- |||||||||| betamethasone / Generic mfg.
Trial completion, Trial completion date: Betamethasone and Severity of Hyaline Membrane Disease (clinicaltrials.gov) - Apr 20, 2019 P=N/A, N=127, Completed, Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Dec 2018
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: FEDOX: Feeding the Critically Ill During Phases of Altered Redox Status (clinicaltrials.gov) - Apr 16, 2019
P=N/A, N=35, Completed, Recruiting --> Completed | Trial completion date: Dec 2018 --> Apr 2019 | Trial primary completion date: Jun 2018 --> Apr 2019 Recruiting --> Completed | Trial completion date: Dec 2019 --> Oct 2018 | Trial primary completion date: Sep 2019 --> Jun 2018
- |||||||||| Enrollment change, Trial termination: BIRRST: Breastfeeding Infants Receiving Respiratory Support Trial (clinicaltrials.gov) - Apr 11, 2019
P=N/A, N=1, Terminated, Recruiting --> Completed | Trial completion date: Dec 2019 --> Oct 2018 | Trial primary completion date: Sep 2019 --> Jun 2018 N=50 --> 1 | Recruiting --> Terminated; Failure to recruit participants due to change in local clinical practice.
- |||||||||| NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date: USEFUL: Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation (clinicaltrials.gov) - Mar 28, 2019 P=N/A, N=7, Completed, N=50 --> 1 | Recruiting --> Terminated; Failure to recruit participants due to change in local clinical practice. Recruiting --> Completed | N=50 --> 7 | Trial completion date: Jun 2019 --> Dec 2018
- |||||||||| Leukine (sargramostim) / Partner Therap
Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date: iGRASP: Inhaled GM-CSF for Respiratory Virus-Associated Severe Pneumonia (clinicaltrials.gov) - Mar 26, 2019 P1, N=0, Withdrawn, Recruiting --> Completed | N=50 --> 7 | Trial completion date: Jun 2019 --> Dec 2018 N=12 --> 0 | Trial completion date: Dec 2017 --> May 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Dec 2017 --> May 2019
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: CRADL: Continuous Regional Analysis Device for Neonate Lung (clinicaltrials.gov) - Mar 21, 2019
P=N/A, N=200, Completed, N=12 --> 0 | Trial completion date: Dec 2017 --> May 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Dec 2017 --> May 2019 Recruiting --> Completed | Trial completion date: Dec 2019 --> Mar 2019 | Trial primary completion date: Dec 2018 --> Mar 2019
- |||||||||| atibuclimab (IC14) / Implicit Biosci
Enrollment change, Trial withdrawal: A Phase 2 Study of IC14 in Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Mar 14, 2019 P2, N=0, Withdrawn, Recruiting --> Completed | Trial completion date: Dec 2019 --> Mar 2019 | Trial primary completion date: Dec 2018 --> Mar 2019 N=160 --> 0 | Not yet recruiting --> Withdrawn
- |||||||||| aspirin / Generic mfg.
Trial completion date, Trial termination, Trial primary completion date: ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial (clinicaltrials.gov) - Mar 13, 2019 P2, N=49, Terminated, N=160 --> 0 | Not yet recruiting --> Withdrawn Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment
- |||||||||| NN1213 / Novo Nordisk
Trial completion: Pilot Study on Pairing Sedation Strategies and Weaning (clinicaltrials.gov) - Mar 13, 2019 P=N/A, N=90, Completed, Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment Recruiting --> Completed
- |||||||||| NN1213 / Novo Nordisk
Trial completion date: The Role of IL33/ST2 Axis in ARDS Patients (clinicaltrials.gov) - Feb 26, 2019 P=N/A, N=200, Completed, Active, not recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2017 Trial completion date: Dec 2017 --> Dec 2019
- |||||||||| Curosurf (poractant alfa) / Chiesi, NN1213 / Novo Nordisk
Trial completion, Trial primary completion date: Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS (clinicaltrials.gov) - Feb 15, 2019 P=N/A, N=206, Completed, Recruiting --> Completed | Trial completion date: Oct 2018 --> Feb 2019 | Trial primary completion date: Oct 2018 --> Feb 2019 Recruiting --> Completed | Trial primary completion date: Dec 2018 --> Sep 2018
- |||||||||| NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck (clinicaltrials.gov) - Feb 8, 2019 P=N/A, N=34040, Completed, N=60 --> 0 | Recruiting --> Withdrawn Recruiting --> Completed | N=3459 --> 34040 | Trial completion date: Jul 2019 --> Sep 2018 | Trial primary completion date: Jan 2019 --> Sep 2018
- |||||||||| NN1213 / Novo Nordisk
Trial completion: The Role of IL33/ST2 Axis in ARDS Patients (clinicaltrials.gov) - Jan 25, 2019 P=N/A, N=200, Completed, Recruiting --> Completed | N=3459 --> 34040 | Trial completion date: Jul 2019 --> Sep 2018 | Trial primary completion date: Jan 2019 --> Sep 2018 Recruiting --> Completed
- |||||||||| NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: pEsition: Position and Esophageal Pressure (clinicaltrials.gov) - Jan 22, 2019 P=N/A, N=11, Completed, Recruiting --> Completed Recruiting --> Completed | N=34 --> 11 | Trial completion date: May 2018 --> Sep 2017 | Trial primary completion date: May 2018 --> Sep 2017
