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122 Companies |
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196 Products |
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196 Products |
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116 Mechanisms of Action |
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3 Trials |
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2338 News |
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- |||| PF-05212377 / Pfizer
Enrollment open, Enrollment change: Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil (clinicaltrials.gov) - May 14, 2015
P2, N=342, Recruiting, Sponsor: Pfizer
Active, not recruiting --> Recruiting | N=131 --> 342
- Enrollment closed: UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM) (clinicaltrials.gov) - May 13, 2015
P=N/A, N=30, Active, not recruiting, Sponsor: University of California, Los Angeles
Active, not recruiting --> Recruiting | N=131 --> 342 Recruiting --> Active, not recruiting
- ||||||| Trial completion: Project ACT: Advancing Caregiving Techniques (clinicaltrials.gov) - May 13, 2015
P3, N=272, Completed, Sponsor: Thomas Jefferson University
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Enrollment change: ICUDelirium: Effect of Daily Interruption of Continuous Sedation on Delirium, Sleep Perception in Intensive Care Unit (ICU) Patients (clinicaltrials.gov) - May 8, 2015
P0, N=52, Completed, Sponsor: University of California, San Francisco
Active, not recruiting --> Completed N=250 --> 52
- PBF-999 / Palobiofarma
Trial primary completion date: Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers (clinicaltrials.gov) - May 7, 2015
P1, N=32, Recruiting, Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
N=250 --> 52 Trial primary completion date: Apr 2015 --> Jul 2015
- Enrollment open: Evaluation Prospectively the Level of Reduction in Cognitive Functions of Cancer Patients Who Are on Active Oncology Treatments and Use Cannabis. The Second Goal is to Identify High-risk Groups for Cognitive Impairment Due to Cannabis Use. (clinicaltrials.gov) - May 7, 2015
P=N/A, N=100, Recruiting, Sponsor: Rambam Health Care Campus
Trial primary completion date: Apr 2015 --> Jul 2015 Not yet recruiting --> Recruiting
- |||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Enrollment status: STAR Extension: Long-term Safety and Tolerability of Idalopirdine (Lu AE58054) as Adjunctive Treatment to Donepezil in Patients With Mild-moderate Alzheimer's Disease (clinicaltrials.gov) - May 6, 2015
P3, N=1770, Enrolling by invitation, Sponsor: H. Lundbeck A/S
Not yet recruiting --> Recruiting Recruiting --> Enrolling by invitation
- lorazepam / Generic mfg., dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine (Precedex®) for Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD) (clinicaltrials.gov) - May 5, 2015
P4, N=150, Recruiting, Sponsor: Denver Health and Hospital Authority
Recruiting --> Enrolling by invitation Trial primary completion date: Mar 2015 --> Mar 2017
- Trial completion, Trial primary completion date: Telephone Support for Dementia Caregivers (clinicaltrials.gov) - May 5, 2015
P2, N=250, Completed, Sponsor: Rhode Island Hospital
Trial primary completion date: Mar 2015 --> Mar 2017 Recruiting --> Completed | Trial primary completion date: Feb 2012 --> May 2013
- Trial primary completion date, Surgery: Perfusion Pressure Cerebral Infarction Trial (PPCI) (clinicaltrials.gov) - May 5, 2015
P=N/A, N=180, Recruiting, Sponsor: Rigshospitalet, Denmark
Recruiting --> Completed | Trial primary completion date: Feb 2012 --> May 2013 Trial primary completion date: Jul 2016 --> Dec 2015
- Trial completion, Enrollment change, Trial primary completion date: Use of Transdermal Clonidine in Trauma Patients (clinicaltrials.gov) - May 5, 2015
P4, N=22, Completed, Sponsor: Memorial Health University Medical Center
Trial primary completion date: Jul 2016 --> Dec 2015 Recruiting --> Completed | N=120 --> 22 | Trial primary completion date: May 2012 --> Aug 2012
