- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Trial completion date, Trial termination, PD(L)-1 Biomarker, Metastases: Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer (clinicaltrials.gov) - May 1, 2019 P2, N=10, Terminated, Completed --> Terminated; recruitment difficulties Trial completion date: May 2020 --> Nov 2018 | Active, not recruiting --> Terminated; Study did not meet first stage requirements of interim analysis
- |||||||||| Clinical data, Trial completion, Surgery: Impact of Pre-operative Steroids on Adrenal Insufficiency (clinicaltrials.gov) - Jan 16, 2019
P=N/A, N=50, Completed, Active, not recruiting --> Completed | Trial completion date: Jan 2018 --> Aug 2018 | Trial primary completion date: Aug 2017 --> Aug 2018 Active, not recruiting --> Completed
- |||||||||| everolimus / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Open-label Study on Treatment of Primary Aldosteronism With Everolimus (clinicaltrials.gov) - Jan 9, 2019 P2, N=12, Completed, Active, not recruiting --> Completed Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2018 | Trial primary completion date: Dec 2018 --> Jun 2018
- |||||||||| Clinical data, Enrollment closed, Surgery: Impact of Pre-operative Steroids on Adrenal Insufficiency (clinicaltrials.gov) - Dec 24, 2018
P=N/A, N=50, Active, not recruiting, Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2018 | Trial primary completion date: Dec 2018 --> Jun 2018 Recruiting --> Active, not recruiting
- |||||||||| Clinical data, Trial completion date, Trial primary completion date, Surgery: Impact of Pre-operative Steroids on Adrenal Insufficiency (clinicaltrials.gov) - Jul 18, 2018
P=N/A, N=40, Recruiting, Trial completion date: Sep 2018 --> Dec 2018 | Trial primary completion date: Sep 2018 --> Dec 2018 Trial completion date: Jun 2018 --> Mar 2019 | Trial primary completion date: Apr 2018 --> Dec 2018
- |||||||||| Biomarker, Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, Surgery: Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery (clinicaltrials.gov) - Jul 13, 2018
P=N/A, N=26, Active, not recruiting, Trial completion date: Jun 2018 --> Mar 2019 | Trial primary completion date: Apr 2018 --> Dec 2018 Recruiting --> Active, not recruiting | N=20 --> 26 | Trial completion date: Dec 2021 --> Sep 2018 | Trial primary completion date: Dec 2020 --> Sep 2018
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: Newborn Screening for Adrenoleukodystrophy (clinicaltrials.gov) - Jul 12, 2018
P=N/A, N=45796, Completed, Recruiting --> Active, not recruiting | N=20 --> 26 | Trial completion date: Dec 2021 --> Sep 2018 | Trial primary completion date: Dec 2020 --> Sep 2018 Recruiting --> Completed | Trial completion date: Jun 2018 --> Aug 2017 | Trial primary completion date: Nov 2017 --> Aug 2017
- |||||||||| Enrollment change, Trial withdrawal: Early Diagnosis Of Childhood Cerebral ALD (clinicaltrials.gov) - Jul 6, 2018
P=N/A, N=0, Withdrawn, Recruiting --> Completed | Trial completion date: Jun 2018 --> Aug 2017 | Trial primary completion date: Nov 2017 --> Aug 2017 N=100 --> 0 | Not yet recruiting --> Withdrawn
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism (clinicaltrials.gov) - Feb 28, 2018
P2, N=4, Completed, Trial primary completion date: Feb 2018 --> Aug 2017 Active, not recruiting --> Completed | Trial primary completion date: Jul 2019 --> Feb 2018 | Trial completion date: Jul 2020 --> Feb 2018
- |||||||||| Signifor (pasireotide) / Recordati
Enrollment change, Trial withdrawal: SOM230 Ectopic ACTH-producing Tumors (clinicaltrials.gov) - Jan 26, 2018 P2, N=0, Withdrawn, Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Aug 2016 N=16 --> 0 | Recruiting --> Withdrawn
- |||||||||| Biomarker, Trial termination: Evaluation of Molecular Markers in Adrenal Tumors (clinicaltrials.gov) - Jan 17, 2018
P=N/A, N=74, Terminated, Recruiting --> Completed | Trial primary completion date: Feb 2016 --> Dec 2017 Completed --> Terminated; Slow/insufficient accrual
- |||||||||| Trial completion, Enrollment change, Trial primary completion date: T2T@PSU: Tweens to Teens Project at Penn State (clinicaltrials.gov) - Jan 8, 2018
P=N/A, N=188, Completed, Completed --> Terminated; Slow/insufficient accrual Recruiting --> Completed | N=300 --> 188 | Trial primary completion date: Jul 2011 --> Jul 2013
- |||||||||| Enrollment change, Trial termination, Trial primary completion date: Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome (clinicaltrials.gov) - Dec 22, 2017
