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93 Mechanisms of Action

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|||||||||| Trial completion: The Jetstream G3™ Calcium Study (clinicaltrials.gov) - Apr 7, 2014
P4, N=53, Completed, Sponsor: MEDRAD, Inc.
Recruiting --> Completed

|||||||||| Trial completion: Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics. (clinicaltrials.gov) - Apr 7, 2014
P1, N=69, Completed, Sponsor: Queen Mary University of London
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial initiation date: Safety Trial Of CTX Cells In Patients With Lower Limb Ischaemia (clinicaltrials.gov) - Apr 2, 2014
P1, N=9, Recruiting, Sponsor: ReNeuron Limited
Active, not recruiting --> Completed Initiation date: Nov 2013 --> Apr 2014

|||||||||| Enrollment open: Safety Trial Of CTX Cells In Patients With Lower Limb Ischaemia (clinicaltrials.gov) - Apr 2, 2014
P1, N=9, Recruiting, Sponsor: ReNeuron Limited
Initiation date: Nov 2013 --> Apr 2014 Not yet recruiting --> Recruiting

|||||||||| Enrollment change: Absolute Pro (clinicaltrials.gov) - Apr 1, 2014
P=N/A, N=143, Active, not recruiting, Sponsor: Abbott Vascular
Not yet recruiting --> Recruiting N=310 --> 143

|||||||||| Enrollment change: MOBILITY AP: Trial to Evaluate the Safety & Efficacy of the Absolute Pro (clinicaltrials.gov) - Apr 1, 2014
P3, N=304, Active, not recruiting, Sponsor: Abbott Vascular
N=310 --> 143 N=151 --> 304

|||||||||| Enrollment closed: Absolute Pro (clinicaltrials.gov) - Apr 1, 2014
P=N/A, N=143, Active, not recruiting, Sponsor: Abbott Vascular
N=151 --> 304 Recruiting --> Active, not recruiting

||||||||||  Xience (everolimus-eluting stent) / Abbott
Trial completion:  REMEDEE-OCT: Study of Vascular Healing With the Combo Stent Versus the Everolimus Eluting Stent in ACS Patients by Means of OCT (clinicaltrials.gov) -  Mar 20, 2014
P2, N=60, Completed,  Sponsor: OrbusNeich
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| Trial completion: Effectiveness of Group Walking Sessions for Increasing Activity in People With Peripheral Arterial Disease (The Group Oriented Arterial Leg Study [GOALS]) (clinicaltrials.gov) - Mar 18, 2014
P3, N=194, Completed, Sponsor: Northwestern University
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  warfarin / Generic mfg.
Trial withdrawal, Head-to-Head:  PRINT-II: Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II (clinicaltrials.gov) -  Mar 17, 2014
P3, N=0, Withdrawn,  Sponsor: McMaster University
Active, not recruiting --> Completed Not yet recruiting --> Withdrawn

||||||||||  warfarin / Generic mfg.
Enrollment change, Head-to-Head:  PRINT-II: Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II (clinicaltrials.gov) -  Mar 17, 2014
P3, N=0, Withdrawn,  Sponsor: McMaster University
Not yet recruiting --> Withdrawn N=3156 --> 0

|||||||||| Enrollment closed: Stenting of the Superficial Femoral and/or Proximal Popliteal Artery Project (clinicaltrials.gov) - Mar 16, 2014
P2, N=57, Active, not recruiting, Sponsor: Boston Scientific Corporation
N=3156 --> 0 Recruiting --> Active, not recruiting

|||||||||| Trial termination, Surgery: The Effect of a Diabetes Action Team in Patients Post Infrainguinal Bypass Surgery With and Without Diabetes (clinicaltrials.gov) - Mar 13, 2014
P=N/A, N=10, Terminated, Sponsor: University of British Columbia
Recruiting --> Active, not recruiting Recruiting --> Terminated; The study was stopped due to lack of resources of the study coordinator's time

|||||||||| Enrollment change, Surgery: The Effect of a Diabetes Action Team in Patients Post Infrainguinal Bypass Surgery With and Without Diabetes (clinicaltrials.gov) - Mar 13, 2014
P=N/A, N=10, Terminated, Sponsor: University of British Columbia
Recruiting --> Terminated; The study was stopped due to lack of resources of the study coordinator's time N=150 --> 10

|||||||||| Enrollment open, Real-world evidence, Real-world: Use and Safety of the LUTONIX® Drug Coated Balloon Catheter in Arteries of the Lower Extremity (clinicaltrials.gov) - Mar 9, 2014
P3, N=500, Recruiting, Sponsor: C. R. Bard
N=150 --> 10 Not yet recruiting --> Recruiting

