| Acromegaly |
2004-004904-19: A two-centre, open label study of weekly pegvisomant treatment for patients with acromegaly |
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| Ongoing | 4 | 22 | Europe | Somavert (pegvisomant), SOM022, Powder and solvent for solution for injection, Pegvisomant | Christie Hospital | This study will investigate the efficacy of once-weekly pegvisomant treatment in patients with acromegaly who have already achieved disease control on daily pegvisomant. The attraction of once weekly pegvisomant is obvious and would have implications for the development of a depot preparation. | | | | |
2007-003741-33: A Study To Determine The Optimum Serum IGF-I Range In Patients With Acromegaly Treated With Pegvisomant |
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| Ongoing | 4 | 12 | Europe | Somavert, Somavert | Barts and the London NHS Trust | Acromegaly | | | | |
| Ongoing | 4 | 100 | Europe | Somatuline Autogel, Sandostatin LAR, Dostinex, Somavert, Somatuline Autogel, Sandostatin LAR, Dostinex, Somavert | Österreichisches Akromegalie Register, Österreichisches Akromegalieregister | Acromegaly | | | | |
NCT01794793 / 2013-000267-84: Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in Novartis-sponsored Studies |
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| Completed | 4 | 337 | Europe, Canada, Japan, US, RoW | Pasireotide, SOM230; Signifor, Cabergoline, dostinex, Pasireotide LAR | RECORDATI GROUP | Cushing's Disease, Acromegaly, Neuroendocrine Tumors, Pituitary Tumors, Ectopic ACTH Secreting (EAS) Tumors, Dumping Syndrome, Prostate Cancer, Melanoma Negative for bRAF, Melanoma Negative for nRAS | 07/23 | 07/23 | | |
2011-004231-31: the effect of the addition of pegvisomant on quality of life and glucose sensitivity in acromegaly patients Pegvisomant-toevoeging bij patiënten met acromegalie: effect op symptomen, kwaliteit van leven en insuline-gevoeligheid |
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| Ongoing | 3 | 60 | Europe | pegvisomant, PN-800467, Powder and solvent for cutaneous solution, Somavert | Erasmus University Medical Centre Rotterdam, Erasmus University Medical Centre Rotterdam | acromegaly acromegalie, acromegaly acromegalie, Diseases [C] - Hormonal diseases [C19] | | | | |
2014-004386-24: Effect of pegvisomant , GH receptor competitor, using glucose in patients with acromegaly Effetto del pegvisomant, un competitore del recettore dell'ormone GH, sull'utilizzo del glucosio in pazienti con acromegalia |
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| Ongoing | 3 | 16 | Europe | somavert, Powder and solvent for solution for injection, SOMAVERT - 10 MG POLVERE E SOLVENTE PER SOLUZIONE INIETTABILE 30 FLACONCINI + 30 FLACONCINI 8 ML SOLVENTE USO SOTTOCUTANEO | DIPARTIMENTO DI MEDICINA CLINICA E CHIRURGIA - UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II, Pfizer srl | acromegaly acromegalia, Growth Hormone (GH) excess disease malattia dovuta all' eccesso di ormone della crescita (GH), Diseases [C] - Hormonal diseases [C19] | | | | |
2015-001292-51: Follow-Up Study in Patients that Participated in the Chiasma Study CH-ACM-01 |
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| Ongoing | 3 | 21 | Europe | Octreolin, | Chiasma, Inc., Chiasma, Inc | Acromegaly | | | | |
| Active, not recruiting | 3 | 56 | Europe, Canada, US, RoW | octreotide capsules, MYCAPSSA, Matching placebo, Placebo | Chiasma, Inc. | Acromegaly | 06/19 | 05/22 | | |
MERGE, NCT03439709: Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma |
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| Not yet recruiting | 3 | 90 | RoW | Gamma knife radiosurgery, Lanreotide 60Mg Solution for Injection | Samsung Medical Center | Acromegaly Due to Pituitary Adenoma | 06/22 | 12/22 | | |
| Completed | 3 | 72 | Europe, US, RoW | CAM2029 (octreotide subcutaneous depot), CAM2029, Matching placebo, placebo | Camurus AB | Acromegaly | 05/23 | 05/23 | | |