- Enrollment change, Trial termination, Trial primary completion date: The Effect of Repeated Transcranial Magnetic Stimulation on Off-line Resting Electroencephalographic Signal in Alzheimer's Disease (clinicaltrials.gov) - May 4, 2015
P=N/A, N=5, Terminated, Sponsor: Lawson Health Research Institute
New data from a published trial requires substantial change in study protocol 2. no funding available to carry the study further
- | Trial completion, Phase classification, Enrollment change, Trial primary completion date: Online Caregiver Psychoeducation and Support for Alzheimer's (clinicaltrials.gov) - May 2, 2015
P2/3, N=53, Completed, Sponsor: Department of Veterans Affairs
no funding available to carry the study further Active, not recruiting --> Completed | Phase classification: P2 --> P2/3 | N=204 --> 53 | Trial primary completion date: Dec 2012 --> Jun 2012
- Trial primary completion date: PRO-MH2: Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease (clinicaltrials.gov) - May 1, 2015
P=N/A, N=50, Recruiting, Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Active, not recruiting --> Completed | Phase classification: P2 --> P2/3 | N=204 --> 53 | Trial primary completion date: Dec 2012 --> Jun 2012 Trial primary completion date: Dec 2014 --> Dec 2015
- |||| Trial completion: Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline (clinicaltrials.gov) - May 1, 2015
P4, N=618, Completed, Sponsor: Avid Radiopharmaceuticals
Trial primary completion date: Dec 2014 --> Dec 2015 Active, not recruiting --> Completed
- Biomarker, Trial primary completion date: A3PM: African American Alzheimer's Progression Markers - CSF and Neuro-Imaging (clinicaltrials.gov) - Apr 30, 2015
P=N/A, N=150, Recruiting, Sponsor: Emory University
Active, not recruiting --> Completed Trial primary completion date: Mar 2015 --> Dec 2015
- Trial primary completion date: Massage Technique for Pain, Anxiety and Delirium in SAH Patients (clinicaltrials.gov) - Apr 30, 2015
P=N/A, N=50, Recruiting, Sponsor: Sara E. Hocker, M.D
Trial primary completion date: Mar 2015 --> Dec 2015 Trial primary completion date: Sep 2014 --> Sep 2016
- | Enrollment change, Trial termination: Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer's Disease (clinicaltrials.gov) - Apr 30, 2015
P2, N=85, Terminated, Sponsor: Rock Creek Pharmaceuticals, Inc.
Trial primary completion date: Sep 2014 --> Sep 2016 N=200 --> 85 | Suspended --> Terminated; Administrative status of active ingredient anatabine
- Trial primary completion date: A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease (clinicaltrials.gov) - Apr 29, 2015
P=N/A, N=30, Active, not recruiting, Sponsor: Virginia Commonwealth University
N=200 --> 85 | Suspended --> Terminated; Administrative status of active ingredient anatabine Trial primary completion date: Dec 2014 --> Dec 2015
- Trial primary completion date: Cognitive Intervention For Delirium in Dementia (clinicaltrials.gov) - Apr 29, 2015
P2, N=256, Active, not recruiting, Sponsor: Penn State University
Trial primary completion date: Dec 2014 --> Dec 2015 Trial primary completion date: Jan 2015 --> Dec 2015
- Trial completion: SensiCare: Sensory Support Care for Elderly Patients Suffering From Alzheimer'S-type Neurodegenerative Disease (clinicaltrials.gov) - Apr 29, 2015
P=N/A, N=31, Completed, Sponsor: Centre Hospitalier Universitaire de Nīmes
Trial primary completion date: Jan 2015 --> Dec 2015 Active, not recruiting --> Completed
- ||| Biomarker, Trial completion: Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements (clinicaltrials.gov) - Apr 28, 2015
P=N/A, N=121, Completed, Sponsor: Pamlab, Inc.
Active, not recruiting --> Completed Enrolling by invitation --> Completed
- bryostatin 1 (NSC 339555) / Synaptogenix
Enrollment change, Trial termination: Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease (clinicaltrials.gov) - Apr 25, 2015
P1/2, N=9, Terminated, Sponsor: Neurotrope Bioscience, Inc.
Enrolling by invitation --> Completed N=15 --> 9 | Recruiting --> Terminated; Part 2 of study replaced by NTRP-101-202, assessing 3 doses of bryostatin.
