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||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg., gemcitabine / Generic mfg.
Enrollment change, Combination therapy, Metastases:  Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Jul 9, 2013
P3, N=0, Withdrawn,  Sponsor: Fox Chase Cancer Center
N=1134 --> 0

||||||||||  MK-2206 / Merck (MSD)
Enrollment closed, Metastases:  MK2206 and Erlotinib Hydrochloride in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Progressed After Previous Response to Erlotinib Hydrochloride Therapy (clinicaltrials.gov) -  May 27, 2013
P2, N=90, Active, not recruiting,  Sponsor: National Cancer Institute (NCI)
N=1134 --> 0 Recruiting --> Active, not recruiting

||||||||||  gefitinib / Generic mfg.
Trial completion, Metastases:  Gefitinib in Treating Patients With Previously Untreated Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  May 11, 2013
P2, N=34, Completed,  Sponsor: Massachusetts General Hospital
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  erlotinib / Generic mfg.
Enrollment change, Metastases:  Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Apr 1, 2013
P2, N=16, Completed,  Sponsor: Vanderbilt-Ingram Cancer Center
Active, not recruiting --> Completed N=101 --> 16

||||||||||  gefitinib / Generic mfg.
Enrollment change, Metastases:  Gefitinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Feb 26, 2013
P2, N=90, Completed,  Sponsor: National Cancer Institute (NCI)
N=101 --> 16 N=145 --> 90

||||||||||  Avastin (bevacizumab) / Roche
Trial initiation date, Metastases:  Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Advanced, Metastatic, or Recurrent Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Feb 25, 2013
P2/3, N=842, Completed,  Sponsor: National Cancer Institute (NCI)
N=145 --> 90 Initiation date: Jul 2001 --> Aug 2002

|||||||||| Enrollment change, Surgery, Metastases: Combination Chemotherapy and Radiation Therapy With or Without Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery (clinicaltrials.gov) - Feb 25, 2013
P3, N=840, Completed, Sponsor: National Cancer Institute (NCI)
Initiation date: Jul 2001 --> Aug 2002 N=620 --> 840

||||||||||  erlotinib / Generic mfg.
Trial termination:  Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With Inoperable Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Jan 30, 2013
P1, N=48, Terminated,  Sponsor: National Cancer Institute (NCI)
N=620 --> 840 Completed --> Terminated; Administratively complete.

||||||||||  Avastin (bevacizumab) / Roche
Trial termination, Metastases:  Bevacizumab, Paclitaxel, Carboplatin, and Radiation Therapy to the Chest in Treating Patients With Locally Advanced Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Jan 22, 2013
P1, N=36, Terminated,  Sponsor: National Cancer Institute (NCI)
Completed --> Terminated; Administratively complete. Completed --> Terminated

||||||||||  Avastin (bevacizumab) / Roche
Trial initiation date, Metastases:  Bevacizumab, Paclitaxel, Carboplatin, and Radiation Therapy to the Chest in Treating Patients With Locally Advanced Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Jan 22, 2013
P1, N=36, Terminated,  Sponsor: National Cancer Institute (NCI)
Completed --> Terminated Initiation date: Aug 2005 --> Jun 2006

||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg.
Enrollment change, Surgery:  Surgery With or Without Chemotherapy in Treating Patients With Stage I Non-small Cell Lung Cancer (clinicaltrials.gov) -  Jan 15, 2013
P3, N=500, Completed,  Sponsor: National Cancer Institute (NCI)
Initiation date: Aug 2005 --> Jun 2006 N=345 --> 500

||||||||||  cisplatin / Generic mfg., docetaxel / Generic mfg.
Trial termination, Surgery:  SWOG-S0332: Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Dec 25, 2012
P3, N=19, Terminated,  Sponsor: Radiation Therapy Oncology Group
N=345 --> 500 Completed --> Terminated; This study terminated early due to low accrual.