P=N/A, N=1, Terminated, Recruiting --> Completed | N=300 --> 188 | Trial primary completion date: Jul 2011 --> Jul 2013 N=10 --> 1 | Recruiting --> Terminated | Trial primary completion date: Jul 2015 --> Nov 2016; Recruitment problems
- |||||||||| Biomarker, Trial completion, Enrollment change: Evaluation of Molecular Markers in Adrenal Tumors (clinicaltrials.gov) - Dec 7, 2017
P=N/A, N=71, Completed, N=10 --> 1 | Recruiting --> Terminated | Trial primary completion date: Jul 2015 --> Nov 2016; Recruitment problems Recruiting --> Completed | N=500 --> 71
- |||||||||| Trial initiation date, Trial primary completion date, IO biomarker: Early Diagnosis Of Childhood Cerebral ALD (clinicaltrials.gov) - Dec 5, 2017
P=N/A, N=100, Not yet recruiting, Recruiting --> Completed | N=500 --> 71 Initiation date: Nov 2017 --> Nov 2018 | Trial primary completion date: Jul 2022 --> Jul 2023
- |||||||||| Clinical data, Trial primary completion date, Surgery: Impact of Pre-operative Steroids on Adrenal Insufficiency (clinicaltrials.gov) - Nov 17, 2017
P=N/A, N=40, Recruiting, Initiation date: Nov 2017 --> Nov 2018 | Trial primary completion date: Jul 2022 --> Jul 2023 Trial primary completion date: Dec 2017 --> Apr 2018
- |||||||||| Trial initiation date, IO biomarker: Early Diagnosis Of Childhood Cerebral ALD (clinicaltrials.gov) - Oct 25, 2017
P=N/A, N=100, Not yet recruiting, Recruiting --> Completed | Trial primary completion date: Feb 2019 --> Nov 2016 Initiation date: Aug 2017 --> Nov 2017
- |||||||||| Qizenday (biotin) / MedDay
Trial completion: MD1003-AMN MD1003 in Adrenomyeloneuropathy (clinicaltrials.gov) - Oct 9, 2017 P2/3, N=67, Completed, Enrolling by invitation --> Completed Active, not recruiting --> Completed
- |||||||||| Enrollment change, Trial termination, Trial primary completion date, Metastases: Antineoplaston Therapy in Treating Patients With Stage IV Adrenal Gland Cancer (clinicaltrials.gov) - Sep 29, 2017
P2, N=6, Terminated, Active, not recruiting --> Completed | Trial primary completion date: Sep 2016 --> Feb 2016 N=40 --> 6 | Recruiting --> Terminated | Trial primary completion date: Dec 2011 --> Jul 2011; Slow enrollment
- |||||||||| veliparib (ABT-888) / AbbVie
Enrollment change, Trial withdrawal, Combination therapy, PARP Biomarker, Metastases: Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor (clinicaltrials.gov) - Sep 28, 2017 P1, N=0, Withdrawn, N=40 --> 6 | Recruiting --> Terminated | Trial primary completion date: Dec 2011 --> Jul 2011; Slow enrollment N=20 --> 0 | Not yet recruiting --> Withdrawn
- |||||||||| Minnebro (esaxerenone) / Daiichi Sankyo
Trial completion: Study of CS-3150 in Patients With Primary Aldosteronism (clinicaltrials.gov) - Aug 14, 2017 P=N/A, N=44, Completed, Not yet recruiting --> Active, not recruiting | Trial primary completion date: Apr 2018 --> Aug 2017 Active, not recruiting --> Completed
- |||||||||| veliparib (ABT-888) / AbbVie
Trial initiation date, Trial primary completion date, Combination therapy, PARP Biomarker, Metastases: Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor (clinicaltrials.gov) - Jul 19, 2017 P1, N=20, Not yet recruiting, Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2017 --> Oct 2017 Initiation date: Aug 2016 --> Dec 2017 | Trial primary completion date: Sep 2018 --> Feb 2019
- |||||||||| Trial completion: Heart Disease Risk Factors in Major Depression (clinicaltrials.gov) - Jun 30, 2017
P=N/A, N=160, Completed, Initiation date: Aug 2016 --> Dec 2017 | Trial primary completion date: Sep 2018 --> Feb 2019 Recruiting --> Completed
- |||||||||| Enrollment closed, Enrollment change, Trial primary completion date: Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism (clinicaltrials.gov) - Jun 9, 2017
P2, N=4, Active, not recruiting, Recruiting --> Completed | N=50 --> 89 | Trial primary completion date: Sep 2015 --> Jun 2016 Recruiting --> Active, not recruiting | N=66 --> 4 | Trial primary completion date: Jul 2018 --> Jul 2019
- |||||||||| prednisone / Generic mfg.
Trial completion, Trial initiation date, Trial primary completion date: Vapreda: Vaginal Prednisone Administration for Prevention of Adrenal Crisis (clinicaltrials.gov) - May 30, 2017 P2, N=12, Completed, Recruiting --> Active, not recruiting | N=66 --> 4 | Trial primary completion date: Jul 2018 --> Jul 2019 Not yet recruiting --> Completed | Initiation date: Apr 2016 --> Jan 2017 | Trial primary completion date: Oct 2016 --> Apr 2017
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