Deglutition Disorders News - LARVOL Sigma

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26 Mechanisms of Action

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||||||||||  ONO-8539 / Ono Pharma
Enrollment closed:  A Study to Investigate the Effect of ONO-8539 on Acid-Induced Oesophageal Hypersensitivity in Healthy Volunteers (clinicaltrials.gov) -  Jan 15, 2014
P1, N=20, Active, not recruiting,  Sponsor: Ono Pharmaceutical Co. Ltd
Recruiting --> Active, not recruiting

|||||||||| Trial completion: Esophageal High Resolution Manometry and Dysphagia (clinicaltrials.gov) - Jan 13, 2014
P=N/A, N=247, Completed, Sponsor: Hospices Civils de Lyon
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  colesevelam (IW-3718) / Ironwood Pharma
New P2 trial:  Ph2a Study to Evaluate IW-3718 in Patients With Gastroesophageal Reflux Not Completely Responsive to Proton Pump Inhibitors (clinicaltrials.gov) -  Jan 7, 2014
P2, N=90, Recruiting,  Sponsor: Ironwood Pharmaceuticals, Inc.

|||||||||| Enrollment closed: Racial Disparity in Barrett's Esophagus (clinicaltrials.gov) - Jan 7, 2014
P=N/A, N=400, Active, not recruiting, Sponsor: University of North Carolina, Chapel Hill
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment closed: Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus? (clinicaltrials.gov) - Jan 7, 2014
P=N/A, N=70, Active, not recruiting, Sponsor: University of North Carolina, Chapel Hill
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| Trial completion: Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients (clinicaltrials.gov) - Jan 7, 2014
P3, N=45, Completed, Sponsor: Reckitt Benckiser Healthcare (UK) Limited
Recruiting --> Active, not recruiting Recruiting --> Completed

||||||||||  lansoprazole / Generic mfg.
Trial termination:  Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD (clinicaltrials.gov) -  Jan 5, 2014
P=N/A, N=24, Terminated,  Sponsor: University of Rochester
Recruiting --> Completed Recruiting --> Terminated; Expected recruitment numbers have not been achieved.

||||||||||  lansoprazole / Generic mfg.
Enrollment change:  Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD (clinicaltrials.gov) -  Jan 5, 2014
P=N/A, N=24, Terminated,  Sponsor: University of Rochester
Recruiting --> Terminated; Expected recruitment numbers have not been achieved. N=40 --> 24

|||||||||| Enrollment change: Barrett's Esophagus & Gastroesophageal Reflux Disease (clinicaltrials.gov) - Dec 30, 2013
P2/3, N=125, Completed, Sponsor: Valley Health System
N=40 --> 24 N=100 --> 125

|||||||||| Trial completion: Barrett's Esophagus & Gastroesophageal Reflux Disease (clinicaltrials.gov) - Dec 30, 2013
P2/3, N=125, Completed, Sponsor: Valley Health System
N=100 --> 125 Recruiting --> Completed

|||||||||| Trial withdrawal: Effect of Pre-emptive Transcutaneous Neuro-muscular Electrical Stimulation for Dysphagia in Long Term Intubated Patients (clinicaltrials.gov) - Dec 21, 2013
P=N/A, N=0, Withdrawn, Sponsor: Ulsan University Hospital
Recruiting --> Completed Recruiting --> Withdrawn

|||||||||| Enrollment change: Effect of Pre-emptive Transcutaneous Neuro-muscular Electrical Stimulation for Dysphagia in Long Term Intubated Patients (clinicaltrials.gov) - Dec 21, 2013
P=N/A, N=0, Withdrawn, Sponsor: Ulsan University Hospital
Recruiting --> Withdrawn N=40 --> 0

||||||||||  Dexilant (dexlansoprazole) / Takeda
Trial completion:  Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis (clinicaltrials.gov) -  Dec 19, 2013
P=N/A, N=50, Completed,  Sponsor: Vanderbilt University
N=40 --> 0 Recruiting --> Completed

||||||||||  ranitidine hydrochloride / Generic mfg.
Enrollment change:  Medical Treatment for Gastroesophageal Reflux Disease (GERD) in Preterm Infants (clinicaltrials.gov) -  Dec 11, 2013
P3, N=18, Completed,  Sponsor: The University of Texas Health Science Center, Houston
Recruiting --> Completed N=34 --> 18

|||||||||| Trial initiation date: POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM) (clinicaltrials.gov) - Dec 9, 2013
P=N/A, N=150, Recruiting, Sponsor: Katholieke Universiteit Leuven
N=34 --> 18 Initiation date: Apr 2013 --> Oct 2013

|||||||||| Clinical: Neuromuscular Electrical Stimulation (NMES) for Dysphagia in Neonates (clinicaltrials.gov) - Dec 9, 2013
P=N/A, N=50, Recruiting, Sponsor: Sanford Health