| Active, not recruiting | 3 | 58 | Europe, US, RoW | Paltusotine, CRN00808, Placebo | Crinetics Pharmaceuticals Inc. | Acromegaly | 07/23 | 06/27 | | |
| Active, not recruiting | 3 | 111 | Europe, US, RoW | Paltusotine, CRN00808, Placebo | Crinetics Pharmaceuticals Inc. | Acromegaly | 01/24 | 01/28 | | |
| Active, not recruiting | 3 | 135 | Europe, US, RoW | CAM2029 (octreotide subcutaneous depot), CAM2029 | Camurus AB | Acromegaly | 06/25 | 06/25 | | |
2005-004300-36: Use of somatostatin analogue therapy as primary medical treatment of acromegaly |
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| Ongoing | 2 | 10 | Europe | Somatuline Autogel, Somatuline Autogel 60mg, Somatuline Autogel 90mg, Somatuline Autogel 120mg, Somatuline Autogel 60mg, Somatuline Autogel 90mg, Somatuline Autogel 120mg | Plymouth Hospital NHS Trust, R&D dept | Acromegaly | | | | |
| Completed | 2 | 34 | Europe, US, RoW | GHR-LRX, ISIS 766720 | Ionis Pharmaceuticals, Inc. | Acromegaly | 07/22 | 05/23 | | |
NCT04261712 / 2019-002193-31: A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance) |
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| Active, not recruiting | 2 | 43 | Europe, US, RoW | Paltusotine, CRN00808 | Crinetics Pharmaceuticals Inc. | Acromegaly | 03/28 | 03/28 | | |
ACTRN12620001261909p: A First-in-Human Study of a Controlled Release Formulation of Lanreotide acetate in healthy male volunteers |
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| Not yet recruiting | 1 | 16 | | | Ascil Australia Pty LTD, Ascil Australia Pty LTD | Acromegaly; Neuroendocrine Tumours | | | | |
ACTRN12620001261909: A First-in-Human Study of a Controlled Release Formulation of Lanreotide acetate in healthy male volunteers |
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| Recruiting | 1 | 16 | | | Ascil Australia Pty LTD, Ascil Australia Pty LTD | Acromegaly, Neuroendocrine Tumours | | | | |
ACTRN12624000390583: Phase I, open-label, sequential-group, three-cohort study to evaluate the pharmacokinetic profile, the safety and the tolerability of a single injection of lanreotide Extended-Release Formulation (ERF) at doses of 120 mg and 240 mg in healthy volunteers |
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| Recruiting | 1 | 36 | | | Ascil Australia, Ascil Australia Pty Ltd | Acromegaly, Neuroendocrine Tumour | | | | |
ACTRN12622000491763: A Phase 1, Open Label, Randomized, Two-Period, Crossover Study to Evaluate the Relative Bioavailability of Two Paltusotine Tablet Strengths in Healthy Volunteers |
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| Completed | 1 | 12 | | | Crinetics Australia Pty Ltd, Crinetics Australia Pty Ltd | Acromegaly | | | | |
ACTRN12622000704796: A Phase 1, Open-label, Multi-Period, Single Sequence Study to Evaluate the Relative Bioavailability, Performance, and Safety of Two Solid Oral Doses (Paltusotine Tablets) in Healthy Volunteers |
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| Completed | 1 | 14 | | | Crinetics Australia Pty Ltd, Crinetics Australia Pty Ltd | Acromegaly | | | | |
NCT05761431: A Single-dose Study of Octreotide Injection in Healthy Adult Subjects |
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| Completed | 1 | 56 | RoW | SYHX2008 injection, Octreotide Acetate Microspheres for Injection injection, Sandostatin ® injection, Placebo to SYHX2008 injection | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | Acromegaly | 06/23 | 06/23 | | |
NCT06372652: A Phase 1 Study of TE-8214 Solution in Healthy Volunteers |
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| Active, not recruiting | 1 | 32 | RoW | TE-8214 - SAD, Placebo | Immunwork, Inc. | Acromegaly | 10/24 | 01/25 | | |
OXTEND-01, NCT05364944: A Study to Assess the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Debio 4126 in Participants With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) |
