Boehringer Ingelheim
Trial initiation date: Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo (clinicaltrials.gov) - Dec 24, 2014
P2, N=288, Not yet recruiting, Sponsor: Boehringer Ingelheim
Trial primary completion date: May 2016 --> Dec 2016 Initiation date: Oct 2014 --> Jan 2015
- Enrollment closed, Trial primary completion date: Cognitive Dysfunction in Postural Tachycardia Syndrome (clinicaltrials.gov) - Dec 24, 2014
P=N/A, N=85, Active, not recruiting, Sponsor: Vanderbilt University
Initiation date: Oct 2014 --> Jan 2015 Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Mar 2018
- Trial completion, Trial primary completion date: Music Therapy in Methodist Homes: a Study Investigating the Impact of a Music Therapy Programme (clinicaltrials.gov) - Dec 24, 2014
P=N/A, N=27, Completed, Sponsor: Methodist Homes for the Aged
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Mar 2018 Active, not recruiting --> Completed | Trial primary completion date: Sep 2013 --> Dec 2014
- midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Metastases: Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients (clinicaltrials.gov) - Dec 24, 2014
P2, N=0, Withdrawn, Sponsor: Fraser Health
Active, not recruiting --> Completed | Trial primary completion date: Sep 2013 --> Dec 2014 N=20 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Oct 2013 --> Nov 2014
- MK0249 / Merck (MSD)
Enrollment change: A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023) (clinicaltrials.gov) - Dec 24, 2014
P1, N=4, Terminated, Sponsor: Merck Sharp & Dohme Corp.
N=20 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Oct 2013 --> Nov 2014 N=44 --> 4
- Clinical: mRNAOrtho: Postoperative Delirium in Hip Arthroplasty Patients (clinicaltrials.gov) - Dec 24, 2014
P=N/A, N=50, Recruiting, Sponsor: Ohio State University
- || Biomarker, Trial primary completion date: Improving Dementia Caregiver Sleep & the Effect on Heart Disease Biomarkers (clinicaltrials.gov) - Dec 19, 2014
P=N/A, N=80, Recruiting, Sponsor: University of South Florida
N=44 --> 4 Trial primary completion date: Apr 2015 --> Apr 2017
- Enrollment status, Trial primary completion date, Surgery: COGCAR: Characterization of Factors Influencing the Cognitive Decline in Patients With Coronary Artery Disease (clinicaltrials.gov) - Dec 19, 2014
P=N/A, N=400, Recruiting, Sponsor: University Hospital, Lille
Trial primary completion date: Apr 2015 --> Apr 2017 Enrolling by invitation --> Recruiting | Trial primary completion date: Jun 2010 --> Jun 2015
- blarcamesine (Anavex 2-73) / Anavex
Enrollment open, PK/PD data: Phase 2a Dose Finding, PK/PD and 12 Month Exploratory Efficacy Study of ANAVEX2-73 in Patients With Alzheimer's Disease (clinicaltrials.gov) - Dec 19, 2014
P2, N=32, Recruiting, Sponsor: Anavex Life Sciences Corp.
Enrolling by invitation --> Recruiting | Trial primary completion date: Jun 2010 --> Jun 2015 Not yet recruiting --> Recruiting
- || Kisunla (donanemab-azbt) / Eli Lilly
Trial primary completion date: A Study of LY3002813 in Participants With Alzheimer's Disease (clinicaltrials.gov) - Dec 19, 2014
P1, N=100, Recruiting, Sponsor: Eli Lilly and Company
Not yet recruiting --> Recruiting Trial primary completion date: May 2015 --> Aug 2015
- Trial primary completion date: Exercise Effects in Huntington's Disease (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=40, Recruiting, Sponsor: University of Zurich
Trial primary completion date: May 2015 --> Aug 2015 Trial primary completion date: Jan 2014 --> Dec 2015
- Enrollment change: The Efficacy And Cognitive Impairment Of Modified Electroconvulsive Therapy (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=280, Recruiting, Sponsor: Shanghai Mental Health Center
Trial primary completion date: Jan 2014 --> Dec 2015 N=420 --> 280
- Enrollment closed, Trial primary completion date: Comparison of Hand Feeding Techniques for Persons With Dementia (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=30, Active, not recruiting, Sponsor: Duke University
N=420 --> 280 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Sep 2014
- Enrollment closed: A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=30, Active, not recruiting, Sponsor: Virginia Commonwealth University
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Sep 2014 Recruiting --> Active, not recruiting
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Enrollment closed, Trial primary completion date, HEOR: COMET-AD: Comparative Research of Alzheimer's Disease Drugs (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=300, Active, not recruiting, Sponsor: Indiana University
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2013 --> Oct 2015
- Trial completion: Virtual Reality Based Balance Training in People With Mild Cognitive Impairment (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=20, Completed, Sponsor: University of Arizona
Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2013 --> Oct 2015 Recruiting --> Completed
- | methylprednisolone sodium succinate / Generic mfg.