|||||||||| Enrollment open: POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM) (clinicaltrials.gov) - Dec 9, 2013
P=N/A, N=150, Recruiting, Sponsor: Katholieke Universiteit Leuven
Initiation date: Apr 2013 --> Oct 2013 Not yet recruiting --> Recruiting

|||||||||| Trial completion: Study of an Oropharyngeal Aerosolized pH Probe for Diagnosing Laryngopharyngeal Reflux (LPR) (clinicaltrials.gov) - Dec 5, 2013
P=N/A, N=45, Completed, Sponsor: Emory University
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Trial completion: RSPT: Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer (clinicaltrials.gov) - Dec 3, 2013
P2, N=58, Completed, Sponsor: Department of Veterans Affairs
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial initiation date: Prospective Trial on the Clinical Feasibility of a New Full Thickness Endoscopic Plication Device for Patients With GERD. (clinicaltrials.gov) - Nov 21, 2013
P=N/A, N=80, Recruiting, Sponsor: Krankenhaus Barmherzige Schwestern Linz
Active, not recruiting --> Completed Initiation date: Apr 2013 --> Aug 2013

|||||||||| Enrollment open: Prospective Trial on the Clinical Feasibility of a New Full Thickness Endoscopic Plication Device for Patients With GERD. (clinicaltrials.gov) - Nov 21, 2013
P=N/A, N=80, Recruiting, Sponsor: Krankenhaus Barmherzige Schwestern Linz
Initiation date: Apr 2013 --> Aug 2013 Not yet recruiting --> Recruiting

|||||||||| Trial completion: A Prospective Evaluation of the Torax Medical Inc. Magnetic Esophageal Sphincter (clinicaltrials.gov) - Nov 21, 2013
P1/2, N=31, Completed, Sponsor: Torax Medical Incorporated
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Trial completion: LINX Reflux Management System Clinical Study Protocol (clinicaltrials.gov) - Nov 21, 2013
P=N/A, N=100, Completed, Sponsor: Torax Medical Incorporated
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  lansoprazole / Generic mfg.
Trial completion:  SARCA: Study of Acid Reflux Therapy for Children With Asthma (clinicaltrials.gov) -  Nov 21, 2013
P=N/A, N=306, Completed,  Sponsor: Emory University
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment change: OPMD: Treatment of Dysphagia in Oculopharyngeal Muscular Dystrophy by Autologous Transplantation of Myoblasts (clinicaltrials.gov) - Nov 13, 2013
P2, N=30, Active, not recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Completed N=10 --> 30

|||||||||| Enrollment closed: OPMD: Treatment of Dysphagia in Oculopharyngeal Muscular Dystrophy by Autologous Transplantation of Myoblasts (clinicaltrials.gov) - Nov 13, 2013
P2, N=30, Active, not recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
N=10 --> 30 Recruiting --> Active, not recruiting

|||||||||| Enrollment open: Voice Analysis Using the LPC (Linear Predictive Coding)Method for the Prediction of Aspiration (clinicaltrials.gov) - Nov 3, 2013
P=N/A, N=34, Recruiting, Sponsor: Ulsan University Hospital
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

|||||||||| Enrollment open: Oropharyngeal Dysphagia in Patients With Community Acquired Pneumonia (clinicaltrials.gov) - Oct 30, 2013
P=N/A, N=180, Recruiting, Sponsor: Vendsyssel Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

|||||||||| Trial completion: Functional Electrical Stimulation in Irradiated Nasopharyngeal Carcinoma (NPC) (clinicaltrials.gov) - Oct 30, 2013
P2, N=20, Completed, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Trial completion: CABS: Bedside Screening Method for Patients With Potential Swallowing Impairment (clinicaltrials.gov) - Oct 28, 2013
P=N/A, N=120, Completed, Sponsor: Nestl
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| New P3 trial: TENSDEG: Evaluation of Transcutaneous Electrical Stimulation in Post Stroke Dysphagia (clinicaltrials.gov) - Oct 27, 2013
P3, N=118, Not yet recruiting, Sponsor: University Hospital, Rouen

|||||||||| Biomarker, Enrollment change: Pepsin As A Biomarker For Aspiration (clinicaltrials.gov) - Oct 21, 2013
P=N/A, N=76, Completed, Sponsor: Medical College of Wisconsin
Recruiting --> Completed N=300 --> 76

|||||||||| Biomarker, Trial completion: Pepsin As A Biomarker For Aspiration (clinicaltrials.gov) - Oct 21, 2013
P=N/A, N=76, Completed, Sponsor: Medical College of Wisconsin
N=300 --> 76 Recruiting --> Completed

