Classic Kaposi Sarcoma MOAs

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Phase N/A 1 2 3 4 Products	0	2	4	6	8	10	12	14	16	18	20



CD20 inhib




IFNα stim




PDGFR inhib




Topoisomerase II inhib




VEGF inhib




mTOR inhib




IL-6 inhib




IL-6 inhib




PDGFR inhib




TNFα inhib




c-KIT inhib




CD20 inhib




DNA synthesis inhib




HDAC2 inhib




IL-10 stim




IL-1β inhib




Protease inhib




Retinoid X receptor mod




Tubulin polymerization promoter




mTOR inhib




AKT inhib




Angiogenesis inhib




Apoptosis stim




BRAF inhib




Bcl2 inhib




Bcl2 inhib




CCR5 receptor antag




CCR5 receptor antag




CD20 inhib




COX2 inhib




Cytokine mod




DHODH inhib




DNA polymerase inhib




GM-CSF agon




GM-CSF agon




HIF-1 inhib




Hedgehog cell-signalling pathway inhib




Histamine H1 receptor antag




IL-12 inhib




Integrin inhib




MEK2 inhib




MEK2 inhib




MMP inhib




Notch inhib




Nucleotide reverse transcriptase inhib




Proteasome inhib




RAF kinase inhib




SMO protein inhib




STAT3 inhib




Viral internalization inhib



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