- | Enrollment closed, Trial primary completion date: OculoMacl: Oculomotor Testing in the Differential Diagnosis of Dementia (clinicaltrials.gov) - Apr 25, 2015
P3, N=100, Active, not recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
N=15 --> 9 | Recruiting --> Terminated; Part 2 of study replaced by NTRP-101-202, assessing 3 doses of bryostatin. Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2014 --> Feb 2016
- Enrollment closed, Trial primary completion date, Surgery: Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery (clinicaltrials.gov) - Apr 25, 2015
P=N/A, N=266, Active, not recruiting, Sponsor: University Health Network, Toronto
Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2014 --> Feb 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Dec 2014
- Trial primary completion date: Volunteers Adding Life in Dementia (clinicaltrials.gov) - Apr 22, 2015
P=N/A, N=30, Recruiting, Sponsor: Queen's University
Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2014 --> Dec 2014 Trial primary completion date: Dec 2014 --> Dec 2015
- Trial primary completion date: PC-DATA: The Primary Care - Dementia Assessment and Treatment Algorithm (clinicaltrials.gov) - Apr 22, 2015
P=N/A, N=135, Recruiting, Sponsor: Queen's University
Trial primary completion date: Dec 2014 --> Dec 2015 Trial primary completion date: Mar 2015 --> Dec 2015
- Enrollment change, Trial withdrawal: Effect of Non-pharmacological Therapy on Cognitive Function of Patients With Cognitive Impairment (clinicaltrials.gov) - Apr 22, 2015
P=N/A, N=0, Withdrawn, Sponsor: National Institute of Medical Sciences and Nutrition, Salvador Zubiran
Trial primary completion date: Mar 2015 --> Dec 2015 N=116 --> 0 | Recruiting --> Withdrawn
- Enrollment change: Pilot and Feasibility Study of a Mirrors Intervention for Reducing Delirium in Older Cardiac Surgical Patients (clinicaltrials.gov) - Apr 22, 2015
P=N/A, N=223, Completed, Sponsor: Papworth Hospital NHS Foundation Trust
N=116 --> 0 | Recruiting --> Withdrawn N=100 --> 223
- Posiphen (buntanetap) / Annovis Bio
Enrollment change, Trial termination, Trial primary completion date: Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN (clinicaltrials.gov) - Apr 22, 2015
P1, N=5, Terminated, Sponsor: QR Pharma Inc.
N=100 --> 223 N=30 --> 5 | Recruiting --> Terminated | Trial primary completion date: Sep 2011 --> Jul 2010; Business decision based on funding
- OMS824 / Omeros
Trial primary completion date: Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease (clinicaltrials.gov) - Apr 21, 2015
P2, N=36, Suspended, Sponsor: Omeros Corporation
N=30 --> 5 | Recruiting --> Terminated | Trial primary completion date: Sep 2011 --> Jul 2010; Business decision based on funding Trial primary completion date: Mar 2015 --> Mar 2016
- sevoflurane / Generic mfg.
Clinical: POCD-MRI: Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction (clinicaltrials.gov) - Apr 21, 2015
P=N/A, N=100, Recruiting, Sponsor: Nicolai Goettel
Trial primary completion date: Mar 2015 --> Mar 2016 Initiation date: Sep 2014 --> Apr 2015 | Trial primary completion date: Dec 2015 --> Mar 2017
- ||| dexmedetomidine / Generic mfg.
Surgery: Reducing Delirium After Cardiac Surgery: A Multifaceted Approach Of Perioperative Care (clinicaltrials.gov) - Apr 21, 2015
P=N/A, N=185, Completed, Sponsor: University Health Network, Toronto
Initiation date: Sep 2014 --> Apr 2015 | Trial primary completion date: Dec 2015 --> Mar 2017 Recruiting --> Completed
- Trial completion, Trial primary completion date: Pilot Study of Aerobic Exercise in Early Alzheimer's Disease(AD) (clinicaltrials.gov) - Apr 21, 2015
P=N/A, N=77, Completed, Sponsor: Jeff Burns, MD
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Jan 2015 --> Apr 2015
- | donepezil / Generic mfg.
Phase classification: Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease (clinicaltrials.gov) - Apr 21, 2015
P=N/A, N=1000, Active, not recruiting, Sponsor: Eisai Co., Ltd.
Recruiting --> Completed | Trial primary completion date: Jan 2015 --> Apr 2015 Phase classification: P4 --> P=N/A
- methylprednisolone sodium succinate / Generic mfg.
Surgery: Preoperative Single Glucocorticoid Hip Fracture Hip Fracture Surgery (clinicaltrials.gov) - Apr 21, 2015
P4, N=120, Recruiting, Sponsor: Hvidovre University Hospital
Phase classification: P4 --> P=N/A Not yet recruiting --> Recruiting
- ||| PF-05212377 / Pfizer
Enrollment closed, Enrollment change: Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil (clinicaltrials.gov) - Apr 20, 2015
P2, N=131, Active, not recruiting, Sponsor: Pfizer
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting | N=342 --> 131
- rilapladib (SB-659032) / GSK
Trial initiation date, Trial primary completion date: Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers (clinicaltrials.gov) - Apr 20, 2015
P1, N=30, Not yet recruiting, Sponsor: GlaxoSmithKline
Recruiting --> Active, not recruiting | N=342 --> 131 Initiation date: Sep 2015 --> Oct 2017 | Trial primary completion date: Dec 2015 --> Jan 2018
- || Trial primary completion date: COGHIC-AV45: Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage (clinicaltrials.gov) - Apr 19, 2015
P=N/A, N=70, Recruiting, Sponsor: University Hospital, Toulouse
Initiation date: Sep 2015 --> Oct 2017 | Trial primary completion date: Dec 2015 --> Jan 2018 Trial primary completion date: Jan 2015 --> Jul 2015
- rilapladib (SB-659032) / GSK
Trial initiation date, Trial primary completion date: Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers (clinicaltrials.gov) - Apr 19, 2015
P1, N=30, Not yet recruiting, Sponsor: GlaxoSmithKline
Trial primary completion date: Jan 2015 --> Jul 2015 Initiation date: Jan 2015 --> Sep 2015 | Trial primary completion date: Apr 2015 --> Dec 2015
- rosiglitazone / Generic mfg.