||||||||||  carboplatin / Generic mfg., paclitaxel / Generic mfg., gefitinib / Generic mfg.
Enrollment change:  Combination Chemotherapy, Radiation Therapy, and Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Dec 18, 2012
P2, N=144, Completed,  Sponsor: National Cancer Institute (NCI)
Completed --> Terminated; This study terminated early due to low accrual. N=63 --> 144

||||||||||  sorafenib / Generic mfg.
Enrollment change, Metastases:  Sorafenib in Treating Non-Smokers or Former Light Smokers With Relapsed or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Dec 17, 2012
P2, N=11, Completed,  Sponsor: Ohio State University Comprehensive Cancer Center
N=63 --> 144 N=20 --> 11

||||||||||  sorafenib / Generic mfg.
Trial completion, Metastases:  Sorafenib in Treating Non-Smokers or Former Light Smokers With Relapsed or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Dec 17, 2012
P2, N=11, Completed,  Sponsor: Ohio State University Comprehensive Cancer Center
N=20 --> 11 Recruiting --> Completed

||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion:  Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Dec 9, 2012
P2, N=109, Completed,  Sponsor: Cancer and Leukemia Group B
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion, Metastases:  Cetuximab in Treating Patients With Recurrent or Stage IIIB or Stage IV Lung Cancer (clinicaltrials.gov) -  Dec 2, 2012
P2, N=72, Completed,  Sponsor: Eastern Cooperative Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  cisplatin / Generic mfg., docetaxel / Generic mfg.
Enrollment change, Surgery:  SWOG-S0332: Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Nov 26, 2012
P3, N=19, Terminated,  Sponsor: Radiation Therapy Oncology Group
Active, not recruiting --> Completed N=574 --> 19

||||||||||  bortezomib / Generic mfg.
Enrollment open, Metastases:  Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer (clinicaltrials.gov) -  Nov 19, 2012
P2, N=74, Recruiting,  Sponsor: National Cancer Institute (NCI)
N=574 --> 19 Completed --> Recruiting

|||||||||| Trial termination, Metastases: S0229, Pulmonary Rehabilitation Education w/wo Exercise Training in Improving Physical Function in Patients Who Are Undergoing Chemo & RT for Locally Advanced Lung Cancer (clinicaltrials.gov) - Oct 30, 2012
P=N/A, N=2, Terminated, Sponsor: Southwest Oncology Group
Completed --> Recruiting Completed --> Terminated; Closed early due to poor accrual.

|||||||||| Enrollment change, Metastases: S0229, Pulmonary Rehabilitation Education w/wo Exercise Training in Improving Physical Function in Patients Who Are Undergoing Chemo & RT for Locally Advanced Lung Cancer (clinicaltrials.gov) - Oct 30, 2012
P=N/A, N=2, Terminated, Sponsor: Southwest Oncology Group
Completed --> Terminated; Closed early due to poor accrual. N=164 --> 2

||||||||||  gefitinib / Generic mfg.
Trial completion, Metastases:  Gefitinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Oct 30, 2012
P2, N=90, Completed,  Sponsor: National Cancer Institute (NCI)
N=164 --> 2 Active, not recruiting --> Completed

||||||||||  pemetrexed / Generic mfg.
Trial termination, Metastases:  S0526: Pemetrexed Disodium in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Oct 2, 2012
P2, N=27, Terminated,  Sponsor: Southwest Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Terminated; Closed due to poor accrual

||||||||||  pemetrexed / Generic mfg.
Enrollment change, Metastases:  S0526: Pemetrexed Disodium in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Oct 2, 2012
P2, N=27, Terminated,  Sponsor: Southwest Oncology Group
Active, not recruiting --> Terminated; Closed due to poor accrual N=99 --> 27

||||||||||  carboplatin / Generic mfg., erlotinib / Generic mfg.
Enrollment closed, Surgery:  Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery (clinicaltrials.gov) -  Sep 5, 2012
P2, N=76, Active, not recruiting,  Sponsor: Cancer and Leukemia Group B
N=99 --> 27 Recruiting --> Active, not recruiting

||||||||||  paclitaxel / Generic mfg.
Enrollment change, Metastases:  S9714: Paclitaxel in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer (clinicaltrials.gov) -  Jul 19, 2012
P2, N=60, Completed,  Sponsor: Southwest Oncology Group
Recruiting --> Active, not recruiting N=50 --> 60

||||||||||  paclitaxel / Generic mfg.
Trial completion, Metastases:  S9714: Paclitaxel in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer (clinicaltrials.gov) -  Jul 19, 2012
P2, N=60, Completed,  Sponsor: Southwest Oncology Group
N=50 --> 60 Active, not recruiting --> Completed