||||||||||  Tyrisa (darapladib) / GSK
Enrollment open, IO biomarker:  Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM) (clinicaltrials.gov) -  Mar 5, 2014
P1, N=16, Recruiting,  Sponsor: GlaxoSmithKline
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

|||||||||| Enrollment change: Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy (clinicaltrials.gov) - Mar 4, 2014
P=N/A, N=116, Completed, Sponsor: Hôpital Edouard Herriot
Not yet recruiting --> Recruiting N=60 --> 116

|||||||||| Trial initiation date: DAG: Screening for Arteriopathy in General Medicine: a Preliminary Feasibility Study (clinicaltrials.gov) - Mar 2, 2014
P=N/A, N=300, Not yet recruiting, Sponsor: Centre Hospitalier Universitaire de N?mes
N=60 --> 116 Initiation date: Feb 2014 --> Dec 2014

|||||||||| Clinical: AICAD: Asymptomatic Intracranial Atherosclerotic Disease in Pakistanis (clinicaltrials.gov) - Feb 25, 2014
P=N/A, N=200, Completed, Sponsor: Aga Khan University

|||||||||| Trial completion: COACH: Reducing Total Cardiovascular Risk in an Urban Community (clinicaltrials.gov) - Feb 23, 2014
P=N/A, N=525, Completed, Sponsor: Johns Hopkins University
Initiation date: Feb 2014 --> Dec 2014 Active, not recruiting --> Completed

|||||||||| Trial completion: Renal Atherosclerotic Revascularization Evaluation: RAVE Study (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=240, Completed, Sponsor: Sunnybrook Health Sciences Centre
Active, not recruiting --> Completed Recruiting --> Completed

||||||||||  simvastatin / Generic mfg.
Trial completion:  SHARP: Study of Heart and Renal Protection (clinicaltrials.gov) -  Feb 22, 2014
P4, N=9438, Completed,  Sponsor: University of Oxford
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Acomplia (rimonabant) / Sanofi
Trial completion:  STRADIVARIUS (Strategy To Reduce Atherosclerosis Development InVolving Administration of Rimonabant - the Intravascular Ultrasound Study) (clinicaltrials.gov) -  Feb 22, 2014
P3, N=839, Completed,  Sponsor: Sanofi
Active, not recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: SHINE: Hexadecasaccharide (SR123781A) in Patients With Unstable Angina or Non-ST-Segment Elevation Myocardial Infarction (clinicaltrials.gov) - Feb 22, 2014
P2, N=1257, Completed, Sponsor: Sanofi
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  atorvastatin / Generic mfg., rosuvastatin / Generic mfg.
Trial completion:  Rho Kinase in Patients With Atherosclerosis (clinicaltrials.gov) -  Feb 22, 2014
P3, N=40, Completed,  Sponsor: Brigham and Women's Hospital
No longer recruiting --> Completed Recruiting --> Completed

||||||||||  atorvastatin / Generic mfg.
Trial completion:  The Effects of Atorvastatin in Patients With Atherosclerosis (clinicaltrials.gov) -  Feb 22, 2014
P3, N=36, Completed,  Sponsor: Brigham and Women's Hospital
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: BVAIT: B-Vitamin Atherosclerosis Intervention Trial (clinicaltrials.gov) - Feb 22, 2014
P2/3, N=506, Completed, Sponsor: National Institute on Aging (NIA)
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Trial of VLTS-934 in Subjects With Intermittent Claudication Secondary to Peripheral Arterial Disease (clinicaltrials.gov) - Feb 22, 2014
P2, N=148, Completed, Sponsor: Valentis
No longer recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Improving Functioning in Peripheral Arterial Disease (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=156, Completed, Sponsor: Northwestern University
No longer recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Efficacy and Safety of NM-702 Tablets for the Treatment of Intermittent Claudication (clinicaltrials.gov) - Feb 22, 2014
P2, N=390, Completed, Sponsor: Nissan Chemical Industries
Active, not recruiting --> Completed No longer recruiting --> Completed

||||||||||  nitroglycerin / Generic mfg.
Trial completion:  Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients With Coronary Artery Disease (clinicaltrials.gov) -  Feb 22, 2014
P2, N=30, Completed,  Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
No longer recruiting --> Completed Recruiting --> Completed