Enrollment change: QTc Study of Rosi XR in Healthy Volunteers (clinicaltrials.gov) - Apr 17, 2015
P1, N=0, Withdrawn, Sponsor: GlaxoSmithKline
Initiation date: Jan 2015 --> Sep 2015 | Trial primary completion date: Apr 2015 --> Dec 2015 N=216 --> 0
- donepezil / Generic mfg.
Enrollment closed: Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil (clinicaltrials.gov) - Apr 15, 2015
P4, N=60, Active, not recruiting, Sponsor: New York State Psychiatric Institute
N=216 --> 0 Recruiting --> Active, not recruiting
- citalopram / Generic mfg., venlafaxine / Generic mfg., donepezil / Generic mfg.
Enrollment closed, Trial primary completion date: DEP-CI: Combination Treatment Study for Memory Impairment and Depression (clinicaltrials.gov) - Apr 15, 2015
P4, N=80, Active, not recruiting, Sponsor: New York State Psychiatric Institute
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Nov 2015
- |||| rivastigmine / Generic mfg.
Enrollment open, Trial primary completion date: INSTINCT: 16w Interventional Study on Titration and Dose/Efficacy Assessment of Exelon in Chinese Alzheimer's Disease Patients (clinicaltrials.gov) - Apr 15, 2015
P4, N=186, Recruiting, Sponsor: Novartis Pharmaceuticals
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Nov 2015 Not yet recruiting --> Recruiting | Trial primary completion date: May 2015 --> Sep 2015
- haloperidol / Generic mfg.
Trial primary completion date, Surgery: HALPCARD: Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium (clinicaltrials.gov) - Apr 15, 2015
P3, N=40, Recruiting, Sponsor: McMaster University
Not yet recruiting --> Recruiting | Trial primary completion date: May 2015 --> Sep 2015 Trial primary completion date: Apr 2015 --> Apr 2016
- donepezil / Generic mfg.
Trial primary completion date: Donepezil and the Risk of Falls in Seniors With Cognitive Impairment (clinicaltrials.gov) - Apr 15, 2015
P=N/A, N=140, Recruiting, Sponsor: Lawson Health Research Institute
Trial primary completion date: Apr 2015 --> Apr 2016 Trial primary completion date: Jun 2015 --> Dec 2015
- || Trial primary completion date: Post-Operative Delirium in Elderly Surgical Patients (clinicaltrials.gov) - Apr 15, 2015
P=N/A, N=210, Recruiting, Sponsor: Johns Hopkins University
Trial primary completion date: Jun 2015 --> Dec 2015 Trial primary completion date: Jan 2015 --> May 2016
- Daytrana (methylphenidate transdermal system) / Hisamitsu
Enrollment change, Trial initiation date, Trial termination: Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia. (clinicaltrials.gov) - Apr 15, 2015
P4, N=12, Terminated, Sponsor: St. Louis University
Trial primary completion date: Jan 2015 --> May 2016 N=40 --> 12 | Initiation date: Mar 2013 --> Nov 2012 | Enrolling by invitation --> Terminated; Administrative Reasons
- | rivastigmine transdermal / Generic mfg.
Enrollment change: RIVET: Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI (clinicaltrials.gov) - Apr 15, 2015
P3, N=138, Recruiting, Sponsor: Department of Veterans Affairs
N=40 --> 12 | Initiation date: Mar 2013 --> Nov 2012 | Enrolling by invitation --> Terminated; Administrative Reasons N=256 --> 138
- tetrabenazine / Generic mfg.
Trial primary completion date: Effect of Tetrabenazine on Stroop Interference in HD (clinicaltrials.gov) - Apr 15, 2015
P4, N=10, Recruiting, Sponsor: New York Medical College
N=256 --> 138 Trial primary completion date: Jan 2014 --> Jan 2016