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| Terminated | 1 | 20 | Europe, RoW | Debio 4126, Sandostatin LAR, Octreotide acetate, Somatuline ATG, Lanreotide acetate | Debiopharm International SA | Acromegaly, GEP-NET | 10/24 | 12/24 | | |
ChiCTR1900021359: Dynamic facial changes in patients with acromegaly before and after surgery: Prospective controlled study based on 3D Facial Analysis |
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| Not yet recruiting | N/A | 33 | | NA | Chinese Academy of Medical Sciences Peking Union Medical College Hospital; Chinese Academy of Medical Sciences Peking Union Medical College Hospital, self-funded | acromegaly | | | | |
NCT04520646: A Pilot Study of Empagliflozin in the Treatment of Acromegalic Cardiomyopathy |
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| Recruiting | N/A | 10 | RoW | Empagliflozin | Huashan Hospital | Acromegaly, Cardiomyopathies | 08/21 | 08/22 | | |
NCT04420000: Effects of Mindfulness Therapy in Patients With Acromegaly and Cushing |
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| Completed | N/A | 60 | Europe | Mindfulness, Control | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, A.O. Ospedale Papa Giovanni XXIII, Consorcio Centro de Investigación Biomédica en Red (CIBER) | Patient Satisfaction | 09/21 | 10/21 | | |
NCT04529356: The TMS Treatment for Postoperative Headache in GH Tumor |
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| Not yet recruiting | N/A | 200 | NA | Transcranial magnetic stimulation, Acetaminophen | Huashan Hospital | Headache, Pituitary Tumor, Acromegaly | 09/21 | 09/22 | | |
| Recruiting | N/A | 50 | RoW | | Seoul National University Hospital | Sleep Apnea | 12/21 | 12/21 | | |
NCT03042026: Developing a Simple Recognition System of Acromegaly |
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| Recruiting | N/A | 80 | RoW | | National Taiwan University Hospital | Acromegaly | 06/22 | 06/27 | | |
| Recruiting | N/A | 20 | Europe | | University of Aarhus | Acromegaly, Growth Hormone Treatment, Sleep Apnea, Cardiovascular Diseases, Bone Diseases | 12/22 | 12/22 | | |
| Not yet recruiting | N/A | 110 | Europe | Performed 3 diagnostic tests (2 OGTT tests with 75 g of Glucose and 1 placebo test with 375 mg of Aspartam, Performed 2 diagnostic tests (2 OGTT tests with 75g of Glucose) | Assistance Publique - Hôpitaux de Paris | Acromegaly | 12/22 | 12/22 | | |
| Completed | N/A | 102 | Europe | Lanreotide autogel, Somatostatin Receptor ligand | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acromegaly | 01/24 | 07/24 | | |
NCT06344650: Cellular, Molecular and Clinical Determinants of Bone Strength in in Vivo and Human Models of GH Excess. |
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| Recruiting | N/A | 100 | Europe | Blood sample, Radiological tests, Questionnaires | IRCCS San Raffaele, Fondazione Policlinico Universitario Campus Bio-Medico, Istituto Auxologico Italiano | Acromegaly | 10/24 | 04/26 | | |
| Active, not recruiting | N/A | 500 | Europe | Acrodat software | University of Aarhus | Acromegaly | 10/23 | 02/25 | | |
NCT03807076: Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor |
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| Completed | N/A | 25 | Europe | GIP-A, Placebo | University of Copenhagen, Rigshospitalet, Denmark, Aarhus University Hospital, Aalborg University Hospital, Odense University Hospital, Herlev and Gentofte Hospital | Acromegaly Due to Pituitary Adenoma | 06/23 | 11/23 | | |
| Completed | N/A | 62 | Europe | | University of Roma La Sapienza | Acromegaly | 12/24 | 12/24 | | |
NCT03043586: Treatment Patterns and Treatment Outcomes for Acromegaly |
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| Active, not recruiting | N/A | 520 | US | | Columbia University, Ipsen | Acromegaly | 07/25 | 07/25 | | |
ChiCTR2100051015: Prediction of difficult airways in patients with acromegaly by preoperative magnetic resonance imaging |
