Acute Respiratory Distress Syndrome
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 32 Companies   26 Products   26 Products   24 Mechanisms of Action   0 Trials   776 News 


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  • ||||||||||  betamethasone / Generic mfg.
    Trial completion, Trial completion date:  Betamethasone and Severity of Hyaline Membrane Disease (clinicaltrials.gov) -  Apr 20, 2019   
    P=N/A,  N=127, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Dec 2018
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  FEDOX: Feeding the Critically Ill During Phases of Altered Redox Status (clinicaltrials.gov) -  Apr 16, 2019   
    P=N/A,  N=35, Completed, 
    Recruiting --> Completed | Trial completion date: Dec 2018 --> Apr 2019 | Trial primary completion date: Jun 2018 --> Apr 2019 Recruiting --> Completed | Trial completion date: Dec 2019 --> Oct 2018 | Trial primary completion date: Sep 2019 --> Jun 2018
  • ||||||||||  Enrollment change, Trial termination:  BIRRST: Breastfeeding Infants Receiving Respiratory Support Trial (clinicaltrials.gov) -  Apr 11, 2019   
    P=N/A,  N=1, Terminated, 
    Recruiting --> Completed | Trial completion date: Dec 2019 --> Oct 2018 | Trial primary completion date: Sep 2019 --> Jun 2018 N=50 --> 1 | Recruiting --> Terminated; Failure to recruit participants due to change in local clinical practice.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change, Trial completion date:  USEFUL: Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation (clinicaltrials.gov) -  Mar 28, 2019   
    P=N/A,  N=7, Completed, 
    N=50 --> 1 | Recruiting --> Terminated; Failure to recruit participants due to change in local clinical practice. Recruiting --> Completed | N=50 --> 7 | Trial completion date: Jun 2019 --> Dec 2018
  • ||||||||||  Leukine (sargramostim) / Partner Therap
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  iGRASP: Inhaled GM-CSF for Respiratory Virus-Associated Severe Pneumonia (clinicaltrials.gov) -  Mar 26, 2019   
    P1,  N=0, Withdrawn, 
    Recruiting --> Completed | N=50 --> 7 | Trial completion date: Jun 2019 --> Dec 2018 N=12 --> 0 | Trial completion date: Dec 2017 --> May 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Dec 2017 --> May 2019
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  CRADL: Continuous Regional Analysis Device for Neonate Lung (clinicaltrials.gov) -  Mar 21, 2019   
    P=N/A,  N=200, Completed, 
    N=12 --> 0 | Trial completion date: Dec 2017 --> May 2019 | Not yet recruiting --> Withdrawn | Trial primary completion date: Dec 2017 --> May 2019 Recruiting --> Completed | Trial completion date: Dec 2019 --> Mar 2019 | Trial primary completion date: Dec 2018 --> Mar 2019
  • ||||||||||  atibuclimab (IC14) / Implicit Biosci
    Enrollment change, Trial withdrawal:  A Phase 2 Study of IC14 in Acute Respiratory Distress Syndrome (clinicaltrials.gov) -  Mar 14, 2019   
    P2,  N=0, Withdrawn, 
    Recruiting --> Completed | Trial completion date: Dec 2019 --> Mar 2019 | Trial primary completion date: Dec 2018 --> Mar 2019 N=160 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  aspirin / Generic mfg.
