Blast Crisis MOAs - LARVOL Sigma

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Phase N/A 1 2 3 4 Products	0	3	6	9	12	15	18	21	24	27	30



Purinergic receptor P1 agon




CD20 inhib




Aurora kinase C inhib




PDGFR inhib




CD20 inhib




DNA methylation inhib




HDAC2 inhib




µ-opioid agon




GCR agon




c-KIT inhib




IL-1 inhib




PDGFR inhib




Aurora kinase A inhib




IFNα stim




IL-2 stim




JAK1 inhib




AKT inhib




CDK5 inhib




COX inhib




CXCL12 inhib




Calcineurin inhib




GM-CSF agon




GM-CSF agon




IMPDH inhib




Immunosuppressant




KIF11 inhib




NMDAR antag




Nucleoside guanosine analog




T-cell activation inhib




TNF inhib




Tubulin polymerization promoter




VEGFR-1 inhib




mTOR inhib




5-lipoxygenase activating protein inhib




5-lipoxygenase inhib




Angiogenesis inhib




Apoptosis stim




BRAF inhib




Bcl2 inhib




Bcl2 inhib




Bone morphogenetic protein receptor type II mod




CD20 inhib




CD80 inhib




Cytomegalovirus replication inhib




DGAT inhib




DGAT-1 inhib




EGFR inhib




ERK5 inhib




Factor X inhib




Farnesyl transferase inhib



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