Acute Myeloid Leukemia, Childhood News

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||||||||||  cyclophosphamide / Generic mfg.
Trial completion, Metastases:  Radiolabeled Monoclonal Antibody, Cyclophosphamide, and Total Body Irradiation Followed By Donor Stem Cell Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia (clinicaltrials.gov) -  Feb 19, 2014
P2, N=40, Completed,  Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Completed

||||||||||  melphalan / Generic mfg., busulfan / Generic mfg., cyclosporine / Generic mfg.
Trial completion:  Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer (clinicaltrials.gov) -  Feb 19, 2014
P2, N=3, Completed,  Sponsor: Roswell Park Cancer Institute
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  thioguanine / Generic mfg.
Trial completion:  Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome (clinicaltrials.gov) -  Feb 19, 2014
P3, N=254, Completed,  Sponsor: Children's Oncology Group
Active, not recruiting --> Completed No longer recruiting --> Completed

||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen
Trial completion:  Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma (clinicaltrials.gov) -  Feb 19, 2014
P2/3, N=19, Completed,  Sponsor: Virginia Commonwealth University
No longer recruiting --> Completed Active, not recruiting --> Completed

||||||||||  cyclophosphamide / Generic mfg., busulfan / Generic mfg.
Trial completion:  High-Dose Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer (clinicaltrials.gov) -  Feb 19, 2014
P2, N=66, Completed,  Sponsor: Case Comprehensive Cancer Center
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Amdray (valspodar) / Novartis
Trial completion:  Combination Chemotherapy Plus PSC-833 in Treating Children With Refractory or Relapsed Acute Leukemia (clinicaltrials.gov) -  Feb 19, 2014
P1, N=3, Completed,  Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed No longer recruiting --> Completed

||||||||||  decitabine / Generic mfg.
Trial completion:  Decitabine and Peripheral Stem Cell Transplantation in Treating Patients Who Have Relapsed Following Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia (clinicaltrials.gov) -  Feb 19, 2014
P1/2, N=14, Completed,  Sponsor: M.D. Anderson Cancer Center
No longer recruiting --> Completed Active, not recruiting --> Completed

||||||||||  thioguanine / Generic mfg.
Trial completion:  Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome (clinicaltrials.gov) -  Feb 19, 2014
P3, N=880, Completed,  Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation (clinicaltrials.gov) - Feb 19, 2014
P2, N=30, Completed, Sponsor: Fred Hutchinson Cancer Research Center
No longer recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Zamyl (lintuzumab) / Pfizer
Trial completion:  Monoclonal Antibody Therapy and Chemotherapy in Treating Patients With Acute Promyelocytic Leukemia in Remission (clinicaltrials.gov) -  Feb 19, 2014
P2, N=40, Completed,  Sponsor: Memorial Sloan-Kettering Cancer Center
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome (clinicaltrials.gov) - Feb 19, 2014
P2, N=280, Completed, Sponsor: Barbara Ann Karmanos Cancer Institute
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  cyclophosphamide / Generic mfg., cytarabine / Generic mfg., thiotepa / Generic mfg.
Trial completion:  Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission (clinicaltrials.gov) -  Feb 19, 2014
P3, N=0, Completed,  Sponsor: Memorial Sloan-Kettering Cancer Center
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  thioguanine / Generic mfg.
Trial completion:  Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome (clinicaltrials.gov) -  Feb 19, 2014
P3, N=0, Completed,  Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  cyclosporine / Generic mfg.
Trial completion:  Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation (clinicaltrials.gov) -  Feb 19, 2014
P3, N=0, Completed,  Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Completed Not yet recruiting --> Completed

||||||||||  imatinib / Generic mfg.
Trial completion:  STI571 in Treating Patients With Recurrent Leukemia (clinicaltrials.gov) -  Feb 19, 2014
P1, N=31, Completed,  Sponsor: Children's Oncology Group
Not yet recruiting --> Completed Active, not recruiting --> Completed

||||||||||  gemcitabine / Generic mfg.
Trial completion:  Gemcitabine in Treating Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia (clinicaltrials.gov) -  Feb 17, 2014
P2, N=32, Completed,  Sponsor: Children's Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment open: Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia (clinicaltrials.gov) - Feb 13, 2014
P=N/A, N=20, Recruiting, Sponsor: Children's Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Recruiting

|||||||||| Biomarker, Enrollment change: Biomarkers in Bone Marrow Samples From Pediatric Patients With High-Risk Acute Myeloid Leukemia (clinicaltrials.gov) - Feb 12, 2014
P=N/A, N=250, Recruiting, Sponsor: Children's Oncology Group
Active, not recruiting --> Recruiting N=200 --> 250