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| Recruiting | N/A | | | | Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, none | acromegaly | | | | |
NCT05184231: Patient and Physician Survey on Satisfaction With Somatostatin Analogue (SSA) Injections in Acromegaly in China |
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| Withdrawn | N/A | 216 | NA | | Ipsen | Acromegaly | 10/23 | 10/23 | | |
NCT00001595: An Investigation of Pituitary Tumors and Related Hypothalmic Disorders |
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| Recruiting | N/A | 2000 | US | MRI, Tissue specimen collection | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Panhypopituitarism, Gigantism/Acromegaly, Prolactinoma, Cushing Disease | | | | |
RAPSODIA, NCT06597383: The RApid Switch From 1st Generation Somatostatin Analogues to PaSireOtiDe In Acromegaly |
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| Recruiting | N/A | 100 | Europe | | IRCCS San Raffaele, University of Turin, Italy, University of Padova, Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acromegaly | 11/24 | 11/24 | | |
NCT00921609: Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly |
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| Active, not recruiting | N/A | 20 | US | Oral glucose tolerance test | Cedars-Sinai Medical Center | Acromegaly | 04/25 | 04/25 | | |
| Recruiting | N/A | 30 | Europe | Medical surgery therapy | Istituto Auxologico Italiano, Politecnico di Milano | Acromegaly | 12/25 | 12/25 | | |
BackSOM, NCT06253897: A Study to Understand Participant's Experiences in Gastro-enteropancreatic Neuroendocrine Tumors (GEP-NETs) and Acromegaly |
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| Completed | N/A | 20 | US | | Ipsen | Gastro-enteropancreatic Neuroendocrine Tumor, Acromegaly | 12/24 | 12/24 | | |
ChiCTR2300072503: Assessment of cardiac structure and function by cardiac magnetic resonance imaging in acromegaly |
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| Recruiting | N/A | 60 | | no | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Discipline Excellence Development 1·3·5 Project of West China Hospital of Sichuan University (No: 2020HXFH034) | acromegaly | | | | |
NCT06326853: Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models |
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| Not yet recruiting | N/A | 200 | NA | | IRCCS San Raffaele | Endocrine Disorders, Adiposity, Pituitary Adenoma, Cushing Syndrome, Acromegaly, Hypopituitarism | 07/24 | 12/26 | | |
ChiCTR2300070856: Clinical study of speckle tracking imaging in early damage and prognosis assessment of acromegaly cardiomyopathy |
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| Recruiting | N/A | | | | 183 Xinqiao Zhengjie, Shapingba District, Chongqing; Xinqiao Hospital，Army Medical University, Chongqing Municipal Health Commission | Acromegaly cardiomyopathy | | | | |
NCT05431803: Real-World Study (RWS) of Lanreotide Autogel (LAN) for the Treatment of Patients With Acromegaly in China |
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| Completed | N/A | 129 | RoW | | Ipsen | Acromegaly | 12/24 | 12/24 | | |
| Recruiting | N/A | 1600 | RoW | Dynamic hormone study and Magnetic resonance imaging | Seoul National University Hospital | Pituitary Disease, Pituitary Incidentaloma, Acromegaly, Central Diabetes Insipidus, Pituitary Stalk Compression Hyperprolactinaemia, Cushing's Disease, Pituitary Tumor, Prolactinoma | 02/25 | 02/25 | | |
| Completed | N/A | 34 | Europe | HR-pQCT, High Resolution peripheral Quantitative Computed Tomography, DXA scan, Dual X-ray Absorptiometry, Bone microindentation, OsteoProbe, Hand grip and leg extension strength, Timed up-and-go test, Stabilometry, Balance board, Nerve conduction test, Visual acuity test | Christian Alexander H Rosendal, Ipsen, Pfizer | Acromegaly | 05/24 | 05/24 | | |
| Recruiting | N/A | 9 | US | Diet | Cedars-Sinai Medical Center | Acromegaly | 03/25 | 03/25 | | |
