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122 Companies |
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196 Products |
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196 Products |
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116 Mechanisms of Action |
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3 Trials |
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2338 News |
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- Trial primary completion date: Retaining Cognition While Avoiding Late-Life Depression (clinicaltrials.gov) - Jan 18, 2016
P=N/A, N=136, Active, not recruiting, Sponsor: University of Pittsburgh
Trial primary completion date: Jun 2015 --> Jun 2016
- Trial primary completion date: Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID) (clinicaltrials.gov) - Jan 18, 2016
P=N/A, N=710, Recruiting, Sponsor: University of California, Los Angeles
Trial primary completion date: Jun 2015 --> Jun 2016 Trial primary completion date: Jan 2016 --> Jan 2017
- || MK-7622 / Merck (MSD)
Trial primary completion date: Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012) (clinicaltrials.gov) - Jan 17, 2016
P2a, N=830, Recruiting, Sponsor: Merck Sharp & Dohme Corp.
Trial primary completion date: Jan 2016 --> Jan 2017 Trial primary completion date: Dec 2019 --> Apr 2018
- lorazepam / Generic mfg.
Trial primary completion date: The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms (clinicaltrials.gov) - Jan 17, 2016
P1, N=75, Recruiting, Sponsor: Mayo Clinic
Trial primary completion date: Dec 2019 --> Apr 2018 Trial primary completion date: Oct 2015 --> Sep 2016
- donepezil / Generic mfg.
Trial completion, Phase classification, Trial primary completion date: Adjunctive Donepezil Therapy and Genetic Risk Factors of Cognitive Dysfunction in Brain Tumor Survivors (clinicaltrials.gov) - Jan 16, 2016
P1, N=25, Completed, Sponsor: Memorial Sloan Kettering Cancer Center
Trial primary completion date: Oct 2015 --> Sep 2016 Active, not recruiting --> Completed | Phase classification: PN/A --> P1 | Trial primary completion date: Oct 2016 --> Jan 2016
- Trial completion: Cognitive Assessment of Elderly Primary Care Patients (clinicaltrials.gov) - Jan 16, 2016
P=N/A, N=524, Completed, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed | Phase classification: PN/A --> P1 | Trial primary completion date: Oct 2016 --> Jan 2016 Active, not recruiting --> Completed
- Enrollment change, Trial withdrawal, Trial primary completion date: A Composite MR Neuroimaging Marker for Alzheimer's Disease (clinicaltrials.gov) - Jan 15, 2016
P=N/A, N=0, Withdrawn, Sponsor: Medical College of Wisconsin
Active, not recruiting --> Completed N=380 --> 0 | Enrolling by invitation --> Withdrawn | Trial primary completion date: Mar 2014 --> Jan 2016
- Phase classification: Enhanced External Counterpulsation and Its Effects on Vascular Hemodynamics in Cognitively Impaired Patients (clinicaltrials.gov) - Jan 15, 2016
P0, N=8, Completed, Sponsor: Patrick Moriarty, MD, FACP, FACC
N=380 --> 0 | Enrolling by invitation --> Withdrawn | Trial primary completion date: Mar 2014 --> Jan 2016 Phase classification: P=N/A --> P0
- Trial completion: Computer-based Cognitive Training for Individuals With Parkinson's Disease (clinicaltrials.gov) - Jan 12, 2016
P=N/A, N=25, Completed, Sponsor: Virginia Commonwealth University
Phase classification: P=N/A --> P0 Active, not recruiting --> Completed
- Trial completion: A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease (clinicaltrials.gov) - Jan 12, 2016
P=N/A, N=32, Completed, Sponsor: Virginia Commonwealth University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- ||| donepezil / Generic mfg.
Trial completion, Trial primary completion date: Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia (clinicaltrials.gov) - Jan 7, 2016
P=N/A, N=88, Completed, Sponsor: Samsung Medical Center
Active, not recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Jun 2010
- ||| donepezil / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Clinical Trial of Donepezil Between the Naive Group and the Switching Group (clinicaltrials.gov) - Jan 7, 2016
P=N/A, N=72, Completed, Sponsor: Samsung Medical Center
Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Jun 2010 Recruiting --> Completed | N=100 --> 72 | Trial primary completion date: Dec 2012 --> Apr 2009
- Biomarker, Enrollment closed, Trial primary completion date: PACE-2: Piedmont Aging, Cognition & Exercise Study-2 (clinicaltrials.gov) - Jan 5, 2016
P=N/A, N=33, Active, not recruiting, Sponsor: Wake Forest University
Recruiting --> Completed | N=100 --> 72 | Trial primary completion date: Dec 2012 --> Apr 2009 Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2015 --> Jul 2016
- ||| Trial completion, Surgery: Predictors of Postoperative Delirium in Elder Patients After Spine Surgery: Regional Cerebral Oxygen Saturation (clinicaltrials.gov) - Jan 5, 2016
P=N/A, N=109, Completed, Sponsor: Yonsei University
Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2015 --> Jul 2016 Recruiting --> Completed
- Enrollment open, Enrollment change: Pharmacokinetic Study Comparing Topical, Rectal, and Oral Quetiapine (clinicaltrials.gov) - Jan 4, 2016
P=N/A, N=16, Enrolling by invitation, Sponsor: Mayo Clinic
Recruiting --> Completed Active, not recruiting --> Enrolling by invitation | N=10 --> 16
- ketamine / Generic mfg.