    Trial completion date, Trial termination, Trial primary completion date:  ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial (clinicaltrials.gov) -  Mar 13, 2019   
    P2,  N=49, Terminated, 
    N=160 --> 0 | Not yet recruiting --> Withdrawn Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion:  Pilot Study on Pairing Sedation Strategies and Weaning (clinicaltrials.gov) -  Mar 13, 2019   
    P=N/A,  N=90, Completed, 
    Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment Recruiting --> Completed
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date:  The Role of IL33/ST2 Axis in ARDS Patients (clinicaltrials.gov) -  Feb 26, 2019   
    P=N/A,  N=200, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2017 Trial completion date: Dec 2017 --> Dec 2019
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  DEXA-ARDS: Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome (clinicaltrials.gov) -  Feb 18, 2019   
    P4,  N=277, Completed, 
    Trial completion date: Dec 2017 --> Dec 2019 Recruiting --> Completed | Trial completion date: Oct 2018 --> Feb 2019 | Trial primary completion date: Oct 2018 --> Feb 2019
  • ||||||||||  Curosurf (poractant alfa) / Chiesi, NN1213 / Novo Nordisk
    Trial completion, Trial primary completion date:  Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS (clinicaltrials.gov) -  Feb 15, 2019   
    P=N/A,  N=206, Completed, 
    Recruiting --> Completed | Trial completion date: Oct 2018 --> Feb 2019 | Trial primary completion date: Oct 2018 --> Feb 2019 Recruiting --> Completed | Trial primary completion date: Dec 2018 --> Sep 2018
  • ||||||||||  Trial completion, Enrollment change:  Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome (clinicaltrials.gov) -  Feb 15, 2019   
    P=N/A,  N=206, Completed, 
    Recruiting --> Completed | Trial primary completion date: Dec 2018 --> Sep 2018 Recruiting --> Completed | N=100 --> 206
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck (clinicaltrials.gov) -  Feb 8, 2019   
    P=N/A,  N=34040, Completed, 
    N=60 --> 0 | Recruiting --> Withdrawn Recruiting --> Completed | N=3459 --> 34040 | Trial completion date: Jul 2019 --> Sep 2018 | Trial primary completion date: Jan 2019 --> Sep 2018
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion:  The Role of IL33/ST2 Axis in ARDS Patients (clinicaltrials.gov) -  Jan 25, 2019   
    P=N/A,  N=200, Completed, 
    Recruiting --> Completed | N=3459 --> 34040 | Trial completion date: Jul 2019 --> Sep 2018 | Trial primary completion date: Jan 2019 --> Sep 2018 Recruiting --> Completed
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  pEsition: Position and Esophageal Pressure (clinicaltrials.gov) -  Jan 22, 2019   
    P=N/A,  N=11, Completed, 
    Recruiting --> Completed Recruiting --> Completed | N=34 --> 11 | Trial completion date: May 2018 --> Sep 2017 | Trial primary completion date: May 2018 --> Sep 2017
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion:  Work of Breathing During Non-invasive Ventilation in Premature Neonates (clinicaltrials.gov) -  Jan 11, 2019   
    P=N/A,  N=15, Completed, 
    Recruiting --> Completed | N=34 --> 11 | Trial completion date: May 2018 --> Sep 2017 | Trial primary completion date: May 2018 --> Sep 2017 Recruiting --> Completed
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury (clinicaltrials.gov) -  Dec 20, 2018   
    P1,  N=13, Terminated, 
    Recruiting --> Completed N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) -  Dec 11, 2018   
    P=N/A,  N=8, Terminated, 
    N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment
  • ||||||||||  Trial termination:  Open Lung Ventilation in ARDS: The PHARLAP Trial (clinicaltrials.gov) -  Nov 28, 2018   
    P=N/A,  N=115, Terminated, 
    N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment Active, not recruiting --> Terminated; Halted by the Management Committee after the publication of the ART Trial
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  Anti-MERS-CoV Convalescent Plasma Therapy (clinicaltrials.gov) -  Nov 21, 2018   
    P2,  N=0, Withdrawn, 
    N=200 --> 120 | Trial primary completion date: Jul 2013 --> Dec 2016 N=20 --> 0 | Trial completion date: Jun 2017 --> Nov 2016 | Active, not recruiting --> Withdrawn | Trial primary completion date: May 2017 --> May 2016
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change:  Esophageal Manometry in Mechanically Ventilated Patients (clinicaltrials.gov) -  Oct 11, 2018   
    P=N/A,  N=20, Completed, 
    N=600 --> 300 Recruiting --> Completed | N=40 --> 20
  • ||||||||||  Curosurf (poractant alfa) / Chiesi, NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS (clinicaltrials.gov) -  Sep 4, 2018   