||||||||||  Advicor (lovastatin/niacin ER) / AbbVie
Trial completion:  The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC (clinicaltrials.gov) -  Feb 22, 2014
P3, N=870, Completed,  Sponsor: Kos Pharmaceuticals
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Epidemiology of Coronary Heart Disease in Men Aged 40 and Over (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=1027, Completed, Sponsor: University of Pittsburgh
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  AM0001 / Eli Lilly
Trial completion:  Study of HGF Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia (clinicaltrials.gov) -  Feb 22, 2014
P2, N=104, Completed,  Sponsor: AnGes
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  ecraprost (AS-013) - LTT Bio / Pharma
Trial completion:  Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease (clinicaltrials.gov) -  Feb 22, 2014
P3, N=280, Completed,  Sponsor: Mitsubishi Tanabe Pharma Corporation
No longer recruiting --> Completed No longer recruiting --> Completed

||||||||||  pravastatin / Generic mfg.
Trial completion:  Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE) (clinicaltrials.gov) -  Feb 22, 2014
P2, N=150, Completed,  Sponsor: Brigham and Women's Hospital
No longer recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion, Preclinical: Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures (clinicaltrials.gov) - Feb 22, 2014
P3, N=1400, Completed, Sponsor: Anesiva, Inc.
Active, not recruiting --> Completed No longer recruiting --> Completed

||||||||||  cilostazol / Generic mfg., clopidogrel / Generic mfg.
Trial completion:  TOSS-2: Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II (clinicaltrials.gov) -  Feb 22, 2014
P4, N=457, Completed,  Sponsor: Asan Medical Center
No longer recruiting --> Completed Recruiting --> Completed

||||||||||  fasudil / Generic mfg.
Trial completion:  The Effect of Fasudil on Vascular Function in Humans (clinicaltrials.gov) -  Feb 22, 2014
P2, N=60, Completed,  Sponsor: Brigham and Women's Hospital
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Exercise Training for Patients With Poor Leg Circulation (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=50, Completed, Sponsor: Department of Veterans Affairs
Recruiting --> Completed Not yet recruiting --> Completed

|||||||||| Trial completion: Inflammatory Profiles of Children at High Risk for Atherosclerosis (clinicaltrials.gov) - Feb 22, 2014
P=N/A, N=300, Completed, Sponsor: Children's Hospital Boston
Not yet recruiting --> Completed No longer recruiting --> Completed

||||||||||  rosuvastatin / Generic mfg.
Trial completion:  Rosuvastatin Affecting Aortic Valve Endothelium (clinicaltrials.gov) -  Feb 22, 2014
P4, N=200, Completed,  Sponsor: Hospital Pedro Hispano
No longer recruiting --> Completed Recruiting --> Completed

||||||||||  ezetimibe / Generic mfg.
Trial completion:  Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia (clinicaltrials.gov) -  Feb 22, 2014
P3, N=3, Completed,  Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion, Metastases: FeAST: Does the Reduction of Total Body Iron Storage (TBIS) Alter Mortality in a Population of Patients With Advanced PVD? (clinicaltrials.gov) - Feb 22, 2014
P3, N=1277, Completed, Sponsor: Department of Veterans Affairs
Recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery (clinicaltrials.gov) - Feb 22, 2014
P1, N=60, Completed, Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
No longer recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: Carotid Artery Thickness in HIV Infected and Uninfected Adults (clinicaltrials.gov) - Feb 19, 2014
P=N/A, N=132, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed No longer recruiting --> Completed

||||||||||  ticagrelor / Generic mfg., clopidogrel / Generic mfg.
Enrollment closed:  EUCLID: A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (clinicaltrials.gov) -  Feb 18, 2014
P3, N=15328, Active, not recruiting,  Sponsor: AstraZeneca
No longer recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| Enrollment closed: OLNAMS: Olive Oil and Nampt on Postprandial Inflammation and Atherosclerosis in the Setting of Metabolic Syndrome (clinicaltrials.gov) - Feb 18, 2014
P=N/A, N=40, Active, not recruiting, Sponsor: National Research Council, Spain
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| New P4 trial: EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study (clinicaltrials.gov) - Feb 17, 2014
P4, N=30, Not yet recruiting, Sponsor: Covidien

|||||||||| Enrollment change: Effects of Pulse Varieties on Blood Vessel Function in Peripheral Artery Disease (clinicaltrials.gov) - Feb 10, 2014
P=N/A, N=62, Completed, Sponsor: University of Manitoba
Recruiting --> Active, not recruiting N=95 --> 62