Trial primary completion date: PODCAST: The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial (clinicaltrials.gov) - Dec 29, 2015
P3, N=600, Recruiting, Sponsor: Washington University School of Medicine
Active, not recruiting --> Enrolling by invitation | N=10 --> 16 Trial primary completion date: Feb 2015 --> Feb 2017
- ||| edonerpic (T-817MA) / Fujifilm Holdings
Enrollment closed, Trial primary completion date: Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202) (clinicaltrials.gov) - Dec 29, 2015
P2, N=450, Active, not recruiting, Sponsor: Toyama Chemical Co., Ltd.
Trial primary completion date: Feb 2015 --> Feb 2017 Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2016 --> Mar 2017
- Trial completion: The DETEcT Study - Delirium in Elderly paTiEnts Admitted to Trauma (clinicaltrials.gov) - Dec 29, 2015
P=N/A, N=672, Completed, Sponsor: Azienda Ospedaliero-Universitaria Careggi
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2016 --> Mar 2017 Recruiting --> Completed
- dexmedetomidine / Generic mfg.
Surgery: Dexmedetomidine and Delirium in Patients After Cardiac Surgery (clinicaltrials.gov) - Dec 29, 2015
P4, N=285, Completed, Sponsor: Peking University First Hospital
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Nov 2015 --> Aug 2015
- donepezil / Generic mfg.
Trial primary completion date: Adjunctive Donepezil Therapy and Genetic Risk Factors of Cognitive Dysfunction in Brain Tumor Survivors (clinicaltrials.gov) - Dec 29, 2015
P=N/A, N=25, Active, not recruiting, Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting --> Completed | Trial primary completion date: Nov 2015 --> Aug 2015 Trial primary completion date: Oct 2015 --> Oct 2016
- Trial primary completion date: Insulin Resistance and Cognitive Dysfunction in Obese Adolescents: Pilot Study (clinicaltrials.gov) - Dec 25, 2015
P=N/A, N=50, Recruiting, Sponsor: Winthrop University Hospital
Trial primary completion date: Oct 2015 --> Oct 2016 Trial primary completion date: May 2015 --> May 2016
- Enrollment open: LESCOD: "Lewy Body Screening in Cognitive Disorders" (clinicaltrials.gov) - Dec 25, 2015
P=N/A, N=180, Recruiting, Sponsor: Nantes University Hospital
Trial primary completion date: May 2015 --> May 2016 Not yet recruiting --> Recruiting
- Trial completion, Trial primary completion date: A Family Intervention for Delirium Prevention (clinicaltrials.gov) - Dec 25, 2015
P=N/A, N=79, Completed, Sponsor: Lawson Health Research Institute
Not yet recruiting --> Recruiting Recruiting --> Completed | Trial primary completion date: Aug 2014 --> Dec 2014
- Enrollment open, Trial primary completion date: Oral Health Intervention Pilot Study for Individuals With Memory Problems (clinicaltrials.gov) - Dec 25, 2015
P=N/A, N=5, Recruiting, Sponsor: Duke University
Recruiting --> Completed | Trial primary completion date: Aug 2014 --> Dec 2014 Active, not recruiting --> Recruiting | Trial primary completion date: Oct 2015 --> Jul 2016
- Biomarker, Trial completion, Enrollment change, Trial primary completion date: Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=1322, Completed, Sponsor: Minneapolis Medical Research Foundation
Active, not recruiting --> Recruiting | Trial primary completion date: Oct 2015 --> Jul 2016 Recruiting --> Completed | N=1000 --> 1322 | Trial primary completion date: Aug 2015 --> Dec 2015
- Trial completion: Instruments for Delirium Assessment Regarding to Analgesia Sedation and Ventilator Status (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=160, Completed, Sponsor: Charite University, Berlin, Germany
Recruiting --> Completed | N=1000 --> 1322 | Trial primary completion date: Aug 2015 --> Dec 2015 Recruiting --> Completed
- donepezil / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: Treatment of Delirium in the Elderly With Donepezil: a Double-blind, Randomized, Placebo-controlled Clinical Trial (clinicaltrials.gov) - Dec 23, 2015
P4, N=19, Terminated, Sponsor: University of Sao Paulo
Recruiting --> Completed N=190 --> 19 | Recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Dec 2015; Difficulty in recruiting subjects for the trial.
