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122 Companies |
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196 Products |
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196 Products |
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116 Mechanisms of Action |
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3 Trials |
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2338 News |
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- carvedilol / Generic mfg.
Trial primary completion date: Trial of Carvedilol in Alzheimer's Disease (clinicaltrials.gov) - Dec 10, 2015
P4, N=50, Recruiting, Sponsor: Johns Hopkins University
Trial primary completion date: Dec 2015 --> Dec 2016
- Trial completion: IGF and Other Neurotrophic Factors in Patients With Dementia (clinicaltrials.gov) - Dec 9, 2015
P=N/A, N=120, Completed, Sponsor: University of Aarhus
Trial primary completion date: Dec 2015 --> Dec 2016 Recruiting --> Completed
- simvastatin / Generic mfg.
Biomarker, Trial completion, Enrollment change, Trial primary completion date: SimBio: Effects of Simvastatin on Biomarkers (clinicaltrials.gov) - Dec 7, 2015
P=N/A, N=49, Completed, Sponsor: University of Washington
Recruiting --> Completed Active, not recruiting --> Completed | N=120 --> 49 | Trial primary completion date: Apr 2015 --> Oct 2015
- Biomarker, Enrollment closed, Trial primary completion date: A3PM: African American Alzheimer's Progression Markers - CSF and Neuro-Imaging (clinicaltrials.gov) - Dec 6, 2015
P=N/A, N=135, Active, not recruiting, Sponsor: Emory University
Active, not recruiting --> Completed | N=120 --> 49 | Trial primary completion date: Apr 2015 --> Oct 2015 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Apr 2016
- Trial primary completion date, Surgery: COGCAR: Characterization of Factors Influencing the Cognitive Decline in Patients With Coronary Artery Disease (clinicaltrials.gov) - Dec 5, 2015
P=N/A, N=400, Recruiting, Sponsor: University Hospital, Lille
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Apr 2016 Trial primary completion date: Jun 2015 --> Jun 2016
- Trial primary completion date: Cataract Removal and Alzheimer's Disease (clinicaltrials.gov) - Dec 5, 2015
P=N/A, N=210, Recruiting, Sponsor: University Hospital Case Medical Center
Trial primary completion date: Jun 2015 --> Jun 2016 Trial primary completion date: Jun 2015 --> Jun 2016
- | Trial completion, Trial primary completion date: FACTS: Facilitating Caregiver Adaptation to Patient Institutionalization (clinicaltrials.gov) - Dec 5, 2015
P3, N=217, Completed, Sponsor: University of Pittsburgh
Trial primary completion date: Jun 2015 --> Jun 2016 Active, not recruiting --> Completed | Trial primary completion date: Mar 2012 --> Mar 2013
- Trial completion: Patients With Behavioural Symptoms and Hospitalized in Cognitive and Behavioural Units (clinicaltrials.gov) - Dec 5, 2015
P=N/A, N=306, Completed, Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Active, not recruiting --> Completed | Trial primary completion date: Mar 2012 --> Mar 2013 Recruiting --> Completed
- Trial termination, Trial primary completion date: UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM) (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=30, Terminated, Sponsor: University of California, Los Angeles
Recruiting --> Completed Active, not recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Aug 2015
- midazolam hydrochloride / Generic mfg.