|||||||||| Biomarker, Enrollment open: Biomarkers in Bone Marrow Samples From Pediatric Patients With High-Risk Acute Myeloid Leukemia (clinicaltrials.gov) - Feb 12, 2014
P=N/A, N=250, Recruiting, Sponsor: Children's Oncology Group
N=200 --> 250 Active, not recruiting --> Recruiting

|||||||||| Enrollment change: DNA Analysis of Bone Marrow and Blood Samples From Young Patients With Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Feb 10, 2014
P=N/A, N=149, Completed, Sponsor: Children's Oncology Group
Active, not recruiting --> Recruiting N=250 --> 149

|||||||||| Trial termination: Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer (clinicaltrials.gov) - Jan 30, 2014
P3, N=22, Terminated, Sponsor: University of South Florida
N=250 --> 149 Active, not recruiting --> Terminated; The study was terminated due to slow accrual.

|||||||||| Enrollment change: Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer (clinicaltrials.gov) - Jan 30, 2014
P3, N=22, Terminated, Sponsor: University of South Florida
Active, not recruiting --> Terminated; The study was terminated due to slow accrual. N=178 --> 22

||||||||||  aminopterin / Syntrix
Trial completion, Grant:  Aminopterin in Treating Patients With Refractory Leukemia (clinicaltrials.gov) -  Jan 1, 2014
P2, N=75, Completed,  Sponsor: Genzyme, a Sanofi Company
N=178 --> 22 Active, not recruiting --> Completed

||||||||||  lestaurtinib (CEP-701) / Teva, Kyowa Kirin
Enrollment closed, Combination therapy:  Lestaurtinib, Cytarabine, and Idarubicin in Treating Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia (clinicaltrials.gov) -  Dec 22, 2013
P1/2, N=14, Active, not recruiting,  Sponsor: Children's Oncology Group
Active, not recruiting --> Completed Completed --> Active, not recruiting

||||||||||  fludarabine IV / Generic mfg., mycophenolate mofetil / Generic mfg.
Enrollment open, Combination therapy, IO biomarker, Post-transplantation:  Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer (clinicaltrials.gov) -  Dec 19, 2013
P1, N=20, Recruiting,  Sponsor: Fred Hutchinson Cancer Research Center
Completed --> Active, not recruiting Active, not recruiting --> Recruiting

||||||||||  bortezomib / Generic mfg.
Enrollment change, IO biomarker:  Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia (clinicaltrials.gov) -  Dec 17, 2013
P2, N=52, Active, not recruiting,  Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Recruiting N=90 --> 52

||||||||||  bortezomib / Generic mfg.
Enrollment closed, IO biomarker:  Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia (clinicaltrials.gov) -  Dec 17, 2013
P2, N=52, Active, not recruiting,  Sponsor: National Cancer Institute (NCI)
N=90 --> 52 Completed --> Active, not recruiting

||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen
Trial completion:  Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia (clinicaltrials.gov) -  Dec 16, 2013
P3, N=0, Completed,  Sponsor: Medical Research Council
Completed --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  azacitidine / Generic mfg.
Enrollment change, Post-transplantation:  Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant (clinicaltrials.gov) -  Dec 9, 2013
P2, N=43, Completed,  Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Completed N=60 --> 43

||||||||||  azacitidine / Generic mfg.
Trial completion, Post-transplantation:  Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant (clinicaltrials.gov) -  Dec 9, 2013
P2, N=43, Completed,  Sponsor: Fred Hutchinson Cancer Research Center
N=60 --> 43 Recruiting --> Completed

||||||||||  Amsidine (amsacrine) / Kyowa Kirin
Trial completion:  Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia (clinicaltrials.gov) -  Nov 25, 2013
P3, N=2000, Completed,  Sponsor: Medical Research Council
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Leukemia (clinicaltrials.gov) - Nov 12, 2013
P1, N=23, Completed, Sponsor: Memorial Sloan-Kettering Cancer Center
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment closed, Post-transplantation: Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies (clinicaltrials.gov) - Oct 30, 2013
P2, N=42, Active, not recruiting, Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

||||||||||  cytarabine / Generic mfg., clofarabine / Generic mfg.
Enrollment closed, Combination therapy:  Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Oct 21, 2013
P1/2, N=74, Active, not recruiting,  Sponsor: Children's Oncology Group
Recruiting --> Active, not recruiting Completed --> Active, not recruiting

||||||||||  Enbrel (etanercept) / Pfizer, Amgen
Clinical:  Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant (clinicaltrials.gov) -  Oct 21, 2013
P2, N=39, Active, not recruiting,  Sponsor: Children's Oncology Group
Completed --> Active, not recruiting Completed --> Active, not recruiting

