Back Pain MOAs - LARVOL Sigma

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Back Pain

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Phase N/A 1 2 3 4 Products	0	3	6	9	12	15	18	21	24	27	30



κ-opioid inhib




COX2 inhib




Serotonin 1B receptor agon




Na+ channel antag




Norepinephrine reuptake inhib




TNFα inhib




Acetylcholine inhib




GCR agon




Glutamate receptor antag




IL-6 inhib




Kappa receptor antag




Nerve growth factor inhib




TNFα inhib




GABA A receptor agon




Histamine H2 receptor antag




IL-1β inhib




NMDAR antag




Prostaglandin receptor antag




Substance P release inhib




µ-opioid receptor partial agon




AChE inhib




AMPA receptor antag




Adrenergic uptake inhib




Anti-inflammatory agent




Bone resorption factor inhib




CACNA2D1 protein mod




Cannabinoid receptor 1 agon




Carbonic anhydrase inhib




IL-10 stim




IL-12 inhib




IL-17A inhib




IL-6 inhib




Kainic acid receptor antag




Monoamine reuptake inhib




Mu-type opioid receptor (MOR-1) agon




N-Type calcium channel blocker




NMDAR inhib




NSAID




Osteoclast inhib




Thymidylate synthase inhib




Undefined mechanism



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