Trial initiation date, Trial primary completion date, Surgery: Decreasing the Incidence of Delirium After Cardiac Surgery (clinicaltrials.gov) - Dec 4, 2015
P4, N=200, Not yet recruiting, Sponsor: University of California, Los Angeles
Active, not recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Aug 2015 Initiation date: Jan 2015 --> Jan 2016 | Trial primary completion date: Dec 2016 --> Dec 2017
- Enrollment closed, Enrollment change: MFYM - P: Move for Your Mind - Pilot Trial (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=19, Active, not recruiting, Sponsor: University of Zurich
Initiation date: Jan 2015 --> Jan 2016 | Trial primary completion date: Dec 2016 --> Dec 2017 Recruiting --> Active, not recruiting | N=60 --> 19
- Trial completion, Enrollment change, Trial primary completion date, Surgery: A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia (clinicaltrials.gov) - Dec 4, 2015
P2, N=15, Completed, Sponsor: University of Pennsylvania
Recruiting --> Active, not recruiting | N=60 --> 19 Recruiting --> Completed | N=12 --> 15 | Trial primary completion date: Oct 2015 --> Apr 2015
- Trial completion: Gray Matters Alzheimer's Disease Prevention Intervention (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=146, Completed, Sponsor: Utah State University
Recruiting --> Completed | N=12 --> 15 | Trial primary completion date: Oct 2015 --> Apr 2015 Active, not recruiting --> Completed
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Trial completion, Enrollment change: Discontinuation of Cholinesterase Inhibitors for the Treatment of Severe Alzheimer's Disease (clinicaltrials.gov) - Nov 30, 2015
P3, N=40, Completed, Sponsor: Sunnybrook Health Sciences Centre
Active, not recruiting --> Completed Active, not recruiting --> Completed | N=50 --> 40
- haloperidol / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: HARPOON: Haloperidol Prophylaxis in Older Emergency Department Patients (clinicaltrials.gov) - Nov 28, 2015
P4, N=242, Completed, Sponsor: VU University Medical Center
Active, not recruiting --> Completed | N=50 --> 40 Active, not recruiting --> Completed | N=780 --> 242 | Trial primary completion date: Sep 2015 --> Apr 2015
- | Trial completion, Trial primary completion date: Florbetapir Calibration to the Centiloid Scale (clinicaltrials.gov) - Nov 27, 2015
P1, N=36, Completed, Sponsor: Avid Radiopharmaceuticals
Active, not recruiting --> Completed | N=780 --> 242 | Trial primary completion date: Sep 2015 --> Apr 2015 Recruiting --> Completed | Trial primary completion date: May 2015 --> Sep 2015
- Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: Post-stroke Triage "DOC": Simple Screening for Depression, Obstructive Sleep Apnea and Cognitive Impairment (clinicaltrials.gov) - Nov 26, 2015
P=N/A, N=1504, Completed, Sponsor: Sunnybrook Health Sciences Centre
Recruiting --> Completed | Trial primary completion date: May 2015 --> Sep 2015 Recruiting --> Completed | N=2800 --> 1504 | Initiation date: Oct 2013 --> Apr 2012 | Trial primary completion date: Oct 2018 --> Apr 2014
- Biomarker, Trial primary completion date: LIDEAL: Relationship Between Protein Biomarkers in Cerebrospinal Fluid and Alzheimer&Apos;s Disease in Patients With Depression (clinicaltrials.gov) - Nov 24, 2015
P=N/A, N=50, Recruiting, Sponsor: Institut Investigacio Sanitaria Pere Virgili
Recruiting --> Completed | N=2800 --> 1504 | Initiation date: Oct 2013 --> Apr 2012 | Trial primary completion date: Oct 2018 --> Apr 2014 Trial primary completion date: Jun 2015 --> Feb 2016
- Enrollment change, Trial termination, Trial primary completion date: Effects of a NeuroAD System, for the Treatment of Alzheimer Disease (clinicaltrials.gov) - Nov 24, 2015
P=N/A, N=1, Terminated, Sponsor: Neuronix Ltd
Trial primary completion date: Jun 2015 --> Feb 2016 N=40 --> 1 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Nov 2015; Administrative decision
- hydrocodone/paracetamol / Generic mfg.
Trial completion: LDOT: Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT) (clinicaltrials.gov) - Nov 22, 2015
P4, N=11, Completed, Sponsor: VA Office of Research and Development
N=40 --> 1 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Nov 2015; Administrative decision Active, not recruiting --> Completed
- Trial primary completion date: Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs) (clinicaltrials.gov) - Nov 22, 2015
P=N/A, N=416, Recruiting, Sponsor: University of Washington
Active, not recruiting --> Completed Trial primary completion date: Nov 2014 --> Feb 2017
- sevoflurane / Generic mfg.
Clinical: POCD-MRI: Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction (clinicaltrials.gov) - Nov 19, 2015
P=N/A, N=100, Recruiting, Sponsor: Nicolai Goettel
Trial primary completion date: Nov 2014 --> Feb 2017 Initiation date: Apr 2015 --> Jul 2015 | Trial primary completion date: Mar 2017 --> Jun 2017
- Trial completion, Enrollment change: Effects of Antimuscarinics on Cognition in Spinal Cord Injury (clinicaltrials.gov) - Nov 17, 2015
P=N/A, N=32, Completed, Sponsor: Swiss Paraplegic Centre Nottwil
Initiation date: Apr 2015 --> Jul 2015 | Trial primary completion date: Mar 2017 --> Jun 2017 Recruiting --> Completed | N=40 --> 32
- |||| Trial completion, Trial initiation date, Trial primary completion date: Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Nov 15, 2015
P2, N=183, Completed, Sponsor: Medivation, Inc.