||||||||||  MK-2206 / Merck (MSD)
Trial completion:  MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia (clinicaltrials.gov) -  Sep 26, 2013
P1, N=45, Completed,  Sponsor: National Cancer Institute (NCI)
Completed --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  decitabine / Generic mfg.
Trial initiation date:  AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia (clinicaltrials.gov) -  Sep 23, 2013
P1, N=54, Recruiting,  Sponsor: Alison Walker
Active, not recruiting --> Completed Initiation date: Mar 2013 --> Sep 2013

||||||||||  decitabine / Generic mfg.
Enrollment open:  AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia (clinicaltrials.gov) -  Sep 23, 2013
P1, N=54, Recruiting,  Sponsor: Alison Walker
Initiation date: Mar 2013 --> Sep 2013 Not yet recruiting --> Recruiting

|||||||||| Trial completion, HEOR: Quality of Life in Children Treated for Cancer (clinicaltrials.gov) - Aug 21, 2013
P=N/A, N=538, Completed, Sponsor: Children's Oncology Group
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Enrollment change: Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia (clinicaltrials.gov) - Aug 20, 2013
P3, N=25, Active, not recruiting, Sponsor: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Active, not recruiting --> Completed N=280 --> 25

||||||||||  Mylotarg (gemtuzumab ozogamicin) / UCB, PDL, Pfizer
Enrollment open:  Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia (clinicaltrials.gov) -  Aug 14, 2013
P=N/A, N=30, Recruiting,  Sponsor: Comprehensive Cancer Center of Wake Forest University
N=280 --> 25 Not yet recruiting --> Recruiting

|||||||||| Trial withdrawal: Identifying Cancer Genes in in Blood and Bone Marrow Samples From Patients With Acute Myeloid Leukemia (clinicaltrials.gov) - Jul 14, 2013
P=N/A, N=0, Withdrawn, Sponsor: Cancer and Leukemia Group B
Not yet recruiting --> Recruiting Recruiting --> Withdrawn

|||||||||| Enrollment change: Identifying Cancer Genes in in Blood and Bone Marrow Samples From Patients With Acute Myeloid Leukemia (clinicaltrials.gov) - Jul 14, 2013
P=N/A, N=0, Withdrawn, Sponsor: Cancer and Leukemia Group B
Recruiting --> Withdrawn N=32 --> 0

||||||||||  lestaurtinib (CEP-701) / Teva, Kyowa Kirin
Enrollment open:  Lestaurtinib With or Without Chemotherapy Agents in Samples From Young Patients With Leukemia (clinicaltrials.gov) -  Jul 8, 2013
P=N/A, N=18, Recruiting,  Sponsor: Children's Oncology Group
N=32 --> 0 Active, not recruiting --> Recruiting

|||||||||| Enrollment closed: A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies (clinicaltrials.gov) - Jul 8, 2013
P1, N=25, Active, not recruiting, Sponsor: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Active, not recruiting --> Recruiting Recruiting --> Active, not recruiting

||||||||||  Proleukin (aldesleukin) / Merck (MSD), Novartis, Iovance Biotherap
Trial completion, Metastases:  Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation (clinicaltrials.gov) -  Jul 2, 2013
P1/2, N=37, Completed,  Sponsor: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  Vanflyta (quizartinib) / Daiichi Sankyo
Enrollment open:  Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia (clinicaltrials.gov) -  Jul 1, 2013
P=N/A, N=10, Recruiting,  Sponsor: Children's Oncology Group
Active, not recruiting --> Completed Active, not recruiting --> Recruiting

||||||||||  cyclophosphamide / Generic mfg., busulfan / Generic mfg.
Trial completion:  Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome (clinicaltrials.gov) -  Jul 1, 2013
P=N/A, N=52, Completed,  Sponsor: Fred Hutchinson Cancer Research Center
Active, not recruiting --> Recruiting Active, not recruiting --> Completed

||||||||||  obatoclax (GX 15-070) / Teva
Trial termination, Combination therapy:  Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia (clinicaltrials.gov) -  Jun 30, 2013
P1, N=22, Terminated,  Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed Active, not recruiting --> Terminated

||||||||||  sirolimus / Generic mfg.
Trial suspension:  Sirolimus in Treating Young Patients With Relapsed or Refractory Acute Leukemia or Non-Hodgkin's Lymphoma (clinicaltrials.gov) -  Jun 30, 2013
P1, N=10, Suspended,  Sponsor: Children's Hospital of Philadelphia
Active, not recruiting --> Terminated Recruiting --> Suspended



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