- Phase classification: PiB PET Scanning in Speech and Language Based Dementias (clinicaltrials.gov) - Dec 23, 2015
P1, N=168, Completed, Sponsor: Mayo Clinic
N=190 --> 19 | Recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Dec 2015; Difficulty in recruiting subjects for the trial. Phase classification: P=N/A --> P1
- ||| atabecestat (JNJ-54861911) / J&J
Enrollment closed: A Safety and Tolerability Study of JNJ-54861911 in Participants With Early Alzheimer's Disease (clinicaltrials.gov) - Dec 21, 2015
P2, N=114, Active, not recruiting, Sponsor: Janssen Research & Development, LLC
Phase classification: P=N/A --> P1 Recruiting --> Active, not recruiting
- Phase classification: Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD (clinicaltrials.gov) - Dec 21, 2015
P1, N=27, Completed, Sponsor: Mayo Clinic
Recruiting --> Active, not recruiting Phase classification: P=N/A --> P1
- donepezil / Generic mfg.
Trial primary completion date: Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318) (clinicaltrials.gov) - Dec 18, 2015
P2, N=36, Recruiting, Sponsor: Merck Sharp & Dohme Corp.
Phase classification: P=N/A --> P1 Trial primary completion date: Apr 2016 --> Aug 2016
- Trial primary completion date: TMS-AD: Enhancing Neuroplasticity and Frontal Lobe Function in Patients With Mild Alzheimer's Disease (clinicaltrials.gov) - Dec 18, 2015
P2, N=56, Recruiting, Sponsor: Centre for Addiction and Mental Health
Trial primary completion date: Apr 2016 --> Aug 2016 Trial primary completion date: Oct 2015 --> Oct 2016
- Tasigna (nilotinib) / Novartis, Inhibikase
Enrollment change: Nilotinib in Cognitively Impaired Parkinson Disease Patients 001 (clinicaltrials.gov) - Dec 16, 2015
P1, N=12, Completed, Sponsor: Georgetown University
Trial primary completion date: Oct 2015 --> Oct 2016 N=36 --> 12
- Enrollment closed, Enrollment change, Trial primary completion date, IO biomarker: IMABio3: Central and Systemic Inflammation in Alzheimer's Disease (clinicaltrials.gov) - Dec 16, 2015
P=N/A, N=125, Active, not recruiting, Sponsor: Assistance Publique - H
N=36 --> 12 Recruiting --> Active, not recruiting | N=170 --> 125 | Trial primary completion date: Dec 2015 --> Jun 2017
- Trial primary completion date: CONFUCIUS: Impact of a Multifaceted Program to Prevent Postoperative Delirium in the Elderly (clinicaltrials.gov) - Dec 16, 2015
P=N/A, N=360, Recruiting, Sponsor: Hospices Civils de Lyon
Recruiting --> Active, not recruiting | N=170 --> 125 | Trial primary completion date: Dec 2015 --> Jun 2017 Trial primary completion date: Apr 2016 --> Apr 2017
- || Biomarker, Enrollment closed, Trial primary completion date: ADDM: Alzheimer's Disease Biomarkers in Cerebrospinal Fluid in Insulin-resistant Men (clinicaltrials.gov) - Dec 15, 2015
P=N/A, N=58, Active, not recruiting, Sponsor: University of Eastern Finland
Trial primary completion date: Apr 2016 --> Apr 2017 Enrolling by invitation --> Active, not recruiting | Trial primary completion date: Sep 2015 --> Dec 2015
- Enrollment open: ProsKuopio: Computational Tools for Early Diagnosis of Memory Disorders (clinicaltrials.gov) - Dec 15, 2015
P=N/A, N=120, Enrolling by invitation, Sponsor: University of Eastern Finland
Enrolling by invitation --> Active, not recruiting | Trial primary completion date: Sep 2015 --> Dec 2015 Active, not recruiting --> Enrolling by invitation
- || GSK2981710 / GSK
Enrollment change: Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects (clinicaltrials.gov) - Dec 14, 2015
P1, N=107, Completed, Sponsor: GlaxoSmithKline
Active, not recruiting --> Enrolling by invitation N=33 --> 107
- Enrollment change, Trial termination: Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones (clinicaltrials.gov) - Dec 12, 2015
P2/3, N=12, Terminated, Sponsor: Wake Forest University
N=33 --> 107 N=45 --> 12 | Suspended --> Terminated; Loss of study staff
- donepezil / Generic mfg.