Surgery: Preoperative Single Glucocorticoid Hip Fracture Hip Fracture Surgery (clinicaltrials.gov) - Dec 17, 2014
P4, N=120, Not yet recruiting, Sponsor: Hvidovre University Hospital
- HEOR: Molecular Cerebral Imaging in Incipient Dementia (MCI-ID) II (clinicaltrials.gov) - Dec 16, 2014
P=N/A, N=1500, Not yet recruiting, Sponsor: University of California, Los Angeles
- Trial completion, Enrollment change, Trial primary completion date: SAM-AKS: Collaboration Between Department of Old Age Psychiatry and Nursing Homes (clinicaltrials.gov) - Dec 13, 2014
P=N/A, N=700, Completed, Sponsor: Sykehuset Innlandet HF
Recruiting --> Completed Recruiting --> Completed | N=1000 --> 700 | Trial primary completion date: Dec 2011 --> Mar 2012
- Trial completion, Trial primary completion date: Multidisciplinary Intervention for Challenging Behaviour (Agitation) in Patients With Dementia (clinicaltrials.gov) - Dec 13, 2014
P=N/A, N=30, Completed, Sponsor: Sykehuset Innlandet HF
Recruiting --> Completed | N=1000 --> 700 | Trial primary completion date: Dec 2011 --> Mar 2012 Recruiting --> Completed | Trial primary completion date: Dec 2011 --> Aug 2011
- Clinical: Acetylcholinesterase in Postoperative Delirium (clinicaltrials.gov) - Dec 13, 2014
P=N/A, N=120, Completed, Sponsor: Heidelberg University
- || simvastatin / Generic mfg.
Biomarker, Enrollment closed, Trial primary completion date: SimBio: Effects of Simvastatin on Biomarkers (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=120, Active, not recruiting, Sponsor: University of Washington
Recruiting --> Completed | Trial primary completion date: Dec 2011 --> Aug 2011 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Apr 2015
- Trial primary completion date: Cognitive Impairment and Balance in Elderly (clinicaltrials.gov) - Dec 10, 2014
P=N/A, N=100, Recruiting, Sponsor: Universidad de Granada
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Apr 2015 Trial primary completion date: Oct 2014 --> Jan 2015
- Trial primary completion date: Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment (clinicaltrials.gov) - Dec 10, 2014
P=N/A, N=66, Recruiting, Sponsor: University of California, Los Angeles
Trial primary completion date: Oct 2014 --> Jan 2015 Trial primary completion date: Sep 2014 --> May 2016
- Trial primary completion date: Insulin Resistance and Cognitive Dysfunction in Obese Adolescents: Pilot Study (clinicaltrials.gov) - Dec 10, 2014
P=N/A, N=50, Recruiting, Sponsor: Winthrop University Hospital
Trial primary completion date: Sep 2014 --> May 2016 Trial primary completion date: Jan 2015 --> May 2015
- midazolam hydrochloride / Generic mfg.
Trial initiation date, Trial primary completion date, Surgery: Decreasing the Incidence of Delirium After Cardiac Surgery (clinicaltrials.gov) - Dec 10, 2014
P4, N=200, Not yet recruiting, Sponsor: University of California, Los Angeles
Trial primary completion date: Jan 2015 --> May 2015 Initiation date: Apr 2014 --> Jan 2015 | Trial primary completion date: Dec 2015 --> Dec 2016
- quetiapine / Generic mfg.
Trial initiation date, Trial primary completion date: Efficacy of Quetiapine for Pediatric Delirium (clinicaltrials.gov) - Dec 10, 2014
P1/2, N=50, Not yet recruiting, Sponsor: Weill Medical College of Cornell University
Initiation date: Apr 2014 --> Jan 2015 | Trial primary completion date: Dec 2015 --> Dec 2016 Initiation date: Mar 2014 --> Feb 2015 | Trial primary completion date: Mar 2015 --> Feb 2016
- Clinical: LLM-AUTH: Cognitive/Physical Computer-Game Blended Training of Elderly: Neuroscientific LLM Studies (clinicaltrials.gov) - Dec 10, 2014
P=N/A, N=581, Completed, Sponsor: Aristotle University Of Thessaloniki