ChiCTR2400090129: To establish an evaluation model of acromegaly disease activity based on doctor-patient co-reporting, and to explore a new model of precision diagnosis and treatment and whole-process management |
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| Recruiting | N/A | 300 | | NA; NA; NA | Peking Union Medical College Hospital; Peking Union Medical College Hospital, Clinical Research Special Project of the Central High-level Hospital of Peking Union Medical College Hospital 2022-PUMCH-A-155 | Acromegaly | | | | |
| Not yet recruiting | N/A | 371 | | no | The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University, Subject of your choice | Pituitary adenoma, acromegaly, prolactinemia, ACTH adenoma, TSH adenoma | | | | |
NCT01809808: A Prospective Study of Outcome After Therapy for Acromegaly |
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| Active, not recruiting | N/A | 250 | US | Surgery for acromegaly, Medications for acromegaly, Drugs used to lower growth hormone, Total body magnetic resonance imaging, Adipose Tissue Biopsy | Columbia University, Icahn School of Medicine at Mount Sinai, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Acromegaly | 06/25 | 06/25 | | |
| Not yet recruiting | N/A | 12 | Europe | Usual clinical practice + hypoproteic diet | Azienda Ospedaliero Universitaria Maggiore della Carita | Acromegaly | 12/25 | 03/26 | | |
NCT05131100: Korean Regulatory Post Marketing Surveillance for Somavert |
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| Recruiting | N/A | 100 | RoW | Somavert | Pfizer | Acromegaly | 09/26 | 09/26 | | |
NCT03158090: The Longitudinal Approach to Acromegaly: A Pattern of Treatment and Comparative Effectiveness Research |
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| Recruiting | N/A | 1965 | RoW | Transnasal butterfly surgery, sandostatin, Lanreotide, radiotherapy | Ginkgo Leaf Center for Rare Disorders | Acromegaly | 12/50 | 01/51 | | |
| Recruiting | N/A | 1965 | | Surgery such as Transnasal butterfly surgery ;Drug treatment includes somatostatin analogues (SSA), dopamine receptor agonists and GH receptor antagonists ;Conventional radiotherapy methods include radiotherapy, linear accelerator X knife, gamma knife | Huiwen Tan, Zhiyong Chen; 1 Affiliated Hospital of Jinan University, Personal donation, Public donation, Fund application | Acromegaly | | | | |
ChiCTR2100049382: A single-center, retrospective+prospective, observational study to understand the clinical profile and cost-effectiveness of acromegaly in a real-world clinical setting |
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| Not yet recruiting | N/A | 300 | | None ;None ;None | The First Affiliated Hospital of Ji'nan University; The First Affiliated Hospital of Ji'nan University, self-raised | Acromegaly | | | | |
NCT00461188: Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA |
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| Recruiting | N/A | 10000 | Europe | | Barts & The London NHS Trust | Acromegaly, Gigantism, Familial Isolated Pituitary Adenoma, FIPA, Pituitary Adenoma Predisposition, PAP | 04/99 | 04/99 | | |
ACTRN12605000445673: Protein turnover and energy expenditure in normal subjects, growth hormone deficiency, acromegaly and Cushing's syndrome |
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| Recruiting | N/A | 80 | | | St Vincent's Hospital, NHMRC | Normal subjects, GH deficiency, Acromegaly, Cushing's syndrome | | | | |
NCT04860037: Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients |
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| Recruiting | N/A | 250 | Europe | | University Hospital, Montpellier | Acromegaly | 04/22 | 12/22 | | |
STOP-SST, NCT05149495: Somatostatin Analogues in the Treatment of Relapsing GH Pituitary Adenomas After Surgery |
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| Recruiting | N/A | 100 | Europe | | University Hospital, Strasbourg, France | Acromegaly | 03/23 | 03/23 | | |