|||||||||| Trial completion: Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients (clinicaltrials.gov) - Oct 21, 2013
P=N/A, N=200, Completed, Sponsor: Hospital Authority, Hong Kong
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial initiation date: Swallowing and Breathing Exercises for Dysphagia in Parkinson Disease (clinicaltrials.gov) - Oct 19, 2013
P=N/A, N=100, Not yet recruiting, Sponsor: Federal University of Bahia
Recruiting --> Completed Initiation date: Apr 2013 --> Apr 2014

|||||||||| Enrollment change: CARPNIC: Comparative Anti-Reflux Procedures in Neurologically Impaired Children (clinicaltrials.gov) - Oct 16, 2013
P=N/A, N=3, Completed, Sponsor: University of Utah
Initiation date: Apr 2013 --> Apr 2014 N=10 --> 3

|||||||||| Trial completion: CARPNIC: Comparative Anti-Reflux Procedures in Neurologically Impaired Children (clinicaltrials.gov) - Oct 16, 2013
P=N/A, N=3, Completed, Sponsor: University of Utah
N=10 --> 3 Recruiting --> Completed

|||||||||| Enrollment closed: Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer (clinicaltrials.gov) - Oct 15, 2013
P2, N=150, Active, not recruiting, Sponsor: Radiation Therapy Oncology Group
Recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment change: Domperidone for Gastroparesis in Solid Organ Transplantation (clinicaltrials.gov) - Oct 13, 2013
P=N/A, N=5, Terminated, Sponsor: David J. Lederer, M.D.
Recruiting --> Active, not recruiting N=25 --> 5

|||||||||| Enrollment open, HEOR: Dysphagia Handicap Index: A Structured Translation From English to German (clinicaltrials.gov) - Oct 7, 2013
P=N/A, N=130, Recruiting, Sponsor: University of Zurich
N=25 --> 5 Not yet recruiting --> Recruiting

|||||||||| New P4 trial: Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric Emptying (clinicaltrials.gov) - Oct 6, 2013
P4, N=132, Not yet recruiting, Sponsor: University of Bari

|||||||||| New P2 trial: Botulinum Toxin Injection in Hypercontractile Esophagus (clinicaltrials.gov) - Oct 4, 2013
P2, N=28, Recruiting, Sponsor: Hospices Civils de Lyon

|||||||||| Enrollment open: Gastroesophageal Reflux Treatment in Scleroderma (clinicaltrials.gov) - Sep 23, 2013
P3, N=250, Recruiting, Sponsor: Khon Kaen University
Not yet recruiting --> Recruiting Active, not recruiting --> Recruiting

||||||||||  lansoprazole / Generic mfg.
New P1/2 trial:  Lansoprazole in Preterm Infants With Gastroesophageal Reflux (GER) (clinicaltrials.gov) -  Sep 18, 2013
P1/2, N=12, Active, not recruiting,  Sponsor: Seoul National University Hospital

|||||||||| Enrollment open: NewBreez Safety and Efficacy Evaluation (clinicaltrials.gov) - Sep 15, 2013
P2/3, N=20, Recruiting, Sponsor: ProTiP Medical
Active, not recruiting --> Recruiting Not yet recruiting --> Recruiting

||||||||||  esomeprazole / Generic mfg.
Enrollment open:  PHARO: Benefit of Pharyngeal and Oesophageal pH-impedance of Patients With High Suspicion of Laryngopharyngeal Reflux (clinicaltrials.gov) -  Sep 12, 2013
P=N/A, N=30, Recruiting,  Sponsor: University Hospital, Bordeaux
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

||||||||||  lansoprazole / Generic mfg.
Trial completion:  Lansoprazole in Preterm Infants With Reflux (clinicaltrials.gov) -  Sep 10, 2013
P2, N=5, Completed,  Sponsor: Seoul National University Hospital
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Enrollment closed: Treatment of Extraesophageal Reflux With the Reza Band UES Assist Device (clinicaltrials.gov) - Sep 4, 2013
P=N/A, N=100, Active, not recruiting, Sponsor: Somna Therapeutics, L.L.C.
Recruiting --> Completed Recruiting --> Active, not recruiting

||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
New P4 trial:  Opioid Effects on Swallowing Comparing Younger and Elderly Volunteers (clinicaltrials.gov) -  Aug 14, 2013
P4, N=24, Recruiting,  Sponsor: University Hospital Orebro

|||||||||| Trial initiation date, Bariatric surgery: Effect of RING on Gastroesophageal Reflux (GERD) After RYGBP (clinicaltrials.gov) - Aug 12, 2013
P=N/A, N=114, Active, not recruiting, Sponsor: Clinica Gastrobese
Recruiting --> Active, not recruiting Initiation date: Mar 2010 --> Oct 2010