- |||||||||| Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury (clinicaltrials.gov) - Dec 20, 2018
P1, N=13, Terminated, Recruiting --> Completed N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding
- |||||||||| NN1213 / Novo Nordisk
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) - Dec 11, 2018 P=N/A, N=8, Terminated, N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment
- |||||||||| Trial termination: Open Lung Ventilation in ARDS: The PHARLAP Trial (clinicaltrials.gov) - Nov 28, 2018
P=N/A, N=115, Terminated, N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment Active, not recruiting --> Terminated; Halted by the Management Committee after the publication of the ART Trial
- |||||||||| NN1213 / Novo Nordisk
Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date: Anti-MERS-CoV Convalescent Plasma Therapy (clinicaltrials.gov) - Nov 21, 2018 P2, N=0, Withdrawn, N=200 --> 120 | Trial primary completion date: Jul 2013 --> Dec 2016 N=20 --> 0 | Trial completion date: Jun 2017 --> Nov 2016 | Active, not recruiting --> Withdrawn | Trial primary completion date: May 2017 --> May 2016
- |||||||||| Curosurf (poractant alfa) / Chiesi, NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS (clinicaltrials.gov) - Sep 4, 2018 P=N/A, N=206, Recruiting, Recruiting --> Completed | N=40 --> 20 Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018
- |||||||||| Phase classification: Effect of Supine or Prone Position After Caesarean Birth (clinicaltrials.gov) - Aug 31, 2018
P=N/A, N=65, Completed, Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018 Phase classification: P1 --> P=N/A
- |||||||||| Enrollment change, Trial completion date, Trial termination, Trial primary completion date: ViPS: Variable Pressure Support Trial (clinicaltrials.gov) - Jul 26, 2018
P=N/A, N=130, Terminated, Trial completion date: Jun 2018 --> Oct 2018 | Trial primary completion date: Jun 2018 --> Oct 2018 N=228 --> 130 | Trial completion date: Aug 2017 --> Jan 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2017 --> Jan 2018; Rate of recruitment
- |||||||||| InfaSurf (calfactant) / Samaritan Pharma, Ony Biotech, AbbVie
Enrollment closed, Trial completion date, Trial primary completion date: Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients (clinicaltrials.gov) - Jun 28, 2018 P3, N=477, Active, not recruiting, Phase classification: P4 --> P=N/A Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Jul 2018 | Trial primary completion date: Dec 2018 --> Jun 2018
- |||||||||| NN1213 / Novo Nordisk
Enrollment change, Trial termination, Trial primary completion date: Stress Index to Individualize Mechanical Ventilation in ARDS (clinicaltrials.gov) - Jun 7, 2018 P=N/A, N=4, Terminated, Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Jul 2018 | Trial primary completion date: Dec 2018 --> Jun 2018 N=10 --> 4 | Recruiting --> Terminated | Trial primary completion date: Jun 2018 --> Dec 2017; The ART Trial was published suggesting harm by the intervention protocol, which was closely related to the protocol in this study, so the study was terminated.
- |||||||||| NN1213 / Novo Nordisk
Trial completion, Stroma: Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) (clinicaltrials.gov) - May 3, 2018 P2, N=60, Completed, N=10 --> 4 | Recruiting --> Terminated | Trial primary completion date: Jun 2018 --> Dec 2017; The ART Trial was published suggesting harm by the intervention protocol, which was closely related to the protocol in this study, so the study was terminated. Active, not recruiting --> Completed
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients (clinicaltrials.gov) - Apr 12, 2018
P=N/A, N=45, Completed, Recruiting --> Active, not recruiting | Trial completion date: Jan 2020 --> Jun 2018 | Trial primary completion date: Jan 2020 --> Jun 2018 Recruiting --> Completed | Trial completion date: Jun 2018 --> Dec 2017 | Trial primary completion date: Jun 2018 --> Dec 2017
- |||||||||| Phase classification, Enrollment change, Trial completion date, Trial termination, Trial primary completion date: PROVAP: Enhanced Lung Protective Ventilation for ARDS Patients With PrismaLung (clinicaltrials.gov) - Mar 13, 2018
P=N/A, N=1, Terminated, N=38 --> 15 Phase classification: P3 --> P=N/A | N=14 --> 1 | Trial completion date: May 2019 --> Dec 2017 | Not yet recruiting --> Terminated | Trial primary completion date: Sep 2018 --> Oct 2017; Insufficient CO2 removal obtained with the PrismaLung membrane oxygenator
- |||||||||| Trial completion, Enrollment change: APRONET: Prevalence of Prone Positioning Use in ARDS Patients (clinicaltrials.gov) - Mar 12, 2018
P=N/A, N=736, Completed, Phase classification: P3 --> P=N/A | N=14 --> 1 | Trial completion date: May 2019 --> Dec 2017 | Not yet recruiting --> Terminated | Trial primary completion date: Sep 2018 --> Oct 2017; Insufficient CO2 removal obtained with the PrismaLung membrane oxygenator Recruiting --> Completed | N=400 --> 736
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