    P=N/A,  N=206, Recruiting, 
    Recruiting --> Completed | N=40 --> 20 Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018
  • ||||||||||  Phase classification:  Effect of Supine or Prone Position After Caesarean Birth (clinicaltrials.gov) -  Aug 31, 2018   
    P=N/A,  N=65, Completed, 
    Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Dec 2017 --> Dec 2018 Phase classification: P1 --> P=N/A
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  ViPS: Variable Pressure Support Trial (clinicaltrials.gov) -  Jul 26, 2018   
    P=N/A,  N=130, Terminated, 
    Trial completion date: Jun 2018 --> Oct 2018 | Trial primary completion date: Jun 2018 --> Oct 2018 N=228 --> 130 | Trial completion date: Aug 2017 --> Jan 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2017 --> Jan 2018; Rate of recruitment
  • ||||||||||  InfaSurf (calfactant) / Samaritan Pharma, Ony Biotech, AbbVie
    Enrollment closed, Trial completion date, Trial primary completion date:  Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients (clinicaltrials.gov) -  Jun 28, 2018   
    P3,  N=477, Active, not recruiting, 
    Phase classification: P4 --> P=N/A Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Jul 2018 | Trial primary completion date: Dec 2018 --> Jun 2018
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment change, Trial termination, Trial primary completion date:  Stress Index to Individualize Mechanical Ventilation in ARDS (clinicaltrials.gov) -  Jun 7, 2018   
    P=N/A,  N=4, Terminated, 
    Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Jul 2018 | Trial primary completion date: Dec 2018 --> Jun 2018 N=10 --> 4 | Recruiting --> Terminated | Trial primary completion date: Jun 2018 --> Dec 2017; The ART Trial was published suggesting harm by the intervention protocol, which was closely related to the protocol in this study, so the study was terminated.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Stroma:  Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) (clinicaltrials.gov) -  May 3, 2018   
    P2,  N=60, Completed, 
    N=10 --> 4 | Recruiting --> Terminated | Trial primary completion date: Jun 2018 --> Dec 2017; The ART Trial was published suggesting harm by the intervention protocol, which was closely related to the protocol in this study, so the study was terminated. Active, not recruiting --> Completed
  • ||||||||||  Enrollment closed, Trial completion date, Trial primary completion date:  Ultra Protective Ventilation Without Extracorporeal Circulation in Severe ARDS Patients (VT4ARDS) (clinicaltrials.gov) -  Apr 13, 2018   
    P=N/A,  N=37, Active, not recruiting, 
    Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial completion date: Jan 2020 --> Jun 2018 | Trial primary completion date: Jan 2020 --> Jun 2018
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients (clinicaltrials.gov) -  Apr 12, 2018   
    P=N/A,  N=45, Completed, 
    Recruiting --> Active, not recruiting | Trial completion date: Jan 2020 --> Jun 2018 | Trial primary completion date: Jan 2020 --> Jun 2018 Recruiting --> Completed | Trial completion date: Jun 2018 --> Dec 2017 | Trial primary completion date: Jun 2018 --> Dec 2017
  • ||||||||||  Trial completion, Phase classification:  Proper Pressure and Duration of Sustained Lung Inflation in Preterm Infants (clinicaltrials.gov) -  Apr 3, 2018   
    P1,  N=100, Completed, 
    Recruiting --> Completed | Trial completion date: Jun 2018 --> Dec 2017 | Trial primary completion date: Jun 2018 --> Dec 2017 Recruiting --> Completed | Phase classification: PN/A --> P1
  • ||||||||||  Phase classification, Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  PROVAP: Enhanced Lung Protective Ventilation for ARDS Patients With PrismaLung (clinicaltrials.gov) -  Mar 13, 2018   
    P=N/A,  N=1, Terminated, 
    N=38 --> 15 Phase classification: P3 --> P=N/A | N=14 --> 1 | Trial completion date: May 2019 --> Dec 2017 | Not yet recruiting --> Terminated | Trial primary completion date: Sep 2018 --> Oct 2017; Insufficient CO2 removal obtained with the PrismaLung membrane oxygenator
  • ||||||||||  Trial completion, Enrollment change:  APRONET: Prevalence of Prone Positioning Use in ARDS Patients (clinicaltrials.gov) -  Mar 12, 2018   
    P=N/A,  N=736, Completed, 
    Phase classification: P3 --> P=N/A | N=14 --> 1 | Trial completion date: May 2019 --> Dec 2017 | Not yet recruiting --> Terminated | Trial primary completion date: Sep 2018 --> Oct 2017; Insufficient CO2 removal obtained with the PrismaLung membrane oxygenator Recruiting --> Completed | N=400 --> 736