Phase classification, Enrollment change, Trial termination, Trial primary completion date, Combination therapy: Study of Combination Therapy With Dimebon and Donepezil (Aricept) in Patients With Alzheimer's Disease (clinicaltrials.gov) - Dec 12, 2015
P2, N=50, Terminated, Sponsor: Medivation, Inc.
N=45 --> 12 | Suspended --> Terminated; Loss of study staff Phase classification: P1 --> P2 | N=21 --> 50 | Active, not recruiting --> Terminated | Trial primary completion date: Nov 2008 --> Aug 2010; The study was halted after a Phase 3 study of dimebon failed to show efficacy.
- Trial completion: InveCeAb: A Longitudinal Multidimensional Population Study on Brain Aging (clinicaltrials.gov) - Dec 12, 2015
P=N/A, N=1321, Completed, Sponsor: Fondazione Golgi Cenci
Phase classification: P1 --> P2 | N=21 --> 50 | Active, not recruiting --> Terminated | Trial primary completion date: Nov 2008 --> Aug 2010; The study was halted after a Phase 3 study of dimebon failed to show efficacy. Active, not recruiting --> Completed
- Enrollment closed, Enrollment change: Short-term Caregiver Psychotherapy (clinicaltrials.gov) - Dec 12, 2015
P2, N=13, Active, not recruiting, Sponsor: University of Rostock
Active, not recruiting --> Completed Recruiting --> Active, not recruiting | N=20 --> 13
- Trial completion, Trial primary completion date: Reducing Care-Resistant Behaviors During Oral Hygiene in Persons With Dementia (clinicaltrials.gov) - Dec 12, 2015
P=N/A, N=91, Completed, Sponsor: Penn State University
Recruiting --> Active, not recruiting | N=20 --> 13 Active, not recruiting --> Completed | Trial primary completion date: Oct 2014 --> Aug 2015
- |||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Trial primary completion date: STAR Extension: Long-term Safety and Tolerability of Idalopirdine (Lu AE58054) as Adjunctive Treatment to Donepezil in Patients With Mild-moderate Alzheimer's Disease (clinicaltrials.gov) - Dec 11, 2015
P3, N=1770, Enrolling by invitation, Sponsor: H. Lundbeck A/S
Active, not recruiting --> Completed | Trial primary completion date: Oct 2014 --> Aug 2015 Trial primary completion date: Aug 2016 --> Oct 2017
- |||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Trial primary completion date: STARBRIGHT: Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With an Acetylcholinesterase Inhibitor (clinicaltrials.gov) - Dec 11, 2015
P3, N=720, Recruiting, Sponsor: H. Lundbeck A/S
Trial primary completion date: Aug 2016 --> Oct 2017 Trial primary completion date: Feb 2016 --> Mar 2017
- |||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Trial primary completion date: STARBEAM: Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil (clinicaltrials.gov) - Dec 11, 2015
P3, N=840, Recruiting, Sponsor: H. Lundbeck A/S
Trial primary completion date: Feb 2016 --> Mar 2017 Trial primary completion date: Jan 2016 --> Mar 2017
- |||| idalopirdine (Lu AE58054) / Otsuka, Eli Lilly, Denovo
Trial primary completion date: STARSHINE: Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With Donepezil (clinicaltrials.gov) - Dec 11, 2015
P3, N=930, Recruiting, Sponsor: H. Lundbeck A/S
Trial primary completion date: Jan 2016 --> Mar 2017 Trial primary completion date: Nov 2015 --> Oct 2016
- quetiapine / Generic mfg.
Trial primary completion date: Efficacy of Quetiapine for Pediatric Delirium (clinicaltrials.gov) - Dec 10, 2015
P1/2, N=50, Recruiting, Sponsor: Weill Medical College of Cornell University
Trial primary completion date: Nov 2015 --> Oct 2016 Trial primary completion date: Mar 2016 --> Mar 2017
- venlafaxine / Generic mfg.
Trial primary completion date: Venlafaxine for Depression in Alzheimer's Disease (DIADs-3) (clinicaltrials.gov) - Dec 10, 2015
P=N/A, N=50, Recruiting, Sponsor: Johns Hopkins University
Trial primary completion date: Mar 2016 --> Mar 2017 Trial primary completion date: Dec 2015 --> Dec 2016
- olanzapine / Generic mfg., haloperidol / Generic mfg.
Trial primary completion date, Metastases: Early Recognition and Optimal Treatment of Delirium in Patients With Advanced Cancer (clinicaltrials.gov) - Dec 10, 2015
P=N/A, N=300, Recruiting, Sponsor: VU University Medical Center
Trial primary completion date: Dec 2015 --> Dec 2016 Trial primary completion date: Aug 2015 --> Aug 2016