Recruiting --> Completed | N=40 --> 32 Active, not recruiting --> Completed | Initiation date: Sep 2006 --> Sep 2005 | Trial primary completion date: May 2008 --> Aug 2006
- | memantine / Generic mfg.
Trial completion: Safety and Tolerability of Dimebon in Patients on Memantine, and Memantine Plus Donepezil (clinicaltrials.gov) - Nov 11, 2015
P1, N=46, Completed, Sponsor: Medivation, Inc.
Active, not recruiting --> Completed | Initiation date: Sep 2006 --> Sep 2005 | Trial primary completion date: May 2008 --> Aug 2006 Active, not recruiting --> Completed
- ||||| verubecestat (MK-8931) / Merck (MSD)
Enrollment closed: EPOCH: An Efficacy and Safety Trial of Verubecestat (MK-8931) in Mild to Moderate Alzheimer's Disease (P07738) (clinicaltrials.gov) - Nov 10, 2015
P2/3, N=1960, Active, not recruiting, Sponsor: Merck Sharp & Dohme Corp.
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- Biomarker, Trial completion: Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment (clinicaltrials.gov) - Nov 10, 2015
P=N/A, N=229, Completed, Sponsor: Qualissima
Recruiting --> Active, not recruiting Recruiting --> Completed
- Trial primary completion date: Computer-based Cognitive Training for Individuals With Parkinson's Disease (clinicaltrials.gov) - Nov 9, 2015
P=N/A, N=30, Active, not recruiting, Sponsor: Virginia Commonwealth University
Recruiting --> Completed Trial primary completion date: Aug 2015 --> Dec 2015
- | Trial completion: PAVeD: Preventing Aggression in Veterans With Dementia (clinicaltrials.gov) - Nov 9, 2015
P3, N=203, Completed, Sponsor: VA Office of Research and Development
Trial primary completion date: Aug 2015 --> Dec 2015 Active, not recruiting --> Completed
- |||| donepezil / Generic mfg.
Trial completion: The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment (clinicaltrials.gov) - Nov 9, 2015
P2, N=165, Completed, Sponsor: Eisai Limited
Active, not recruiting --> Completed No longer recruiting --> Completed
- | idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Trial completion, Enrollment change, Trial primary completion date: Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function (clinicaltrials.gov) - Nov 9, 2015
P1, N=16, Completed, Sponsor: H. Lundbeck A/S
No longer recruiting --> Completed Recruiting --> Completed | N=32 --> 16 | Trial primary completion date: Mar 2016 --> Sep 2015
- Trial primary completion date: Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198 (clinicaltrials.gov) - Nov 6, 2015
P=N/A, N=150, Recruiting, Sponsor: National Eye Institute (NEI)
Recruiting --> Completed | N=32 --> 16 | Trial primary completion date: Mar 2016 --> Sep 2015 Trial primary completion date: Oct 2015 --> Oct 2016
- Trial completion, Enrollment change: Evaluation of [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948 as Tracers for Positron Emission Tomography (PET) Imaging of Tau in Healthy and Alzheimer's Disease (AD) Participants (clinicaltrials.gov) - Nov 5, 2015
P1, N=8, Completed, Sponsor: Hoffmann-La Roche
Trial primary completion date: Oct 2015 --> Oct 2016 Recruiting --> Completed | N=34 --> 8
- |||| verubecestat (MK-8931) / Merck (MSD)
Trial primary completion date: APECS: Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019) (clinicaltrials.gov) - Nov 1, 2015
P3, N=1500, Recruiting, Sponsor: Merck Sharp & Dohme Corp.
Recruiting --> Completed | N=34 --> 8 Trial primary completion date: Mar 2018 --> Jul 2019
- || Trial primary completion date: HIAD: Hearing Instruments in Alzheimer's Disease (clinicaltrials.gov) - Oct 30, 2015
P=N/A, N=120, Recruiting, Sponsor: Phonak AG, Switzerland
Trial primary completion date: Mar 2018 --> Jul 2019 Trial primary completion date: Jul 2016 --> Dec 2016
- Trial primary completion date: Establishment of a Bank of Biospecimens for Future Research on Age-related Cognitive Disorders (clinicaltrials.gov) - Oct 30, 2015
P=N/A, N=1000, Enrolling by invitation, Sponsor: William Beaumont Hospitals
Trial primary completion date: Jul 2016 --> Dec 2016 Trial primary completion date: Jul 2015 --> Dec 2016
- pioglitazone / Generic mfg.