||||||||||  GVAX lung cancer vaccine - Dana / Farber Cancer Institute, Novartis
Trial termination, Metastases:  S0310: Vaccine Therapy in Treating Patients With Stage IIIB or Stage IV Bronchoalveolar Lung Cancer (clinicaltrials.gov) -  Jul 19, 2012
P2, N=19, Terminated,  Sponsor: Southwest Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Terminated; closed due to lack of availability of vaccine

||||||||||  paclitaxel / Generic mfg.
Trial completion:  Paclitaxel in Treating Patients With Lung Cancer (clinicaltrials.gov) -  Jun 28, 2012
P2, N=25, Completed,  Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Active, not recruiting --> Terminated; closed due to lack of availability of vaccine Active, not recruiting --> Completed

||||||||||  carboplatin / Generic mfg., cisplatin / Generic mfg.
Trial completion, Surgery:  Chemotherapy Followed by Surgery or Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer (clinicaltrials.gov) -  Jun 28, 2012
P3, N=640, Completed,  Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  topotecan / Generic mfg., vinorelbine tartrate / Generic mfg.
Trial completion, Combination therapy:  Topotecan and Vinorelbine in Treating Patients With Recurrent Lung Cancer (clinicaltrials.gov) -  Apr 25, 2012
P1, N=36, Completed,  Sponsor: Medical University of South Carolina
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  carboplatin / Generic mfg., thalidomide / Generic mfg., paclitaxel / Generic mfg.
Trial termination:  Carboplatin, Paclitaxel, and Radiation Therapy With or Without Thalidomide in Patients With Stage III Non-small Cell Lung Cancer (clinicaltrials.gov) -  Mar 22, 2012
P3, N=589, Terminated,  Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed Active, not recruiting --> Terminated; Trial was stopped early for futility

||||||||||  Orplatna (satraplatin) / Yakult Honsha, Agennix, BMS
Trial termination, Metastases:  Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy (clinicaltrials.gov) -  Mar 20, 2012
P1/2, N=20, Terminated,  Sponsor: Agennix
Active, not recruiting --> Terminated; Trial was stopped early for futility Active, not recruiting --> Terminated; Sponsor decided to discontinue study drug development.

||||||||||  Orplatna (satraplatin) / Yakult Honsha, Agennix, BMS
Enrollment change, Metastases:  Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy (clinicaltrials.gov) -  Mar 20, 2012
P1/2, N=20, Terminated,  Sponsor: Agennix
Active, not recruiting --> Terminated; Sponsor decided to discontinue study drug development. N=30 --> 20

||||||||||  Neulasta (pegfilgrastim) / Amgen, Kyowa Kirin, Roche
New P2 trial, Metastases:  Docetaxel, Cisplatin, Pegfilgrastim, and Erlotinib Hydrochloride in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Mar 18, 2012
P2, N=45, Completed,  Sponsor: Comprehensive Cancer Center of Wake Forest University

|||||||||| Enrollment closed, Gene Expression Profile: Chemotherapy or Observation in Treating Patients With Early Stage Non-Small Cell Lung Cancer (clinicaltrials.gov) - Dec 1, 2011
P3, N=1620, Active, not recruiting, Sponsor: Cancer and Leukemia Group B
N=30 --> 20 Recruiting --> Active, not recruiting

||||||||||  gefitinib / Generic mfg., docetaxel / Generic mfg.
Trial completion:  Gefitinib, Docetaxel, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Nov 30, 2011
P1, N=45, Completed,  Sponsor: Comprehensive Cancer Center of Wake Forest University
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  Avastin (bevacizumab) / Roche
Trial completion, Combination therapy, Metastases:  Topotecan and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Did Not Respond to Previous Systemic Chemotherapy (clinicaltrials.gov) -  Oct 18, 2011
P2, N=46, Completed,  Sponsor: Masonic Cancer Center, University of Minnesota
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  temozolomide / Generic mfg.
Enrollment change:  Temozolomide and Radiation Therapy in Treating Patients With Brain Metastasis Secondary to Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Sep 25, 2011
P2, N=26, Completed,  Sponsor: Eastern Cooperative Oncology Group
Active, not recruiting --> Completed N=53 --> 26

||||||||||  temozolomide / Generic mfg.
Trial completion:  Temozolomide and Radiation Therapy in Treating Patients With Brain Metastasis Secondary to Non-Small Cell Lung Cancer (clinicaltrials.gov) -  Sep 25, 2011
P2, N=26, Completed,  Sponsor: Eastern Cooperative Oncology Group
N=53 --> 26 Active, not recruiting --> Completed



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