Trial primary completion date: POEM: Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI) (clinicaltrials.gov) - Oct 30, 2015
P2, N=300, Active, not recruiting, Sponsor: University of Colorado, Denver
Trial primary completion date: Jul 2015 --> Dec 2016 Trial primary completion date: Jan 2013 --> Jan 2016
- Cerebrolysin (porcine brain-derived proteolytic peptide fraction) / Novartis, EVER Pharma
Enrollment change, Trial withdrawal: Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT) (clinicaltrials.gov) - Oct 27, 2015
P4, N=0, Withdrawn, Sponsor: Ever Neuro Pharma GmbH
Trial primary completion date: Jan 2013 --> Jan 2016 N=510 --> 0 | Not yet recruiting --> Withdrawn
- Trial completion: Memory Training in Patients With Amnestic Mild Cognitive Impairment (clinicaltrials.gov) - Oct 27, 2015
P=N/A, N=30, Completed, Sponsor: University of Sao Paulo General Hospital
N=510 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Completed
- Trial completion, Trial primary completion date, Surgery: Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery (clinicaltrials.gov) - Oct 26, 2015
P=N/A, N=99, Completed, Sponsor: Johns Hopkins University
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Jun 2014
- || MK-7622 / Merck (MSD)
Trial primary completion date: Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012) (clinicaltrials.gov) - Oct 23, 2015
P2a, N=830, Recruiting, Sponsor: Merck Sharp & Dohme Corp.
Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Jun 2014 Trial primary completion date: Apr 2020 --> Dec 2019
- || osoresnontrine (BI 409306) / Boehringer Ingelheim
Trial primary completion date: Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo (clinicaltrials.gov) - Oct 23, 2015
P2, N=288, Recruiting, Sponsor: Boehringer Ingelheim
Trial primary completion date: Apr 2020 --> Dec 2019 Trial primary completion date: Sep 2016 --> May 2017
- Trial primary completion date: Neurocognitive Effects of Bilateral STN Versus GPi DBS in Parkinson's Disease Patients With MCI (clinicaltrials.gov) - Oct 23, 2015
P=N/A, N=50, Enrolling by invitation, Sponsor: St. Joseph's Hospital and Medical Center, Phoenix
Trial primary completion date: Sep 2016 --> May 2017 Trial primary completion date: Aug 2015 --> Dec 2015
- Enrollment change, Trial withdrawal: PreDeLight-ICU: Prevention of Delirium With Light in the Intensive Care Unit (clinicaltrials.gov) - Oct 23, 2015
P=N/A, N=0, Withdrawn, Sponsor: Charite University, Berlin, Germany
Trial primary completion date: Aug 2015 --> Dec 2015 N=96 --> 0 | Recruiting --> Withdrawn
- Enrollment open: Implementation of a Multicomponent Intervention to Prevent Physical Restraints in Nursing Home Residents (IMPRINT) (clinicaltrials.gov) - Oct 23, 2015
P=N/A, N=10800, Recruiting, Sponsor: University of Luebeck
N=96 --> 0 | Recruiting --> Withdrawn Not yet recruiting --> Recruiting
- dexmedetomidine / Generic mfg.
Surgery: Dexmedetomidine and Delirium in Patients After Cardiac Surgery (clinicaltrials.gov) - Oct 23, 2015
P4, N=284, Recruiting, Sponsor: Peking University First Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- encenicline (EVP-6124) / Forum Pharmaceuticals, Mitsubishi Tanabe
Enrollment change, Trial withdrawal: Study of the Safety of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease Currently Receiving Memantine (clinicaltrials.gov) - Oct 22, 2015
P2, N=0, Withdrawn, Sponsor: FORUM Pharmaceuticals Inc
Not yet recruiting --> Recruiting N=150 --> 0 | Not yet recruiting --> Withdrawn
- | PBF-999 / Palobiofarma
Trial completion, Trial primary completion date: Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers (clinicaltrials.gov) - Oct 22, 2015
P1, N=32, Completed, Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
N=150 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Oct 2015
- Trial completion, Enrollment change: Distance Savvy: Testing Tele-Savvy, a Distance Dementia Family Caregiver Education Program (clinicaltrials.gov) - Oct 21, 2015
P=N/A, N=42, Completed, Sponsor: Emory University
Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Oct 2015 Recruiting --> Completed | N=75 --> 42
- midodrine hydrochloride / Generic mfg.
Trial completion: Body Temperature in Persons With Tetraplegia When Exposed to Cold (clinicaltrials.gov) - Oct 20, 2015
P4, N=30, Completed, Sponsor: James J. Peters Veterans Affairs Medical Center
Recruiting --> Completed | N=75 --> 42 Active, not recruiting --> Completed